CN104903327B - 用于治疗疼痛的作为autotaxin抑制剂的吡啶并-或吡咯并-稠合嘧啶衍生物 - Google Patents

用于治疗疼痛的作为autotaxin抑制剂的吡啶并-或吡咯并-稠合嘧啶衍生物 Download PDF

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Publication number
CN104903327B
CN104903327B CN201480004482.6A CN201480004482A CN104903327B CN 104903327 B CN104903327 B CN 104903327B CN 201480004482 A CN201480004482 A CN 201480004482A CN 104903327 B CN104903327 B CN 104903327B
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CN
China
Prior art keywords
mmol
dihydro
ylamino
inden
pyrimidin
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Expired - Fee Related
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CN201480004482.6A
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English (en)
Chinese (zh)
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CN104903327A (zh
Inventor
T.J.博尚
稻茵
S.B.琼斯
B.H.诺尔曼
L.A.普菲菲尔
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Eli Lilly and Co
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Eli Lilly and Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
CN201480004482.6A 2013-01-11 2014-01-07 用于治疗疼痛的作为autotaxin抑制剂的吡啶并-或吡咯并-稠合嘧啶衍生物 Expired - Fee Related CN104903327B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361751363P 2013-01-11 2013-01-11
US61/751363 2013-01-11
US201361777201P 2013-03-12 2013-03-12
US61/777201 2013-03-12
PCT/US2014/010400 WO2014110000A1 (en) 2013-01-11 2014-01-07 Pyrido- or pyrrolo-fused pyrimidine derivatives as autotaxin inhibitors for treating pain

Publications (2)

Publication Number Publication Date
CN104903327A CN104903327A (zh) 2015-09-09
CN104903327B true CN104903327B (zh) 2016-09-07

Family

ID=50031555

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480004482.6A Expired - Fee Related CN104903327B (zh) 2013-01-11 2014-01-07 用于治疗疼痛的作为autotaxin抑制剂的吡啶并-或吡咯并-稠合嘧啶衍生物

Country Status (13)

Country Link
US (1) US8969555B2 (enExample)
EP (1) EP2943494B1 (enExample)
JP (1) JP6285461B2 (enExample)
KR (1) KR101757997B1 (enExample)
CN (1) CN104903327B (enExample)
AU (1) AU2014205642B2 (enExample)
BR (1) BR112015015812A2 (enExample)
CA (1) CA2893253C (enExample)
EA (1) EA025106B1 (enExample)
ES (1) ES2636248T3 (enExample)
MX (1) MX2015008971A (enExample)
TW (1) TWI499591B (enExample)
WO (1) WO2014110000A1 (enExample)

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TW201500356A (zh) * 2013-04-12 2015-01-01 Lilly Co Eli 二氫吡啶并嘧啶化合物
HRP20210957T1 (hr) 2013-11-22 2021-09-17 Sabre Therapeutics Llc Spojevi inhibitori autotaksina
US9051320B1 (en) 2014-08-18 2015-06-09 Pharmakea, Inc. Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor
GB201501870D0 (en) 2015-02-04 2015-03-18 Cancer Rec Tech Ltd Autotaxin inhibitors
GB201502020D0 (en) 2015-02-06 2015-03-25 Cancer Rec Tech Ltd Autotaxin inhibitory compounds
EP4026549A1 (en) 2015-05-27 2022-07-13 Sabre Therapeutics LLC Autotaxin inhibitors and uses thereof
WO2016197009A1 (en) 2015-06-05 2016-12-08 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of demyelinating diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
US10961242B2 (en) 2017-05-17 2021-03-30 Legochem Biosciences, Inc. Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
KR101798840B1 (ko) 2017-05-17 2017-11-17 주식회사 레고켐 바이오사이언스 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물
EP3805234B1 (en) * 2018-05-24 2024-09-04 Guangzhou Henovcom Bioscience Co., Ltd. Aromatic heterocyclic compound, and pharmaceutical composition and use thereof
EP3823620A4 (en) * 2018-07-16 2022-09-14 The Scripps Research Institute OPIOID HAPTENES, CONJUGATES, VACCINES AND METHODS OF GENERATING ANTIBODIES
CA3126176C (en) * 2019-02-01 2023-08-29 Wuhan Humanwell Innovative Drug Research and Development Center Limited Company Pyrrolopyrimidine derivative and use thereof
IL291114B2 (en) * 2019-09-06 2025-09-01 Wuhan Humanwell Innovative Drug Res And Development Center Limited Company Pyrimidine compound and method for preparing same
US20220411388A1 (en) * 2019-09-17 2022-12-29 Bial - R&D Investments, S.A. Substituted imidazole carboxamides and their use in the treatment of medical disorders
CN112778334B (zh) * 2019-11-07 2022-04-15 广州市恒诺康医药科技有限公司 芳杂环化合物、其药物组合物及其应用
TW202128682A (zh) * 2019-12-11 2021-08-01 大陸商四川海思科製藥有限公司 含氮雜環類自分泌運動因子抑制劑及其組合物和用途
CN113943296B (zh) * 2020-07-16 2025-07-04 武汉人福创新药物研发中心有限公司 吡咯并嘧啶衍生物及其应用
CN113943295B (zh) * 2020-07-16 2025-08-12 武汉人福创新药物研发中心有限公司 吡咯并嘧啶类化合物及其用途
EP4190783A4 (en) * 2020-07-28 2024-08-07 Wuhan Humanwell Innovative Drug Research and Development Center Limited Company SALTS OF A NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND SOLID FORMS OF SALTS, PHARMACEUTICAL COMPOSITION AND USE THEREOF
TW202214644A (zh) * 2020-07-28 2022-04-16 大陸商武漢人福創新藥物研發中心有限公司 含氮雜環化合物的固體形式及其藥物組合物和用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001032632A2 (en) * 1999-11-01 2001-05-10 Eli Lilly And Company Pharmaceutically active 4-substituted pyrimidine derivatives
WO2006119504A2 (en) * 2005-05-04 2006-11-09 Renovis, Inc. Fused heterocyclic compounds, and compositions and uses thereof
US20070249631A1 (en) * 2004-04-28 2007-10-25 Gruenenthal Gmbh Substituted 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl compounds and 5,6,7,8-tetrahydroquinazoline-2-yl compounds
WO2012009258A2 (en) * 2010-07-13 2012-01-19 Edward Roberts Peptidomimetic galanin receptor modulators
WO2012085167A1 (en) * 2010-12-22 2012-06-28 Merz Pharma Gmbh & Co. Kgaa Metabotropic glutamate receptor modulators

Family Cites Families (7)

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EP1552842A1 (en) 2002-06-07 2005-07-13 Kyowa Hakko Kogyo Co., Ltd. Bicyclic pyrimidine derivatives
CA2745041C (en) * 2008-12-01 2017-08-22 Kai Schiemann 2, 5-diamino-substituted pyrido [4, 3-d] pyrimidines as autotaxin inhibitors against cancer
US9000025B2 (en) * 2010-08-20 2015-04-07 Amira Pharmaceuticals, Inc. Autotaxin inhibitors and uses thereof
WO2013054185A1 (en) * 2011-10-13 2013-04-18 Pfizer, Inc. Pyrimidine and pyridine derivatives useful in therapy
ES2748656T3 (es) * 2011-10-28 2020-03-17 Inhibitaxin Ltd Derivados de piridazina útiles en terapia
TW201520219A (zh) * 2013-03-12 2015-06-01 Lilly Co Eli 咪唑並吡啶化合物
TW201500356A (zh) * 2013-04-12 2015-01-01 Lilly Co Eli 二氫吡啶并嘧啶化合物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001032632A2 (en) * 1999-11-01 2001-05-10 Eli Lilly And Company Pharmaceutically active 4-substituted pyrimidine derivatives
US20070249631A1 (en) * 2004-04-28 2007-10-25 Gruenenthal Gmbh Substituted 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl compounds and 5,6,7,8-tetrahydroquinazoline-2-yl compounds
WO2006119504A2 (en) * 2005-05-04 2006-11-09 Renovis, Inc. Fused heterocyclic compounds, and compositions and uses thereof
WO2012009258A2 (en) * 2010-07-13 2012-01-19 Edward Roberts Peptidomimetic galanin receptor modulators
WO2012085167A1 (en) * 2010-12-22 2012-06-28 Merz Pharma Gmbh & Co. Kgaa Metabotropic glutamate receptor modulators

Also Published As

Publication number Publication date
TW201437209A (zh) 2014-10-01
AU2014205642A1 (en) 2015-07-02
EP2943494A1 (en) 2015-11-18
JP2016505010A (ja) 2016-02-18
WO2014110000A1 (en) 2014-07-17
ES2636248T3 (es) 2017-10-05
KR20150092761A (ko) 2015-08-13
TWI499591B (zh) 2015-09-11
CA2893253A1 (en) 2014-07-17
EP2943494B1 (en) 2017-02-22
KR101757997B1 (ko) 2017-07-13
US8969555B2 (en) 2015-03-03
CA2893253C (en) 2017-11-28
BR112015015812A2 (pt) 2017-07-11
CN104903327A (zh) 2015-09-09
MX2015008971A (es) 2015-09-28
EA025106B1 (ru) 2016-11-30
EA201591098A1 (ru) 2015-11-30
JP6285461B2 (ja) 2018-02-28
AU2014205642B2 (en) 2016-02-25
US20140200231A1 (en) 2014-07-17

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Granted publication date: 20160907