MX2015008971A - Derivados de pirimidina pirido- o pirrolo-fusionados como inhibidores de autotaxina para tratar dolor. - Google Patents
Derivados de pirimidina pirido- o pirrolo-fusionados como inhibidores de autotaxina para tratar dolor.Info
- Publication number
- MX2015008971A MX2015008971A MX2015008971A MX2015008971A MX2015008971A MX 2015008971 A MX2015008971 A MX 2015008971A MX 2015008971 A MX2015008971 A MX 2015008971A MX 2015008971 A MX2015008971 A MX 2015008971A MX 2015008971 A MX2015008971 A MX 2015008971A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrido
- pyrrolo
- pyrimidine derivatives
- treating pain
- autotaxin inhibitors
- Prior art date
Links
- 102100021977 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Human genes 0.000 title abstract 2
- 108050004000 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361751363P | 2013-01-11 | 2013-01-11 | |
| US201361777201P | 2013-03-12 | 2013-03-12 | |
| PCT/US2014/010400 WO2014110000A1 (en) | 2013-01-11 | 2014-01-07 | Pyrido- or pyrrolo-fused pyrimidine derivatives as autotaxin inhibitors for treating pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2015008971A true MX2015008971A (es) | 2015-09-28 |
Family
ID=50031555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015008971A MX2015008971A (es) | 2013-01-11 | 2014-01-07 | Derivados de pirimidina pirido- o pirrolo-fusionados como inhibidores de autotaxina para tratar dolor. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8969555B2 (enExample) |
| EP (1) | EP2943494B1 (enExample) |
| JP (1) | JP6285461B2 (enExample) |
| KR (1) | KR101757997B1 (enExample) |
| CN (1) | CN104903327B (enExample) |
| AU (1) | AU2014205642B2 (enExample) |
| BR (1) | BR112015015812A2 (enExample) |
| CA (1) | CA2893253C (enExample) |
| EA (1) | EA025106B1 (enExample) |
| ES (1) | ES2636248T3 (enExample) |
| MX (1) | MX2015008971A (enExample) |
| TW (1) | TWI499591B (enExample) |
| WO (1) | WO2014110000A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201500356A (zh) * | 2013-04-12 | 2015-01-01 | Lilly Co Eli | 二氫吡啶并嘧啶化合物 |
| PE20160654A1 (es) | 2013-11-22 | 2016-07-15 | Pharmakea Inc | Compuestos de inhibidor de autotaxina |
| US9051320B1 (en) | 2014-08-18 | 2015-06-09 | Pharmakea, Inc. | Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| CN116059203A (zh) | 2015-05-27 | 2023-05-05 | 赛博治疗有限责任公司 | 自分泌运动因子抑制剂及其用途 |
| US10118904B2 (en) | 2015-06-05 | 2018-11-06 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of Demyelinating Diseases |
| WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| KR101798840B1 (ko) | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
| US10961242B2 (en) | 2017-05-17 | 2021-03-30 | Legochem Biosciences, Inc. | Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same |
| JP7274767B2 (ja) * | 2018-05-24 | 2023-05-17 | ▲広▼州市恒▲諾▼康医▲薬▼科技有限公司 | 芳香族複素環式化合物及びその医薬組成物 |
| US20220081400A1 (en) * | 2018-07-16 | 2022-03-17 | The Scripps Research Institute | Opioid haptens, conjugates, vaccines, and methods of generating antibodies |
| KR102629358B1 (ko) * | 2019-02-01 | 2024-01-24 | 우한 휴먼웰 이노베이티브 드러그 리서치 앤드 디벨롭먼트 센터 리미티드 컴퍼니 | 피롤로피리미딘 유도체 및 그의 용도 |
| CA3149062A1 (en) * | 2019-09-06 | 2021-03-11 | Xuejun Zhang | Pyrimidine compound and preparation method therefor |
| CA3150700A1 (en) * | 2019-09-17 | 2021-03-25 | Renato T. Skerlj | IMIDAZOLE SUBSTITUTE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| WO2021088957A1 (zh) * | 2019-11-07 | 2021-05-14 | 广州市恒诺康医药科技有限公司 | 芳杂环化合物、其药物组合物及其应用 |
| US20230069174A1 (en) * | 2019-12-11 | 2023-03-02 | Sichuan Haisco Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic autotaxin inhibitor, and composition containing same and use thereof |
| CN113943296B (zh) * | 2020-07-16 | 2025-07-04 | 武汉人福创新药物研发中心有限公司 | 吡咯并嘧啶衍生物及其应用 |
| CN113943295B (zh) * | 2020-07-16 | 2025-08-12 | 武汉人福创新药物研发中心有限公司 | 吡咯并嘧啶类化合物及其用途 |
| TWI894325B (zh) * | 2020-07-28 | 2025-08-21 | 大陸商武漢人福創新藥物研發中心有限公司 | 含氮雜環化合物的鹽及其鹽的固體形式、藥物組合物和用途 |
| CN113999235B (zh) * | 2020-07-28 | 2025-06-10 | 武汉人福创新药物研发中心有限公司 | 含氮杂环化合物的固体形式及其药物组合物和用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SV2002000205A (es) | 1999-11-01 | 2002-06-07 | Lilly Co Eli | Compuestos farmaceuticos ref. x-01095 |
| AU2003242252A1 (en) | 2002-06-07 | 2003-12-22 | Kyowa Hakko Kogyo Co., Ltd. | Bicyclic pyrimidine derivatives |
| DE102004020908A1 (de) | 2004-04-28 | 2005-11-17 | Grünenthal GmbH | Substituierte 5,6,7,8,-Tetrahydro-pyrido[4,3-d]pyrimidin-2-yl- und 5,6,7,8,-Tetrahydro-chinazolin-2-yl-Verbindungen |
| JP5198256B2 (ja) * | 2005-05-04 | 2013-05-15 | エボテク エージー | 縮合複素環式化合物、並びにそれらの組成物及び使用 |
| US8530650B2 (en) * | 2008-12-01 | 2013-09-10 | Merck Patent Gmbh | 2, 5-diamino-substituted pyrido [4, 3-D] pyrimidines as autotaxin inhibitors against cancer |
| WO2012009258A2 (en) * | 2010-07-13 | 2012-01-19 | Edward Roberts | Peptidomimetic galanin receptor modulators |
| EP2606031B1 (en) * | 2010-08-20 | 2017-09-27 | Amira Pharmaceuticals, Inc. | Autotaxin inhibitors and uses thereof |
| AR084515A1 (es) * | 2010-12-22 | 2013-05-22 | Merz Pharma Gmbh & Co Kgaa | Derivados heterociclicos nitrogenados, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades asociadas al sistema nervioso central tales como parkinson y alzheimer, entre otras |
| WO2013054185A1 (en) * | 2011-10-13 | 2013-04-18 | Pfizer, Inc. | Pyrimidine and pyridine derivatives useful in therapy |
| EP3243815B1 (en) * | 2011-10-28 | 2019-07-10 | Inhibitaxin Limited | Pyridazine derivatives useful in therapy |
| TW201520219A (zh) * | 2013-03-12 | 2015-06-01 | Lilly Co Eli | 咪唑並吡啶化合物 |
| TW201500356A (zh) * | 2013-04-12 | 2015-01-01 | Lilly Co Eli | 二氫吡啶并嘧啶化合物 |
-
2013
- 2013-12-30 TW TW102149122A patent/TWI499591B/zh active
-
2014
- 2014-01-07 CN CN201480004482.6A patent/CN104903327B/zh not_active Expired - Fee Related
- 2014-01-07 EA EA201591098A patent/EA025106B1/ru not_active IP Right Cessation
- 2014-01-07 KR KR1020157018295A patent/KR101757997B1/ko not_active Expired - Fee Related
- 2014-01-07 WO PCT/US2014/010400 patent/WO2014110000A1/en not_active Ceased
- 2014-01-07 JP JP2015552726A patent/JP6285461B2/ja not_active Expired - Fee Related
- 2014-01-07 EP EP14702336.0A patent/EP2943494B1/en active Active
- 2014-01-07 CA CA2893253A patent/CA2893253C/en not_active Expired - Fee Related
- 2014-01-07 ES ES14702336.0T patent/ES2636248T3/es active Active
- 2014-01-07 MX MX2015008971A patent/MX2015008971A/es unknown
- 2014-01-07 AU AU2014205642A patent/AU2014205642B2/en not_active Ceased
- 2014-01-07 BR BR112015015812A patent/BR112015015812A2/pt not_active IP Right Cessation
- 2014-01-07 US US14/148,775 patent/US8969555B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2893253C (en) | 2017-11-28 |
| KR101757997B1 (ko) | 2017-07-13 |
| AU2014205642B2 (en) | 2016-02-25 |
| AU2014205642A1 (en) | 2015-07-02 |
| JP6285461B2 (ja) | 2018-02-28 |
| ES2636248T3 (es) | 2017-10-05 |
| BR112015015812A2 (pt) | 2017-07-11 |
| TWI499591B (zh) | 2015-09-11 |
| EA025106B1 (ru) | 2016-11-30 |
| US8969555B2 (en) | 2015-03-03 |
| TW201437209A (zh) | 2014-10-01 |
| EP2943494A1 (en) | 2015-11-18 |
| CN104903327B (zh) | 2016-09-07 |
| EA201591098A1 (ru) | 2015-11-30 |
| CN104903327A (zh) | 2015-09-09 |
| EP2943494B1 (en) | 2017-02-22 |
| JP2016505010A (ja) | 2016-02-18 |
| CA2893253A1 (en) | 2014-07-17 |
| US20140200231A1 (en) | 2014-07-17 |
| KR20150092761A (ko) | 2015-08-13 |
| WO2014110000A1 (en) | 2014-07-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TN2011000400A1 (en) | Inhibitors of beta-secretase | |
| NZ708909A (en) | Substituted reverse pyrimidine bmi-1 inhibitors | |
| MX2011009034A (es) | Formas de profarmaco de inhibidores de cinasa y su uso en la terapia. | |
| PH12016501822A1 (en) | Cyclopropaneamine compound | |
| NZ718055A (en) | Substituted pyrimidine bmi-1 inhibitors | |
| PH12014500883A1 (en) | Uracil derivatives as axl and c-met kinase inhibitors | |
| MX2012003499A (es) | Inhibidores de demetilasa-1 especificos de lisina y su uso. | |
| PH12016501440A1 (en) | Novel heterocyclic compounds | |
| JO3398B1 (ar) | مشتقات 2،3- ثانى هيدرو- بنزو[1,4] أوكسازين والمركبات المتعلقة بها كمثبطات كيناز فسفواينوسيتيد-3 (pi3k) لمعالجة على سبيل المثال التهاب المفاصل الروماتيدي | |
| MY192109A (en) | Aminopyrimidinyl compounds as jak inhibitors | |
| CA2875877C (en) | Syk inhibitors | |
| EA201001619A1 (ru) | Ингибиторы протеинкиназ | |
| NZ732649A (en) | Picolinamides and related compounds | |
| MD20160105A2 (ro) | 2-Amino-6-metil-4,4a,5,6-tetrahidropirano[3,4-d][1,3]tiazin-8a(8H)-il-1,3-tiazol-4-il amide | |
| NZ712352A (en) | Novel inhibitors of glutaminyl cyclase | |
| EA201790713A1 (ru) | N-АЛКИЛАРИЛ-5-ОКСОАРИЛОКТАГИДРОЦИКЛОПЕНТА[c]ПИРРОЛЬНЫЕ НЕГАТИВНЫЕ АЛОСТЕРИЧЕСКИЕ МОДУЛЯТОРЫ NR2B | |
| MX2012006805A (es) | Indolil-piperidinil bencilaminas como inhibidores de beta-triptasa. | |
| BR112015015812A2 (pt) | derivados de pirimidina fundidos a pirido ou pirrolo como inibidores de autotaxina para tratamento de dor | |
| JO2741B1 (en) | Spiro-cyclic nitroblast as protease inhibitors | |
| MX341341B (es) | Derivados de benzamida y su uso como inhibidores de proteina de choque termico 90 kda (hsp90). | |
| MX2016007861A (es) | Compuestos de ácido dimetilbenzoico. | |
| JOP20190239A1 (ar) | مركبات مثبطة لـ vmat2 وتركيبات منها | |
| PH12019500839A1 (en) | Therapeutic compounds and methods of use thereof | |
| MX2010000658A (es) | Derivados de pirimidina 934. | |
| MX2018001992A (es) | Compuestos triciclicos heterociclicos como inhibidores de fosfoinositol 3-quinasa. |