CN104888347A

CN104888347A - Multi-channel nerve stimulation device and application thereof

Info

Publication number: CN104888347A
Application number: CN201510177588.2A
Authority: CN
Inventors: 徐志强
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-12-21
Filing date: 2015-04-15
Publication date: 2015-09-09
Anticipated expiration: 2035-04-15
Also published as: CN108273191A; CN108126274B; CN108273191B; CN108042916B; CN108126275B; CN108096705A; CN108379736A; CN108096705B; CN108079435A; CN108379736B; CN108187228B; CN104888349B; CN108079435B; CN108042916A; CN108126275A; CN108187228A; CN104888346A; CN104888349A; CN108175939A; CN104888346B

Abstract

A multi-channel nerve stimulation device comprises a host and a plurality of sets of output electrodes. The host comprises a pulse generation module and output modules and further comprises an output time sequence control circuit, and the output time sequence control circuit is used for controlling stimulation pulse signals output by the output modules so that stimulation pulses, relative to the a reference electrode, output by the output electrodes can have the sequent output time sequence relation. The pulse stimulation with the time sequence relation can be carried out on nerve cells at different joints on one neural pathway at the same time through the sets of output electrodes respectively, the neural pathway is forced to generate the continuable action potential firing with the signal directional transmission relation, and accordingly the multi-channel nerve stimulation device is applied to stimulating and recovering certain neural activities with physiological functions.

Description

Multi-channel nerve stimulating apparatus and application thereof

Technical field the present invention relates to the nerve stimulation device of cranial nerve medical field, and application technology.

Background technology is by carrying out electric pulse stimulation to the neuron of brain, and affect the nerves first activity, thus reach the object of some disease of brain for the treatment of, is the prior art in neuromedicine field.But applicant finds, the stimulation that prior art just isolates the neuron of some position mostly, affect these neuronic activities, such as stimulating some nerve nucleus, its function of nervous system is made to produce the change strengthening or weaken, or for intervening the signal transmission of nerve nucleus, the transmission such as intercepting pain signal reaches the object of electronics pain relieving.And to for starting certain concrete neural activity, especially to produce or change the continuable action potential granting between nerve nucleus with the directed transitive relation of signal, there is between neuron due to each neural link of brain centres nerve Nervons projection and signal transmission relation, so, existing isolated cranial nerve stimulating technology, dyschezia is to produce such technique effect, and applicant finds in some significant certain applications, often just need that there is such technique effect.And, prior art to the particular location of electricity irritation, apply the details etc. of mode and electric pulse without specific aim, the technology taked often is followed for being the same during peripheral nerve stimulation, but in fact, to the neuronic stimulation of maincenter, there is its particularity, such as, study according to the electric discharge of some neural circuiies of brain, be applied to neuronic electric pulse, frequency and pulse amplitude too low time cannot triggering action potentials electric discharge, frequency or pulse amplitude too high time then can to neuron signal transmission formed suppress, even make its inactivation.

Summary of the invention the present invention seeks to the multichannel nerve stimulation device of open one, is suitable for carrying out impulse stimulation to the neuron of the diverse location of some nervous pathway simultaneously, impels nervous pathway generation to have the action potential granting of the directed transitive relation of signal.

The present invention is also open to be optimized output signal, more effectively inducing neural unit can provide the technology of action potential.

The present invention discloses some application of above-mentioned nerve stimulation device simultaneously, comprises the transmission usefulness for strengthening some neurotransmission path, for waking degree of depth coma patient up, and for brain death activation at short notice.

Nerve stimulation device of the present invention, comprise main frame and the electrode being connected main frame, electrode includes ground electrode (or claiming reference electrode) and output electrode, main frame includes the pulses generation module for generation of stimulation pulse signal, connect each output module for stimulation pulse signal being outputted to output electrode of each output electrode, it is characterized in that: described output electrode includes the output electrode of more than two groups or two groups, (such as three groups of output electrodes); Main frame also includes output timing control circuit, for controlling the stimulation pulse signal that each output module exports, each output electrode is exported have relative to the boost pulse of reference electrode before and after the sequential relationship that exports successively.

Pulses generation module belongs to prior art, and the pulse produced can adopt square wave, triangular wave, trapezoidal wave or imitate the waveform of neuron action potential pulse.Pulse width T 0 is 0.5-10 milliseconds, is more suitably 1-5 milliseconds, is equivalent to the pulse width of neuron action potential.The pulse signal that each output electrode exports, relative to the current potential of reference electrode (being also ground electrode), the crest voltage amplitude of pulse signal, regulates between 20-1000 millivolts, enters neuronic state and different according to electrode contact locations and electrode.

Main frame of the present invention also comprises pulse period regulating circuit, the pulse period T of former and later two pulses exported for regulating same group of output electrode (first, second, and third output electrode).For different application, pulse period T is different, generally between 25 milliseconds to 1000 milliseconds, is 1-40 hertz, sees below described in applying portion corresponding to frequency.

Main frame of the present invention also comprises regulating circuit time delay, for regulating in the same pulse output cycle, and Ts time delay between former and later two pulses that former and later two electrodes (such as the first output electrode and the second output electrode) export.

Output timing control circuit is for controlling the work of each output module, the sequential relationship of the boost pulse that each group of output electrode is exported is: in a pulse period T, after last output electrode exports a boost pulse, through time delay of setting after Ts, a rear output electrode just exports a boost pulse.Concrete control method can be: pulses generation module produces a pulse signal, then after a time delay Ts, produce a pulse signal again, and then after a time delay Ts, produce a pulse signal again, sequential control circuit exports the gating that three output modules carry out successively, is exported successively by these three pulse signals from three output modules, thus respectively exports a pulse signal successively in three groups of output electrodes.(noticing that the output pulse frequency of at this moment pulses generation module is 3 times of output electrode output pulse frequency), such control belongs to common electronic technology, can be realized by simple MCU or digital circuit.

Nerve stimulation device of the present invention has organizes output electrode more, and each output electrode can export the stimulation pulse signal relative to reference electrode, and the sequential relationship that the stimulation pulse signal that each group output electrode exports exports before and after having successively.Use the present invention can be had the impulse stimulation of front and back sequential relationship respectively to the neuron of node different on a certain nervous pathway by each group of output electrode simultaneously, force nervous pathway generation to have the continuable action potential granting of the directed transitive relation of signal, thus can be applicable to excite and recover the neural activity that some has physiological function.(seeing below disclosed application of the present invention).

As a kind of important optimization, the present invention is also arranged accurately to the sequential relationship of this output pulse.Two groups of output electrode (such as first and second output electrodes before and after it, second and the 3rd output electrode) Ts time delay of two pulses that exports, with pulse period T, pulse width T 0, three has following relation: 0 < Ts < 1/2T-T0; Be expressed as: the time delay that two groups, front and back output electrode exports pulse is greater than 0, and is less than the value of " half of pulse period deducts a pulse width ".This set is based on the STDP synaptic plasticity principle of cranial nerve, (Spike Timing-Dependent Plasticity, the i.e. synaptic plasticity of Temporal dependency), its meaning is: to have the boost pulse of such sequential relationship, respectively impulse stimulation is carried out to the nerve nucleus of the different node in front and back on a certain nervous pathway, this nervous pathway not only can be forced in the process providing boost pulse to produce directed activation action, thus force the neural activity producing signal transmission, and, this impulse stimulation has specific sequential relationship, the synapse between the neuron of two groups, stimulated front and back can be made to transmit and to produce enhancement effect, improve synapse and transmit usefulness.So, such impulse stimulation, has stimulating neuronal and the directed effect improving synaptic plasticity between neuron simultaneously, is conducive to the signal transmission usefulness recovering nervous pathway self, thus recover its physiological function, so may be used for the rehabilitation of the nervous pathway of a few thing exception.

In the stimulating method stated on the invention and device, its output characteristics of carrying out the electric pulse string of neural stimulation is very important.So, applicant is carefully according to the specific works principle of neuron snapping motion current potential, three kinds of schemes be optimized the output signal of output electrode are disclosed, make output pulse signal can inducing neural unit snapping motion current potential more accurately, and this action potential can continue to provide, and the axoneuron being more conducive to irriate forms continuable signal transmission.

Of the present invention the first export prioritization scheme, comprising: described pulses generation module, with positive pulse outfan and negative pulse outfan, can export respectively relative to ground electrode is two kinds of pulse output signals of positive potential and nagative potential; (this can be produced by positive-negative power, is common electronic technology); Positive pulse and negative pulse two outfans are switched by change-over switch, and the output of change-over switch is re-used as the outfan of pulses generation module, is connected to each output module.Change-over switch can be mechanical switch or electrical switch.If be adopt the mode opening cranium when implementing brain stimulation, and adopt the patch-clamp or nerve microelectrode that are exclusively used in cranial nerve stimulation, output electrode can be thrust in the neuron membrane that will stimulate, then change-over switch can be switched to positive pulse outfan, make electrode output be connected to positive pulse outfan, at this moment output electrode is the pulse signal exporting positive potential.This mode is the ways customary that current laboratory carries out neuronal activation, can Induced by Stimulation neuron snapping motion current potential reliably, but microelectrode accurately will be thrust in target nerve unit film, obviously needs to carry out operation of opening cranium, extremely bothers.So, if change-over switch of the present invention is switched on negative pulse outfan, electrode output is made to be connected to negative pulse outfan, what at this moment output electrode exported is the pulse signal of nagative potential, can directly put on outside neuronic film, by dragging down film volta potential, relatively reduce film resting potential, and EAP.At this moment common electrode can be adopted, and on brainpan, open aperture or open aperture by nasal cavity or larynx deutomala, then under the cooperation of neuroendoscopy is assisted, output electrode inserted and be placed on the required target location stimulated, only need make outside the film of output electrode contact or close neurocyte, and without the need to accurately thrusting neuron, so more convenient to operate.

The second of the present invention exports prioritization scheme, for connecting the electrode output of each output electrode on main frame, and between the outfan of each output module (comprising the first output module, the second output module and the 3rd output module), be added with output control circuit, (more suitably, a resistor R also can be serially connected with, for cushioning and produce certain voltage difference) between the outfan and output control circuit of output module; Electrode output is also connected to the input of a voltage detecting circuit, and the outfan of voltage detecting circuit is connected to a voltage comparator circuit, compares with the output pulse signal from output module; The outfan of voltage comparator circuit is connected to the control end of output control circuit, is controlled by output control circuit paired pulses output signal.When the voltage signal of the electrode output that voltage detecting circuit detects, and the difference between the voltage signal that output module exports is greater than when setting numerical value, then close output control circuit, the output signal of output module to electrode output is closed, until next pulse period just reopens in the time of this pulse period remainder.Each output electrode that each output module connects to it, its control circuit is the same.

According to such output control program, during work, in each output pulse period of each output module, first output control circuit is opened, pulse output signals puts on neuron by electrode output and output electrode, voltage signal simultaneously on voltage detecting circuit detecting electrode outfan (being equivalent to output electrode), and compare with the pulse output signals of output module.When the pulse signal of output electrode acquires a certain degree to neuronic stimulation, neuron snapping motion current potential, produce ion overshot phenomenon, the current potential inside and outside film is caused to occur sharply changing, electrode output is delivered to by output electrode, cause the voltage on electrode output to occur larger fluctuation, and be that the pulse output signals exported with output module significantly changes asynchronous.This voltage pulsation is detected by voltage detecting circuit, and compared by voltage comparator circuit and pulse output signals, be identified as neuron snapping motion current potential, so the output of voltage comparator circuit closes output control circuit, the output of output module to electrode output is closed, until the next pulse cycle just reopens in the time of this pulse period remainder.Can make neuron after the outburst of action potential each time, no longer be subject to the stimulation of external pulse like this, film polarized state can be recovered, to prepare to carry out integration and snapping motion current potential again to stimulating next time, form the sustainable action potential granting carried out.This technical scheme, more meet the working mechanism of axoneure, can either inducing neural unit snapping motion current potential, inactivation can not be suppressed to cause neuron or sustain damage by overstimulation neuron again, EAP can be continued, form continuous print pulse to provide, and make neuronic ion motion and physiological function recover normal gradually.

Of the present invention the third exports prioritization scheme, electrode output for connecting each output electrode on main frame is connected with a voltage detecting circuit, (can share with the voltage detecting circuit of other technologies above), voltage detecting circuit is used for the background voltage of detecting electrode outfan, so also can be described as background voltage testing circuit, the output of voltage detecting circuit is connected with a voltage hold circuit, maintenance memory is carried out to the background voltage value that voltage detecting circuit exports, (be equivalent to voltage memory circuit, if circuit adopts analog circuit, electric capacity then can be adopted to coordinate discharge circuit to form, if circuit is digital circuit, then can directly remember its magnitude of voltage), the magnitude of voltage that voltage hold circuit exports is connected to a voltage overlaying circuit, the pulse output signals that each output module exports, superpose with background voltage in voltage overlaying circuit, be connected to electrode output.Voltage hold circuit, the work of voltage overlaying circuit and each output module, be subject to the control of a state switching circuit, (also can being controlled by the control circuit that main frame is total), specific works process is: carrying out cranial nerve stimulation at every turn, after ground electrode and output electrode are placed in target area, or when readjusting the position of output electrode and ground electrode in work, circuit working is switched in " detection " state by state switching circuit, close the output of output module, first by the voltage on voltage detecting circuit detecting electrode outfan, (the potential difference of this voltage also namely between current output electrode and ground electrode, also be background voltage, may be just also may be negative), its output voltage values is undertaken keeping (also namely remembering) by voltage hold circuit, and deliver on voltage overlaying circuit, afterwards, by state switching circuit, circuit working is switched to " output " state, close the input of voltage hold circuit, (magnitude of voltage of input before making the maintenance of its output voltage), open the work of output module, the pulse signal that output module exports, superposes with background voltage, is connected to electrode output in voltage overlaying circuit.Like this, the pulse signal that output electrode exports, just offsets the potential difference between two electrodes, can eliminate the impact of background voltage pulse signals stimulating effect.

Nerve stimulation device of the present invention has organizes output electrode more, and each group output electrode exports the boost pulse relative to reference electrode, and the sequential relationship that the boost pulse that each group output electrode exports exports before and after having successively.The present invention may be used for some Nervons projection path abnormal that works to brain centres nerve damage, the sensation input channel of such as audition, sense of touch, or some motorial output channel, different nerve nucleus for the front and back node to these nervous pathways have the impulse stimulation of front and back sequential relationship simultaneously, nervous pathway generation is forced to have the action potential granting of the directed transitive relation of signal, and strengthen its synapse transmission usefulness, thus recover the signal transfer function of these injured nerve paths.

The present invention also can be used for impaired perineural rehabilitation.Peripheral nerve comprises that somatic movement is neural and somesthesia neural, when being subject to fracture, mechanical trauma, excessively to oppress, pultrusion time, can be impaired and cause losing sensibility or the dyskinesia.Perineural regeneration capacity is comparatively strong, even if not carrying out that operation is most also can self-recovery, but generally needs time several months to recover gradually.The present invention is used to have the device of two groups of output electrodes, two groups of output electrodes are crossed over the both sides of nerve damage position around along the direction of nerve signal transmission, ground electrode contact skin, two sections, the front and back of injured nerve are had to the impulse stimulation of front and back sequential relationship, can analog neuron signal be passed through action, bring out and accelerate its neuranagenesis, greatly accelerate rehabilitation speed, and than adopting Sing plus to carry out the better effects if stimulated.

Below the special applications of the present invention at nervus centralis.Certainly, before these technology of use carry out nerve stimulation, must first eliminate the various cause of disease, repair wound, recover normal blood supply oxygen supply, improve the nursing such as microcirculation and trophic nerve.

1, the present invention is used for waking up degree of depth coma patient.Stupor is mostly caused by cerebrum ischemia (anoxia), also part is had to be because brain trauma causes, or the chemical substance of exception enters brain barriers affect neural activity and causes, after the various cause of disease of elimination, some patients is still had to lie in a comatose condition and cannot sense of independence be recovered.At this moment patient has the vital signs such as breathing, circulation, but is in degree of depth comatose state, and stimulation does not to external world have higher nerve to react.Typical if long-term degree of depth stupor, the plant man be namely commonly called as.There is the technology adopting electric pulse and alternating magnetic field to stimulate brain at present, but because the working mechanism of the mental awareness activity to human brain is unclear, there is no theoretical foundation, so to the particular location of electromagnetic stimulation, apply the details such as frequency of mode and pulse also without specific aim, effect is still very limited.

When the present invention is applied to and carries out brain impulse stimulation to coma patient, need employing three groups of output electrodes, its method is:

(1), by the first output electrode be placed in the position of reticular formation of brain stem medial area (being also formatio reticularis mesencephali), and contact or thrust the neuron at this position; (be more suitably contact or thrust the neuron that formatio reticularis mesencephali projects to intralaminar nuclei); Second output electrode is placed in intralaminar nuclei, and contacts or thrust the neuron at this position; (being more suitably contact or thrust in intralaminar nuclei the neuron sent out side shoot and project to thalamic reticular nucleus); 3rd output electrode is placed in the position of thalamic reticular nucleus, and contacts or thrust the neuron at this position; (be more suitably contact or thrust the neuron that thalamic reticular nucleus projects to formatio reticularis mesencephali); Ground electrode is contacted with human body; (proper contact position is tremulous pulse, cerebrospinal fluid at the bottom of the vertebra of brain, and more suitably position is the brain liquid place around the cerebral tissue at output electrode place);

(2), carry out the impulse stimulation with timing by three groups of output electrodes to the neuron of three positions.Optional 125-25 milliseconds of its pulse period, (corresponding pulse frequency is 8-40 hertz, is that brain is in the brain wave rhythm of regaining consciousness with during thinking mistake area).

, impulse stimulation preferably intermittent, after namely carrying out the impulse stimulation of 1-3 seconds, stop stimulation 1-3 seconds.Stopping in the interval stimulated, detect the brain wave (EEG) of coma patient simultaneously, if continue to detect that pulse frequency is greater than the eeg signal of 8 hertz, (the α ripple of such as frequency 8-13 hertz or the β ripple of frequency more than 14 hertz), or observe the reaction that sense of independence appears in patient, then stop providing impulse stimulation, otherwise proceed impulse stimulation next time.

According to research, the essence of thinking is the chain type activation activity of the relay cell in cerebral cortex district (especially akrencephalon association cortex), and the essence of consciousness is the self-perception of brain to thinking activities (being also the chain type activation activity of relay cell), (the neuronic aixs cylinder side shoot that association cortex upper chain type activates projects to the associating sensory region of sensory cortex).But although the neuron activity of thinking and consciousness mainly occurs in Cerebral cortex, its activity is subject to the control of thalamus (mainly intralaminar nuclei) to the action potential synchronization motivationtheory pulse of cortical projection.Further research finds, the synchronization motivationtheory pulse that thalamus is provided to Cerebral cortex, its origin is the oscillating loop generation that between " formatio reticularis mesencephali-thalamus ", the pulse of round granting synchronization motivationtheory is formed, applicant is referred to as " pressed on ring oscillating loop " or be called for short " upper loop ", its concrete projection relation is also pulse granting pass is " formatio reticularis mesencephali → intralaminar nuclei → thalamic reticular nucleus → formatio reticularis mesencephali ", and simultaneously carry out the granting of synchronization motivationtheory pulse by intralaminar nuclei to cortical areas widely, the neural activity controlling cortex is also thinking activities.(see the schematic diagram of two neural circuitry up and down between the reticular formation of brain stem of Fig. 5 and thalamus and hypothalamus, the pressed on ring oscillating loop that what thought system related to is wherein).When brain because hypoxic-ischemic or injured time, the neuronal damage of this oscillating loop, to the integration of exciting signal and trigger action slower, the oscillatory rhythms causing it to provide is too low, the granting rhythm and pace of moving things of the synchronization motivationtheory pulse that intralaminar nuclei is provided to cortex is too low, (lower than 4 hertz, namely brain wave rhythm when deep sleep and stupor), the relay cell of cortex cannot be made to carry out synapse integration and triggering action potentials and form chain type with this to activate, so also just conscious thinking activities cannot be produced, be in the state being similar to deep sleep.So, the order that the present invention provides according to its synchronization motivationtheory pulse, the neuron of electric pulse to three of this loop nodes with timing is adopted to stimulate successively, force the granting rhythm and pace of moving things (being greater than 8 hertz) of the synchronization motivationtheory pulse improving and recover this loop, enable the relay cell of cortex form chain type to activate, also namely recover conscious thinking activities.And there is specific sequential relationship due to output pulse of the present invention, usefulness is transmitted in synapse between the neuron that can also strengthen this loop, the autonomous nerve being conducive to recovering this loop provides action, thus finally can not rely on impulse stimulation of the present invention and form autonomous normal neural thinking activities.

2, the present invention is used for the activation to the brain of brain death.Brain death mentioned here is not the aging death of whole human body, but unexpected death.Human brain is extremely sensitive to blood oxygen, in cardiac arrest, drown, suffocate, under wound causes the situations such as cerebral blood supply interruption, completeness cerebral anoxia can cause brain bioelectric and brain function to stop completely for two minutes, not single human thinking activity stops completely, and the activity of visceral nervous system stops completely, body loses autonomous respiration and heart beating, if cerebral anoxia was more than four, five minutes, even if give cardiac pacing and artificial respiration again, be also difficult to rescue and come.At this moment neural activity, autonomous respiration and heart beating stops completely, does not have vital sign, is namely that the human body on legal sense and medical significance is dead.Conventionally, brain death is irreversible, and be the termination of life, human body at this moment is not called patient, but corpse.

For brain death, at this moment brain is not singly the neuron stopping action potential granting of the pressed on ring oscillating loop controlling thinking activities " formatio reticularis mesencephali ← → thalamus ", and visceral nerve (or claiming autonomic nerve, vegetative nerve) system more importantly controlling visceral motility is also stopped action.According to analysis, the visceral nervous system controlling visceral motility comprises two large loops: (see Fig. 5), one is the rudimentary reflex loop in brain stem aspect be made up of " internal organs (sensation) nerve → nucleus solitarius → dorsal nucleus of vagus nerve → internal organs (motion) are neural ", is felt respectively by simple directly reflex loop and is reflected the activity of each internal organs; Two is the associated reflex loops be made up of " reticular formation of brain stem LHA ← → hypothalamus ", accept various internal organs feel import into, and accept the modulation input of other nervous system of brain (thinking nervous system, kinetic system, emotion nervous system, endocrine nervous system), after Combined Treatment, the activity of the rudimentary reflex loop of brain stem is encouraged and modulated, thus balance control is carried out to the work of internal organs, such as, regulate the frequency and amplitude of breathing, regulate the speed of heart beating, regulate blood pressure etc.This reflex loop that " reticular formation of brain stem LHA ← → hypothalamus " is formed controls and maintains the basic activity of life, wherein send driving pulse to be formed by the cholinergic nerve of reticular formation of brain stem LHA (especially comprising parabrachialis medialis, nucleus lateralis) the pulse granting coming and going vibration to hypothalamus (especially comprising lateral hypothalamic region, back zone, paraventricular nucleus etc.), applicant calls " lower ring oscillation loop " it or is called for short " lower loop ".When the neuron of the rudimentary reflex loop of brain stem is stopped action, then internal organs are also stopped action, when the neuron of " lower ring oscillation loop " is stopped action, then internal organs work is disorderly, rudimentary reflex loop even also can be made to stop action because can not get excitation, cause internal organs to be stopped action equally, breathe and heart beating stopping, human body is dead.

So, will carry out brain activation to the brain of brain death makes it recover neural activity, and the electricity irritation can combined the related Neurons of these two reflex loop, makes it activate and recover action potential granting, excitation internal organs reactivate, thus recover heart beating and autonomous respiration.It should be noted that, for the consideration of Operative risk and legal perspective, tradition should be carried out to patient to rescue as far as possible, in confirmation tradition, all rescue measures proved ineffectual, confirm patient's heart beating stopping, autonomous respiration stopping and brain death, also namely confirm that patient has been in the dead state on legal sense and medical significance, after belonging to a corpse, then adopts brain Activiation method of the present invention to rescue.

When the present invention is applied to and carries out brain impulse stimulation to the brain of brain death, also need employing three groups of output electrodes, its method is:

(1), the first output electrode is placed in the position of reticular formation of brain stem LHA (especially comprising parabrachial nuclei), and contact or thrust the neuron at this position; (more suitable be contact or thrust reticular formation of brain stem LHA and comprise the neuron that parabrachial nuclei projects to hypothalamus); Second output electrode is placed in lateral hypothalamic region or back zone, and contacts or thrust the neuron at this position; (more suitable be contact or thrust the neuron that lateral hypothalamic region or back zone project to dorsal nucleus of vagus nerve); 3rd output electrode is placed in the position of dorsal nucleus of vagus nerve, and contacts or thrust the neuron at this position; (more suitable be contact or thrust the neuron that dorsal nucleus of vagus nerve projects to postganglionic neuron); Ground electrode is contacted with human body; (proper contact position is tremulous pulse, cerebrospinal fluid at the bottom of the vertebra of brain, and more suitably position is the brain liquid place around the cerebral tissue at output electrode place);

(2), carry out the impulse stimulation with timing by three groups of output electrodes to the neuron of three positions.Its pulse period, T was 250-1000 milliseconds, and corresponding pulse frequency is 1-4 hertz.(see below to the analysis of this pulse period and determine).

, impulse stimulation preferably intermittent, namely after granting impulse stimulation a period of time, stop the time of a spacer segment phase, then carry out the impulse stimulation of lower a period of time.Can be specifically: after carrying out the impulse stimulation of about 3 seconds stop stimulation about 2 seconds.The object of intermittent granting is: stopping in the interval stimulated, detect the brain wave (EEG) of irriate brain simultaneously, if EEG signals do not detected, then proceed impulse stimulation next time, if spontaneous EEG signals detected in interval, illustrate that brain has started to have autonomous brain electrical acti, can stop providing impulse stimulation, whether be the stable vital signs that continue, then determine to stimulate the need of continuation if observing its active situation.

Determination about carrying out the pulse period of impulse stimulation to lower ring oscillation circuit neuron: in the various experiment and nerve stimulation application technology of existing neurobiology, according to existing theory, be not easy to be formed excited integration and snapping motion current potential during underfrequency due to impulse stimulation, and the impulse stimulation of low frequency easily produces synapse transmission suppression, so high-frequency impulse will be selected inevitably to stimulate, i.e. tetanic stimulation.But applicant finds, for application scenario of the present invention, when the frequency of impulse stimulation is too high, neuron stimulated and snapping motion current potential after, still constantly can be subject to impulse stimulation, then can affect the nerves the motion of the ion reflux after first snapping motion current potential, it is made cannot again to form the physiological activities such as normal film polarization, so, at this moment neuron is just triggered by tetanic stimulation completely passively and produces accidental unordered action potential, and continuable rhythmic action potential granting cannot be formed, neuron more cannot be made to recover physiological function and the normal action potential granting of final spontaneous generation, even may more damage its physiological function and cause its inactivation.When only having the frequency of electric pulse stimulation to be close with the original work rhythm and pace of moving things of oscillating loop, just may bring out and recover the original physiological function of neuron, form the rhythmic action potential granting continued, and make neuron finally occur the action potential granting of rhythmicity spontaneous normally.And, applicant thinks, synapse is transmitted and is suppressed to be generally the aminergic neuron work resulting from neuromuscular juinction path, its physiological significance depends on synaptic plasticity and produces memory usefulness, and for lower ring oscillation loop involved in the present invention, belong to driving pulse granting, its physiological significance controls and maintains visceral nervous system and the neural work of endocrine, and with pressed on ring oscillating loop phase inter-modulation, the Nervons projection mainly cholinergic neuron of this loop, can't produce synapse and transmit the problem suppressed.This lower ring oscillation loop is there is because existing theory never discloses, data is not more had to show the rhythm and pace of moving things of its oscillatory work, (be also frequency, namely the rhythm providing action potential pulse is come and gone between " reticular formation of brain stem ← → hypothalamus "), but because This move current potential is as the neururgic pumping signal of visceral nervous system, its rhythm and pace of moving things will faster than any neururgic rhythm and pace of moving things of visceral nervous system, applicant according to: (1), the fastest neural activity of visceral nervous system, the rhythm of the heart of also i.e. heart beating is normally at 1-2 hertz; , brain go into a coma or deep sleep time, the brain wave (δ ripple) obtaining frequency and be less than 4 hertz can also be detected, and lower ring oscillation loop and pressed on ring oscillating loop exist and interact.So, the frequency of this brain wave is or close to the work rhythm and pace of moving things of lower ring oscillation loop, (this rhythm and pace of moving things is called life basilic rhythm by applicant), the electric pulse of the frequency range of 1-4 hertz can be adopted to carry out electricity irritation to the neuron of lower loop, and corresponding pulse period T is 250-1000 milliseconds.

If brain death is due to contingency, such as outer wound, drowned, the reason such as to suffocate makes the complete hypoxic-ischemic of brain cause, and hypoxic-ischemic time be not very long, (within best tens minutes), neurocyte not yet loses physiologically active, then by adopting the neuron of said method to lower ring oscillation loop to carry out electricity irritation, (and synchronously carry out cardiac pacing and respirator Hold up voltage, or adopt mechanical pump to carry out interim blood supply oxygen supply), just can bring out its neuron and produce the rhythmic action potential granting continued, and finally make neuron recover physiological function, make lower ring oscillation loop produce autonomous rhythmic action potential and come and go granting, realize reactivating of brain.Certainly, if cerebrum ischemia anoxia exceedes certain hour, neurocyte is inactivation, such as loses transmembrane potential, loses the effect of bio-pump, then brain stimulation is just completely meaningless.

Also have, if recover the pulse granting of lower ring oscillation loop, human body just recovers the work of visceral nervous system and hormonal system, if at this moment pressed on ring oscillating loop does not normally work, then brain is still in degree of depth comatose state, this is not obviously desired by us, so also need the thinking consciously recovering brain simultaneously.And, according to analysis, phase inter-modulation is there is in the neuron activity of upper and lower two oscillating loops between " reticular formation of brain stem medial area and reticular formation of brain stem LHA ", so, carrying out in the process of electric pulse stimulation to lower ring oscillation loop, the neuron of pressed on ring oscillating loop is stimulated simultaneously, be conducive to two loops are intermodulated, recover normal work faster.So, when carrying out the above-mentioned activation to brain death, an other nerve stimulation device of the present invention can be used, (or two covers nerve stimulation device of the present invention is set in an impulse stimulation device simultaneously), according to foregoing for the method waken up to degree of depth coma patient, impulse stimulation being carried out to pressed on ring oscillating loop simultaneously, when recovering life basic activity, thinking consciously can also be recovered.

The present invention is according to the working mechanism of brain and control loop, analyze the essence of large coma and brain death, and with a definite target in view for the neuron of brain ad-hoc location, apply the impulse stimulation of signal specific, nerve stimulation can be carried out to the brain of stupor or brain death, make it recover thinking activities or realize brain to activate.In addition, applicant wishes by mode this disclosed in patent application document, by the essence of applicant about the thinking of human brain, consciousness and attention, the work of human brain in neuron aspect and control mechanism, and sleep, daydream, sleep-walking and more psychotic results of study are carried out open, be conducive to society to study further this, and research and develop more medical applications technology with this.

The method each output electrode being placed in each target location of brain described in present specification, the technology of existing electrical brain stimulation can be adopted, such as: open cranium and directly electrode to be punctured target nerve unit, or at the pre-buried electrode in brain internal object position, more suitably scheme, be on brainpan, open aperture or open aperture by nasal cavity or larynx deutomala, then under the cooperation of neuroendoscopy is auxiliary, output electrode inserted in brain and to be placed on target location.And the electrode used, can adopt existing for the electricity irritation of cranial nerve and the electrode of electrical signal detection, the microelectrode adopting cranial nerve special when thrusting neuron, or patch-clamp, adopt ordinary electrode when only contact neuron membrane is outer.

Electrode described in present specification, comprises the first output electrode, the second output electrode, and the 3rd output electrode etc., can be an electrode, also can be one group of (many) electrode, depending on job demand.In general, for peripheral nerve, only single electrode need be adopted, and for nervus centralis, be more suitably adopt many electrodes as same output electrode, impulse stimulation is carried out to adjacent multiple neurons of same position simultaneously, be conducive to forming signal integration, produce neural activity.

Description of drawings 1 is the structural representation of nerve stimulation device operation principle of the present invention.Fig. 2 is the sequential chart of the boost pulse that each output electrode exports.Fig. 3 is a kind of operation principle block diagram output pulse signal being carried out to more conservative control.Fig. 4 is another kind of operation principle block diagram output pulse signal being carried out to more conservative control.Fig. 5 is the Nervons projection schematic diagram of two oscillating loops up and down between reticular formation of brain stem and thalamus and hypothalamus.

Fig. 6 is Biont information process scantling plan.Fig. 7 is information processing system schematic diagram inside and outside organism.Fig. 8 is sensory information processing system schematic diagram inside and outside human brain.Fig. 9 is the relay cell syndeton schematic diagram of thinking passage.Figure 10 is the schematic diagram of the first neuron projections mode of " thinking → consciousness ".Figure 11 is the schematic diagram of the second neuron projections mode of " thinking → consciousness ".Figure 12 is the signal projective structure schematic diagram of human brain visual channel.Figure 13 is the signal projective structure schematic diagram of human brain auditory channel.Figure 14 is the operation principle schematic diagram of the oscillating loop of thought system.Figure 15 is the neuron projections schematic diagram of thought system oscillating loop.Figure 16 is the signal projective structure schematic diagram of thought system oscillating loop.Figure 17 is the signal projection schematic diagram of " Hippocampus " average information process loop.Figure 18 is the signal projection schematic diagram of kinetic system control loop.Figure 19 is the signal projection schematic diagram of visceral nervous system.Figure 20 is the signal projection schematic diagram of emotional system.Figure 21 is the signal projection schematic diagram of the cholinergic nerve of septal area and basal forebrain.

Be to principle of the present invention and describing of specifically implementing below detailed description of the invention.

Fig. 1 is the structural representation of nerve stimulation device of the present invention.Comprise main frame and the electrode being connected main frame, electrode includes reference electrode (or claiming ground electrode) and output electrode, main frame includes the pulses generation module for generation of stimulation pulse signal, connect each output module for stimulation pulse signal being outputted to output electrode of each output electrode, i.e. the first output module, the second output module, the 3rd output module, it is characterized in that: described output electrode includes the output electrode of more than two groups or two groups, Fig. 1 is first, second and the 3rd output electrode, totally three groups of output electrodes; Main frame also includes output timing control circuit; The stimulation pulse signal that output timing control circuit exports for controlling each output module, each output electrode is exported have relative to the boost pulse of reference electrode before and after the sequential relationship that exports successively.As Fig. 2.

Pulses generation module belongs to prior art, and the pulse produced can adopt square wave, triangular wave, trapezoidal wave or imitate the waveform of neuron action potential pulse.Pulse width T 0 is 0.5-10 milliseconds, is more suitably 1-5 milliseconds, is equivalent to the pulse width of neuron action potential.Output module also belongs to prior art, for the pulse signal of received pulse generation module, and outputs to output electrode, and its effect is the amplitude of isolation buffer and regulation output pulse.The pulse signal that each output electrode exports, relative to reference electrode (also i.e. ground electrode), its crest voltage amplitude, can regulate between 20-1000 millivolts, enters neuronic state and different according to electrode contact locations and electrode.

Main frame of the present invention also comprises pulse period regulating circuit, the pulse period T of former and later two pulses exported for regulating same group of output electrode (first, second, and third output electrode).For different application, pulse period T is different, generally between 25 milliseconds to 1000 milliseconds, sees below described in applying portion.

Output timing control circuit is for controlling the work of each output module, the sequential relationship of the boost pulse that each group of output electrode is exported is: in a pulse period T, after last output electrode exports a boost pulse, through time delay of setting after Ts, a rear output electrode just exports a boost pulse.Such as: device Fig. 1 like this to three groups of output electrodes, in a pulse period, after first output electrode exports a boost pulse, after a time delay Ts, second output electrode exports a boost pulse again, and then after a time delay Ts, the 3rd output electrode exports a boost pulse again, the like.Concrete control method can be: pulses generation module produces a pulse signal, then after a time delay Ts, produce a pulse signal again, and then after a time delay Ts, produce a pulse signal again, and output timing control circuit exports the gating that three output modules carry out successively, these three pulse signals are exported from three output modules successively, thus respectively export a pulse signal successively in three groups of output electrodes.(noticing that the output pulse frequency of at this moment pulses generation module is 3 times of output electrode output pulse frequency), such control belongs to common electronic technology, can be realized by simple MCU or digital circuit.

Nerve stimulation device of the present invention has organizes output electrode more, and each output electrode can export the output pulse relative to reference electrode, and the sequential relationship that the stimulation pulse signal that each group output electrode exports exports before and after having successively.Use the present invention can be had the impulse stimulation of front and back sequential relationship respectively to the neuron of node different on a certain nervous pathway by each group of output electrode simultaneously, force nervous pathway generation to have the continuable action potential granting of the directed transitive relation of signal, thus can be applicable to excite and recover the neural activity that some has physiological function.(seeing below disclosed application of the present invention).

As a kind of important optimization, the present invention is also arranged accurately to the sequential relationship of this output pulse.Two groups of output electrode (such as first and second output electrodes before and after it, second and the 3rd output electrode) Ts time delay of two pulses that exports, with pulse period T, pulse width T 0, three has following relation: 0 < Ts < 1/2T-T0; Be expressed as: the time delay that two groups, front and back output electrode exports pulse is greater than 0, and is less than the value of " half of pulse period deducts a pulse width ".Thisly arrange based on neuronic STDP synaptic plasticity principle accurately, (Spike Timing-Dependent Plasticity, the i.e. synaptic plasticity of Temporal dependency), according to the STDP plasticity that synapse is transmitted, synaptic plasticity has strict time dependence, the sequential that the pulse peak current potential of usefulness and presynaptic caudacoria is transmitted in its synapse has substantial connection: if the spike potential of presynaptic membrane is early than the spike potential of postsynaptic membrane, then produce synapse and transmit enhancing phenomenon, and the delay of spike potential less then synapse transmission enhancement effect is larger; If the spike potential of presynaptic membrane is slower than the spike potential of postsynaptic membrane, then produce synapse and transmit suppression phenomenon, and the delay of spike potential is less, it is larger that synapse transmission weakens effect.Synapse between the front and back neuron of the nervous pathway stimulated to make the present invention produces transmits usefulness enhancing, then need to ensure in the same pulse period (namely stimulating action with pulsatile once), the time delay of the pulse that last output electrode and a rear output electrode export, the time delay of the pulse that an output electrode and last output electrode export after being greater than.

With reference to the output pulse sequence figure of Fig. 2, it calculates that process is as follows: for the situation having two groups of output electrodes, then in a pulse period T, include two pulse width T 0, with two sections time delay Ts1 and Ts2, Ts1 time delay between first pulse that first pulse exported in order to ensure the first output electrode and the second output electrode export, be less than first pulse that the second output electrode exports and Ts2 time delay of second pulse that the first output electrode exports, then need 2T0+2Ts1 < T, release according to this and have Ts1 < 1/2T-2/2T0, also Ts < 1/2T-T0 time delay is namely required.For the situation with three groups and more multi output electrode, because each output electrode exports successively in order, as long as ensure the output signal of former and later two electrodes meet above situation about analyzing, so equally need Ts < 1/2T-T0, again because Ts needs to be greater than 0, so there is 0 < Ts < 1/2T-T0.Such as, pulse period T is 50 milliseconds, and pulse width T 0 is 5 milliseconds, then time delay 0 < Ts < 20 milliseconds, such as optional 10 milliseconds.

The meaning of such setting is: to have the boost pulse of such sequential relationship, respectively impulse stimulation is carried out to the nerve nucleus of front and back different rings joint on a certain nervous pathway, this nervous pathway singly can not forced in the process providing boost pulse to produce directed activation action, thus force the neural activity producing signal transmission, and, this impulse stimulation has specific sequential relationship, the synapse between the neuron of two groups, stimulated front and back can be made to produce STDP plasticity, especially LTP synapse enhancement effect, improves synapse and transmits usefulness.So, such impulse stimulation, has stimulating neuronal and the directed effect improving synaptic plasticity between neuron simultaneously, is conducive to the signal transmission usefulness recovering nervous pathway self, thus recover its physiological function, so may be used for the rehabilitation of the nervous pathway of a few thing exception.

In nerve stimulation device of the present invention, the output characteristics of its electric pulse string is also very important.The existing technology for carrying out brain stimulation, its output signal adopts often with other human body electric pulse stimulations or treatment technology (the such as electrotherapy technology of various middle low-and high-frequency, acusector technology, Cardiac Pacing) the same, its impulse waveform is that setting exports, namely regulate the positive pulse of certain frequency, waveform, dutycycle and voltage amplitude or positive and negative alternating impulse by pulse generating module, then directly act on target stimulation sites.These electric pulse stimulation technology existing, if for stimulating myocyte or muscular nerve or myocardial cell, as long as have enough pulse widths and voltage amplitude, just can these cells of effective stimulus to produce reaction.But, if be used for stimulating the carrying out of the relay cell of nervus centralis and bringing out the granting of continuous print action potential, that is just different, at this moment be just not only that the requirement stimulation of carrying out enough pulse widths and voltage amplitude to neuron is just passable, inappropriate impulse stimulation not only inducing neural unit can not provide action potential, even also can suppress its physiological activity, obtain contrary result.

According to neurobiology, due to the effect of ion motion, can form stable potential difference inside and outside the film of neurocyte is also resting potential, the resting potential of the relay cell of human brain is approximately-70 to-90mV, also be neuron membrane inner potential 70-90mV lower than film volta potential, form film polarization.Make neuron snapping motion current potential, needing is its depolarization, reduces the potential difference inside and outside film, when depolarization meets or exceeds a certain threshold value, just can open a large amount of voltage dependent ion channels on film, make cation a large amount of in flow and form positive feedback, thus snapping motion current potential.The Time Of Release of action potential generally only has several milliseconds, and afterwards, after action potential granting completes, the time that needs is restored to original polarized state for cation outflow, can upper once stimulate time snapping motion current potential again.

According to the Burst mechanism of action potential, if Induced by Stimulation neuron snapping motion current potential will be carried out by outside electric pulse, two kinds of modes can be had: 1, be electrode is thrust (and can not be connected with outside cell membrane) in neuronic cell membrane, the electricity irritation of positive potential is applied in film, when the rising value of the film inner potential that this stimulation produces is greater than activation threshold value, just membrane depolarization can be made and snapping motion current potential.2, be that electrode is placed in outside neuron membrane, but need the electricity irritation applying nagative potential at film outward, the electricity irritation of this nagative potential has dragged down the current potential outside film, thus the potential difference relatively also dragged down in film outside relative film, when the changing value of this potential difference is greater than threshold value, membrane depolarization can be made equally and snapping motion current potential.So, electrode is usually placed in a certain brain position by prior art, then strong positive pulse or positive and negative alternating impulse are applied to electrode, its result caused in fact not inducing neural unit produces action potential granting orderly normally, but produce sporadic action potential due to strong potential fluctuation stimulating neuronal, but the ion proper motion of often inhibitory neuron, makes it cannot produce lasting action potential granting, it more cannot be made to recover spontaneous normal neural activity afterwards.Typically, before in brain stimulation experiment, when applying electric pulse stimulation to the neuron of epithalamic pain transmission path, it not often algesiogenic sensation, but inhibit pain, this is also often used as brain stimulation pain relieving (SPA), although and do not know its concrete mechanism of analgesic.

So, applicant is carefully according to the specific works principle of neuron snapping motion current potential, the output signal of output electrode is optimized, make it possible to inducing neural unit snapping motion current potential more accurately, and this action potential can continue to provide, and the axoneuron being more conducive to irriate forms continuable signal transmission.

The first output pulse signal prioritization scheme of the present invention, comprising: described pulses generation module, and with positive pulse outfan and negative pulse outfan, can export respectively relative to ground electrode is two kinds of pulse signals of positive potential and nagative potential; (this can be produced by positive-negative power, is common electronic technology); Positive pulse and negative pulse two outfans are switched by change-over switch, and the output of change-over switch is re-used as the outfan of pulses generation module, is connected to each output module.Change-over switch can be mechanical switch or electrical switch.If be adopt the mode opening cranium when implementing brain stimulation, and adopt the patch-clamp or nerve microelectrode that are exclusively used in cranial nerve stimulation, (this microelectrode is usually used in neuroanatomical laboratory, for detecting the neuronic signal of telecommunication, tinsel or micro-glass tubing is adopted to make, tip only has 1 micron or less, and only have eletrode tip place to conduct electricity, can directly thrust in the film of neuronic cell space or aixs cylinder), output electrode can be thrust in the neuron membrane that will stimulate, then change-over switch can be switched to positive pulse outfan, electrode output is made to be connected to positive pulse outfan, at this moment output electrode is the pulse signal exporting positive potential.This mode is the ways customary that current laboratory carries out neuronal activation, can Induced by Stimulation neuron snapping motion current potential reliably, but microelectrode accurately will be thrust in target nerve unit film, obviously needs to carry out operation of opening cranium, extremely bothers.So, if change-over switch of the present invention is switched on negative pulse outfan, electrode output is made to be connected to negative pulse outfan, what at this moment output electrode exported is the pulse signal of nagative potential, can directly put on outside neuronic film, by dragging down film volta potential, relatively reduce film resting potential, and EAP.At this moment common electrode can be adopted, and on brainpan, open aperture or open aperture by nasal cavity or larynx deutomala, then under the cooperation of neuroendoscopy is assisted, output electrode inserted and be placed on the required target location stimulated, only need make outside the film of output electrode contact or close neurocyte, and without the need to accurately thrusting neuron, so more convenient to operate, wound is also less.

In addition, if the electric pulse stimulation put on neuron is too strong, particularly after neuron is induced action potential, still strong electricity irritation is subject to, then can have a strong impact on the normal ion motion inside and outside neuron membrane, the polarization of normal film cannot be recovered, so the triggering of action potential next time also just cannot be carried out after making neuron snapping motion current potential.So such electric pulse stimulation can inhibit neuronic activity on the contrary conversely, even make its inactivation, the integration that continues and activation cannot be carried out.(usually strong electric pulse stimulation is applied to the brain region of pain transmission path before, for carrying out pain relieving, in fact be this reason because at this moment the neuron of its pain transmission path suppress by strong stimulation to be even damaged, the sensation of pain cannot be transmitted).So, the signal of existing electric pulse stimulation technology export, can be used for brain stimulation, but neuron produces simply unordered electric discharge owing to being subject to strong impulse often, and sustainable regular event Electric spike repeatedly cannot be produced, or even play inhibitory action, can be used for pain relieving or treat the disease of various neuron paradoxical discharge, such as epilepsy, but be used for this application scenario that inducing neural unit continues repeatedly to provide action potential of wishing, then and improper, will adjust in other words and obtain suitable stimulation width and amplitude, be more difficult.

Applicant improves this, the second output signal prioritization scheme of the present invention, as Fig. 3, main frame (comprises first for connecting each output electrode, second and the 3rd output electrode) electrode output, (electrode output that is to say the lead-out terminal for connecting the outside each output electrode of main frame that main frame is arranged, general employing electric connector), (first is comprised with each output module, second and the 3rd output module) outfan between, be added with an output control circuit, (be equivalent to electronic switching circuit, more suitable scheme, a resistor R is also serially connected with between the outfan and output control circuit of output module, for cushioning and produce certain voltage difference), electrode output is also connected to the input of a voltage detecting circuit, and the outfan of voltage detecting circuit is connected to a voltage comparator circuit, compares with the output pulse signal from output module, the outfan of voltage comparator circuit is connected to the control end of output control circuit, is controlled by output control circuit paired pulses output signal.When the voltage signal of the electrode output that voltage detecting circuit detects, and the difference between the voltage signal that output module exports is greater than when setting numerical value, then close output control circuit, the output signal of output module to electrode output is closed, until next pulse period just reopens in the time of this pulse period remainder.Because the first output module is to the first output electrode, the second output module is to the second output electrode, and the 3rd output module is the same to the control circuit of the 3rd output electrode, so Fig. 3 only draws a road.

According to such output control program, during work, in each output pulse period (i.e. the cycle of individual pulse output) of each output module, first output control circuit is opened, output pulse signal puts on neuron by electrode output and output electrode, voltage signal simultaneously on voltage detecting circuit detecting electrode outfan (being equivalent to output electrode), and compare with the output pulse signal of output module, (both permissions have certain difference).When the pulse signal of output electrode acquires a certain degree to neuronic stimulation, there is depolarization in neuron, opens the ion channel on film, flows and form positive feedback, make neuron snapping motion current potential in a large amount of ion.At this moment due to a large amount of ion sharply interior stream, form overshot phenomenon, neuron membrane inner potential is made to become positive potential by nagative potential, film is outer becomes nagative potential by positive potential, this potential change sharply, electrode output can be delivered to by output electrode, cause the voltage on electrode output to occur larger fluctuation, and be that the pulse output signals exported with output module significantly changes asynchronous.This voltage pulsation is detected by voltage detecting circuit, and compared by voltage comparator circuit and pulse output signals, when both difference are greater than setting value (such as 10%), identifiable design is neuron snapping motion current potential, so, the output of voltage comparator circuit closes output control circuit, closes the output signal of output module to electrode output in the time of this pulse period remainder, until the next pulse cycle just reopens.Can make neuron after action potential outburst each time, no longer be subject to the stimulation of outside electric pulse like this, make the normal ion motion inside and outside its film unaffected, film polarized state can be recovered, to carry out integration and snapping motion current potential again to stimulating next time, form continuable action potential granting repeatedly.This technical scheme, more meet the working mechanism of axoneure, can either inducing neural unit snapping motion current potential, inactivation can not be suppressed to cause neuron or sustain damage by overstimulation neuron again, for stimulating the neuron at the positions such as thalamus, network structure, hypothalamus, EAP can be continued, forming continuous print pulse and providing, and make neuronic ion motion and physiological function recover normal gradually, the lock-out pulse granting that final appearance is spontaneous.

Also have, as previously described, different with other pulse electrotherapy technologies, when carrying out the sustainable granting of electricity irritation with EAP to nervus centralis, than more sensitive to the stimulation amplitude of electric impulse signal, should be enough to make its depolarization, but consequently can not inhibit its physiologically active too greatly.Applicant is also noted that also there is a problem here: when output electrode and ground electrode are placed in different brain position, because the liquid around cerebral neuron exists the negative ions of heterogeneity and variable concentrations, just certain potential difference is there is between output electrode and ground electrode when not working, (can be described as background voltage), and this potential difference is with the difference of the different and residing brain position of the relative position of two electrodes, its potential difference is also different.When providing electric impulse signal between output electrode and ground electrode, if exported with a kind of pulse amplitude of setting, then this potential difference originally just existed, just the amplitude of pulse signals can form overlaying influence, disturb the accuracy of pulse signal stimulus intensity.

So, the present invention to the third prioritization scheme of output pulse signal, as Fig. 4.Its electrode output is connected with a voltage detecting circuit, (can share with the voltage detecting circuit of other technologies above), voltage detecting circuit is used for the background voltage of detecting electrode outfan, so also can be described as background voltage testing circuit, the output of voltage detecting circuit is connected with a voltage hold circuit, maintenance memory is carried out to the background voltage value that voltage detecting circuit exports, (be equivalent to voltage memory circuit, if circuit adopts analog circuit, electric capacity then can be adopted to coordinate discharge circuit to form, if circuit is digital circuit, then can directly remember its magnitude of voltage), the magnitude of voltage that voltage hold circuit exports is connected to a voltage overlaying circuit, the pulse output signals that pulses generation module exports, superpose with background voltage in voltage overlaying circuit, if (circuit adopts analog circuit, discharge circuit can be adopted, or adopt technology virtually, both are superposed, if employing digital circuit, then both numerical value are carried out plus and minus calculation), be connected to electrode output.Voltage hold circuit, the work of voltage overlaying circuit and pulse output module (comprising the first output module and the second output module), be subject to the control of a state switching circuit, (also can being controlled by the control circuit that main frame is total), specific works process is: carrying out cranial nerve stimulation at every turn, after ground electrode and output electrode are placed in target area, or when readjusting the position of output electrode and ground electrode in work, circuit working is switched in " detection " state by state switching circuit, close the output of output module, first by the voltage on voltage detecting circuit detecting electrode outfan, (the potential difference of this voltage also namely between current output electrode and ground electrode, also be background voltage, may be just also may be negative), its output voltage values is undertaken keeping (also namely remembering) by voltage hold circuit, and deliver on voltage overlaying circuit, afterwards, by state switching circuit, circuit working is switched to " output " state, close the input of voltage hold circuit, (magnitude of voltage of input before making the maintenance of its output voltage), open the work of output module, the pulse signal that output module exports, superposes with background voltage, is connected to electrode output in voltage overlaying circuit.Like this, the pulse signal that output electrode exports, just offsets the potential difference between two electrodes, can eliminate the impact of background voltage pulse signals stimulating effect.

Application of the present invention, comprise for coma patient wake up and for the activation to brain death, carry out abundant and detailed describing in " summary of the invention " part, (can refer to Fig. 5), no longer repeats here.Its theoretical foundation can with reference to auxiliary information below.

Auxiliary information: about thinking and the essence of consciousness and the research data of human brain working mechanism.Applicant for the research of the working mechanism in the essence of human thinking, consciousness, attention and neuron aspect thereof, analysis and description with lower part.These contents may not have direct relation with technical solution of the present invention, but contribute to operation principle and the design considerations of understanding the present invention and application thereof.

In the neural activity of brain, the most basic action is exactly the granting of neuronic action potential.Certain or certain organize neuronic activity, by synapse transmission, excitatory stimulation is formed to another neuron, when the accumulation of these excitements exceedes a certain threshold value, also namely neuronic transmembrane potential integrates the activation threshold value exceeding its action potential, then this neuron just activates snapping motion current potential, and forming stimulation by aixs cylinder to next neuron, this is the basic acts of cerebral activity, and brain is also to realize the function of various information processing with this.Does is problem: how brain realizes various brain function by this neuronic basic activity? such as memory, thinking, attention, consciousness? that is to say, how the working mechanism of various brain function is described by neuronic active actions?

1. the origin of brain and evolution.Understand the working mechanism of brain, first we need the source understanding human thinking activity, understands brain how to occur and formation of evolving along with biological evolution.

" the simple principle " of 1. biological evolution.No matter how complicated and mysterious brain is, if we admit that humans and animals is all evolve in the natural environment of the earth, this evolutionary process is not subject to the manipulation of non-natural strength (god), so, we seem assert this point: the Nature does not have designer to design in advance, all objects of the Nature are all that material changes under natural environment, and in the very long time, slowly accumulate these changes and formed.And cause the principle of these changes and accumulation should be all simple and natural.The Nature is followed this " simple principle ", utilizes simple reason, by very long accumulation, forms various complexity and object cleverly.

Such as snowflake, although exquisite and ingenious, but we know that is moisture inadvertently self-assembling formation in the h and c of natural environment changes.Such as natural views, grand and exquisite howsoever, but we know that is that rock and soil are dissolved by the long air slaking of the Nature and formed.Such as flower, howsoever magnificent mansion, but we know that is also that various plants cell is formed through merisis.Same, no matter how complicated 26S Proteasome Structure and Function is for the brain of the mankind, and that also should be that neurocyte links according to certain simple principle, and slowly accumulates in very long evolution, and evolves and form current this 26S Proteasome Structure and Function.

1. 2. from biological evolution process, the evolutionary process of organism and respective change are followed in the formation of brain (human brain or animal brain) and evolution, and it is the various external information of animal process and internal body information and the neuronic tissue set controlled self various activity.

When life is evolved as unicellular organism from some micels, as antibacterial, at this moment not also without the need to reflex system, the program of just solidifying according to DNA is carried out division and is copied.

When life concern is the organism with simple structure, there is the most basic eating and absorption function, be also provided with the necessary locomotive function of biological existence (being eaten to take food and escaping).At this moment need to control effectively to the vital movement of these digestion and movement, so evolve, certain intermediate cell connects the organ-tissue of two kinds of difference in functionalitys, make being excited of a kind of organ-tissue, the stress of another kind of organ-tissue can be caused, reach and eat or the action of movement.The intermediate cell of this link different organ and tissue is neurocyte.At this moment biology relies on simple and direct reflex arc and reflex action to realize stimulating the reaction controlling inputted, and this is the most original and simple nervous system.

Along with biological evolution goes out various biosystem, comprise digestive system, blood circulation, respiratory system, hormonal system etc., at this moment organism also evolve corresponding nervous tissue to the work of these systems carry out perception and reflection process, various information when receiving their work and internal body information, and the memory structures formed by long-term evolution (be recorded in gene, heritable) control their work.These neural reflex tissue aggregation together, and each other by interacting and modulating, carry out the work of each system of cooperation control, form the processing system of an internal body information, they are in the bottom of spinal cord and brain mostly, are the parts of brain early origin.

And along with biology is to various external information (image, sound, mechanical stimulus, abnormal smells from the patient etc.) perception and the needs of reaction, organism is evolved out vision, audition, sense of touch etc., the sensory perceptual system of each external information such as olfactory sensation, the corresponding nervous tissue that evolves receives these external informations, set, memory and reflection, the nervous tissue of these process external informations concentrates in together separately, constitute the echo area corresponding to various sensation, comprise vision area (optic zone), listen district (acoustic area), somathetic area (somatic sensory area), etc..Simultaneously, the complexity of external environment condition and information, also the more complicated activity of biological needs is made to conform, from moving about to crawling into, flight is to running, to the action of various more complicated body more accurately, the biological corresponding nervous tissue that also evolves carries out cooperation control to the muscle movement of body, these flock together to the nervous tissue that muscle movement carries out cooperation control, define the kinetic system comprising cerebellum etc., and how according to various external information, react and control the gathering of nervous tissue of body movement, just each motion subregion in cortex is constituted.Various sensory system and kinetic system, together constitute the external information processing system of organism, for receiving various external information, and reacted by the memory structures of long-term habits and control the athletic performance of organism.

The internal information processing system of body and external information processing system obviously need each other and existence contacts and influences each other.Such as when engine body exterior information processing system carries out more violent motion, internal information processing system is needed to provide more oxygen and nutrition; When internal information processing system perceives hunger, external information processing system is needed to carry out the action of looking for food.Total so from aspect, be exactly the set of the internal information processing system of the actual organism of brain and external information processing system two systems, and there is a kind of passage of phase inter-modulation, two systems influenced each other and modulated.So form the scantling plan of Biont information process as shown in Figure 6.

Abundant and complicated along with various information, organism needs the input simultaneously receiving multiple interior external information, can not be simple reflex to the reaction of these information, and various information must be integrated and make the reaction of the various information of balance according to the long-term adaptability custom (namely remembering) formed.Such as, biology will be gone to for the odiferous information of food, and the dangerous information of the vision of near food allows biology need to escape, and so biological needs compares the signal intensity gone to and escape and integrate, and finally can only export one action---and go to or escape.So organism is evolved out the Combined Treatment part comparing various input information and average information, switch, integrate, and wherein just defines so-called thought system to the Combined Treatment part of external information.Information processing system schematic diagram inside and outside organism as shown in Figure 7.(for simplicity, Fig. 7 only marks inside and outside each two information processing passages).

So 1. 3., the result of biological evolution, to the set of the various nervous tissues that information reflects, just constitutes brain.Due to the complexity even contradiction of various inside and outside information, brain evolve a large amount of relay cells connect various sensation input nervous tissue, compare, switch, coordinate and integrate various information by these relay cells, this part defines the cerebral tissue such as reticular formation of brain stem, thalamus, Hippocampus, end thalamus, striatum, cerebellum, upper hypothalamus of brain.Afterwards, along with various information is complicated further, part core group extends further and expands, and forms cerebral cortex, comprises akrencephalon.As shown in Figure 8.(for simplicity, Fig. 8 only draws partial information passage).

And along with the gregarious life of animal and the complicated of living environment, in order to better survive and live, zoogenesis creates the language for exchange of information.Here voice are broad sense, comprise the language of sound, body language, and the language of various bio information is as abnormal smells from the patient.For the mankind, also more distinguishingly create abundant language and the word of correspondence.For input and output and the process of these language and Word message, brain is also that the set by evolving a series of relay cell realizes.Comprise: the auditory speech centre (obedient maincenter) being positioned at superior temporal gyrus rear portion, for identifying the linguistic information in the acoustic information listening district to receive.Be positioned at the broca's speech center Broca (maincenter of speaking) at inferior frontal gyrus rear portion, the muscle controlling oral cavity and throat realizes speaking.Be positioned at the sense of vision speech center (reading maincenter) on the angular convolution of inferior parietal lobule, the Word message in the visual information receive vision area identifies.Being positioned at mobility's word maincenter (cheirokinesthetic center) at middle frontal gyrus rear portion, realizing writing of word by controlling finger muscles.

Because linguistic information and Word message so enrich, the quantity of information that they are formed is very huge and complicated, to understanding, speaking, read, write the input and output of each maincenter and the work of computing with words, also in cortex, a large amount of relay cells is defined, for linking these maincenters, the language that the neuron of these maincenters inputs or outputs is connected with Word message, remembers, recombinates, reacts, is exported, etc., be formed into the message sense of the language of the section of conspiring to create.Such as, by the language that obedient maincenter inputs, or the word of the maincenter of reading input, preserve memory in the relay cell of cortex, and the incidence relation set up between them, when hearing these language or see these words next time, original those neurons preserving memory of cortex can be activated, identify the language of input and the meaning (meaning of a word) of word with this.On the other hand, when the relay cell of brain association cortex is in activity (i.e. thinking), also project the neuron of the maincenter of speaking or cheirokinesthetic center by feedback, exported by these neuronic activation, the bit string of human thinking is exported, is formed and speak or write.

1. 4. so, the work of brain, be adopt neuron to carry out the various input and output information of perception, memory and reflection, and adopt relay cell to carry out integration process, to carry out cooperation control to the various outputs of body to various input/output information and average information.Along with the development of body and environmental concerns and body construction itself tend to complicated and meticulous, also there is corresponding complicated and meticulous evolution in brain, and make the link of its information processing become complexity owing to producing Inter Modulation between each several part.Wherein along with the complicated of various sensory information and athletic performance with become more meticulous, especially the sensation of language inputs and movement output, and integration process also i.e. thinking and the memory to these information, the neuronal quantity of cerebral cortex especially akrencephalon is correspondingly increased fast, and enlarged volume becomes human brain the best part.

These existing knowledge of brain evolutionary process are described, object is to express this point: from the angle of biological evolution, human brain entering mammal, each nerve nucleus that reptile is even formed when entering Fish and information processing mechanism (being similar to shown in Fig. 8) thereof, just substantially constant.Just the position of existence is formed in early days as reticular formation of brain stem in human brain, core and leading position is remained in the system works of brain, and the position that the evolution of some later stages is formed is as cortex especially cortex of telencephalon, although bulky, but formation is expanded by the small nut group just because information increase causes neuron to increase, it remains the status of subordinate in the system works of human brain.(can not just think that both legs replace brain and become the core of human physiological activity and dominate in human body evolutionary process because of the thick prosperity of thigh as us).So, although the neural activity of the identification of information and large higher brain function such as cognition, thinking and memory, movement output etc. occurs in cortex especially akrencephalon mostly, but to these neururgic control, also the core of the control mechanism of i.e. whole brain system work, do not lie in cortex, do not lie in akrencephalon, and be the brain stem that biological evolution earliest period just exists and diencephalon one band, comprise reticular formation of brain stem, thalamus, upper hypothalamus etc.(control mechanism of brain is emphasis, and incite somebody to action the 3rd part later, namely " control mechanism of 3. human thinking activity " is described in detail).

2. the essence of thinking and consciousness.Want analytical thinking and consciousness, also need to understand cognitive and memory, this is two bases and the prerequisite of thinking.Cognition be brain to the perception of various stimulation and identification, and preserved through cognitive information by memory, afterwards, brain, to through cognitive information and the process of reacting through the average information of memory and reintegrating, just forms thinking.

2. the essence 1. remembered and working mechanism.In the description of the Chinese patent application " analog of neutral net and method " of the application number 2014106066977 that applicant submitted on October 30th, 2014, to essence, the formation remembered, impermanent memory is from the different of longterm memory and transform, and is described.In brain neuron network, the essence of memory is neuronic " uniqueness reflection ".When a neutral net obtains the stimulation that some information (the most basic minimum information word) inputs, also namely obtain the action potential of one or one group neuronal activation import stimulation into time, the syndeton of this neutral net, it is had and only has another or another group neuron to obtain excited fully integration, activate snapping motion current potential and export new information word, this is the basic neuron activity of memory.At brain, identification and the memory of external information are present in cerebral cortex, and the memory of various average information are first betided to the center-aisle of information transmission, (as Hippocampus), after repeatedly stimulating, just form longterm memory at cerebral cortex.Specific works with reference to application documents before, can be not described in detail here.

2. cognitive working mechanism.Cognition is also basis and the prerequisite of thinking, or perhaps the front one procedure of thinking.Traditionally cognitive and thinking mixed sometimes for together with, but in fact cognitive and thinking is two different processes, and adopts differentiated working method to realize.Cognitive activities is present on various sensory neuron and primary sensory cortex, parallel mode is adopted to carry out information processing, and thinking is the relay cell of cortex especially association cortex, the average information that output information and the thinking self of cognition produce is launched, reacts and reintegrated, and export the process of control information or new average information, adopt the mode of serial to carry out work.

About cognition especially about the cognitive process of vision, audition and sense of touch, more pertinent literature is had to carry out its neural link and work open, the concurrent working mode that only summary is cognitive here.Cognition is the process that brain cog-nitive target to external world carries out perception and identification, because cog-nitive target has complicated and diversified information, in order to realize the identification to them, need their multiple information of perception simultaneously, jointly limit a cog-nitive target, so the concurrent working mode of information that what the perception of cognitive process and identifying adopted is, is then limited by many-to-one projection and identifies cog-nitive target.Such as, for the visual cognition of an object, image due to object includes the much informations such as size, shape, color, brightness, will according to the needs that can realize identifying, perception is carried out to wherein one or more information simultaneously, and often kind of information has different values, also may need to carry out perception to the size of its value, finally jointly limit according to the information of these perception again and identify this object.The chances are for concrete flow process: (1), brain is by several sensory neurons of eyes, come shape and the size of perceptual image, colouring information, monochrome information, and the speed provided by action potential and sequential, also namely frequency coding and time encoding export the value transmitting this several information, and this coded system is conducive to the nervous pathway reduced and simplification information is transmitted.(2), Visual output information is projected onto on lateral geniculate body and primary visual cortex.This projection is that much information path all projects, but is the projection relation of one-to-many on each truck.Primary visual cortex has array architecture that is very tight and ordered arrangement, the granting speed of the neuron action potential that can input according to each pathways for vision and sequential, the neuron of varying number and diverse location in arrangement architecture is activated, that is to say the frequency coding of each vision input information and time encoding, be converted into the space encoding of one group of neuron activity of spatially varying number and diverse location.(3), primary visual cortex projects associating optic cortex.This projection is many-to-one relation on locus, the space encoding that height of formation is summarized.Namely action potential is provided in primary visual cortex multiple (or many groups) neuronic common activation, jointly collaborative stimulation is carried out to (or one group) neuron of combining on optic cortex, integrated by the film of excitement and make this (or one group) neuron obtain activating granting.Thus realize correspond to multiple (many groups) neuron of much information and different value, jointly map and limit (one group) neuron, and this (or one group) neuron, just uniqueness correspond to original cog-nitive target, thus realize identification to cog-nitive target.If (4) visual signal relates to word, then the neuron of combining on optic cortex also projects to sense of vision speech center (read maincenter, reading maincenter belongs to associating optic cortex equally), identifies word., associating visual cortical neurons provision, the information become through cognition exports, by the activity of the relay cell of relay cell especially association cortex, carry out thinking and various reflex response activity.

As for audition, sense of touch and other cognitive processs felt, be similar with vision.Wherein auditory information enters brain stem by cochlear hair cell by acoustic nerve, at medial thalamus geniculate body relaying, to primary auditory cortex projection, then is projected to associating auditory cortex by primary auditory cortex, realizes the identification to sound.If auditory information relates to language, then combine auditory cortex also to auditory speech centre (obedient maincenter) projection, language is identified.But, from brain function, associating optic cortex should have Nervons projection path directly to motor cortex, and combines auditory cortex and do not have this projection, so brain directly can control the athletic performance of body according to visual information without the need to attention and thinking, but audition can not.In addition, the various sensory cortexs comprising vision and audition seem a region jointly projected, to make the various sensory informations of same cog-nitive target obtain intersecting correspondence.Such as, to the vivid identifying information of someone, carrying out correspondence with name and sound, just can recall its name and image when hearing sound.And read the region of the crosswise projection of maincenter and obedient maincenter, that is to say so-called semantic cortical areas.

2. the essence of 3. thinking.And the activity of the cortex especially relay cell of association cortex, if under various modulation condition, define controlled, orderly, successively, (or by group) step-type activation one by one, also namely chain type activates, (activation that is to say snapping motion current potential) is the primitive form of the neuron activity of thinking.Specifically, as shown in Figure 9, the aixs cylinder of a certain neuron such as neuron a can set up synaptic contact with other ten hundreds of neuronic dendrons or cell space, the dendron of another neuron such as neuron b also can set up synaptic contact with other ten hundreds of neuronic aixs cylinders, these synaptic structures set up by various sign stimulus before being, (comprising direct imformation memory and other indirect association), make when neuron a is activated and produces action potential, passing to neuron b by synapse applies excited, and neuron b is under the excitement excitation that other neurons are collaborative, (also namely excited spatial integration, comprise the neuronic modularity effect of modularity, with the cooperative exiting of lock-out pulse, describe in detail later), also be activated and snapping motion current potential, namely neuron a → neuron b is had.Same, the activation of neuron b, its action potential granting can to other neurons such as neuron c, neuron d etc. form excited stimulation, make neuron c below, neuron d is also sequentially activated, and forms neuron a → b → c → d →... ... Deng chain type activate.Because each or each group neuron correspond to the most basic a certain information also i.e. information word, such as neuron a corresponding informance unit A, neuron b corresponding informance unit B, neuron c corresponding informance unit C, etc., then neuron a → b → c → d →... ... this information word corresponding to activation chain, just a string message sense A → B → C → D →... exported successively is formed this in neutral net neuron produce controlled, orderly, the chain type of stepping activates action successively, it is the most basic neural activity form of thinking, that is to say the essence of the thinking in neuron aspect.Neuron described here can be one or one group, is corresponding and the basic neural unit of a restriction information word.Described activation is that neuron breaks out once or the action potential of continuous several times, and due to synaptic facilitation, it may be continuous several times that a lot of neuronic activation is provided.

2. the working method of 4. thinking.The working method of thinking, that is to say that neuron such as the transmission of how exciting signal activates to carry out chain type in the mode realizing information processing.Because the synaptic contact between neuron is enormous amount and baroque, the reason that neuron a activates and causes neuron b to activate is many-sided, and this can be following several.

2. the synaptic contact 4. 1. set up because of imformation memory.Namely the information of A → B was once repeatedly inputted before, and generation establishes directly and transmits the enough powerful synaptic contact of usefulness between neuron a and neuron b, (synapse transmission usefulness is generally the synapse quantity owing to being formed each other, determine with the transmission usefulness of each synapse), when neuron a being activated and neuron b is stimulated, neuron b integrates and triggering generation action potential owing to obtaining enough excitements, produce neuron a → b → reflex chain, the thinking of this form exports, essence is also recall process to original remembered information, work can describing with reference to No. 2014106066977 Chinese patent application in more detail for it.

2. the 4. 2. neuronic modulating action of modularity.From other neural activities such as emotional system, kinetic system, the modularity neuron that it produces is to the modulating action of neuron b, comprise the enhancing of enhancement modulation, or inhibition modulation weaken, make when neuron a activates, neuron b integrates due to synapse and is activated, produce neuron a → b → reflex chain.(separately have after specific works and describe).

2. the cooperative exiting effect of self-synchronous exciting pulse is 4. 3. carried out.Particularly from the effect of thought system " attention " control loop.The activation of neuron a, stimulated to a large amount of rear neuron grantings by aixs cylinder, but obviously after these, neuron is not all activated, only have when the region at neuron b place is pointed in the lock-out pulse granting of thinking " attention " control loop, neuron b is just integrated by collaborative stimulations of lock-out pulse and activates, generation neuron a → b → reflex chain.And if the lock-out pulse of " attention " control loop provides to other neuronic regions, then may be that another neuron such as neuron f is activated, produce neuron a → f → reflex chain.Should say, under same emotion and same physiological status, the thinking activities of brain, more mainly the control of the synchronization motivationtheory pulse being subject to " attention " control loop, and the chain type that also lock-out pulse makes neuronic activity be formed " stepping " formula orderly in same path just activates and can not be chaotic, lock-out pulse plays the sequencing contro effect of clock signal in the central processing unit being similar to electronic technology field.The working mechanism of " attention " is the emphasis of brain work, and incite somebody to action the 3rd part later, namely " control mechanism of 3. human thinking activity " is described in detail.

2. the comprehensive function of 4. various excitement excitation.Because the synaptic contact between neuron is huge and baroque, the Production conditions that neuron chain type activates and approach, directly fixing reflection contact can be had without the need to setting up each other, but trigger the activation because of the co-integration of the relay cell of other indirect associations.Such as, original direct and unfixing reflective relation between neuron e and neuron f, (namely there is no imformation memory relation) yet, so, the more weak general synaptic contact of usefulness is transmitted although set up between neuron e and neuron f, (owing to being subject to the stimulation of indirectly information between relevant neuron, set up each other and have synaptic contact general widely, if and the synapse negligible amounts set up each other, lower with the transmission performance of each synapse, then the transmission usefulness of this synapse is just more weak), the excitation that this weak synaptic contact can transmit is more weak, the activation of original neuron e is not enough to cause neuron f also to produce activation, but, if before neuron e activates, there is neuron a, b, c, the activation of d, (being also the neuronal activation of relevant information), repeatedly give neuron f to stimulate, these stimulate repeatedly makes neuron f that film excitement occurs, and form film integration, (this is also one of producing cause of working memory, the film that working memory is transmitted due to synapse integrates and short-term synaptic journey plasticity produces), and also have the neuronic modulating action of modularity simultaneously, so that provide when neuron e activates, and during the excitation of the lock-out pulse of simultaneous " attention " control access, neuron e passes to the weak excitatory stimulation of neuron f, be enough to the threshold value that the excitement value after neuron f synapse is integrated exceedes action potential, thus triggering action potentials, produce neuron e → f → reflex chain.In this case, the excitement stimulation of neuron e plays last pivotal role, (last straw).The chain type that this mode causes activates, it is the principal mode of human thinking, also be the reason that brain can carry out free thinking, it has direct memory relation without the need to front and back information in foundation before, but integrate generation by whole message structure, so, again recalling of it and non-information, but the output of the new message sense do not had before can producing, produce the thinking of " freedom ".Certainly, the thinking of so-called " freedom " is relative, refer to the new message sense do not had before can producing, but its generation is still the restriction being subject to other various collateral informations.When in the face of information input, the travel direction that chain type activates also is the thinking of thinking, is subject to the syndeton of related Neurons and the joint effect of multiple modulation path and " attention " control access.Wherein the syndeton of related Neurons that is to say the memory structures of original relevant information, comprises knowledge, event, experience etc., and this is the basis forming intelligence; And the effect power of " attention " control access and each modulation path also can be variant in different people, this is the main cause forming different " personality ".

2. 4. 5. neuronic spontaneous discharge.Corticocerebral neuron, because synaptic contact is each other widely, so, other neurons outside the activation chain of thinking passage, at a time, also part may be had to stimulate owing to being constantly subject to various excitement and to produce film integration and triggering action potentials, produce so-called spontaneous discharge.But applicant infers, because this spontaneous discharge is sporadic, fail again to form synergism action with other excited excitations such as comprising lock-out pulse, generally fail again to encourage next neuron and form chain type and activate, so do not become thinking activities, and just isolated spontaneous discharge.But this spontaneous discharge also has its biological significance: due to neuron spontaneous discharge once in a while, the physiological activity that neuronic cell space and synapse can be made to keep certain, maintains its physiologically active.And stimulate owing to receiving the excitement with the related Neurons of synaptic contact, and its spontaneous discharge forms stimulation to these related Neurons, so can " refresh " and these neuronic synaptic contacts, improve the effectiveness of its synaptic contact, that is to say the memory structures enhancing and rely on this synaptic contact and set up.This mechanism should be the other system such as kinetic system that there is brain.And this mechanism seems also can have an effect when sleeping, so we can find sometimes, through information or the technical ability of repetition learning or exercise, even if do not go study or contact later again, some can become more clear or more skilled in a few days.

2. the essence 5. realized.Consciousness is one of the most mysterious function of brain.Applicant, according to the link of brain in information processing and flow process, thinks: consciousness is the self-perception of brain to thinking activities.When brain carries out thinking, also be that the Wright's nerve metanetwork of brain association cortex is when carrying out thinking activities, the neuronic activation of thinking passage, its aixs cylinder one side forwardly other neurons forms neuromuscular juinction to continue to encourage thinking activities, also the neuron of corticopetal associating sensory region forms projection simultaneously on the other hand, make the neuronic activity of thinking passage by the perception of institute of cortical sensibility district, so, brain just perception and recognize the thought and being of " I ".The neuron activity of this association cortex, to the neuronic projection of sensory cortex, enables the thinking activities of sensory cortex to association cortex produce self-perception, and this is the essence of consciousness.Normal person, and under normal waking state, this accept projection sensory cortex seem mainly audio associating sensory region, especially speech center, so we daily " consciousness " to " thinking " be carry out with language mostly.(for congenital deafness mute, because it cannot form perception of sound, and neutral net has plasticity and compensatory, then can the sign language of sense of vision carry out, this sign language also belongs to language).Certainly, our said audio sensory region and sense of vision sensory region, being all artificial definition, is in fact all realize with the relay cell of nervus centralis.The projection of this thinking process to sensory cortex and the biological significance of self-perception, should be the various average informations that thinking process is produced, as new information, project sensory region and carry out perception and input, so as this average information to be remembered or and original information recombinate, (first this memory shows as working memory, is converted into long-term memory and longterm memory more in some cases afterwards), constantly improves the message structure of its memory with this.But again project just because of this, make thinking process can by the perception of the sensory cortex of brain institute, make us " know " and " consciousness " to the content of thinking and process, just make us create this marvellous " consciousness ".If there is no this path again projecting perception, then brain just just reflects input information and reacts output, and there is no " knowing " and " consciousness ", also can not ego integrity message structure, just just belonging to the neural reflex mechanism of elementary biology, similarly is more an automatic machinery in other words.Obviously, this is also the place of the essential distinction of current artificial intelligence and human brain: current artificial intelligence only possesses the ability of perception to external input information, identification, process, reaction and output, and lack the ability self-perception of information process and the average information that produced by information process being incorporated in real time to original information structure, also namely lack " self consciousness " and " ego integrity " ability.Obviously, not to understanding and the understanding of the essence of human brain " consciousness ", the artificial intelligence really with " consciousness " be designed and just do not know where to begin at all.Applicant is according to the essence of above-mentioned human brain " thinking " and " consciousness " and operation principle, also has " attention " control mechanism about thinking described later, and solve wherein the most difficult by the technology of average information real-time integration to " ego integrity " in original information structure in mode cleverly, devise the artificial intelligence system of brand-new operation principle, open by carrying out in the patent application of " there is autopsychic artificial intelligence system " of proposing afterwards.

Applicant also thinks: brain exists the modulation path from hypothalamus or brain stem, i.e. sleep and the modulation path of awakening, make normal person under waking state, the relay cell of association cortex is when carrying out thinking activities, its neuron activating chain mainly projects to associating Auditory cortex, and suppressed to the projection of vision and other sensory cortexs, so brain is to the self-perception of thinking and consciousness, mainly feel to realize with audio.This is mainly because the visual cortex also have direct projection to motor cortex to carry out unconscious daily routines; and audition does not have; if the visual information of thinking activities also projects to the visual cortex, then may cause the confusion that " vision-motion " reacts.Only under non-waking state, (sleep is had a dream, or certain psychosis is as schizophrenia), the suppression of the visual cortex is removed singularly, the information that thinking activities produces just can project to the visual cortex, brain is made to produce appreciable image hallucination, just as seeing.(about daydream and schizophrenia, after be described elsewhere).

2. the producing method 6. realized.The producing method of consciousness, be also the feedback mode of delivery of relay cell to cortical sensibility district of association cortex thinking path in thinking process, this may have two kinds of modes:

2. 6. 1. first kind of way is that the relay cell of thinking path directly carries out chain type activation, such as neuron a1 → b1 → c1 → activation chain, its activity is not by the impact in cortical sensibility district, just in this course, neuron a1, b1, c1 send out side shoot simultaneously and project to cortical sensibility district, make neuron such as this thinking process of neuron a2, b2, c2 perception of its correspondence, namely produce a2 → b2 → c2 → self-perception, thus produce oneself " consciousness ".In this fashion, thinking is directly produced by the relay cell of association cortex, and sensory cortex is perception passively and recognizes this thinking activities.Its neuron projections mode as shown in Figure 10.

2. 6. 1. the second way is that the chain type of thinking activities activates to come and go between association cortex neuron with sensory cortex neuron and intersects and carry out, and its neuronic mode of delivery as shown in figure 11.(1), neuronic every one-step activation of thinking path its process comprises:, and such as neuron a1 activates, and just carries out projection to the corresponding neuron a2 of next neuron b1 and sensory cortex simultaneously and encourages; (2), the neuron a2 of sensory cortex is triggered the activation this information of perception; , the activation of sensory cortex neuron a2, carry out projection excitation to the neuron (including neuron a2) of association cortex conversely again; (4), the neuron b1 of association cortex accepts the excitation of a1 and a2 simultaneously, triggers the activation; , the activation of neuron b1, carry out projection to the corresponding neuron b2 of next neuron c1 and sensory cortex again simultaneously and encourage; (6), sensory cortex neuron b2 activates this information of perception; , the activation of sensory cortex neuron b2, carry out projection excitation to the neuron (including neuron c1) of association cortex conversely again; (8), neuron c1 accepts the excitation of b1 and b2 simultaneously, triggers the activation Finally, association cortex thinking path occurred equally neuron a1 → b1 → c1 → activation chain, and the neuron of sensory cortex create too a2 → b2 → c2 → self-perception and form consciousness, but this process be with a1 → a2 → b1 → b2 → c1 → c2 → the mode of round projection carry out.In this fashion, sensory neuron be real-time perception thinking activities each step, and participates in and define thinking activities the next one activation action.

2. 6. 2. owing to lacking detailed and reliable anatomical documentation, applicant directly cannot determine that consciousness perception carries out in above-mentioned any mode, but applicant is by a kind of special thinking, and namely the thinking of language is carried out this analyzing and inferring.The mankind, thinking Many times carries out with language, only has a few special just to have the thinking of non-language.The language thinking of the mankind is generally carried out with the first mother tongue, but also can comprise the second mother tongue to carry out with foreign language, this is that applicant thinks that consciousness is the reason of thinking passage to the projection of associating sensory cortex, and this provides a kind of approach to the mode of delivery of consciousness for our analytical thinking: if thinking is first kind of way to the projection of consciousness, namely thinking activities is that the relay cell of association cortex independently carries out, associating sensory cortex (the sensation identification of language is also the associating sensory region belonging to sensory cortex) just this activity of passive perception, so, no matter be carry out thinking with mother tongue or with foreign language, thinking activities all should be able to normally carry out swimmingly and produce result of thinking, just thinking not necessarily by reliable perception and can be recognized sometimes, on the contrary, if thinking is the second way to the projection of consciousness, namely thinking comes and goes to carry out between association cortex and the neuron of sensory cortex, so, when carrying out thinking with unskilled foreign language, thinking activities will inevitably have some setbacks, and can be obstructed, cannot produce result of thinking when proceeding to unacquainted foreign language word.Practical situation is the latter, brain is when carrying out thinking with unskilled foreign language, usually discontinuous, be obstructed and be difficult to go on, so applicant infers, the thinking of brain, it is at least the thinking of language, be the relay cell at association cortex thinking path, and between the neuron of sensory cortex, come and go and carry out chain type activation.Certainly, this work process is also subject to lock-out pulse simultaneously affects with the modulation of other modulation intelligences.(see " 2. 4. 3. from the synergism of lock-out pulse ".Also has the 3rd part " control mechanism of human thinking activity " below).

If 2. 6. 3. thinking and consciousness are carried out by this way, namely between thinking path and the neuron of sensory cortex, come and go projection realize, the cooperative exiting of the lock-out pulse of " attention " control loop is needed due to thinking activities, so, in the thinking activities of language, each stepping of neuron activity, just more lock-out pulse is needed to carry out cooperative exiting, the neuronal activation of thinking path at least needs once, the neuronal activation of sensory cortex at least needs once, (say here at least, because neuron needs lock-out pulse more than once to encourage just generation once to activate granting sometimes).And we know, the lock-out pulse of cerebral activity, can be detected and obtain, and is also brain wave.So in the thinking activities of language, even in the fastest the most nervous thinking, the speed of thinking, the quantity of the word of the thinking activities namely can recognized in certain hour, can not exceed the half of the brain wave rhythm and pace of moving things the soonest.This can be verified by contrived experiment.

2. 6. 4. applicant thinks, the mode that thinking and consciousness are carried out with this round crosswise projection also has its biological significance and reasonability.Each step activity of thinking process projects sensory cortex all in real time, make the timely perception of brain and integrate this information, the perception of sensory cortex projects again again to be got back in thinking path, again affects and limits, impel thinking to carry out more accurately in relevant information on thinking activities.And, from the anatomical structure of brain, cerebral cortex has the neuron of the dense arrangement of enormous amount, (especially cones and granular cell), and the neuronic quantity (changing first number) of any direct Nervons projection link is all few in brain, be 2 to 5 neuronic projection links mostly, but our thinking activities can input, export and integrate the message sense of the surprising serial of length, such as, remember or recite the article reaching K word! Obviously, the article of the huge bunchiness of this byte number is remembered and exported to brain just by carrying out coming and going the model of action projected between the huge sensory cortex of neuronal quantity and association cortex.Wherein, sensory cortex has remembered the single word of language and word, and association cortex has remembered the connection relation between them.When we read and remember one section of article, be that the syndeton of the relay cell by changing association cortex (comprising the cortex of hippocampal formation) remembers the connection relation between word with front and back sequential; And when we recall this section of article, under the control of synchronization motivationtheory pulse, these have the relay cell of sequential connection relation to activate association cortex successively in a stepping manner, and reading maincenter that is real-time and sensory cortex carries out round projection, so sensory cortex is these words of perception one by one, produce the language perception of bunchiness, realize recalling article.(this recalling original article remembered also belongs to a kind of form of thinking activities, sees " synaptic contact 2. 4. 1. set up because of imformation memory ").

2. 6. 5. in the thinking process of above-mentioned this language, in cortex language sensory region neuronal activation while, can also to the relevant motor region of language in cortex, comprise the maincenter of speaking and cheirokinesthetic center projects.But these two maincenters are being closed output at ordinary times, (by the neuronic suppression of modularity, or/and there is no the cooperative exiting of lock-out pulse), only when needs are spoken or write, these two motoriums are just opened, and (modularity neuron suppresses to remove, or/and effective granting excitation of lock-out pulse), so the information of language thinking activities can carry out movement output, namely carries out speaking or writing simultaneously.

If with 2. 6. 2. mode as a same reason analyze, consequently: speak maincenter or cheirokinesthetic center just accept the information projection of thinking activities passively and descendingly to export to nervus motorius, and do not participate in the process of thinking.So paralambdacism, words can not be write, and all can not affect normally carrying out of thinking activities, even sometimes also there will be the situation of brain " that thinks is different with what say ".

What 2. 6. certainly go up surface analysis is the thinking activities of thought system " consciously ", and for other system, such as motor system, because cortical motor areas both can accept the output projection of association cortex, also the projection in cortical sensibility district can directly be accepted, so the athletic performance of motor system both can be control by the output of thought system, also directly can carry out without the need to thought system " attention " and " consciousness ", its macro manifestations is, in the face of external information stimulates, body directly produces reaction action, then just note by thought system and perception.

2. 7. thinking, relation between consciousness and attention.Thinking is that the orderly chain type of carrying out successively of the relay cell of association cortex activates, and consciousness is the self-perception of sensory cortex to thinking activities, so consciousness depends on thinking and produces.And according to the working mechanism of brain " attention ", (seeing below content described in the 3rd part), " attention " is that the control loop of thought system accepts various sensory stimuli, through comparing, competing and suppressing mutually, integrate out a kind of control mode of multiple information processing passage being carried out to cooperation control.The sensing of " attention " determines at a time, which partial nerve unit of the thought system of brain accepts perception and inputs and carry out thinking activities, and these neuronic thinking activities feedbacks project sensory region, by the perception of sensory region neuron institute, create " consciousness ".So " attention " is a kind of control mode, " thinking " is a kind of reflex activity, and " consciousness " is a kind of perception." attention " controls " thinking ", and " thinking " creates " consciousness ".

In the ordinary course of things, this three is often interdependent, and the place of brain institute " attention " is the content of thinking activities, also can be arrived by brain institute " consciousness " simultaneously.Especially when thinking be with the form of language when carrying out, thinking activities feedback projects the sensory region (should be auditory speech centre) of carrying out language identification, make us experience the thinking processes of this language consumingly, experience the existence of " consciousness " consumingly.But in the thinking activities of some other non-language, in the thinking process of the operability work of lifting such as, because action both can be have " attention " by thought system and have " consciousness " to control, also directly can carry out without the need to thought system " attention " and " consciousness ", the procedural memory that even can also depend on motor system carries out, so easily make us not make " attention ", association between " thinking " and " consciousness " and difference clear.

3. the control mechanism of human thinking activity.The signal processing of brain and control mechanism are the most important contents of brain.Before, we can understand the Nomenclature Composition and Structure of Complexes of brain by anatomy, understand the general projection relation of each neural link of brain, even can understand the structure and working principle of single neuron and synapse, but still the memory of brain, the essence of thinking and consciousness and work cannot be understood, its main cause, the mechanism of the working mechanism to whole brain (being at least to thought system wherein) entirety, especially its signal processing and control, lack a systematic understanding, this causes us to the understanding of brain as the limitation as taking a part for the whole.And once understand transmission and the control mechanism of this signal, much about the problem of brain, even some psychotic essence and causes, just can be readily solved.

3. 1. about the Railway Project of thinking.Analyze the most basic neuron action of thinking activities above, namely neuronic chain type activation is the primitive form of brain thinking, is also the essence of thinking.Neuron due to orderly activation successively, and forms chain type activation, and the output successively of the information word corresponding to neuron that this chain type activates, forming message sense, is thinking.

, forming thinking if only activated with neuronic chain type, at least also there is Railway Project in that:

If 3. 1. there is no otherwise coordinative role, so neuronic activation, possibly cannot cause separately next neuronal activation, also multiple rear neuron may be caused to activate simultaneously, at this moment just not occur that orderly chain type activates, but there is radial large-scale neuronal activation, this does not obviously meet the serial of our thinking and orderly feature.

3. 1. 2. brain stimulates the input of (the various sensation such as vision, audition) in the various external informations of synchronization, all may cause the activation of brain related Neurons, if there is no certain control mechanism, so these outside stimuluss all may cause many chain types activation simultaneously, form multiple thinking to carry out, obviously this does not meet our thinking just single " thinking " feature of carrying out at one time yet simultaneously.(refer to the thinking of " consciousness " here, do not comprise health to the unconscious reflex response of outside stimulus, that is other reflex system, after separately have analysis).

If 3. 1. 3. thinking is only activated by the chain type of relay cell to carry out, so, the speed of thinking should be basically identical, because in " input-triggering action potentials-output " this process, neuronic speed of action is basically identical, even if consider the time that excited film is integrated, also difference can not be very large., in fact, thinking speed and the information output speed of brain are variable, or even can freely the controlling of " consciously ".Such as, when thinking deeply with language, or with language read silently recite one section of word time, speed both can be very slow, slow to 1 words per second, also can be very fast, seemed the soonest to reach 10 several words per second.Obviously, the neuronic activity of this part of association cortex not being chain type activates determines, but needs other signal of another one to control.

If 3. 1. 4. thinking is only activated by the chain type of relay cell to carry out, so, thinking, once start, just can only be carried out, and thinking cannot be turned to otherwise content in related related Neurons (being also relevant information).But in fact, brain can turn to other guide in thinking process.Such as: can associate in thinking process or be switched to other guide, " thinking " being switched between different information content, (certainly, single thinking is still only had to carry out at synchronization).For another example, in thinking process when there being other sensation (vision, audition, sense of touch etc.) inputs, brain both can switch " attention " at once and process these sensation inputs, also can ignore these sensations and proceed original thinking.Obviously, this also needs a control mechanism and carries out this judging and switching.

3. 1. 5. the pulse width of neuron action potential only has several milliseconds, and the time-histories of thinking activities and athletic performance mostly on the order of a second, and the activity cycle of longer time-histories can be formed, obviously, the action potential being difficult to rely on Millisecond directly forms the information activities of level second.

3. 1. 6. these problems above-mentioned, its essence is the control mechanism of thinking.Brain is carrying out thinking, also namely in the activity carrying out the activation of neuron chain type, the control of certain control mechanism must be subject to, make at a time can only to have certain or certain organize specific neuron in activation, make neural activity be carry out in order in the mode of " stepping ", ensure that thinking activities carries out in order with single thinking at a certain passage.And this control mechanism also controls thinking and between various different thinking and the input of different objective sensations, can carry out suitable attention, judgement and switching, namely form the control mechanism of " attention ".

Applicant analyzes discovery, this control mechanism of human thinking system, by what jointly form for generation of the thinking oscillating loop of lock-out pulse " network structure-thalamus " and several modulation path.(lock-out pulse is the address by being accustomed to providing to cortex thalamus action potential pulse in the past, but its essence is not for Synchronization Control, but between " network structure-thalamus ", come and go the pulse of granting action potential, form oscillatory rhythms, and provide pulse, to encourage the relay cell of cortex to carry out chain type activation successively by thalamus to cortex, so seem to be called that driving pulse is more suitable, but be still called lock-out pulse out of habit, or synchronization motivationtheory pulse).This oscillating loop and several modulation path effect difference, the control mechanism of common construction idea, and the control mechanism that should be motion and other processing systems.Carry out this below describing.

3. the 2. control access of " attention ", the working mechanism of lock-out pulse oscillating loop.We know, thalamus is ceaselessly providing action potential to cortex, (this is also the reason producing brain wave), by current understanding, this is seemingly in the work controlling cortical neuron, and the granting of thalamus lock-out pulse seems also relevant with network structure.So, do are how its concrete work process and control mechanism? applicant by analysis, is described in detail this.

3. 2. 1. first, thalamus and reticular formation of brain stem define the oscillating loop that a cyclic provides action potential.Reticular formation of brain stem medial area, more accurately say be medial area formatio reticularis mesencephali to intralaminar nuclei projection provide action potential, this granting does not comprise concrete information content, but has certain specificity.Current neuroanatomy does not carry out more detailed subregion to formatio reticularis mesencephali, but applicant thinks that formatio reticularis mesencephali at least has packet configuration, its each group neuron correspondence is also connected to the input of a certain category information, (input such as such as vision, audition, sense of touch, and from neuronic each bar Descending Projections path of association cortex thinking activities).Each group neuron of formatio reticularis mesencephali, Ascending Projections to the particular zones of in intralaminar nuclei, a certain neuron in a certain grouping of formatio reticularis mesencephali, Ascending Projections the one group of neuron that control in the corresponding subregion in intralaminar nuclei.The neuron that formatio reticularis mesencephali projects to intralaminar nuclei, belong to cholinergic neuron, its synapse transfer reaction speed is fast, the hormesis caused is powerful, when a certain group of neuronal activation of formatio reticularis mesencephali is provided, this group neuron of the intralaminar nuclei projected much is activated by excitement and provides action potential, but should be unable to produce synaptic plasticity, so do not have memory effect, its projection relation is fixing.

3. 2. the neuron axon of intralaminar nuclei projects to cortex and thalamic reticular nucleus simultaneously; Cortex also carries out Descending Projections to intralaminar nuclei and reticular nucleus simultaneously.(the corticopetal projection of intralaminar nuclei and cortex to intralaminar nuclei be incident upon rear separately have describe).Intralaminar nuclei is to the projection of reticular nucleus, and cortex is to the projection of reticular nucleus, and both exist the corresponding relation of launching position, makes both pulse grantings can carry out excitement and integrates, the neuronic activation of common activation reticular nucleus.

3. the neuron of 2. 3. thalamic reticular nucleus, carries out Descending Projections to formatio reticularis mesencephali.This projection does not carry specifying information, provides feedback to encourage mainly to the neuron of formatio reticularis mesencephali, can continue to carry out with the round granting maintaining oscillating loop.But the specificity of grouping location may be had, i.e. a certain group of neuron projecting to reticular nucleus of intralaminar nuclei, with reticular nucleus project one group of neuron to formatio reticularis mesencephali, belong to same truck.

3. 2. 4. like this, brain work time, between formatio reticularis mesencephali and thalamus come and go pulse distribution process be: formatio reticularis mesencephali certain or certain group neuronal activation, to intralaminar nuclei granting, the one group of neuronal activation making it project; The neuron of intralaminar nuclei, to reticular nucleus granting, makes by the neuronal activation projected; (intralaminar nuclei provides lock-out pulse to cortex simultaneously); The neuron of reticular nucleus, to the neuron granting of the correspondence of formatio reticularis mesencephali, activates the neuron of formatio reticularis mesencephali again.So, between formatio reticularis mesencephali and thalamus, according to the projection relation of " formatio reticularis mesencephali → intralaminar nuclei → thalamic reticular nucleus → formatio reticularis mesencephali ", form the closed-loop that a cyclic provides " the formatio reticularis mesencephali ← → thalamus " of action potential pulse, as shown in figure 12.This loop, by the oscillating loop that its working forms is a kind of round granting, by the control loop that its function is again a kind of cooperation control, so applicant is referred to as " thought system lock-out pulse oscillating loop ", be called for short " thinking oscillating loop ", or " thought system control loop ", is called for short " thinking control loop ".

3. 2. 5. intralaminar nuclei, to while reticular nucleus projection, also carries out Ascending Projections to cortex, i.e. " non-specific import into " projection of cortex.This projection is diversity, namely few to many projections, but actual have position corresponding relation, each subregion of intralaminar nuclei, Ascending Projections is to the corresponding bigdos of in cortex, (visual sense feeling district, audition sensory region, tactile sensation district etc., and the multiple association cortex districts carrying out thinking etc.); One group of neuron in a certain subregion of intralaminar nuclei, Ascending Projections is to a certain partial nerve unit in this corresponding great Qu of cortex; The a certain neuron of intralaminar nuclei, Ascending Projections is to one group of neuron in this part of cortex.When the specific neuron of intralaminar nuclei activates being subject to the up granting of formatio reticularis mesencephali, the neuron projected to cortex carries out pulse granting, define the synchronization motivationtheory signal of the neuron thinking activities of cortex, the activity of cortical neuron is activated in an orderly manner one by one successively, form step-type chain type activation and thinking, (lock-out pulse plays the sequencing contro effect of clock signal in the central processing unit being similar to electronic technology field).Simultaneously, by the different neuron of intralaminar nuclei to the different neuronic pulse granting of cortex diverse location, also control thinking activities to carry out and switch between the different neuron of cortex, define " attention " sensing transfer in same class communication channel in thinking activities.(see describing of " 2. the essence of thinking and consciousness " part).

Meanwhile, cortex also forms Descending Projections to intralaminar nuclei, and projects to reticular nucleus simultaneously, and this Descending Projections is polymerism, and namely multipair few convergence projection, contrary with Ascending Projections, but its projection relation is identical in position.Cortex, to the Descending Projections granting of intralaminar nuclei and reticular nucleus, forms excited excitation to the neuron of intralaminar nuclei and reticular nucleus, although be not the principal element determining that it activates, affect its excited speed integrated, thus have impact on the granting rhythm and pace of moving things of whole loop.When cortex produces thinking activities, cortex carries out feedback granting to intralaminar nuclei and reticular nucleus, is integrated and accelerates intralaminar nuclei and the neuronic activation granting of reticular nucleus, thus improve the oscillatory rhythms of oscillating loop by excitement.

The neuron coming and going projection between intralaminar nuclei and cortex belongs to aminoacid serotonergic neuron, the granting of its single neuron action potential pulse is not enough to projected cortical neuron is directly activated and triggering action potentials by excitement, collaborative irritability excitation can only be produced, the neuron of cortex needs other excited cooperative exitings stimulated, (other the neuronic excitements activated before the chain type activation pathway of also i.e. thinking stimulate, and the neuronic excitement of other modularities stimulates), just integrate triggering action potentials by spatial integration and time.But aminoacid serotonergic neuron can produce synaptic plasticity in granting action, its projection relation (being also connecting structure) can produce modification along with neuron activity, so, neuron between intralaminar nuclei and cortex, may not be the effect that lock-out pulse is provided, but take part in memory and the integration of information.

3. the 2. 6. corticopetal projection of intralaminar nuclei and granting, with the projection granting of cortex to intralaminar nuclei, although also there is round pulse granting, but its essence does not form oscillating loop, and be the thinking oscillating loop of " formatio reticularis mesencephali ← → thalamus " on intralaminar nuclei node to extension.If cut-out thalamus contacts with the projection of cortex, the oscillating loop of " formatio reticularis mesencephali ← → thalamus " still can maintain vibration, conversely, if cut off the projection contact between " formatio reticularis mesencephali ← → thalamus ", then thalamus is provided with being formed between cortex to come and go.Wherein, the corticopetal pulse granting of intralaminar nuclei, defines the synchronization motivationtheory signal of cortical neuron thinking activities, and cortex is to the feedback granting of intralaminar nuclei and reticular nucleus, also forms feedback to the work of thinking oscillating loop, and may form impact to its oscillatory rhythms.

3. the neuron work of 2. 7. formatio reticularis mesencephali, decide the oscillatory rhythms of thinking oscillating loop, which the group neuron that also control formatio reticularis mesencephali carries out pulse granting to intralaminar nuclei.Owing to lacking more detailed anatomical documentation, applicant cannot determine in formatio reticularis mesencephali at present, to the neuron of intralaminar nuclei Ascending Projections, be with the neuron receiving reticular nucleus Descending Projections, same group of neuron or two groups, front and back neuron? applicant is partial to be have two groups, front and back neuron.But no matter be same group of neuron or two groups, front and back neuron, this part neuron of formatio reticularis mesencephali, (1), the excitement of reticular nucleus Descending Projections excitation needing to receive the excitement from several respects and modulation signal simultaneously, comprising:, proceeding for maintaining the vibration integrating oscillating loop; (2), from other modularity nerve nucleus and the modulating action from other control loops, for modulating the speed that neuronic excitement is integrated, thus modulate the oscillatory rhythms of whole oscillating loop; (3) the exciting signal of truck and cortex Descending Projections path, is inputted from each, for the excitement degree (may sequential be also had) according to each truck, first certain the group neuron controlling a certain truck activates, to intralaminar nuclei granting; (4), from the neuronic inhibition modulation of the different communication channel of formatio reticularis mesencephali, when first activating to intralaminar nuclei granting pulse for making formatio reticularis mesencephali group neuron, suppress the neuron of other communication channels cancellated can not activate granting again within this pulse period simultaneously.The exciting signal of these several respects and modulation signal carry out integration and compare and synergistic result, make thinking oscillating loop at synchronization, formatio reticularis mesencephali can only have one group of neuron in a certain communication channel to carry out lock-out pulse granting to intralaminar nuclei, thus make at synchronization, intralaminar nuclei can only have one group of neuronal activation and a certain partial nerve unit in corticopetal a certain subregion carries out lock-out pulse granting, it is encouraged to produce thinking activities, and feedback simultaneously projects sensory cortex, self-perception is carried out to thinking, produces " consciousness ".So, brain is by the grading control of " formatio reticularis mesencephali-thalamus-cortex ", define and only lock-out pulse is provided to a certain partial nerve unit of cortex thought system at synchronization, to encourage the neuron of this part to carry out thinking activities, point to monistic " attention " that this forms thought system.This is also the Forming Mechanism that thought system " attention " is pointed to.

3. the input transmission channels of information.And brain will be analyzed how control that " attention " point to and switching are carried out to various information, also need the transmission path understanding various information input channel.The information processing of brain comprises outside sensory information and the perception process to internal body information, with the mainly external information process that thinking is relevant with " attention ".And two aspects are comprised to the perception process of external information: one is extraneous various sensory informations, and comprise vision, audition, olfactory sensation etc., come from various sensory input, difference feels to have different input transmission channels; Two is average informations that brain produces at thinking process, the Descending Projections that the relay cell coming from cortex produces in thinking activities, and the cortex of zones of different has respective Descending Projections path.For the input transmission channels of various sensation, research is before many, here only for the vision of wherein more complicated and audition input channel, analyzes itself and the incidence relation of thinking with " attention ".

3. the input transmission channels of 1. visual information.According to current anatomical research, the neuronic output of amphiblestroid multiple visual sense feeling and optic nerve, be divided into two large transmission paths after optic chiasma.(the human brain visual channel signal projective structure schematic diagram with reference to Figure 13).

Article 1, the neuron of vision transmission path is a lot, form larger tractus opticus, what transmit is the visual information comprising particular content, primary visual cortex is projected again by the pregeniculate transfer of thalamus, belong to " specificity imports into " projection of cortex, visual information is converted to locus by time encoding and frequency coding and encodes, complete various visual information (shape, size, position, color, brightness etc.) preliminary identification, (with reference to above " 2. cognitive working mechanism "), associating optic cortex is projected again in many-to-one mode, complete the identification to visual object.Afterwards, for direct visual information (concrete object, image, picture etc.), directly project that association cortex carries out remembering, thinking and response activity, and for relating to the visual information of word, then project the cortex of " reading maincenter ", complete the identification to word, then project imformation memory and thinking activities that association cortex carries out language.Associating optic cortex directly can also project motor cortex.Motor cortex and cerebellum (seeming to also have striatum) etc. form motor system, motor system does not belong to thought system, both can control by the output of thought system, also can directly reflect according to visual information without the need to thought system controls and control muscular movement, also the learning and memory of combining and reaction treatment can be carried out, (memory here that is to say so-called " procedural memory "), completes the unconscious most of actions carried out in our daily life.

The neuron of the Article 2 vision transmission path after optic chiasma is less, but reality is prior, and this transmission path in fact at least comprises three aspects: (1), project to hypothalamus.Bright with dark information in the just visual information that this projection is transmitted, reflex circuit is formed by hypothalamic coker, tuberal nucleus, the nipple core etc. looked, up to thalamus and the extensive region of cortex, the descending projection carrying out modularity to brain stem and spinal cord etc. again, (belonging to histaminergic neuron), in order to form Circadian rhythm and to carry out the control of sleeping and awakening.(2), project to pretectal area, then project to formatio reticularis mesencephali.This projection does not comprise concrete visual information, also i.e. non-specific projection, be presence or absence and the intensity of transfer vision information, (should be the transmission being realized information strength by the granting frequency of action potential), so this Nervons projection, applicant calls that " report " formula projects.This " report " signal projects the visually row of channels of formatio reticularis mesencephali, and project other inhomogeneities cancellated feel that " report " signal of (audition, olfactory sensation etc.) carries out " competition " with same, if the visually row of channels that network structure projects to thalamus can be activated, be " causing " cancellated " attention ".There is neuron Descending Projections pretectal area to eyes simultaneously, in order to feedback regulation crystalline lens, is regulated the light intensity entering eyes by pupillary reflex.(3), project to superior colliculus.Superior colliculus has with primary visual cortex and neuronicly connects modulation each other, and superior colliculus also has neuron Descending Projections to the oculomotorius of eyes simultaneously, carries out that eye is dynamic to be controlled.So, applicant infers that the effect of superior colliculus is when visual information is subject to " attention ", control which part concrete " lime light " of vision being placed on visual information, also be which position in the visual field, and the control that superior colliculus is dynamic to eye, just the focus of eye lens is incident upon on which position amphiblestroid.

Obviously, the (2) and (3) " attention " of two aspects just with thinking relevant, wherein project to pretectal area the (2) aspect be cause network structure to visual information " attention ", and projection to superior colliculus the (3) aspect vision " lime light " invested which position in the visual field.It is worth mentioning that: superior colliculus does not need through cortical motor areas and cerebellum to the projection of oculomotorius, and directly control the eye action of eyes.When having a dream, there is neuron activity in thought system, but the output of the kinetic system such as motor cortex and cerebellum is suppressed, body action can not be produced, only have oculomotorius both can be subject to the control of motor system, directly can be subject to again the control of network structure and superior colliculus, the reason of action, the action that goes out to lose face when this that is to say daydream so the activity (dreamland) can following thought system goes out to lose face.(separately have below and carry out describing to daydream).

3. the information input channel of 2. audition is similar with this, as shown in figure 14: Article 1 audition transmission path (lateral lemniscus pathway) passes through medial geniculate body relaying from cochlea, to primary auditory cortex projection, for transmitting the auditory information comprising particular content; Article 2 audition transmission path (the outer path of fillet), from superior olivary nucleus branch, projects to reticular formation of brain stem, and this transmission path does not comprise concrete auditory content, just transmits presence or absence and the intensity of audition, belongs to the projection of " report " formula yet.This " report " signal carries out " competition " at network structure " report " signal with other inputs, to cause network structure to " attention " of auditory information.Article two, audition transmission path connects each other at inferior colliculus, inferior colliculus has neuron mutually to get in touch with primary auditory cortex simultaneously, so, applicant infers that the effect of inferior colliculus is when auditory information is subject to " attention ", controlling which part main " lime light " of audition being placed on auditory information, is also the sound of which position and which frequency band.The input channel of other information (sense of touch, olfactory sensation and somesthesia etc.) with visual channel and auditory channel similar, no longer describe here.

3. and for brain when carrying out thinking, the projection process of the average information that the relay cell activity of association cortex produces, does not have the correlational study of this respect at present.Applicant researchs and analyses, this average information is except projecting to other relay cells to continue thinking activities, also deposit projection both ways: feedback projection is carried out in corticopetal associating sensory region on the one hand, make the average information produced in thinking activities by perception again, (also being carried out remembering and integrating in some cases), define brain and namely also " consciousness " is formed to the self-perception of thinking activities, (see part 2, the content of " essence of thinking and consciousness " part); Carry out Descending Projections on the other hand, (aminoacid can be neural), this Descending Projections is the projection of multipair few polymerism, i.e. movable common activation descending neuron of multiple relay cell in cortex, and should be have grouping specific, namely the different grouping of cortex has respective projection tract, and (this grouping is not limited to the region analysis anatomically defined, but the formation of neuron long term activity of earthquake plasticity, so be called that grouping is more suitable).The result of polymerism projection, it is the specifying information that this superframe signal does not comprise neuron activity, and whether just transmit the corresponding neuron divided into groups in activity, and the active degree of activity, (speed being provided frequency by action potential is transmitted).Each projection tract that these cortex are descending, after relaying, (relaying carries out signal integration and is again polymerized), enter into reticular formation of brain stem, become the projection of " report " formula, carry out " competition " with other report signals, to cause network structure to " attention " of the cortical neuron activity of this grouping.This cortex of thought system to the meaning of cancellated Descending Projections path is, when the cortex of this grouping is when carrying out thinking activities, this " attention " can maintain formatio reticularis mesencephali and thalamus continues to carry out lock-out pulse granting to the cortex of this grouping, to continue the carrying out of the thinking activities maintaining this grouping.

3. the 4. control of " attention ", maintenance and switching.According to the research and analysis of applicant, the control that in thinking activities, " attention " is pointed to and switching, not in the past recognize in order that produce at the cortex of telencephalon of information processing top layer, go other parts controlling brain again, but produce on formatio reticularis mesencephali and switch, then the neuron activity in other regions such as upload control thalamus and cortex.What thought system " attention " was pointed to switch in two aspects carries out: what formatio reticularis mesencephali was responsible for is which communication channel " attention " sensing is switched to, i.e. " attention " which kind of information; What thalamus was responsible for is which particular location " attention " pointed in this communication channel, i.e. which part of " attention " this category information; And cortex especially akrencephalon association cortex just under the control of " attention ", carry out concrete information processing.

3. 4. 1. network structure control that " attention " is pointed to.As aforementioned, various information passage, comprise the neuron activity of extraneous input communication channel passages such as () vision, audition, olfactory sensation and cortex thinking passage, have the nerve after polymerism (multipair few) is integrated to export to project to formatio reticularis mesencephali, the presence or absence that these projection tracts transmission of information stimulates and intensity (provide frequency by action potential and carry out transfer strength), and do not comprise concrete information content, belong to the projection of " report " formula.Formatio reticularis mesencephali have multiple side by side carry out to thalamus the Upstream driver path that projects, corresponding these " report " formulas from each communication channel that receive project, and these Upstream driver paths arranged side by side project alternately each other and suppress mutually, there is the phenomenon of similar " competition ": be carved with when a certain certain group neuron be subject to excited activate and up to thalamus carry out pulse provide time, it exports to produce the neuron of other paths simultaneously and suppresses, the neuron of other paths cannot reactivation be exported within the same pulse period, monistic " attention " defined in formatio reticularis mesencephali aspect is pointed to.

As within a pulse period, which group neuron can be activated and up granting lock-out pulse, then depend on the co-integration of several signal: the signal (1), from nonspecific " report " formula of each information input channel projected, this signal is main, and its signal power plays a decisive role; (2), from the lock-out pulse granting of thalamic reticular nucleus Descending Projections, proceed for the vibration maintaining oscillating loop, also because which form each pulse period; (3), from other neururgic modulating actions such as brain stem and hypothalamus, for modulating the oscillatory rhythms of whole oscillating loop; (4), from other neuronic inhibition modulation of network structure, for carrying out " competition "; These signals jointly carry out excitement and integrate, cause within a pulse period of oscillating loop, always there is certain to organize neuronic excitement and integrate first triggering action potentials and activating, be equivalent to its " report " compete and successfully replied and cause " attention ", export on the one hand to the up granting lock-out pulse of intralaminar nuclei so it activates, immediately the neuron of other paths is produced on the other hand and suppress, make them reactivation export.Afterwards, in the pulse period of the next pulse of the descending granting of thalamic reticular nucleus, above-mentioned integration and competition process are carried out once more.Go round and begin again, make within each pulse period, formatio reticularis mesencephali has and only has " report " of a truck compete successfully and cause " attention ", and uply carry out driving pulse granting to intralaminar nuclei, by the lock-out pulse projection required for information processing to this truck, achieve the control of " attention " sensing " which kind of " information to thinking activities.

3. 4. 2. thalamus control that " attention " is pointed to.People, the major function of thalamus is relaying, comprises information relay and lock-out pulse relaying.What be responsible for information relay is " specificity relay nucleus group ", mainly comprises lateral nuclear group, ventral nuclear group and geniculate body nuclear colony, for carrying out relaying and primary treatment to the information input of polyesthesia (vision, audition etc.); Also have ventral anterior nucleus and ventral lateral nucleus, for the average information of transmitting movement system.These specificity relay nucleus are rolled into a ball corticopetal projection and are belonged to " specificity imports into ", and responsible lock-out pulse relaying is so-called " non-specific core group ", in fact the granting of lock-out pulse has specific projection relation, so also there is specificity, only lock-out pulse provide specificity but not the specificity of information content.The relay nucleus of lock-out pulse roll into a ball the lock-out pulse granting receiving network structure Ascending Projections, (cholinergic nerve projection), and it exports a side shoot on the one hand and projects reticular nucleus, then Descending Projections gets back to reticular formation of brain stem formation closed loop oscillating loop; The output of these relay nucleus group is also to multiple region project such as cerebral cortex and basal nuclei, limbic system and cerebellum on the other hand, (namely so-called non-specific import into), carry out the granting of synchronization motivationtheory pulse, the neuron in excitation and these regions of cooperation control carries out the information processing such as thinking and motion.

Analyze according to existing anatomical documentation, at thalamus, the relay nucleus group relevant with synchronized-pulse control mainly comprises anterior nuclear group of thalamus, sections inner side nuclear colony and intralaminar nuclear group.Wherein anterior nuclear group and medial nuclear group accept the granting of the lock-out pulse of brain stem pedunculopontine reticular tegmental nucleus and lateral dorsal nucleus, its output projects to part cerebral cortex and limbic system (especially Hippocampus and corpus amygdaloideum) cortex, is mainly used in memory and the integration of the average information controlling thought system and emotional system; And intralaminar nuclei, accept the lock-out pulse granting of formatio reticularis mesencephali, it exports the extensive region projecting akrencephalon basal nuclei, striatum and cortex of telencephalon, information processing for Collaborative Control thought system is also thinking activities, the motion process of the part motor cortex also having the hard to bear thought system of energy to control.Wherein main " attention " control access that take part in thought system with intralaminar nuclei: when the cancellated a certain information upstream projection tract of midbrain neuronal activation and to intralaminar nuclei correspondence position neuron provide lock-out pulse time, this part neuron of intralaminar nuclei activate by up lock-out pulse granting, its aixs cylinder exports provides lock-out pulse so that the mode of dispersing projection is up to the corresponding neuron of cortex, make the cooperative exiting that can be obtained lock-out pulse by this partial nerve unit projecting granting, form excited integration and carry out chain type activation, namely thinking activities is carried out.(the corticopetal mutual granting of intralaminar nuclei see 3. 2. 5. part description).And the side shoot projection of thalamic reticular nucleus dash receiver kernel and the feedback of cortex thinking passage relay cell project, more descendingly carry out feedback projection to formatio reticularis mesencephali.

So, formatio reticularis mesencephali, intralaminar nuclei and thalamic reticular nucleus constitute " attention " control loop of thought system, receive the signal of " report " formula projection of each communication channel, again synchronization motivationtheory pulse granting is carried out, to carry out the control that thinking " attention " is pointed to which partial nerve unit of which communication channel of thought system.As shown in figure 15, the signal projection of each passage as shown in figure 16 for its concrete neuron projections.Which group neuron that wherein the up granting of formatio reticularis mesencephali decides intralaminar nuclei can activate output, and neuronic activation of this group of intralaminar nuclei exports which the partial nerve unit that decide cortex and can carry out information processing.What formatio reticularis mesencephali was responsible for is that " attention " is pointed to be switched to which communication channel, i.e. " attention " which kind of information; And thalamus is responsible for is that the partial nerve where " attentions " pointed in this communication channel is first, i.e. which part of " attention " this category information; And brain association cortex is responsible concrete information processing (thinking and memory), and by this processing procedure of sensory cortex oneself perception, also namely produce oneself's " consciousness ".Such as, formatio reticularis mesencephali controls " attention " to point to visual information, and thalamus controls " attention " which object in visual, and association cortex is then be responsible for identifying this object, and simultaneously by the activity of sensory cortex perception association cortex, " consciousness " is to the existence of this object.

3. the maintenance of 4. 3. " attention ".When a thinking process is when carrying out, the cortical neuron activity of this thinking passage is in excitatory state, these neuronic activation actions, except continuing to provide forward to carry out except chain type activation, also simultaneously by the projection of gathering, produce the superframe signal that two-way is descending: the feedback of first via downstream signal is issued to intralaminar nuclei, being integrated by excitement makes intralaminar nuclei be continued to provide to this passage by next synchronous pulse, chain type can be proceeded with the neuron maintaining this passage to activate, first via downstream signal is also sent out side shoot simultaneously and is projected thalamic reticular nucleus, oscillating loop is impelled to proceed, (especially during high rhythmic oscillations), second road downstream signal is the projection carrying out " report " formula to formatio reticularis mesencephali, maintains formatio reticularis mesencephali to the continuation " attention " of this passage by competition.This two-way Descending Projections signal jointly maintains thinking control loop and points to " attention " of this passage, and this that is to say the working mechanism that " attention " of thinking activities maintains.

3. the 4. switching of " attention ".Cause " attention " sensing appearance to switch, probably have this several situation following.

(1), the content of thinking activities changes.In thinking process, the information content of original thinking is associated or is transformed into otherwise information, also namely the neuron activity of original thinking path reflexes to otherwise neuron due to integration, the neuronal excitation of this part is caused to activate, and this part neuronic activation, two-way Descending Projections signal is produced according to same mechanism, feedback projects intralaminar nuclei on the one hand, make intralaminar nuclei be continued to provide to this partial nerve unit by next synchronous pulse, maintaining this partial nerve unit can continue activity; Another aspect is descending carries out " report " projection to formatio reticularis mesencephali, if this partial nerve unit does not belong to same thinking passage with original thinking, has then attracted formatio reticularis mesencephali to " attention " of new tunnel.So far, " attention " of thinking is pointed to, switches between different thinking.

(2), the competition of external input information.In thinking process, if there is the input of external information, (what is seen, what is heard, what is felt, etc.), can its input channel can be carried out " report " to formatio reticularis mesencephali by non-specific transmission, as cause " attention ", then will see its signal intensity.If input information is strong, (such as see unexpected thing, hear harshness, be subject to sharp, etc.), this action potential that can be reflected in its " report " signal is provided in frequency, so the neuronic excitement of this communication channel can be made to integrate faster and trigger the activation, to the up granting lock-out pulse of thalamus, and " attention " passage is before suppressed simultaneously, be also " competition " success and obtain " attention " that formatio reticularis mesencephali inputs this information.So far, " attention " of thinking is pointed to, is switched in the process to this external input information.

(3), the impact of other modulation path.In thinking process, the impact of the modulation signal of other modulation path, the state of such as kinetic system, the emotion influence of emotional system, the burst change of internal organs and hormonal system, the effect of ethanol, medicine, drugs and other chemical substances, etc., all may impact the neuron activity of each communication channel, thus have impact on formatio reticularis mesencephali " attention " of various communication channel is controlled, cause the switching that " attention " is pointed to.

(4), the neuron operation irregularity of " attention " control access.The effect carrying out suppressing mutually between each information upstream projection tract of particularly formatio reticularis mesencephali occurs abnormal.In this case, when a certain truck successfully causes " attention " and in the process of carrying out information processing, if at this moment cannot maintain, other trucks are effectively suppressed, just other trucks may be caused to occur unexpected activation and cause " attention ", at this moment " attention " cannot continue to maintain on a certain truck by formatio reticularis mesencephali, but carries out improper switching in different communication channel.This is macroscopically, show as focus on difficulty and persistence of attention of short duration, brain cannot be absorbed in something, becomes a kind of psychological problem, i.e. " attention " defect.(the mental sickness part seen below, the description about " attention " defect (ADD)).

3. 4. 5. summarize it, thinking control loop points to " attention " of thought system and controls, maintains and switch.Wherein formatio reticularis mesencephali be responsible for by information processing " attention " sensing " which kind of " information: by the lock-out pulse provided up and down between " formatio reticularis mesencephali ← → thalamus ", input signal strength (action potential granting frequency) with various external information and average information compares integration, cancellated Upstream driver pulse is changed to the subregion of intralaminar nuclei granting and packet positions, to select to turn to " which kind of " communication channel, (such as, point to vision, audition, sense of touch etc., or point to the average information passage that cortex is carrying out thinking).And thalamus is responsible for " which part " in " attention " of information processing sensing same class communication channel: when certain group neuron of a certain subregion of thalamus is subject to the pulse excitation of the up granting of network structure, its neuronal activation the part neuron projected in cortex provide synchronization motivationtheory pulse, being integrated by excitement makes this partial nerve unit in cortex carry out chain type activation and thinking activities, thus " attention " that control thinking activities is pointed in the information corresponding to this part neuron, (such as, " attention " which individual in visual information, " attention " which sound in numerous sound, " attention " content in which in thinking activities).And cortex is responsible for concrete information processing: the relay cell that association cortex correspond to each information word, under the granting excitation of thalamus lock-out pulse, to carry out orderly stepping one by one or by group successively to activate, formation chain type activates, and realizes brain to the identification of information, thinking, reaction and memory function, (such as, Who is that over there, what that sound says, what that problem is, etc.); And project sensory cortex simultaneously, by the activity of sensory cortex perception association cortex, formed and namely also " consciousness " is formed to the self-perception of thinking activities, (such as, recognize the existence of that people, recognize that sound, recognize what thinking " I " is carrying out, etc.).

3. the 4. 6. switch speed of " attention " and brain electricity " N400 " current potential.For normal thinking activities, owing to being carry out chain type activation between the related Neurons of association cortex, what rely on is the excitation of the lock-out pulse that thalamus is provided to cortex, so thinking can be carried out with speed faster, when having enhancement modulation (being in excitement or nervous thinking), the stepping rate that the chain type of thinking activates can reach more than tens steppings per second, and also namely each stepping is consuming time less than 100 milliseconds.But, for the switching that " attention " is pointed to, no matter be between the different sensory informations of the onrelevant from the external world, or between the different content of thought of the onrelevant from thinking process, or switch between inside and outside different information, a certain information will obtain new " attention ", the neuron of this communication channel is needed first to activate granting, project formatio reticularis mesencephali through polymerization again to carry out " report ", excited to integrate and " attention " passage before following is competed is carried out again at formatio reticularis mesencephali, the ascending nerve competing this passage of formatio reticularis mesencephali successfully carries out projection to intralaminar nuclei again and provides, intralaminar nuclei carries out lock-out pulse granting with the neuron that this information is relevant again in cortex, at this moment could produce with the relevant perception of this information or thinking, cause " attention ".So the speed that " attention " switches is slow, its estimation consuming time is about hundreds of millisecond.

Applicant infers, brain carries out " attention " and to point to when switching the neururgic change of control loop that causes and delay between the different information not having relatedness, the producing cause of Hz ERP " N400 " in EEG research just: read silently one section of sentence and end of the sentence is semanteme there is no a word of relatedness time, or when presenting the two complete incoherent pictures of width, namely brain does not have between two of relatedness kinds of different information what cannot associate yet, carry out the switching of " attention ", cause delaying and changing of the lock-out pulse granting of thinking control loop, create " N400 " phenomenon of brain electricity Evoked ptential." attention " due to thought system is pointed to and is occurred in the input perception of information, identification and intermediate treatment link, and have nothing to do with movement output, so " N400 " that Wernicke aphasia is also sensory aphasia patient can not produce, and " N400 " that Broca aphasia is also motor aphasia patient can produce.

3. the 5. rhythm and pace of moving things change of thinking oscillating loop and the impact on brain work.

3. the change of the 5. 1. granting rhythm and pace of moving things of thinking oscillating loop.Thinking oscillating loop forms continuable lock-out pulse by the circulation granting of " formatio reticularis mesencephali → intralaminar nuclei → thalamic reticular nucleus → formatio reticularis mesencephali ", the granting rhythm and pace of moving things of this oscillating loop, the granting frequency of lock-out pulse in other words, be subject to impact and the modulation of multiple signal, form with this passive change and active accommodation that oscillating loop provides the rhythm and pace of moving things.These modulation signals comprise: (1), from the Descending Projections of cortical neuron.When intralaminar nuclei provides lock-out pulse to cortex, if the neuron of cortex is carrying out thinking activities, then cortex can carry out feedback granting to intralaminar nuclei and reticular nucleus, accelerates the granting rhythm and pace of moving things of loop.(2), from the Inter Modulation of the neuron activity of other brain core group.Such as, from the modulation of " emotion " processing system (another information processing system in brain), when excited, by the impact on oscillating loop neuron activity, the granting rhythm and pace of moving things of loop can be accelerated.(3), from the Inter Modulation of " the lower ring control loop " of " reticular formation of brain stem (center district) ← → hypothalamus "." lower ring control loop " is responsible for controlling and regulating the endocrine of human body and the work of internal organs, its duty defines the health of human body, the duty of lower ring control loop can be modulated thinking control loop, so the change of health also can form impact to the oscillatory rhythms on thinking road.(4), the impact of neuromodulator, medicine.Such as, ethanol, medicine etc. can affect neuromuscular juinction and the integration of circuit neuron, thus affect the oscillatory rhythms of loop.

3. the relation of 5. 2. thinking oscillating loop oscillatory rhythms and brain duty.The oscillatory rhythms of thinking oscillating loop, also namely thalamus provides the rhythm and pace of moving things of lock-out pulse to cortex, decides the duty of human thinking system.

(1), when the lock-out pulse granting rhythm and pace of moving things is greater than 14 hertz, cortical neuron excitement integration and activation are very fast, and neural activity enlivens, and brain is in the state of the exciting or quick thinking of anxiety.If be also subject to the synergism of the modulation signal of other modulation path simultaneously, aminoacid serotonergic neuron can also be made to produce memory effect.(in the cortex of hippocampal formation, the lock-out pulse excitation of the high rhythm and pace of moving things can make aminoacid serotonergic neuron break out the action potential of the V1.2 hypotype of high threshold, makes neuron produce long term synaptic plasticity, forms long-term memory.See the description in the Burst mechanism of neuron different subtype action potential in the description of applicant's No. 2014106066977 patent applications).

(2), when the lock-out pulse granting rhythm and pace of moving things is 8-13 hertz, at this moment neuronic film integrate and moving speed medium, brain is in state that is clear-headed, quiet or that close one's eyes, there is no concrete " attention " point, do not carry out nervous thinking activities, thinking fragment may be produced, but the content of thinking process is not remembered mostly.

(3), when the lock-out pulse granting rhythm and pace of moving things is 4-7 hertz, integrate although the excitement excitation of lock-out pulse still can make the partial nerve unit of cortex carry out excitement and activate, but excited integration slowly, neuron activity is inactive, coherent activation chain cannot be formed, although so at this moment brain also exist " consciousness ", blunt to various irritant reaction, thinking is fuzzy, and cannot remember the content of thinking process.Before brain is felt just before going to bed, or very sleepy, or when physical condition is very poor, belong to this situation.

(4), when the lock-out pulse granting rhythm and pace of moving things is 0.5-3 hertz, although at this moment thalamus still provides lock-out pulse to cortex, but because the pulse granting rhythm and pace of moving things is very low, gap periods between pulse is oversize, (hundreds of millisecond is to thousands of millisecond), make cortical neuron can only produce film excitement, but the film of excitement integrates the activation threshold value that cannot reach action potential all the time, so there is not the situation of sustained activation and transmission in the neuron of cortex, so at this moment brain loses " attention " and " thinking " activity, also just without " consciousness ".Under the state that this situation appears at brain deep sleep (i.e. S sleep) or stupor or anesthesia.

(5), lock-out pulse provides the rhythm and pace of moving things is 0, also namely the action potential granting of the thinking oscillating loop of brain stops completely, and at this moment the neural activity of midbrain, thalamus and cortex stops, to stimulation not reaction, brain loses Premium Features, belongs to the brain death medically defined at present.It should be noted that, although electroencephalogram is isoelectric level straight line in this case, namely brain wave is not received, but in fact just thinking oscillating loop stopped lock-out pulse granting, if brain death mainly causes due to cerebral hypoxia ischemia, and the brain death time is not very long, in this case the most neurons of brain does not still lose cytoactive, so, at this moment organism does not still thoroughly lose biological activity, if the normal blood supply oxygen supply to brain can be recovered, suitable electric pulse stimulation is applied to the neuron of the key link of oscillating loop simultaneously, still also neuronic action potential granting is likely again encouraged, recover the round granting of oscillating loop, reactivate the work of brain.

It should be noted that, thalamus provides the rhythm and pace of moving things of lock-out pulse to cortex, although decide the speed of cortex thinking activities, but the stepping rate that the neuron chain type being not equal to thinking activates, the excitation of several lock-out pulse simultaneously may be needed just to complete excited integration (integration of temporal summation) this is because neuronic action potential triggers, and neuron is once trigger granting, due to the reason of synaptic facilitation, then easily produce continuous multiple action potential granting, so both not one to one.

3. 6. more modulation path on the impact of thinking.Thinking is the activity of cortical neuron, this process is subject to the restriction of the syndeton of related Neurons, (these syndetons are also the structure of imformation memory, comprise knowledge, event, experience etc., this is the basis forming memory), be subject to the real-time control of the synchronization motivationtheory pulse of thought system " attention " control loop, the step-type chain type forming single path activates simultaneously, and this activity is also subject to the modulating action of some other modulation path.The modulating action that these modulation path produce, control in real time unlike lock-out pulse, but it is slow and lasting, by affecting the activity of the release of the neuronic mediator of chain type activation pathway, absorption and ion channel, affect film to integrate and action potential granting, thus thinking activities is had an impact.

3. 6. 1. emotional system on the impact of thinking.Brain emotional system receives multiple input information, comprise the outer aobvious sensory information such as vision, olfactory sensation, audition, sense of touch, also the average information of thought system is comprised, also comprise the non-outer aobvious sensory information from internal body, produce various sensation, and export various modulation signal by various monoaminergic nerve core group, act on thought system, thinking (thinking) is affected.The relay cell of thought system is when carrying out chain type and activating, even if accept same from exciting signal above and the same synchronization pulse from thalamus, but because the neuronic suffered modulating action of rear class is different, film is caused to integrate different with action potential trigger condition, cause triggering different rear class neurons, chain type is activated carry out towards different directions, (such as: a → b → c or a → b → d), thus produce different thinkings.So in the face of same thing, under different emotions, brain can produce different result of thinking.(emotional system except on thinking formed impact, also widely on motor nervous system unify endocrine, visceral nervous system formed impact, this will later separately describe).

3. the modulating action of 6. 2. sleep and awakening.Control the modulation signal that brain carries out sleeping and awakening, mainly come from hypothalamic histamine nerve nucleus.Vision Afferent Projections from amphiblestroid transmission Lighting information looks coker to hypothalamic, reflex circuit is formed with tuberal nucleus, nipple core etc., produce the signal of Circadian rhythm change, then intermodulate with the signal of network structure oscillatory rhythms, export the modulation signal controlling sleep and awakening.This modulation signal is up to thalamus, cerebellum, limbic system and cortex (comprising sensory cortex, association cortex, motor cortex etc.), descendingly to project widely to brain stem and spinal cord, neuronic activity is modulated, in order to carry out the control of sleeping and awakening.Its effect is mostly inhibition modulation, to reduce neuronic active level.Such as, suppress extraneous and the input of the various sensory informations of body by the path projected to sensory cortex, thinking activities is suppressed by the path projected to thalamus and cortex, various movement output is suppressed by the path projected to cerebellum and spinal cord, the internal organs of body and endocrine activity is regulated by the path projected to hypothalamus and brain stem, etc.When these modulation path can normally produce or stop modulating action together, brain can normally be changed in sleep or wakefulness, and when the modulating action of these modulation path inharmonious inconsistent time, brain then can be caused to occur various abnormal and interesting performance, such as, have a dream, sleep-walking, insomnia.(the other generation mechanism to these phenomenons carries out describing later).

3. 6. 3. brain biochemical environment on the impact of thinking.The existence of the multiple biochemical substances inside brain and concentration constitute the biochemical environment of brain.These biochemical substances comprise two large classes: a class biochemical substances is secreted by body self, for the various organ of regulating and controlling body and the work of system, i.e. and hormonal system, (reality also comprises various neurotransmitter and neuromodulator).Another kind of biochemical substances is not that body self produces, but the existence of these biochemical substances of body perception and content, by hypothalamus one with the reaction treatment of nerve nucleus, go each organ of regulating and controlling body and the work of system.Oxygen in such as blood, carbon dioxide, blood glucose, ethanol, various medicine and drugs, etc.If the reaction treatment of this two classes biochemical substances is combined, the Biochemistry Reaction System of brain also can be referred to as.

Brain biochemical environment on the modulation of thinking and impact, mainly through two large approach: one is by the impact on network structure neuron activity, have impact on the round oscillatory rhythms of thinking oscillating loop, thus have impact on the neuron activity state of thought system.(referring to the relation of 2. thinking oscillating loop oscillatory rhythms and brain duty " 3. 5. ").Two is by each the core group of monoaminergic nerve unit on hypothalamus, midbrain, diencephalon, (Hippocampus is comprised to thalamus, cortex, the actual cortex of cerebellum also comprising motor system) project various modularity neuron, carry out the neuron activity that directly modulation affects thought system.Brain biochemical environment is on the impact of thinking, due to biological qualitative diversity and complexity, its impact is not often isolated the having an effect of single channel, but number of ways comprehensive function, both have impact on the duty of thinking oscillating loop, by modulation neuron, relevant range is modulated again, collaborative generation effect.

3. 6. 4. visceral nervous system on the impact of thinking.The visceral nervous system of brain, carries out perception by visceral sensory nerve to the duty of each internal organs, carries out reflection process, then gone the work of regulating and controlling internal organs by sympathetic nerve and parasympathetic nervous by some nerve nucleus of brain stem, hypothalamus etc.The work of visceral nervous system, is affected thinking activities by two approach: one is also the link at reticular formation of brain stem, affects, thus have impact on the thinking activities of thought system to the thinking oscillating loop of thought system.Two is the biochemical environment by have impact on brain, then is affected by the thinking of biochemical environment on thought system.(see above 3. 6. content 3.).

3. " Hippocampus " average information process loop of 7. thought system." formatio reticularis mesencephali-intralaminar nuclei and reticular nucleus-cortex " to be that thalamus is topmost relate to the widest control loop, and " attention " of carrying out thought system is pointed to and the control of duty.Also there is the very important control loop of another one in thalamus, namely be the synchronized-pulse control loop of " reticular formation of brain stem-nucleus anterior thalami and mediodorsal nucleus-thalamic reticular nucleus-reticular formation of brain stem ", and " Hippocampus " average information process loop of cingule gyrus construction idea system together with Hippocampus dependency structure with cortex.This process loop is both relatively independent, but be alternatively the branch belonging to thinking control loop, play refinement and supplementary function, it is not directly involved in identification to various objective sensation information and cognition, and only relate to intermediate treatment and the integration of the average information of the thought system after associating sensory cortex, especially relate to the impermanent memory (in short-term journey and long-term memory) of average information.

3. 7. 1. the Nervons projection structure of this loop as Figure 17.Wherein reticular formation of brain stem (seemingly the core group of tegmen of midbrain) carries out projecting (cholinergic neuron) to nucleus anterior thalami (and mediodorsal nucleus), nucleus anterior thalami projects to thalamic reticular nucleus, reticular nucleus carries out descending feedback projection to reticular formation of brain stem, formed the circulation oscillating loop of " reticular formation of brain stem-nucleus anterior thalami-thalamic reticular nucleus-reticular formation of brain stem " with this, formed the round granting of driving pulse.This oscillating loop carries out synchronization motivationtheory pulse granting (aminoacid can be neural) at nucleus anterior thalami (and mediodorsal nucleus) to cortex cingule gyrus, the Descending Projections of the oriented nucleus anterior thalami of cingule gyrus and thalamic reticular nucleus, " attention " control loop that the granting of its synchronization motivationtheory pulse and control mechanism are formed with formatio reticularis mesencephali-intralaminar nuclei etc. is similar.In information transmission process, other cortical area of brain especially association cortex and cingule gyrus have two-way projection widely, and cingule gyrus follows the entorhinal area of hippocampal formation to have two-way projection, realizes the bi-directional process of information with this.Inner at hippocampal formation, the information of input hippocampal formation carries out integration process by the loop of " entorhinal area-dentate gyrus-CA3-CA1-subiculum cortex-entorhinal area ", again project entorhinal area and output to cingule gyrus again, realize integrating process to the middle of information of cortex with this.The subiculum of Hippocampus has the Descending Projections directly to reticular formation of brain stem, and by hypothalamus nipple core indirectly Descending Projections, these play the effect being similar to " report form " and projecting.When " attention " sensing is switched to " Hippocampus average information treatment channel " by " attention " control loop of thought system, namely also the neural activity of thought system concentrates on hippocampal formation relevant average information when integrating process, and this treatment channel of Hippocampus is used for " attentions " control of the detail of thinking process and the integration process to average information and declarative information.

3. 7. 2. the particularly important is, the information processing of hippocampal formation is also subject to the control of the Septum Medialis of septal area and the Nervons projection of diagonal band nuclei simultaneously, and the Nervons projection of Septum Medialis and diagonal band nuclei belongs to cholinergic nerve, its neuromuscular juinction has quick and strong characteristic, controlled neuron can be made to form strong film excited, and break out the high threshold action potential of V1.2 hypotype, thus produce neuronic synaptic plasticity, (STDP plasticity), forms memory effect.(this point refers to the content of " 4. 6. the neuron of different neurotransmitter at the not same-action of brain information process " part below).So, under the control obtaining " attention ", during the integration process of neuron underway the information of hippocampal formation, directly can produce synaptic plasticity and form memory, be i.e. so-called Hippocampus memory.Notice that this point is different with the neuron work of thought system on association cortex: at the information processing passage of association cortex, in the middle of it, the direct projection directly not accepting the cholinergic nerve of formatio reticularis mesencephali is integrated in neuronic information transmission, but the control of the synchronization motivationtheory pulse provided by intralaminar nuclei, and intralaminar nuclei is aminoacid serotonergic neuron to cortical projection, the same with the neuron of information processing passage, its neuromuscular juinction is not fast with strong, be difficult to the high threshold action potential triggering V1.2 hypotype in most instances, and just trigger the Low threshold action potential of V1.6 hypotype, action potential just carries out unidirectional delivery to aixs cylinder and forms thinking activities, and back transfer cannot be carried out to cell space and dendron, so cannot synaptic plasticity be produced.These neuronic memory effects need the synapse recurring structure change depended between neuron connection, generation synaptic remodelling even generates new synapse etc. and changes neuronic syndeton, this change needs time of more growing and more sign stimulus, but once it is higher to form its stability, so the memory that thought system is formed on association cortex can be described as longterm memory or permanent memory.And the memory that hippocampal formation is formed depends on the Long-term plasticity of synapse, can be formed fast, but stability is lower, expiry date is shorter, is called long-term memory or impermanent memory.

3. 7. 3. the process of brain formation declarative memory is: when new declarative information input brain association cortex, under the control that " attention " is pointed to, information passed through cingule gyrus, entorhinal area before this to hippocampal projections, under the neural lock-out pulse provided at Septum Medialis and diagonal band nuclei cholinergic nerve of aminoacid energy on hippocampal formation encourages, rely on the interface channel that STDP synaptic plasticity forms information processing, also namely produce impermanent memory; If this information is repeatedly inputted or recalls, then the aminoacid serotonergic neuron on association cortex is subject to excited stimulation repeatedly, produces the structural change of Synaptic junction, even generates new synapse, forms the direct channel of information processing, also namely produces longterm memory.And cortical neuron is once form direct channel, information transmission is just no longer by the indirectly interface channel of hippocampal formation, indirect interface channel then on hippocampal formation just weakens, ultimate failure owing to not having information transmission, and related Neurons discharges for setting up new impermanent memory.So hippocampal formation plays crucial and indispensable transit bridge beam action when forming impermanent memory and being converted into longterm memory, but longterm memory is finally be kept on cerebral cortex.This Hippocampus impermanent memory needs a process to the conversion of cortex longterm memory, relevant with frequent degree with the dependency of information, the time of sign stimulus.When these cholinergic nerve core of septal area group provides insufficiency of function, just the ability that hippocampal formation is formed and maintains memory can be affected, cause amnesia, and during Hippocampus excision, such as famous amnesiac patients H.M., its brain cannot form new longterm memory, the retrograde memory loss of memory time of occurrence laminarity before.(about Hippocampus memory and cortex memory more detailed description, can application reference people submit application number 2014106066977 Chinese patent application " analog of neutral net and method " description in, the content to the essence of memory and formation, impermanent memory and the different of longterm memory and transform portion).

It should be noted that, Septum Medialis, diagonal band nuclei, in addition Meynert basal nuclei also carry out cholinergic nerve projection to sensory cortex and motor cortex, so cerebral cortex can directly to external world sensory information and movement output form memory, and to have nothing to do with hippocampal formation.

3. the work of 7. 4. hippocampal formation, is also subject to the modulation of the Nervons projection from emotional system corpus amygdaloideum simultaneously, and from the nucleus ceruleus of brain stem, the noradrenaline serotonergic neuron of midbrain nucleus raphes dorsalis, the modulation of 5-HT serotonergic neuron.This point, it is the same for catching up with and state " 3. 6. more modulation path on the impact of thinking ".

4. the other control system of brain.Except thought system, brain also has other several nervous system, especially kinetic systems.Strictly speaking, kinetic system is the nervous system that animal is more early formed, the action of animal is controlled for environmentally information, to realize looking for food, the activity such as hedging, and thought system essence is on the basis of kinetic system, one that evolves out processes, so that the information consolidation processing system of cooperation control movement output for carrying out integration to various external information especially average information.Just people, due to the appearance of language, this average information processing system is evolved extremely complicated and careful, seem more important.

4. 1. kinetic system.Motor cortex-cerebellum-striatum-spinal cords etc. form the kinetic system of brain, for controlling body athletic performance according to input information, and carry out learning and memory to this process.Wherein motor cortex carries out reflecting or reacting according to input information, the action message that output region is position encoded, under the synergism action of cerebellum, the control signal of output time coding and frequency coding, by pyramidal system Descending Projections to spinal cord, control muscle and complete various concrete action.

4. 1. the input information of kinetic system comprises two sources, aspect: one is the direct projection deriving from sensory cortex, comprise vision, audition, sense of touch, olfactory sensation etc., the sensory information of motor cortex perceptually cortical projection, directly reflect and react, comprise unconditioned reflex, trained reflex and the association response by learning and memory, control muscle and carry out athletic performance, this control has nothing to do, so be the control not needing " attention " and " consciousness " with thought system.Most of actions that we just complete in daily life unconsciously, just belong to this.Two be the relay cell deriving from association cortex output projection, be the Output rusults of human thinking activity.We are under the state having " consciousness " to have " attention ", according to needs or the result of thinking, " think " will what do, just belong to this initiatively.

4. 1. 2. no matter have " consciousness " to do action or without the reaction action of " consciousness ", the information of the set of actions of motor process can learning and memory, and this that is to say " procedural memory " alleged by existing theory.Procedural memory seems to need striatal participation, the information of set of actions is first remembered in striatum, form impermanent memory, after memory repeatedly or reflex activity, action message forms structural longterm memory (or being permanent memory) on motor cortex.The memory Forming Mechanism of this action message, with in thought system, by Hippocampus and association cortex, average information (i.e. so-called declarative information) being formed to impermanent memory and is converted into the mechanism of longterm memory, is the same.

4. the synchronized-pulse control loop of 1. 3. kinetic system.The synchronized-pulse control loop acting on kinetic system is not mentioned in cranial nerve research in the past, but applicant thinks, kinetic system equally needs lock-out pulse to encourage activity neuronic with cooperation control, and its synchronized-pulse control loop exists independent of thought system.Both have similar structure and working mechanism, and existence crosses one another, because the action of " consciously " that thought system exports needs to project motor system to perform, and the part output action of kinetic system also projects thought system by its " attention ".

The control loop of thought system forms oscillating loop by " formatio reticularis mesencephali ← → thalamus " to carry out coming and going granting, this loop is stretched out by intralaminar nuclei and carries out the round granting of lock-out pulse with cerebral cortex, to encourage and to control the activity of cerebral cortex neurons.Applicant analyzes, because kinetic system includes motor cortex and cerebellum two large divisions, its synchronized-pulse control is also divided into two parts, but two parts exist interknit: (1), motor system motor cortex part synchronized-pulse control loop by " tegmentum network structure ← → end thalamus " form oscillating loop carry out come and go provide, (cholinergic nerve); Stretched out carried out the round granting of synchronization motivationtheory pulse with striatum (comprising pallidum) by subthalamic nucleus (its effect is similar to the intralaminar nuclei of thalamus) again, (aminoacid can be neural), to encourage and to control striatal neuron activity, (striatum belongs to the relay cell of motor cortex); Striatum carries out the feedback projection of polymerism to the network structure nuclear colony (seemingly rubrum or entopeduncular nucleus, its effect is similar to the reticular nucleus of thalamus) of end thalamus, then Descending Projections is to tegmentum network structure, the vibration of maintenance loop.(2), motor system is at the synchronized-pulse control loop of cerebellum part, the oscillating loop forming " tegmentum network structure ← → nucleus basalis " by midbrain vestibule or tegmentum network structure and certain core group (seemingly nucleus basalis) carries out coming and going to be provided, (cholinergic nerve), nucleus basalis carries out synchronization motivationtheory pulse by climbing fiber to the Purkinje cell of cortex of cerebellum again and comes and goes and provide, (aminoacid can be neural), to encourage and to control the activity of cerebellar slice.And from the interconnection undertaken by granular cell and Purkinje cell of MF of pontine nucleus group, be only the path that the transmission of movable information and integration comprise learning and memory.(the signal projective structure schematic diagram with reference to the kinetic system control loop of Figure 18).

Two parts synchronized-pulse control of motor system, although there is different projection passages, but both are unified (being at least close ties) in the origin and tegmentum network structure of lock-out pulse granting, make both pulse grantings there is rapport, the signal exported with the action realizing motor cortex and cerebellum keeps coordinating.(in other words, the synchronized-pulse control of motor cortex and the synchronized-pulse control of cerebellum, essence be the same synchronized-pulse control loop of motor system two issuer to?).

The lock-out pulse that kinetic system synchronized-pulse control loop is provided to motor cortex and cerebellar projection, applicant infers that its effect is: (1), motor cortex export space encoding actuating signal, project the neuron that cerebellum tightly arranges, under the synergism of lock-out pulse, be converted to the output signal of time encoding and frequency coding, carry out athletic performance accurately to control muscle.(2) the working mechanism, by " attention " being similar to thought system being formed and switch, the action coming cooperation control motor cortex and cerebellum exports, the contradiction avoiding occurring that action exports and conflict.(3), by the granting rhythm and pace of moving things of lock-out pulse, the rhythm and pace of moving things is provided in the pulse that controlled motion cortex and cerebellar neuron export, thus controls the speed of body athletic performance.(be similar to thought system and provide by lock-out pulse the step rate that the rhythm and pace of moving things controls thinking activities).

4. 1. 4. motor cortex is the output area of kinetic system, motor message is exported by the descending output fiber of pyramidal system, control body and carry out various motion, but the program how each athletic performance is specifically completed and details, then coordinated by cerebellum.The information of motor cortex process remains locus coding, namely transmit according to the neuron activity of the diverse location of space structure and reflect various action message, the output of motor cortex projects simultaneously and is input to cerebellum, cerebellum is under the synergism of lock-out pulse, being Time Of Release by the convert information of this space encoding, the action potential pulse different with providing frequency is provided, and (parallel signal being similar to electronic technology is converted to serial signal.This conversion process inputs the processing procedure of the transformation from serial to parallel projecting optic cortex from lateral geniculate body with feeling to input such as vision, seem just contrary), and as the output signal of cerebellum, again cortex (or spinal cord) is projected, synergism action is carried out with the output signal of cortex, finally be integrated into the motorial output signal of each bar, by providing the time order and function (time encoding) of action potential pulse to controlled muscle and providing frequency (frequency coding), control the contraction of this muscle in athletic performance or lax time and dynamics, realize the coordination to athletic performance and accurately control.So, this part motor system be made up of motor cortex and striatum, primary responsibility be " what does " action, it is the combination of actions of the sequencing be made up of multiple action, (especially comprising with the relevant combination of actions of the output of thought system), and the learning and memory of these actions (i.e. sequencing memory).And cerebellum is responsible for is " how doing ", by completing various action to the accurate control of muscle, (may comprise and not have the reflection of related direct body and reaction action with thought system).Applicant infers, evolves to people from animal, and a large amount of program of the action (comprise and speak and write) that implementation language exports due to cerebellum store recording and details, so just result in the sharply increase of corpus of cerebellum sum neuronal quantity.

4. 1. 5. kinetic system is subject to the control of the modulation signal of some nerve nucleus in hypothalamus and brain stem too.Comprise the dopaminergic Nervons projection from black substance, from the Nervons projection of the noradrenaline energy of locus coeruleus, from the Nervons projection of the 5-HT energy of network structure medial area, etc., the effect of these modularity signals is the neural duties of controlled motion, to match with the duty of thought system and visceral endocrine system and to adapt.

4. 2. visceral nervous system.By visceral sensory nerve, perception is carried out to each internal organs duty, carry out reflection process by some nerve nucleus of brain stem, hypothalamus etc., then gone the work of regulating and controlling internal organs by sympathetic nerve and parasympathetic nervous.According to existing anatomical documentation, the major nerve core group of visceral nervous system, at hypothalamus, comprises the lateral hypothalamic region and back zone that control sympathetic reaction, stimulates this region palpitating speed, blood pressure can be caused to raise, breathe the reactions such as increase; Control anterior hypothalamic region and the medial area of parasympathetic reaction, the reactions such as heart beating slows down, peripheral blood vessel expansion that stimulate this region to cause.Below seeing 4. 1. part content.

4. 3. Biochemistry Reaction System (comprising immunity-hormonal system).By the content of endocrine substance various in perception body and non-endocrine biochemical substances, be with by information projection to upper hypothalamus one, by the reaction treatment of its nerve nucleus, then feedback goes control the secretion of various endocrine substance or regulate the work of internal organs.According to current anatomical documentation, the major nerve core group of Biochemistry Reaction System is at epithalamus (such as pinus) and hypothalamus subregion (depending on coker, paraventricular nucleus etc.).Owing to lacking detailed anatomical documentation, cannot be described in detail specific works process.

4. external information process loop and internal information process loop.Various for brain information processing, according to the control mechanism of organism to external information and internal information, is summarized as two large loops, i.e. " external information control loop " and " internal information control loop " by applicant.The former includes thought system and kinetic system, perception is carried out to various external information (vision, audition, olfactory sensation, sense of touch etc.) and integrates process, and export control signal body movement action is controlled, (comprise and speak and write this special motion); The latter comprises visceral nervous system and Biochemistry Reaction System (comprising immunity-hormonal system), perception carried out to the information (internal organs duty, endocrine substance, non-endocrine biochemical substances) in various body and integrates process, and exporting control signal internal organs, immunity-hormonal system are controlled.The former activity is due to can by the perception of thought system institute, so can have consciousness and consciousness, the latter then mostly cannot by the perception of thought system institute, so be imperception and unconscious; The former nerve nucleus mainly concentrates on the opposite upper parts of the physical location of brain, so also can be described as " upper ring processing loop ", be called for short " upper loop ", the nerve nucleus of the latter mainly concentrates on brain opposing lower portions, so also can be described as " lower ring process loop ", be called for short " lower loop ".In the inside of same loop, relatively directly and obviously, and between inside and outside two loops, also there is the effect of phase inter-modulation in the excitement impact between each system and modulating action.Wherein go up before being operated in of loop and have description, below lower loop is described.

4. the formation of 1. internal information control loop (lower loop).Mainly comprise visceral nervous system, Biochemistry Reaction System (containing immunity-hormonal system) and the control loop between them.Because the quantity of information of the various internal information of body is less, information change is slow, so the perception input of its information, identify, memory, reaction, to export the neuronal quantity of various links controlled all less, mostly do not form independently nerve nucleus, but be gathered in same core group.

Wherein the signal projection of visceral nervous system as shown in figure 19.On the one hand, in spinal cord position, the simple reflex arc of forming section internal organs, carries out feedback control to visceral motility, and on the other hand, visceral sensory fiber concentrates on vagus nerve and enters brain stem by spinal cord and mainly project nucleus solitarius.Nucleus solitarius is the main relay nucleus group of visceral sense information, and it exports a road and projects dorsal nucleus of vagus nerve, forms the rudimentary reflex loop in brain stem aspect of visceral nervous system, sends out by dorsal nucleus of vagus nerve the work that Visceromotor nerve removes to control internal organs; Another road directly projects the regions such as hypothalamus NPO, paraventricular nucleus, dorsomedial nucleus, transmits visceral sense information; Also have a road to project reticular formation of brain stem LHA, especially comprise inner and outer parabrachial nuclei, the other core of interior outer webs is sent out cholinergic nerve and is projected to hypothalamus.Hypothalamic output, then by dorsal nucleus of vagus nerve, sends out the work that Visceromotor nerve removes cooperation control internal organs.Applicant infers that visceral nervous system has synchronized-pulse control loop equally, its loop is formed primarily of " reticular formation of brain stem LHA ← → hypothalamus ", wherein the path transmission that projects directly to hypothalamus of nucleus solitarius is splanchnesthetic specifying information content, and is do not comprise the projection of specifying information " report " formula to the projection that reticular formation of brain stem LHA carries out; And reticular formation of brain stem LHA (especially comprising the other core of interior outer webs) is the synchronization motivationtheory pulse of control loop to the cholinergic nerve that hypothalamus projects; Meanwhile, hypothalamus also carries out Descending Projections to reticular formation of brain stem LHA; Also be " lower ring oscillation loop " with the oscillating loop that this forms the round granting of " reticular formation of brain stem LHA ← → hypothalamus ".

So, in brain, the visceral nervous system controlling visceral motility comprises two large loops: one is the rudimentary reflex loop in brain stem aspect be made up of " internal organs (sensation) nerve → nucleus solitarius → dorsal nucleus of vagus nerve → internal organs (motion) are neural ", is felt respectively by simple directly reflex loop and is reflected the activity of each internal organs; Two is the associated reflex loops be made up of " reticular formation of brain stem LHA ← → hypothalamus ", accept various internal organs feel import into, and accept the modulation input of other nervous system of brain (thinking nervous system, kinetic system, emotion nervous system, endocrine nervous system), after Combined Treatment, the activity of the rudimentary reflex loop of brain stem is encouraged and modulated, thus balance control is carried out to the work of internal organs, such as, regulate the frequency and amplitude of breathing, regulate the speed of heart beating, regulate blood pressure etc.Owing to lacking data, applicant cannot infer the oscillatory rhythms of this oscillating loop, but judge from the rhythm and pace of moving things of heart beating and the rhythm and pace of moving things of thinking oscillating loop, estimation is lower, (may lower than 3 to 4 hertz), and, also cannot infer whether this control loop follows the control loop of thought system to be the same working mechanism.Visceral nervous system also receives the modularity Nervons projection of some modularity nerve nucleus of brain stem, and as the noradrenergic nerve from locus coeruleus projects, the 5-HT from nucleus raphes dorsalis and superior central nucleus can Nervons projection.

And the information processing core of Biochemistry Reaction System is in epithalamus and hypothalamus subregion, and supposition has a control loop equally, is made up of " reticular formation of brain stem (center district)-epithalamus (and hypothalamus subregion) ".Because the anatomical documentation of Biochemistry Reaction System (comprising hormonal system) this respect is little, so cannot be described in more detail.

4. the phase inter-modulation of loop is 2. descended.Lower loop comprises visceral nervous system and Biochemistry Reaction System (containing hormonal system), maintains close ties with and interact between these two systems, the common Collaborative Control formed internal body viscera organ and endocrine work.Because these two systems are closely related with the health status of body, if specific works process and the mechanism of these two systems can be disclosed, and the phase inter-modulation relation between them, just to the origin cause of formation of various internal organs and cryptorrhea disease and treatment, the directive significance of shooting the arrow at the target can be brought.This respect applicant intends in other patent application open, no longer sets forth here.

4. 3. upper and lower the interacting of loop.It influences each other and modulates and carries out mainly through following two aspects.

(1), the influencing each other of neuron activity of upper and lower loop.Because the core link of two control loops is all on reticular formation of brain stem, if the network structure neuron activity of a certain loop is more active, the network structure neuron activity contention of nutrient substance (blood oxygen, blood glucose, various neurotransmitter and modified and synthesis material etc.) being affected to another loop can be caused, and can modulate another loop by modularity nerve nucleus, thus have impact on the work of another loop.Wherein descend loop on the modulation of upper loop and impact, can see above 3. 2. 7., 3. 5. 1., 3. 6. 3., the 3. content of 6. 4. part.And upper loop is on the impact of lower loop, is the internal activity of health due to what relate to and reacts slowly, so more hidden.Such as, when brain is in nervous thinking, the oscillatory rhythms of thinking oscillating loop is accelerated, and providing action at the neuronal activation of this link of reticular formation of brain stem increases, the job insecurity of lower loop can be affected, thus negative effect is caused to internal organs and hormonal system.And when thought system neural activity declines, such as, during deep sleep, thinking oscillating loop oscillatory rhythms is very low, slow at the neuron activity of network structure link, be conducive to the work of lower loop, internal organs and hormonal system are restored.

(2), carry out two-way modulation by emotional system.Applicant thinks, the emotional system of brain directly connects inside and outside two loops, extensively receives the information of two loops, carries out two-way modulation conversely to their work, so that the adaptation enabling body more coordinate and tackle the change of various interior external information.This will carry out independent description below.

4. 5. emotional system.Applicant once repeatedly hung back and emotional system is divided in upper loop still descends loop, because emotional system can either directly receive various external information, (comprise vision, audition, the external informations such as olfactory sensation and average information be " event " such as), also various internal information can directly be received, (comprise the information of biochemical substances in internal organs working condition and body, although at this moment the thought system of our brain " is not known "), significantly impact can either be produced to thought system and motor system, (the talking nonsense such as during excitement, excitation time strength of action increases), also significantly impact can be produced on internal organs and hormonal system, (such as palpitating speed during excitement, time frightened, adrenal hormone increases, with one's hair standing on end), afterwards when analyzing the phase intermodulation effect of inside and outside two loops, just understand that organism connects two loops by emotional system just, for carrying out coordination and two-way modulation to their work.

According to existing anatomical documentation, the major nerve core group of emotional system is corpus amygdaloideum.The signal projection of the input and output of corpus amygdaloideum is as Figure 20.Wherein input projection to comprise: (1), from the input of the average information of cerebral cortex and Hippocampus widely, such as people can be made to move from the content of language or Word message or indignant; (2), from the direct input of the objective sensation information of olfactory sensation and the sense of taste, such as special olfactory sensation or the sense of taste can make people feel happy or feel sick; (visual information cannot directly sway the emotion, and needs the content after identifying to sway the emotion); (3), from lower loop, mainly through the input of internal information of hypothalamus and brain stem projection, such as people can be made to feel painful or feel bad from the exception of biochemical substances in internal organs or body; (4) the signal, from brain stem modularity nerve nucleus inputs.And the output of corpus amygdaloideum and modulating action comprise: (1), to the projection of stricture of vagina body, to affect the neural activity of kinetic system, speed or the dynamics of motion time such as excited or frightened, can be strengthened; (2), to the projection of cortex and Hippocampus, to affect the neural activity of thought system, time such as exciting, thinking is accelerated or easily makes mistakes; (3), to the projection of hypothalamus, nucleus solitarius and dorsal nucleus of vagus nerve, to affect the activity of visceral nervous system and hormonal system, palpitating speed time such as exciting, time frightened, adrenal hormone increases, with one's hair standing on end; (4), to the projection of brain stem, to affect the activity of multiple modularity nerve nucleus, and then affect the work of brain other system further.Can find out from these input/output relations of corpus amygdaloideum and impact thereof, take corpus amygdaloideum as inside and outside two the information processing loops of emotional system close ties of core, coordination and two-way modulation are carried out to their neural activity, thus affects their activity and output, to tackle information change better.Emotional system equally can learning and memory to the input of information and reaction, and its working mechanism is similar with the Hippocampus of thought system.With reference to the working mechanism of other neural reflex systems of brain, applicant infers, corpus amygdaloideum seems also to roll into a ball formation control loop with the core of thalamus and certain projection cholinergic nerve, but owing to lacking anatomical documentation, cannot further describe.

4. 6. the neuron of different neurotransmitter at the not same-action of brain information process.There is multiple different neurotransmitter and membrane receptor thereof in brain, also there are the different neurons of these neurotransmitteies of release, comprises cholinergic neuron, aminoacid serotonergic neuron, monoaminergic nerve unit and neuropeptide neuron etc.Often there is multiple different neuron in a lot of nerve nucleus of brain simultaneously; and form different Nervons projection; and these different Nervons projection both may project same brain district or brain core group jointly; also possibility projection intersected with each other; and; the neuron operation irregularity of different neurotransmitter but can cause same brain function exception or disease sometimes, and these cause puzzlement and mislead all easily to the information transfering path of analysis brain and working mechanism.According to transmission characteristic and the Nervons projection path of various different neurotransmitter, and input in conjunction with the perception of foregoing brain for information, transmit, remember, reflect the working mechanism and control mechanism that export, analyze the not same-action of neuron in brain information process of different transmitter, can better analyze and understand the working mechanism of brain with this.

4. 6. 1. aminoacid serotonergic neuron.Its neurotransmitter comprises glutamic acid (Glu) and the aspartic acid (Asp) of excitatory amino acid, and the gamma-aminobutyric acid of inhibitory aminoacid (GABA) and glycine (Gly).Aminoacid is as neurotransmitter, its transmission channels is easily by impact and the modulation of other mediators, and synaptic plasticity (STDP plasticity) can be formed, so aminoacid serotonergic neuron is the most topmost neuron of fundamental sum of brain configuration information treatment channel.Central nervous system's nearly all information transmission and all main the working in coordination with excitatory amino acid energy and inhibitory aminoacid serotonergic neuron of process path are formed, realize the input of information, transmission, integration, reflection and output with this, and form the brain function of memory, thinking and consciousness.Aminoacid serotonergic neuron is component part modularity nervous pathway also.

4. 6. 2. cholinergic neuron.Its neurotransmitter is acetylcholine (ACh).At nervus centralis, the gated channel reaction of cholinergic neurotransmitter is exceedingly fast, depolarization is pre-existing in without the need to cell membrane, when under resting potential with hyperpolarization, once part and receptors bind just can directly cause gated channel open, calcium ion is interior stream fast, and cause strong film excited, large multipotency directly causes the outburst of action potential.And the aixs cylinder release ACh of cholinergic neuron is of short duration again fast, and after release, ACh is except with receptors bind, also can spread out from synaptic space and be degraded rapidly by acetylcholine esterase, and the ACh also namely discharging post-synapse gap can be removed fast.So, after cholinergic neuron snapping motion current potential, its time of having an effect and failing is all extremely of short duration, and projected rear class neuron can be made to produce the excited also snapping motion current potential of strong film, this is transmission characteristic strongly and fast, cholinergic neuron is made to be mainly used in synchronization motivationtheory in neural activity, especially lock-out pulse oscillating loop is formed, just the pulse granting of cyclic can be formed voluntarily without the need to the synergism of other nervous pathways, and other neural activities are controlled sequential in this, as synchronization motivationtheory signal, the neural activity of brain information process is carried out in order, the sequencing contro effect of the clock signal being similar to electronic computer is played at this lock-out pulse.And if the neuron projected is that aminoacid energy is neural, the excitement excitation that cholinergic nerve is quick and strong, can also make it break out the action potential of high threshold, thus produce synaptic plasticity, form memory effect.The transmission characteristic of cholinergic neuron also makes it be applicable to nervus motorius output, the input of nerve-neuromuscular junction, cardiac muscle, smooth muscle and part sensory information and transmission, but is not generally suitable for the direct channel of imformation memory process.

4. 6. 3. monoaminergic nerve is first.Its neurotransmitter is the biogenic amine containing monoamine group.Monoaminergic nerve unit comprises dopaminergic neuron, 5-hydroxytryptamine serotonergic neuron, noradrenaline serotonergic neuron and adrenal neurons and histamine.The effect of monoaminergic nerve unit is modulated neural activity.Especially participate in emotional system, the unify information processing of visceral nervous system of thought system, motor nervous system is modulated.Wherein: (1), norepinephrine (NE) neural mainly can exist the nerve nucleus (such as nucleus ceruleus) of oblongata and pons, project to extensive region such as cerebral cortex, thalamus, hypothalamus, limbic systems, it acts on mainly inhibition modulation, suppresses the neuron activity of institute projected area.When the effect of NE is crossed strong, can the neuron activity of extra-inhibitory thought system, cause that neuron activity is abnormal to decline, as there is depression.(2), can mainly there is the core group such as superior central nucleus of pons and midbrain nucleus raphes dorsalis by nerve in 5-hydroxy tryptamine (5-HT), project to the extensive region such as thalamus, cerebral cortex, its projected area is similar with NE, but it acts on mainly enhancement modulation, the neuron activity of institute projected area is played and strengthens the excited effect integrated.Easily there is depression when 5-HT is very few, and easily occur mania time too much.(3), neural mainly can there is the nerve nucleus (such as black substance) of midbrain and diencephalon in dopamine (DA), and project to the region such as cerebral cortex and limbic system, its effect is also mainly enhancement modulation.(4), histaminergic nerve is mainly present in the tuberomammillary nucleus of PH, the up extensive region to forebrain, descendingly to project to brain stem and spinal cord, and the modulation of sleeping and awakening mainly is carried out in its effect.The neuronic so-called enhancement of modularity and inhibition modulating action are also nisi, because inherently there is the phenomenon suppressed mutually in the neuron activity of information processing path, aminoacid energy nerve is also divided into irritability and inhibition two kinds, inhibition modulation is carried out to inhibitory neuron, is in fact just equivalent to carry out enhancement modulation to suppressed excitatory neuron.These complicated and cross one another modulation path of monoaminergic nerve unit just, the Nervons projection path of brain is made to seem very complicated, also these complicated and interactional modulating actions just, the thinking activities of brain is made to produce complicated various changes, and create the higher brains such as emotion, emotion, personality, desire, motivation, also have the phenomenons such as daydream and various psychosiss.

4. 6. 4. neuropeptide serotonergic neuron.Its neurotransmitter is macromolecular polypeptides and neuropeptide (SP).Neuropeptide is of a great variety.Its effect produces slowly and lasting, mainly to the physiological activity of brain self neural unit, and regulates the internal organs of body and endocrine work.

Also have purine substance in addition, nitric oxide, carbon monoxide etc., also participate in neuronic activity, form impact to neural activity.

4. 6. 5. other cholinergic nerves of brain project.The neuromuscular juinction of cholinergic neuron has quick and powerful feature, is used as synchronization motivationtheory pulse in neural activity.Except mainly there is reticular formation of brain stem and thalamus, upper hypothalamus etc. form lock-out pulse oscillating loop, brain also has other to send the main core group of cholinergic nerve projection, the Septum Medialis of the septal area of limbic system and the Meynert basal nuclei of diagonal band nuclei, in addition basal forebrain, (basal forebrain complex).Its relevant signal projection is as Figure 21.Projection and the effect of these cholinergic nerve core group comprise: (1), uply to project to cortex especially sensory cortex and motor cortex, carry out cooperative exiting to the integration process of sensory information and movable information, the especially collaborative synaptic plasticity that produces is to form cognition and memory and motor memory; (2), to cingule gyrus and hippocampal formation project, carry out cooperative exiting to the integration process of the average information (i.e. declarative information) of thought system, the especially collaborative synaptic plasticity that produces is to form Hippocampus memory; (3), with corpus amygdaloideum and hypothalamus carry out two-way mutual projection, to carry out phase inter-modulation to work each other, and collaborative formation emotional memory; (4), to the projection of some core of midbrain group.On the other hand, these cholinergic nerve core group is subject to norepinephrine energy, 5-HT energy, the dopaminergic neuromodulation from nucleus ceruleus, midbrain nucleus raphes dorsalis, tegmen of midbrain veutro too.

Septal area and these cholinergic nerve core groups of basal forebrain, and between reticular formation of brain stem cholinergic nerve core rolls into a ball, undertaken coming and going contact by medial forebrain bundle.Owing to lacking more detailed anatomical documentation, applicant does vague, the control that septal area and these nerve nucleus of basal forebrain are subject to reticular formation of brain stem on earth, or reticular formation of brain stem is subject to the control of these core group? based on whom? still work alone toward each other and just interact? from the popularity of the control related to whole brain information process, it is even more important to seem reticular formation of brain stem.

In addition, in inside such as cerebellum, cerebral cortex, striatum, Hippocampus, also there is the short local projection of cholinergic nerve, infer that its effect is the extension of the long projection to accepted cholinergic nerve, play the effect of cooperative exiting equally.

4. 7. simple neural activity mode and powerful brain function.Described in above comprehensive, overall structure from brain: brain is made up of multiple information processing system set such as thought system, kinetic system, emotional system, visceral nervous system, endocrine nervous system, these system transposition affect, and realize carrying out perception and process to various external information and internal body information.From neuronic classification: brain mainly adopts aminoacid energy nerve to come the main channel of configuration information process, adopt cholinergic nerve to produce driving pulse to encourage and sequencing contro information processing, adopt single (group) amine energy nerve and neural peptidergic nerve to carry out various modulation to information processing, jointly realize the Combined Treatment to information with this.From neuronic model of action: brain generally adopts and comes and goes by the neuron of 2 to 5 grades the neural minor loop that projection forms closed loop, integrate with excitement and come and go the mode providing action potential and carry out certain information processing one's own.For a certain neural minor loop, in loop, the neuron of some node receives the projection of other neural circuitry to realize information input or modulation input on the one hand, in loop, the neuron of some node also carries out projection to realize information output or modulation output to other neural circuitry on the other hand, and " all linked with one another " defines huge neutral net.

The neural minor loop of this round projection only need carry out the process of " one's own " signal integration according to oneself fixing simple model of action, and how complicated the signal " need not comprehending " whole neutral net is, so be conducive to keeping the in stable condition of loop self neural activity, and carry out the various information of input and output by mutual projection crisscross between ring and ring.And, although each neuron is just carrying out simple excited integration and action potential granting, each neural minor loop is also just transmitting information with same simple reflex action and is reflecting, but due to: (1), neural minor loop quantity is extremely huge, (2), neuron has the excited function integrated, integration process can be carried out to the information input of other neural circuitry multiple simultaneously, and this integration process has accurate analog quantity processing capacity, (3), Nervons projection between neural minor loop inside and neural minor loop, its synapse has the plasticity transmitting usefulness, (4), between each neural minor loop, can cancel or be formed new Nervons projection contact by synaptic remodelling, (5), there is multiple different neuron, with different neurotransmitter and modified, different receptors and different ion channels carry out different nerve action, so, the huge neutral net that these neural minor loops are formed can carry out powerful Combined Treatment to various complex information.Brain, just with the neural minor loop of enormous amount, by the mode of this " all linked with one another ", " infinitely extending ", realizes the process of the information of the magnanimity to various complexity.

And, in biological evolution process, various neural minor loop can correspondingly according to the increase of quantity of information be accelerated, and by the structure of this " all linked with one another ", continue to keep projection mutually, forming almost can the neutral net of infinite expanding, and in the process of expansion, the basic framework of its Nervons projection can keep stable, can keep continuity and the stability of biological evolution.So the brain of people and mouse, the basic framework of its information transmission process is the same, the neuronal quantity of the different just nervous tissues at each position.

Also just because of the structure of this mutual projection, so, for same abnormality of nerve function or disease, both may be the neuron operation irregularity due to its relevant neural circuitry, and directly cause information processing abnormal; Also may be owing to encouraging this neural circuitry and the neuron operation irregularity of Synchronization Control, making it cannot form normally orderly work; May be also the neuron operation irregularity due to the various modulation path of modulating this neural circuitry, and make it be subject to improper modulation and operation irregularity.When treating these diseases, needing to analyze this, just can obtain more suitably therapeutic scheme.

5. to the explanation of several phenomenon of brain.Applicant finds, according to above to the essence of " thinking ", " attention " and " consciousness ", and the analysis to " attention " control mechanism, can be easy to and explain some brain phenomenons well, comprise the disease that some are difficult to the psychological problem explained at present, below some of them are simply described.

5. 1. brain wave.Thought, brain wave is that in cortex, a large amount of neuron is under the control of thalamus lock-out pulse, and granting action potential produces simultaneously, and detected signal is the variable signal of the postsynaptic potential of a large amount of synchronous snapping motion current potentials of cortical neuron in the past.Therefore, also think that thinking is that a large amount of relay cells depending on cortex carry out synchronously activating to provide carrying out.

5. 1. applicant admits brain wave is that the granting of thalamus lock-out pulse causes, but thinks, brain wave is not that a large amount of neurons of cortex synchronously activate and produced, and its reason is as follows.

(1). the neuron activity of cortex is the basis of human thinking, memory and various reaction, so, if have a large amount of neurons synchronous spike action potential together in synchronization cortex, a large amount of neuronic syndeton then can be caused to take place at the same instant change or upgrade, and this will inevitably cause the thinking of brain, the confusion of memory and reflex activity and instability.

(2). do not meet the principle of as far as possible saving power consumption of biological evolution.Neuronic action potential granting is the activity that a power consumption is larger, from the angle of biological evolution, organism should not adopt the synchronous movement of a large amount of cortical neurons to produce the information change of a least unit, and more can select to evolve to a small amount of (preferably one) the neuronic activity of employing to realize this result, to save non-essential power consumption as far as possible.

(3). the amplitude variations of the different wave of brain wave cannot be explained.If brain wave is cortex, a large amount of neuron action potential granting produced, so when brain is in excited and quick thinking, (there is β ripple), at this moment Cerebral cortex has more neuron participation activity, normally brain wave amplitude just should be larger, and brain is when deep sleep or stupor, (occurring δ ripple), at this moment Cerebral cortex only has little neuron in activity, and the amplitude of brain wave should be very little normally.But practical situation is just contrary, occurs that the amplitude of brain wave during β ripple is less, only has ten a few to tens of microvolts, and when there is δ ripple, brain wave amplitude is maximum, and more than 50 microvolts, microvolt even up to a hundred, presents the negative correlation phenomenon of oscillatory rhythms and amplitude.

(4). brain wave there is no the information of action potential pulse.If brain wave is cortex, a large amount of neuron synchronous spike action potential produced, even these neurons provide the postsynaptic potential generation after action potential, so, on the basis of change information (being also existing obtained electroencephalogram) these postsynaptic potential being detected, the pulse information of the very sharp very narrow but action potential that amplitude is very high at axonal transport also should be detected, current detection technique can be accomplished completely, but in fact do not have, pulse information when action potential breaks out do not detected.

5. the 1. 2. working mechanism that thinking controlled according to thinking and thinking oscillating loop of applicant, think: brain wave be not in cortex a large amount of neuron synchronously activate provide action potential produce, but after thalamus carries out lock-out pulse granting to cortex, a large amount of neurons in cortex fail to integrate triggering action potentials owing to only relying on the stimulation of lock-out pulse, and the film local excitation of Decay Rate can only be there is, the expansion cloth of Decay Rate is synchronously carried out in these a large amount of neuronic film local excitations, the electric field synchronization fluctuate that it causes is only the true cause producing brain wave.

The corticopetal Nervons projection of thalamus is diffusible, and one group of (N number of) neuron namely in each neuronic axonal projections of thalamus and cortex sets up synaptic contact.The a certain moment, when one group of (M) neuron of thalamus activates by cancellated up granting, this group neuron carries out lock-out pulse granting to a large amount of (M × N number of) neuron in the territory, relevant partitions in cortex simultaneously, but lock-out pulse just forms excitement on the one hand and stimulates, the neuron triggering action potentials making separately cortex irriate is still not enough under most cases, only have those simultaneously (or before short time) be subject to indivedual neurons of other excited excitations, (being also the related Neurons on chain type active link), could owing to there is enough excitement integration and triggering action potentials, (and provide pulse to thalamus feedback, cause next synchronous pulse, to maintain proceeding of chain type activation).And the neuron of other those a large amount of (M × N number of), owing to lacking excited integration and cannot triggering synchronous pulse, the lock-out pulse of thalamus can only make them produce postsynaptic film local excitation, and on film, carries out expansion cloth and decay.So these a large amount of neurons in cortex, be subject to the excitement excitation of lock-out pulse simultaneously, do not have triggering action potentials equally again, its local excitation synchronously expands cloth on film, forms the synchronization fluctuate of electric field, just defines brain wave.So brain wave is not that a large amount of neuron of cortex " together synchronously activate (triggering action potentials) " produces afterwards, though a large amount of neurons in cortex produce because " together irriate " " fails to activate " afterwards together.

5. 1. 3. such working mechanism more meets the principle of as far as possible saving power consumption of biological evolution, also can explain the phenomenon of brain wave oscillatory rhythms and amplitude negative correlation.When brain be in excitement, excitement and fast thinking time, (there is β ripple), " attention " of at this moment human thinking activity is pointed to very concentrated, thalamus only carries out lock-out pulse granting fast to the cortex that projection scope is smaller, so, it is less to fail the neuronal quantity of triggering action potentials after stimulating by lock-out pulse, and the amplitude of the brain wave that the synchronous expansion cloth of the film local excitation that their produce produces is naturally just less.And brain is when deep sleep or stupor, (there is δ ripple), at this moment brain does not have thinking activities, concrete " attention " is not had to point to yet, thalamus and network structure carry out oscillating firing slowly, and lock-out pulse granting is carried out to the neuron of cortex extensive region, but because lock-out pulse interval is excessive and cannot encourage these neuronic activation, so, it is very many to fail the neuronal quantity of triggering action potentials after cortex stimulates by lock-out pulse, and the amplitude that the brain wave that cloth produces synchronously is expanded in their film local excitation is naturally just larger.

5. 1. 4. according to such explanation, at a time, no matter the lock-out pulse granting of thalamus is to cortex among a small circle or extensive region projects, in cortex, most neuron is all fail triggering action potentials after excited target, the just minute quantity neuron of triggering action potentials can be activated, although the neuronic action potential signal amplitude of this minute quantity is higher, but quantity is few after all, and be overshadowed among the signal that synchronously spreads of neuronic local excitation failing in a large number to activate, so we fail to detect the signal of these action potentials in electroencephalogram.Only when brain operation irregularity (some neuropathy), thalamus carries out high rhythm and pace of moving things pulse singularly simultaneously and provides to the multiple region of cortex, cause the neuron triggering action potentials simultaneously of the multiple position of cortex, at this moment we just likely detect and obtain this not only high frequency but also the brain wave of high amplitude.

Certainly, also may there is the activation electric discharge of non-thinking activities in cortical neuron, i.e. so-called spontaneous discharge, but applicant thinks that spontaneous discharge should be scattered accidental, so also can not make a big impact on electroencephalogram, may be faint noise.See " 2. 4. 5. neuronic spontaneous discharge " part.In addition according to anatomical documentation, cortex seems also there is a small amount of cholinergic neuron, applicant infers that these cholinergic neurons do not belong to information processing path, but the continuing of lock-out pulse, they may be followed lock-out pulse and activate electric discharge, play the effect of similar lock-out pulse, but negligible amounts.

5. 1. 5. thought that brain wave was that a large amount of neuron of cortex synchronously activates the theory providing action potential in the past, also make to cause very large misleading to the understanding of the working mechanism of human thinking in the past, think that the action each time of brain thinking all needs a large amount of neuronic synchronous movement depending on cortex to realize, so think that cortex is adopt a large amount of neuron by time encoding or frequency coding to the memory of information and reflection, realized by accurate synchronous spike under the control of lock-out pulse.But in fact, time encoding and frequency coding are mainly present in be felt to import in the path with movement output: in feeling to import into, sensory neuron adopts time encoding and frequency coding to record and transmit character and the intensity of various sensory stimuli; In movement output, employing time encoding and frequency coding realize the accurate control to muscular movement direction and dynamics; So brain is concurrent working importing into output facet, we can experience the input of many-sided sensation simultaneously, also can carry out multiple muscle movement simultaneously.And brain is in the memory of average information and thinking, what adopt is that locus coding realizes, be exactly that specific one or one group of neuron correspond to a specific information, movable successively (chain type activation) that these single or single group neurons are orderly, just define flow of information, what define thinking or information recalls output.So the thinking of brain is work in series, only have one at synchronization " thinking ", when thinking adopts language to carry out, thinking can only word for word be undertaken by word.

The essence of 5. 2. sleeping, startup and maintenance.Existing research discloses sleep may roll into a ball triggering by some core of hypothalamus, vision forms reflex circuit by hypothalamic coker, the mammillary body etc. looked, produce Circadian rhythm (i.e. biological clock) control signal, up to thalamus and cortex, the descending projection carrying out modularity to brain stem and spinal cord etc. again, (histaminergic neuron), controls sleep and awakening.But its concrete control mechanism be it be unclear that.And such theory is difficult to explain that brain can control sleep by subjective consciousness, comprises behaviors such as staying up late and get up late once in a while.

The essence of 5. 2. 1. sleeping.Applicant thinks, the essence of sleep is the one low rhythm and pace of moving things duty of brain external information control loop: when the oscillatory rhythms of " network structure-thalamus " oscillating loop is lower, during lower than 3 hertz, thalamus is excessive to the interval of the lock-out pulse that cortex is provided, cortical neuron cannot be made to obtain continuous print excitement and integrate triggering action potentials, chain type activates cannot carry out, so thought system loses attention, thinking and consciousness, enters sleep state.

The Initiated Mechanism of 5. 2. sleeping.According to " the 3. 5. rhythm and pace of moving things change of thinking oscillating loop and the impact on brain work." content, applicant thinks, makes brain enter sleep state, even if also the oscillatory rhythms of thought system oscillating loop is reduced to less than 3,4 hertz, has the Starting mode that two kinds are main: (1), by lower ring control loop to the modulating action of thinking control loop.This comprises the modulation of the Circadian rhythm signal from pars mamillaris hypothalami, (impact of biological clock), also the modulation from visceral nervous system and hormonal system is comprised, the impact of state (tired, uncomfortable etc.), these modulation signals directly suppress the neuron activity of thinking control loop links (especially formatio reticularis mesencephali), make it come and go the oscillatory rhythms provided to decline gradually, finally enter sleep.This mode is the needs of body interior, is to start sleep passively.(2), by cortex thinking activities, the oneself of thinking control loop is suppressed.The Descending Projections of neuron activity on intralaminar nuclei and reticular nucleus due to cortex can affect the speed that its neuronal excitation is integrated, the movable excitement that can affect cancellated " attention " path on cancellated Descending Projections of cortical neuron, thus affect the granting rhythm and pace of moving things of whole loop, so, by reducing thinking activities, (make oneself tranquil, do not think deeply), reduce the downstream driver signal of Cortical neurons activity, thus reduce the oscillatory rhythms of thinking control loop gradually, finally enter sleep.This be subjective want sleep, be initiatively start sleep.

These two kinds of Starting mode, each can both start sleep, but wherein a kind of startup of mode is again often with alternative response, and both form positive feedback and jointly make brain enter sleep.When both occur inharmonious, whether can start sleep and just see that the effect of which aspect is more powerful: when uncomfortable, although subjective you not sleepy sleep health make you sleep have dizzy spells, such as drowsiness; Or subjective sleepy is slept but health makes again you can't fall asleep, and such as has a sleepless night.When somagenic need sleep, you also can work within a certain period of time and adhere to not sleeping, and such as stay up late; Or when health does not need, but time boring, you can make to continue to sleep yourself, such as get up late.(3), the modulation of emotional system in addition, according to " 3. the 5. rhythm and pace of moving things change of thinking oscillating loop and impact on brain work ", two kinds of modes are also had to affect sleep:.Depressedly easily enter sleep, excited excitement is then not easy to enter sleep.(4), the effect of medicine.Such as anaesthetize, directly suppress neural activity, enter a kind of special sleep.

The active state of brain when 5. 2. 3. sleeping.Enter the process of sleep, the thinking loop oscillation rhythm and pace of moving things reduces gradually, when oscillatory rhythms drops to 7-4 hertz of scopes, belong to critical state, at this moment the excitation of lock-out pulse still can make cortical section neuron carry out excitement to integrate and activate, but excitedly integrates slowly, and neuron activity is inactive, cannot be formed links up activates chain clearly, only has the isolated thinking fragment that some is accidental.Although at this moment brain also exists " consciousness ", blunt to various irritant reaction, thinking is fuzzy, and generally not easily forms memory.This is the situation of (when comprising very sleepy) before brain is felt just before going to bed.

Under deep sleep: (1), human thinking system is suppressed, do not produce thinking activities; (2), the input of the objective sensation of brain is suppressed, the reactionless or bradykinesia of stimulation to external world; (3), the kinetic system of brain is also suppressed, do not form action and exports.If but this three is simultaneously not suppressed, some aspect is suppressed and some aspect does not have suppressed, and be not just deep sleep, at this moment brain there will be interesting situation, comprises and having a dream and sleep-walking.(being described elsewhere below).

The maintenance of 5. 2. 4. sleeping.Sleep is once trigger, also be that thinking control loop oscillatory rhythms is lower than 3, 4 hertz, at this moment thalamus provides driving pulse with this low rhythm and pace of moving things to cortex, driving pulse due to this low rhythm and pace of moving things cannot make cortical neuron complete excited integration and activate, so the neuron of cortex does not just carry out descending feedback granting to thalamus and network structure yet, and this makes intralaminar nuclei, reticular nucleus and network structure all cannot be carried out excitement at faster speed and be integrated, thus make whole thinking oscillating loop continue to maintain low rhythmic oscillations state, simultaneously, by modulation relation each other, also the suppression of modularity nerve nucleus maintenance to thought system of lower loop is made, common maintenance sleep state.

5. 2. 5. have a sleepless night.According to the Initiated Mechanism of sleep, cause insomnia also namely sleep cannot start and also have several factor: (1), lower loop to the undermodulation of thinking oscillating loop, cannot be reduced it and provide the rhythm and pace of moving things, so cannot sleep be started.Because lower loop and upper loop are more mutual inhibitory action, when older, during lower loop Underactivity, not enough to the suppression of thinking oscillating loop, so more easily have a sleepless night., thought active, the neuron activity of thinking path enlivens, and cannot reduce the granting rhythm and pace of moving things of thinking oscillating loop, so cannot start sleep.(3), emotion is too excited, and the neuron activity similarly affecting thinking path is too active, cannot start sleep., the impact of medicine, directly make neural activity active and cannot sleep.According to these factors causing having a sleepless night, the related application technology of Cure for insomnia can be developed.

5. the startup of 3. awakening and thinking.Awakening is the inverse process of sleep, when thinking oscillating loop is converted into the higher rhythm and pace of moving things (higher than 8 hertz) vibration again from the low rhythm and pace of moving things, the driving pulse that thalamus is provided to cortex is shorter for interval, carry out excitement integration so be enough to again excitation cortical neuron and trigger the activation, so start thinking activities again, enter waking state, and by cancellated impact with modulate neuronic modulating action, also make kinetic system derepression, recover normal operating conditions.

Cause being converted to awakening from sleep, the factor that also namely causes thinking oscillating loop oscillatory rhythms to raise mainly comprises: (1), from the change of the modulation signal of lower loop.When ambient light brightens (or the length of one's sleep is enough), hypothalamic modulation signal (biological clock signal) acts on thinking oscillating loop, and the granting rhythm and pace of moving things of oscillating loop is improved.(2), from the neururgic stimulation of thinking loop self.Comprise the stimulation of extraneous sensory information, such as stronger audition or tactual stimulation, when also comprising daydream Cortical neurons movable too strong time descending stimulation, these strong stimulations project formatio reticularis mesencephali, encourage its neuron activity and cause oscillating loop and provide the rhythm and pace of moving things and raise.Regardless of with which kind of factor, be all the suppression of lower loop is weakened raise with the oscillatory rhythms of thinking loop, and form positive feedback and accelerate this process further.And once oscillatory rhythms is increased to more than 7,8 hertz, then the lock-out pulse provided to cortex of thalamus, being enough to again excitation cortical neuron produces continuous print chain type and activates, and thinking activities just produces naturally, (certainly gushing of thinking) thereupon.And the thinking activities of cortex is once produce, its neuron activity on the one hand downstream driver thalamus and network structure maintains high rhythmic oscillations, and cause cancellated " attention ", on the other hand produce " consciousness " to sensory cortex projection, so " attention ", " thinking " and " consciousness " just all recover.Thinking activities during awakening can from various incidental information, the content in the information of such as audition sense of touch, dream, the content of thought before sleep etc., but once form thinking, just revert to the control that thought system " attentions " is machine-processed.

5. 4. have a dream.Applicant thinks: daydream is under sleep state, and the inhibitory action that each passage of brain is subject to is asynchronous produced.Corticocerebral neural activity is subject to from the granting of thalamus lock-out pulse, hypothalamus, brain stem modularity nerve nucleus, the various control of limbic system and Meynert basal nuclei, under waking state, sensation input, thinking activities, exporting three with nervus motorius all can not be suppressed, sensation input information can project thought system and produce the sensations such as auditory visual, the output of thought system also can project motor system generation body action or speak writes, the activity of thought system also projects associating Auditory cortex (especially auditory speech centre) simultaneously and produces self-perception and also namely produce consciousness, but thought system is suppressed to the projection of the associating visual cortex, (its biological significance avoids inputting information with vision to interfere with each other, in order to avoid make movement output confusion), so human thinking activity comprises the imagination all can not produce image vision perception.And when deep sleep, thought system, sensation input, movement output three are suppressed simultaneously, so there is no thinking activities, insensitive, attonity of flaccid muscles.

If but this three is not suppressed simultaneously, wherein the neural activity of sensation input and movement output is suppressed, and thought system does not have suppressed or suppresses not enough, just the oscillatory rhythms of thinking control loop is caused to raise, thalamus carries out the lock-out pulse granting of the high rhythm and pace of moving things to cortex, (so when having a dream, electroencephalogram manifests the brain wave of the high rhythm and pace of moving things), activate so cortical neuron produces coherent chain type, also namely produce thinking activities.Suppressed owing at this moment feeling input, thinking activities can not receive real sensory information, and just carry out between the relay cell of association cortex, so have a dream, present are mostly a kind of thinking activitiess being similar to the imagination, but the projection that at this moment thought system comprises associating optic cortex to associating sensory cortex does not have suppressed yet, so the information of the various imaginations that thinking process produces, all project associating sensory cortex, produce and be similar to the sensation seen or hear, also namely have a dream.During owing to having a dream, nervus motorius exports also suppressed, so the action that produces of dreamland generally can not performed by passive movement system, limb muscle still relaxes, and only has oculomotorius both to control by kinetic system, again by superior colliculus and cancellated control, so there will be eye action when having a dream.For the stopping of the startup of dream, dream, the recalling of dreamland, applicant is described in detail in addition with relevant invention of having a dream, and no longer describes here.

5. dream of.Applicant thinks: sleep-walking is also under sleep state, the modulating action that each passage of brain is subject to is asynchronous produced, but different with having a dream, sleep-walking is that thought system is suppressed, and feels to input especially vision input and nervus motorius and export and do not have suppressed or suppress deficiency.Because vision input channel and movement output do not have suppressed, so visual information can be projected onto associating optic cortex, sleepwalker can see.And directly project to motor cortex because associating optic cortex has projection passage not need the control through thought system, and cause the reaction of motor cortex and output program sexual act, (this projection and reaction be body developmental process learn obtain procedural memory, be kept in kinetic system, without the need to the control by thought system, brain rely on just this direct projection and procedural memory to complete various without the need to " attention " also without the action of " consciousness ", as having a meal, walking, the everyday actions such as avoiding barrier), so, motor cortex receives the superframe signal of associating optic cortex, when not having thought system to participate in, according to the procedural reaction action remembering existence before, export motor message, control body and carry out athletic performance, comprise and getting up, walking, switch gate, the actions such as stair activity, also namely there is situation about dreaming of.

During sleep-walking, eyes by motor cortex control and open, sleepwalker can see, but due to thought system suppressed, so at this moment its vision does not have " attentions ", show as eyes without god, do not have eye move or eye move abnormal.Do not realize during sleep-walking, the content that sleep-walking occurs by memory in thought system, namely can not have declarative memory yet, if but repeatedly carry out a certain action, then this action by memory in kinetic system, can become procedural memory.During sleep-walking, thought system is repressed, but before some sleeps of association cortex, relatively more active neuron may have influence on the projection relation of sensory cortex to motor cortex, so sleep-walking occurrence can have certain relation with content of thought before.

Can see from the generation mechanism of above-mentioned daydream and sleep-walking, when sleeping, if the objective sensation input of the external information loop of brain, thought system (average information processing system) and nervus motorius export, when the suppression that this three is subject to is asynchronous, just abnormal sleep may be produced, produce when wherein thought system suppresses not enough separately and have a dream, objective sensation and nervus motorius export when suppressing not enough and produce sleep-walking.Applicant infers with this: when objective sensation input constraint is not enough separately, and sleep is easily waken up; When the neural output of independently moving suppresses not enough, there is unconscious movement and muscular tones such as standing up when sleeping, (owing at this moment not having the projection of external information and thought system, motor system self cannot produce more action); When objective sensation input and thought system suppress not enough, objective sensation information can affect dreamland content, or sleep is easily waken up; When thought system and nervus motorius export and suppress not enough, daydream can produce action and export, and at this moment often causes daydream and sleep to be waken up with a start.

5. 6. psychosis.The operation irregularity of brain, the disease that various brain is relevant can be caused, whether custom was according to having organic disease and these diseases are divided into neuropathy and psychosis in the past, (even also having mental illness), in fact all disease of brain are all the operation irregularity of cranial nerve after all, and only abnormal position is different with mode.Wherein the existing research of this kind of disease such as epilepsy, parkinson, Alzheimer is a lot.Here simple analysis, several psychosiss relevant with thought system, namely the thinking under waking state (also namely having " consciousness " state) is abnormal, is that the collaborative work of thought system " attention " control loop and neuromodulation path causes extremely.

As aforementioned, thinking activities is that the neuron of thought system carries out chain type activation, and is subject to the collaborative modulation of " attention " control access and multiple modulation path.When the stimulation of information input, the travel direction that chain type activates also is the thinking of thinking, be subject to the syndeton (also namely remember, comprise knowledge, event, experience etc.) of related Neurons and the joint effect of multiple modulation path and " attention " control access.In different people, the effect power meeting slightly difference of these control access and modulation path, therefore causes different people its thinking when in the face of the input of same information different with Output rusults, forms different cognitive preferences and different personality.If but the difference of these modulating actions and normal person exceedes to a certain degree, become abnormal, just can cause the exception of thinking.Concrete, if under waking state, effect and the strong and weak generation thereof of these " attentions " control and modulation path are abnormal, at this moment the thought system of patient is still can carry out thinking activities under the modulating action of these exceptions, but because thinking activities is now subject to improper control or modulation, the thinking of its thinking and result are also that behavior expression is just made a world of difference with normal person, and this thinking and behavior expression also cannot be able to be understood by normal person, and institute is to be called as psychosis.

5. 6. 1. attention deficit disease.In " control 3. 4. noted, maintenance and switching " part, applicant analyzes the working mechanism that thought system " attention " controls, maintains and switch, namely brain is by the grading control of formatio reticularis mesencephali-thalamus-cortex, form the control that thinking " attention " is pointed to, what wherein formatio reticularis mesencephali was responsible for is which communication channel " attention " is pointed to, and what thalamus was responsible for is which part " attention " pointed in same communication channel.Various information passage, comprise extraneous input communication channel (vision, audition, olfactory sensation etc.) and the neuron activity of thinking passage, there is the nerve integrated through polymerism to export and carry out " report form " projection to formatio reticularis mesencephali, formatio reticularis mesencephali compares integration by the intensity that inputs various information and time, select " attention " which communication channel, and once produce " attention " to this communication channel, then can by the feedback of the movable Descending Projections of the Cortical neurons of this passage, with the maintenance realized the suppression of other communication channels " attention ", until the information input having other communication channels stronger, produce " attention " to switch.

According to the working mechanism that " attention " maintains, if the movable intensity to the feedback signal of formatio reticularis mesencephali Descending Projections of Cortical neurons is not enough, or formatio reticularis mesencephali each information upstream passage mutual inhibitory action is each other not enough, just certain communication channel can be caused by after " attention ", normally cannot carry out the maintenance of " attention ", make the sensing of " attention " be easy to singularly switch between each communication channel.This is macroscopically, and just showing as brain cannot give more sustained attention a certain thing, easily diverts one's attention absent-minded etc., has also namely occurred " attention " defect.

" attention deficit " is thought system " attention " control mechanism, also namely for providing the control loop appearance of synchronization motivationtheory pulse to thinking activities extremely, " attention " sensing normally cannot be maintained and caused, relating to thought system aspect.And owing to there is control loop and the control mechanism of the pulse of this granting synchronization motivationtheory too at kinetic system, when similar exception appears in kinetic system, be hyperkinetic syndrome.Hyperkinetic syndrome patient there will be the behaviors of abnormal many dynamic and impulsions, and relate to the control of action of detail and harmony bad.Current study general is classified as a kind of disease attention deficit (ADD) and hyperkinetic syndrome (HKS), i.e. " attention-deficit hyperactivity disease " (ADHD), and ADHD is divided into attention deficit type, many ejector half and mixed type.

And, because kinetic system includes by thought system control section (conscious action) with not by thought system control section (unconscious action), when the exception of this control mechanism occurs in the part that kinetic system do not control by thought system, just tic disease (Tics, or title Tourette syndrome) can be caused.Patient can produce not by involuntary movement output that consciousness controls, comprise and make various action in face or health in spite of oneself, i.e. action type (Mot or Tic), or send various strange sound in spite of oneself, i.e. sound type (Vocal Tic), (sound is in fact also that a kind of action exports).

5. 6. 2. infantile autism.According to analysis, infantile autism is also that human thinking system " attention " control mechanism operation irregularity caused, but it is contrary with attention deficit disease, infantile autism is not that " attention " cannot maintain, infantile autism is that human thinking system " attention " sensing cannot carry out normal " attention " switching between each communication channel, and on some neural channel that concentrations and maintaining processes inner average information singularly, thus also relatively inhibit other neural channels are particularly inhibit vision, audition, " attention " of the external information input channels such as sense of touch, information can perception to external world to cause patient, but not easily cause " attention ", so these external informations just cannot obtain the normal process of thought system.Because patient can perception external information; so the action (also namely without the need to the action of thought system control) that walking waits the instinct such as daily routines and hedging can be carried out; also there will not be hallucination; but various extraneous input information (vision, audition, sense of touch etc.) not easily cause " attention " of formatio reticularis mesencephali " attention " control access, be also just difficult to obtain the process (also namely lacking the granting excitation of lock-out pulse) of thought system.So patient comprises extraneous event to various extraneous input information, others information such as conversation content is not easy " attentions ", react extremely blunt compared with overly soft pulse, and wholwe-hearted " attention " of exception is in some thinking activities of oneself.And, process due to communication often needs to carry out arbitrarily and frequently switching between different information content, and the thought system of patient is difficult to carry out normal " attention " switching, so there will be difficulty and obstacle when patient carries out communication with other people, of a specified duration just can avoid this interchange due to difficulty.And due to " attention " of information to external world more weak, patient is also not easy " attention " to the information of other people these faint details such as expression, sight, the tone, emotion, what reaction causing other people to oneself Emotion expression and these performances more " can not be noted ", so patient cannot be formed oneself with other people emotion with the normal perception of expression and reaction, in the past for a long time, patient was just caused to lack normal Emotion expression and affective interaction.That is, the communication obstacle of infantile autism and these symptoms of athymia, in fact point to due to its thought system " attention " and cannot carry out normally switching the result caused.Exception is switched in various degree according to " attention ", infantile autism also can have the multiple performance that degree is different, time serious, " attention " sensing long term maintenance can be ignored various external information completely by patient on the neural activity of some average information, cause communication to degenerate even finally to lose, even owing to losing " attention " to other things and the suppression lost oneself behavior, produce Impulsive or aggression.Because infantile autism is " attention " anomalous concentration, be not easy to carry out " attention " and switch, so infantile autism patient should be not easy " N400 " current potential being induced brain electricity, to need in other words more strongly or more lasting stimulation just can be induced N400 current potential.

From the control mechanism that brain " attention " points to, (content see " 3. the input transmission channels of information " and " control 3. 4. noted, maintenance and switching " part).The exception that this " attention " switches, Ke Nengshi: (1), extraneous input channel is excessively weak to the superframe signal of formatio reticularis mesencephali itself, cannot cause " attention "; , the thinking passage of cortex to the Descending Projections overflow of formatio reticularis mesencephali, thus " attention " that cause formatio reticularis mesencephali " attention " control access is pointed to more strongly; (3), the effect that suppresses mutually between each data feedback channel of formatio reticularis mesencephali is excessively strong, certain passage once obtain " attention " just exception suppress compete signal of other passages consumingly.From the performance patient of infantile autism to external world information be not easy to note, seemingly (1), but applicant be more partial to infer main or below two kinds especially the (3) plant, reason comprises: (1) if the project information of extraneous input channel itself is excessively weak, just should be that certain customizing messages passage passages such as one of () vision, audition, senses of touch is excessively weak, and should not be that " attention " is all not easy to all external worlds input information; (2), patient not " cannot note " external information, just be difficult to switch normally, patient also can be absorbed in some external information sometimes for a long time, such as to play for a long time article or be absorbed in for a long time and do a certain thing, the exception that main still " attention " of infantile autism switches is described.(3), studies have found that in addition; some infantile autism patient is very sensitive to some sound; usually can feel very noisy; but obstacle is existed to talk, patient is described not to Auditory Perception deficiency, but can perception but cannot " note "; cannot these acoustic informations of normal process; and just assign it as noise, (vision can be avoided by " not seeing ", but audition cannot be avoided by " not listening ").So infer that infantile autism is the Descending Projections overflow of association cortex thinking passage to formatio reticularis mesencephali, or the effect suppressed mutually between each data feedback channel of formatio reticularis mesencephali is excessively strong, " attention " of formatio reticularis mesencephali is pointed to and excessively maintains some thinking passage, and be difficult to carry out normal " attention " switching.And, also there is multiple different grouping and different passage in the thinking passage due to brain, each thinking passage is projected to formatio reticularis mesencephali by respective Descending Projections path, infantile autism should be that the projection of wherein some passage is excessively strong, so infantile autism patient the content of thought be absorbed in also be unilateral, and may therefore cause the ability of thinking of some aspect excessively weak, and pointed to strong passage in its " attention ", owing to carrying out information processing at these passages for a long time, the ability of thinking of this aspect may be caused superpower, so that become the talent laid particular stress in a certain respect of deformity.

The exception of infantile autism this " attention " control mechanism, possible major part is genetic, and namely brain just forms the structural abnormal development of neural channel when infant grows.Acquired disposition also may be due to some neurotransmitter or modified exception, or abnormal from the modulating action of brain stem modularity nerve nucleus, causes the effect of Descending Projections overflow or mutual suppression excessively strong; Even, the Descending Projections passage due to cortex belongs to aminoacid can be neural, its signal transmission be have plastic, so it is learned for also not getting rid of this " attentions " exception.The common phenomenon that there is Inter Modulation of each neural channel due to brain, so, cause infantile autism Producing reason, must also can have an impact to other neural activities, otherwise brain function is abnormal to cause some patient to occur, makes infantile autism seem more complicated.When treating infantile autism, should be noted that " attention " sensing that its perception is abnormal, in fact characteristic symptoms such as talk obstacle and athymia etc. is its thought system switches the abnormal result caused for a long time, treatment needs could be more effective for its essence.

5. 6. 3. schizophrenia.Psychotic disorder has various clinical symptoms, and land symptom, negative symptoms, cognitive symptom, anxiety symptom etc., be medically all classified as schizophrenia, owing to can not find physiopathology basis, be considered to belong to functional disease at present.Applicant thinks, schizophrenia is also the abnormal initiation of modulating action of brain modularity path, and different symptoms has different modulation extremely.The essence of the lower surface analysis wherein neural activity exception of the most typical positive symptom.

Analyze above, corticocerebral neuron activity is subject to from hypothalamus or/and the modulation of the modulation signal of brain stem (comprising the modulation signal of sleep/awakening), under waking state, sensation input, thinking activities, exporting three with nervus motorius all can not be suppressed, sensation input information can project thought system and produce the sensations such as auditory visual, the output of thought system also can project motor system generation body action or speak writes, the activity of thought system also project simultaneously associating Auditory cortex especially auditory speech centre produce self-perception and also namely produce consciousness, but thought system is suppressed to the projection of the associating visual cortex, avoid inputting information with real vision to interfere with each other, in order to avoid cause thinking and movement output confusion, so the thinking activities of brain comprises the visually-perceptible that the imagination all can not produce image.If but under waking state, thought system does not have suppressed to the projection of the associating visual cortex or suppresses not enough, the hallucination that the information relating to vision that then thinking process produces especially is imagined out, just the associating visual cortex can be projected and perceived, as a kind of real visual pattern, and superpose with the real external image that eyes input, form the image of compound.At this moment patient institute perception, namely also patient institute " is seen ", is the combination picture that external image that his eyes are seen superposes with the hallucination that himself is imagined out in fact, and, the thought system of patient is just reacted this combination picture, carries out corresponding thinking and action output.And be based upon on basis that actual visual superposes with hallucination because this thinking and action export, so it seems from other people, the existing normal segments of behavior of patient, also namely to the reactive moieties of actual visual, comprises the behaviors such as walking, avoiding barrier; Also there is part impervious to reason, also namely to the reactive moieties of hallucination, comprise talking nonsense, (actual is at the talk with hallucination).

More troublesomely be, these hallucination and the abnormal thinking information produced because of hallucination, (the such as people of a hallucination, and follow the exchanges and dialogues of hallucination people), normal information and event can be treated as equally and be memorized, in the relevant hallucination of upper once appearance or when expecting related content, these abnormal informations can be activated, (hallucination people occur again, and with the exchanges and dialogues of the other side before remembering), in the perception again entering patient and thinking activities, (again exchanges and dialogues), thus these hallucination of strengthening and abnormal information further.So repeatedly after strengthening, these hallucination and abnormal information are occupied an leading position gradually in the thought system of patient, and impact the normal perception of patient, and patient believes hallucination more more than believing real perception, so patient just lives in hallucination more.Certainly, if the visual information in the external world still can be transfused to, then patient generally can also carry out the daily routines such as conventional walking, because visual information can without thought system to the projection of motor cortex.

Upper surface analysis be the essence of the neural activity exception causing the schizophrenia positive symptom.This abnormal reason is caused to be that modularity nerve nucleus caused the modulating action of thought system is abnormal.And since this modulating action can produce result serious so extremely, so just also can cause the exception of otherwise neuron activity, comprising the control mechanism of attention, emotional system all may be influenced, and causes other Novel presentations or symptom.And when the exception of modulating action is removed, (comprising Drug therapy), then thought system will normally be suppressed again to the projection of the associating visual cortex, so hallucination can not produce, patient can carry out thinking and activity as normal person.

5. 7. nervous system and healthy.Namely the internal information processing system of brain also descends loop control system, controls and regulates the various internal organs of body and endocrine activity, therefore also causes direct impact to the body constitution of body and health.The physical strength of human body and a lot of non-organic diseases such as three-hypers, and the dysfunction of various internal organs non-organic, also have the yin, yang of the said body constitution of the traditional Chinese medical science, Sheng, void, heat, tremble with fear, etc., be exactly in fact the different and abnormal performance of the duty of visceral nervous system and hormonal system.Because the autonomic nervous system of brain does not directly control by thought system, so people cannot rely on consciousness to adjust the work of internal organs, medicine can only be relied on.Its Chinese and western medicine is directly by the organ of drug effect in exception, and advantage is that effect is directly obvious, and shortcoming is not started with from root to some disease, often could not eradicate.The traditional Chinese medical science seems wish to come regulating plant nerve and hormonal system by medicine, thus regulating body constitution and disease preventing and treating, problem is the theoretical foundation that it can hardly be explained wherein, and medication is also hodgepodge, do not understand fully various medicine is how what composition is working, and cannot form the theory of system.

Human body is as the society of same complexity, by the body that cell, tissue, organ, System's composition one are complicated, each organ and system have relatively independent work and intermodulate, and, mostly realize information integration and cooperation control by neural neuron activity, form an organic whole, so the health of nervous system and body is closely related.For health care of body and the control to functional disease, key also should research and analyse the lower loop control system of brain to healthy influencing mechanism, comprise the concrete information linking road of each information control loop affecting internal organs and endocrine duty, the not outer perception input all including information of these links, identify and reflection, this three large link of regulation output, which partial nerve unit researchs and analyses these links is, how to realize sensation and identify, how to carry out reflection feedback, export and how to realize regulating, adopt any mediator work, work is by the impact of which biochemical substances, etc., just essence and the producing cause of various disease can be disclosed, and how to prevent and treat these functional diseases.

The mankind are in long-term life, and also obtaining some affects autonomic nervous system by self consciousness thus for keeping fit the method for beneficial body, (user that its founder is even current certainly may not know this side's ratio juris yet).The qigong of Here it is China, the Yoga of India, the buddhist of Buddhism is sat, and also has the deep in thought of west.The form of these methods is different, and can essence be all the same, be that a kind of oneself of consciousness suppresses behavior.The work rhythm and pace of moving things that the lower ring control loop of people has it natural, under this natural rhythm and pace of moving things, duty is best.Although lower loop can not by the direct control of thought system, but by the impact of thinking control loop work, if thinking control loop oscillatory rhythms is fast and fluctuation is frequent, then frequently can have influence on the work rhythm and pace of moving things of lower loop, thus negative effect is caused to the working condition of internal organs and hormonal system.And the practitioner realizing self-suppression behavior is by concentrating on a certain simple focus for a long time by consciousness; the degree of depth is gone to suppress the neural activity of human thinking system; the round granting rhythm and pace of moving things of thinking control loop is become slowly and evenly; and be in the state of this even and low rhythm and pace of moving things for a long time; therefore the interference reduced lower ring control loop and suppression; lower ring control loop can be worked under the natural rhythm and pace of moving things; thus enable internal organs and hormonal system work better, reach constitutional effect.The degree of depth inhibitory state of this consciousness is similar to deep sleep and is better than normal sleep, carry out because the process of normal sleep can periodically circulate between each oscillatory regime, its deep sleep's time is also few, comprise and can have a dream, during daydream, thought system can be in strenuous activity, make the oscillatory rhythms of thinking control loop very high and big ups and downs, thus the work of lower ring control loop can be disturbed.And these actions such as picture Tai Ji, fitness exercise etc. are light and regular rhythmic motions, seem also there is similar effect.

Claims

1. a multi-channel nerve stimulating apparatus, comprise main frame and the electrode being connected main frame, electrode includes ground electrode (or claiming reference electrode) and output electrode, main frame includes the pulses generation module for generation of stimulation pulse signal, for stimulation pulse signal being outputted to each output module of output electrode, it is characterized in that: described output electrode includes the output electrode of more than two groups or two groups, (such as three groups of output electrodes); Main frame also includes output timing control circuit, for controlling the stimulation pulse signal that each output module exports, each output electrode is exported have relative to the boost pulse of reference electrode before and after the sequential relationship that exports successively.

2. a kind of multi-channel nerve stimulating apparatus according to claim 1, it is characterized in that: the sequential relationship of the boost pulse that described each group of output electrode exports is: after last output electrode exports a boost pulse, after the time delay of setting, a rear output electrode just exports a boost pulse.

3. a kind of multi-channel nerve stimulating apparatus according to claim 2, it is characterized in that: two groups of output electrode (such as first and second output electrodes before and after it, second and the 3rd output electrode) Ts time delay of two pulses that exports, with pulse period T, pulse width T 0, three has following relation: 0 < Ts < 1/2T-T0; Character express is: the time delay that two groups, front and back output electrode exports pulse is greater than 0, and is less than the value of " half of pulse period deducts a pulse width ".

4. a kind of multi-channel nerve stimulating apparatus according to claim 1, is characterized in that: main frame also comprises pulse period regulating circuit, the pulse period of former and later two output pulses exported for regulating same group of output electrode; Main frame also includes regulating circuit time delay, the time delay between former and later two pulses exported for regulating former and later two electrodes.

5. a kind of multi-channel nerve stimulating apparatus according to claim 1, it is characterized in that: described pulses generation module, with positive pulse outfan and negative pulse outfan, can export respectively relative to ground electrode is two kinds of pulse output signals of positive potential and nagative potential; Positive pulse and negative pulse two outfans are switched by change-over switch, and the output of change-over switch is connected to each output module.

6. a kind of multi-channel nerve stimulating apparatus according to claim 1, is characterized in that: on main frame for the outfan of the electrode output and each output module that connect each output electrode and between, be added with output control circuit; Electrode output is also connected to the input of a voltage detecting circuit, and the outfan of voltage detecting circuit is connected to voltage comparator circuit, compares with the pulse signal from output module; The outfan of voltage comparator circuit is connected to the control end of output control circuit, is controlled by output control circuit paired pulses output signal.

7. a kind of multi-channel nerve stimulating apparatus according to claim 1, is characterized in that: the electrode output for connecting each output electrode on main frame is connected with voltage detecting circuit, and voltage detecting circuit is used for the background voltage of detecting electrode outfan; The output of voltage detecting circuit is connected with voltage hold circuit, carries out maintenance memory to the background voltage value that voltage detecting circuit exports; The magnitude of voltage that voltage hold circuit exports is connected to a voltage overlaying circuit; The pulse output signals that pulses generation module exports, superposes with background voltage, is connected to electrode output in voltage overlaying circuit.

8. coma patient is carried out to a method for brain impulse stimulation, comprising:

(1), the first output electrode is placed in the position of reticular formation of brain stem medial area, and contact or thrust the neuron at this position; Second output electrode is placed in intralaminar nuclei, and contacts or thrust the neuron at this position; 3rd output electrode is placed in the position of thalamic reticular nucleus, and contacts or thrust the neuron at this position; Ground electrode is contacted with human body;

(2), carry out the impulse stimulation with timing by three groups of output electrodes to the neuron of three positions.

(3), impulse stimulation is intermittent, after namely carrying out the impulse stimulation of 1-3 seconds, stops stimulation 1-3 seconds.Stopping, in the interval stimulated, detecting the EEG signals of coma patient simultaneously, if continue to detect that pulse frequency is greater than the EEG signals of 8 hertz, or observe the reaction that sense of independence appears in patient, then stop providing impulse stimulation.

9. the brain of brain death is carried out to a method for brain impulse stimulation, comprising:

(1), the first output electrode is placed in the position of reticular formation of brain stem LHA, and contact or thrust the neuron at this position; Second output electrode is placed in lateral hypothalamic region or back zone, and contacts or thrust the neuron at this position; 3rd output electrode is placed in the position of dorsal nucleus of vagus nerve, and contacts or thrust the neuron at this position; Ground electrode is contacted with human body;

(3), impulse stimulation is intermittent, namely after granting impulse stimulation a period of time, stops the time of a spacer segment phase, detects the EEG signals of irriate brain in interval, if EEG signals do not detected, then proceed impulse stimulation next time.

10. impulse stimulation method according to claim 8 or claim 9, it is characterized in that: the sequential relationship of the boost pulse that described each group of output electrode exports is: in a pulse period T, according to the order of the first output electrode, the second output electrode, the 3rd output electrode, after last output electrode exports a boost pulse, through Ts time delay of setting, a rear output electrode just exports a boost pulse.