CN110548233A - Portable double-channel transcranial ultrasonic stimulation device for nerve regulation - Google Patents
Portable double-channel transcranial ultrasonic stimulation device for nerve regulation Download PDFInfo
- Publication number
- CN110548233A CN110548233A CN201910945471.2A CN201910945471A CN110548233A CN 110548233 A CN110548233 A CN 110548233A CN 201910945471 A CN201910945471 A CN 201910945471A CN 110548233 A CN110548233 A CN 110548233A
- Authority
- CN
- China
- Prior art keywords
- unit
- signal
- ultrasonic
- channel
- external
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0021—Neural system treatment
- A61N2007/0026—Stimulation of nerve tissue
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Percussion Or Vibration Massage (AREA)
Abstract
The application discloses a portable two-channel transcranial ultrasonic stimulation device for nerve regulation. The device of the invention is used for outputting an ultrasonic signal matched with an ultrasonic probe, and comprises: the device comprises a main control unit, a signal generator unit, a power amplifier unit, a resonant impedance matching unit, a display control panel unit and a power supply system unit; the device comprises a first channel and a second channel which are independent of each other, wherein the first channel comprises a first ultrasonic excitation signal branch and a first external trigger signal branch which are connected with a main control unit; the second channel comprises a second ultrasonic excitation signal branch and a second external trigger signal branch which are connected with the main control unit; the device also comprises an external cooperative unit, and the working modes of the external cooperative unit comprise a synchronous trigger mode and an asynchronous trigger mode. The transcranial ultrasonic stimulation device has the advantages of concise working integration, flexible control and rich functions, and can meet the nerve regulation and control requirements of various stimulation modes.
Description
Technical Field
The application relates to the technical field of nerve regulation, in particular to a portable double-channel transcranial ultrasonic stimulation device for nerve regulation.
background
The neural regulation and control technology is an important tool for neuroscience research and neural engineering and clinical application, and the common neural regulation and control means at present include Deep Brain Stimulation (DBS), Transcranial direct current Stimulation (tDCS), Transcranial Magnetic Stimulation (TMS), and optogenes (optogenes), and Transcranial Ultrasonic Stimulation (TUS). DBS has micron-scale spatial resolution, but the application of DBS has the limitation that surgical trauma and stimulation target change are not flexible, and risks of postoperative infection and the like exist. Although the TMS and tDCS technologies have the advantages of non-invasive type, the defects of low stimulation spatial resolution and shallow penetration depth exist, and the requirements of some occasions cannot be met; the optical gene genetic technology has incomparable action precision, but can be realized by surgical operation methods such as virus transfection and invasive optical fiber implantation, and is difficult to be used for clinical treatment of brain diseases. The transcranial ultrasonic stimulation technology is a technical means for stimulating nerves or functional areas of the brain by using low-frequency focused ultrasound so as to modulate the brain function, has the advantages of non-invasiveness, high resolution, large stimulation depth, good electromagnetic compatibility and the like, has great potential clinically, and is widely concerned internationally.
As a novel nerve regulation and control technology, transcranial ultrasound has great development potential, but an ultrasonic stimulation system used in experimental research at the present stage is basically constructed by self manually and is formed by splicing a plurality of devices, so that the size is heavy, the operation difficulty is high, and the movement is difficult. Through the search of the prior documents, corresponding portable transcranial ultrasonic stimulation devices, such as a transcranial ultrasonic stimulation device and a stimulation method, have appeared at the present stage (patent number: 20150021745.0); a novel portable transcranial ultrasonic stimulation and electroencephalogram signal acquisition device (201520514405.7); an ultrasonic nerve stimulation apparatus and system (201520996080.0). However, these are single-channel transcranial ultrasound devices, however, in brain science research and clinical application, some scenes and application objects need to receive stimulation of two targets or even multiple targets simultaneously; in particular, stimulation of these targets may be synchronous stimulation or asynchronous stimulation with a specific timing sequence to study synergistic effects and causal relationships between the respective targets. Such studies particularly require multi-channel ultrasound stimulation devices that precisely control the timing of the stimulation of each channel to complete the experiment. Meanwhile, in the experimental process, the ultrasonic stimulation device often cooperates with other devices such as electroencephalogram devices and electromyogram devices, and external triggering delay is needed in some occasions, such as input and output of advance or delay synchronous signals. The technology and the equipment can not meet the accurate time sequence control of multi-channel stimulation, do not realize asynchronous triggering, and are difficult to meet the real-time closed-loop transcranial ultrasonic stimulation cooperated with other equipment (such as electroencephalogram or electromyogram) in the literature retrieval.
Therefore, a double-channel transcranial ultrasonic stimulation device which has the advantages of multi-channel stimulation, accurate time sequence control, asynchronous triggering, capability of working in cooperation with external electroencephalogram and electromyogram and other devices, convenience in operation, small size and portability is not available in the field.
Disclosure of Invention
The portable double-channel transcranial ultrasonic stimulation device for nerve regulation and control is provided with two independent channels, asynchronous triggering with external equipment can be achieved, real-time closed-loop transcranial ultrasonic stimulation with other equipment (such as electroencephalogram or electromyogram) can be further achieved, and multiple parameters can be displayed in real time.
The invention provides a portable double-channel transcranial ultrasonic stimulation device for nerve regulation, which is used for outputting an ultrasonic signal matched with an ultrasonic probe, and is characterized by comprising the following components: the device comprises a main control unit, a signal generator unit, a power amplifier unit, a resonant impedance matching unit, a display control panel unit and a power supply system unit;
The main control unit is configured to process information transfer among the units and process data of the units; the signal generator unit is used for receiving the control instruction transmitted by the main control unit and generating a required pulse signal; the power amplifier unit is used for modulating and amplifying the pulse signal from the signal generator unit; the resonant impedance matching unit is configured to match the power amplifier unit output impedance with an impedance of an ultrasound probe while filtering an output signal of the power amplifier unit; the display control panel unit is used for displaying and inputting the operating parameters of the device; the power supply system unit is used for supplying power to the device;
The device comprises a first channel and a second channel which are independent of each other, wherein the first channel comprises a first ultrasonic excitation signal branch and a first external trigger signal branch which are connected with a main control unit; the second channel comprises a second ultrasonic excitation signal branch and a second external trigger signal branch which are connected with the main control unit;
the device further comprises an external coordination unit, wherein the external coordination unit is configured to be used for the coordination work of the transcranial ultrasonic stimulation device and external other equipment so as to generate or receive an external trigger signal; the working modes of the external cooperative unit comprise a synchronous trigger mode and an asynchronous trigger mode.
In another preferred example, the synchronous trigger mode refers to that, in the same channel, the generation of the ultrasonic excitation signal sent to the ultrasonic probe in the corresponding ultrasonic excitation signal branch is synchronous with the generation of the external trigger signal sent outwards in the external trigger signal branch.
In another preferred example, the asynchronous trigger mode refers to that, in the same channel, the generation of the ultrasonic excitation signal sent to the ultrasonic probe in the corresponding ultrasonic excitation signal branch is asynchronous with the generation of the external trigger signal sent outwards in the external trigger signal branch.
In another preferred example, the first ultrasonic excitation signal branch and the second ultrasonic excitation signal branch each independently output synchronous or time-sequential ultrasonic excitation signals for driving the ultrasonic probe.
In another preferred example, the working modes of the first ultrasonic excitation signal branch and the second ultrasonic excitation signal branch include an independent output mode and a cooperative output mode.
In another preferred example, in the independent output mode, the first ultrasonic excitation signal branch and the second ultrasonic excitation signal branch are independent from each other and do not interfere with each other, and both can drive the ultrasonic probe.
In another preferred example, in the cooperative output mode, the first ultrasonic excitation signal branch and the second ultrasonic excitation signal branch are associated with each other and cooperate with each other, at this time, respective stimulation parameters of the first ultrasonic excitation signal branch and the second ultrasonic excitation signal branch are independent, and the second ultrasonic excitation signal branch sends out a signal after T millisecond delay after the first ultrasonic excitation signal branch outputs a pulse signal under the control of the display control panel unit.
In another preferred example, the first ultrasonic excitation signal branch and the second ultrasonic excitation signal branch cooperatively output excitation signals, and the ultrasonic probe generates corresponding ultrasonic stimulation signals based on the ultrasonic excitation signals output by the first ultrasonic excitation signal branch and the second ultrasonic excitation signal branch.
In another preferred example, the apparatus further comprises a voltage regulating unit, which is powered by the power supply system unit and generates different output voltages to be supplied to the power amplifier.
In another preferred embodiment, the device further comprises an upper computer unit, wherein the upper computer unit comprises a computer, and the upper computer unit is in communication connection with the main control unit.
in another preferred example, a plurality of parameters of the device are controlled at the computer terminal.
In another preferred embodiment, the plurality of parameters is selected from the group consisting of: an ultrasonic stimulation signal center frequency, a pulse duration duty cycle DC, a number of acoustic pulse bursts NTB, a stimulation interval time ISI, an excitation pulse voltage Vpp, an asynchronous trigger time T, or a combination thereof.
In another preferred example, the upper computer unit communicates with the main control unit in a USB or wireless manner.
In another preferred embodiment, the upper computer unit can receive information given by external equipment (such as electroencephalogram or electromyogram equipment), automatically adjust stimulation parameters, and realize closed-loop control of the transcranial ultrasonic stimulation device and the external equipment.
In another preferred embodiment, the display control panel unit includes a display panel unit and a control panel unit, wherein the display panel unit displays multiple stimulation parameters of the first ultrasonic excitation signal branch and the second ultrasonic excitation signal branch in the working process of the device in real time, and the multiple stimulation parameters are selected from the following group: an operating mode, a fundamental frequency F, a pulse duration TBD, a duty cycle DC, a number of acoustic pulse bursts NTB, a stimulation interval time ISI, a probe loading voltage Vpp, a spatial peak pulse mean intensity Isppa, an external trigger delay T, or a combination thereof.
In another preferred example, the control panel unit comprises a key and a rotary encoder, and is used for controlling multiple output parameters of the first ultrasonic excitation signal branch and the second ultrasonic excitation signal branch of the device in real time.
in another preferred embodiment, the plurality of output parameters are selected from the group consisting of: an operating mode, a fundamental frequency F, a pulse duration TBD, a duty cycle DC, a number of acoustic pulse bursts NTB, a stimulation interval time ISI, a probe loading voltage Vpp, a spatial peak pulse mean intensity Isppa, and an external trigger delay T.
in another preferred embodiment, the signal generator unit comprises a signal source and an amplifying circuit, wherein the signal source is a direct digital frequency synthesizer DDS with adjustable output frequency; the amplifying circuit amplifies and outputs the DDS output signal through a linear voltage amplifier.
In another preferred embodiment, the power amplifier unit has a first power amplifier and a second power amplifier which are independent of each other, the power amplifier has a modulation signal input and an analog signal input, the modulation signal input is connected with a modulation signal of the main control unit, the modulation signal is a TTL level, and the power amplifier is controlled to be turned on and off by changing the TTL level; the analog signal input is from the analog signal output by the signal generator unit.
In another preferred example, the power amplifier includes a control circuit, a signal modulation circuit, a MOS transistor driving circuit, a MOS transistor, a transformer, and a resonant circuit;
The signal modulation circuit receives the analog signal output by the signal generator unit and converts the signal into two paths of complementary square wave signals; the MOS tube driving circuit comprises two drivers, wherein the input end of the MOS tube driving circuit is connected with a square wave signal, and the output end of the MOS tube driving circuit is connected with an MOS tube; the MOS tube is connected with the driver and the transformer, and amplification of square wave signals is completed through on-off of the MOS tube and amplification of the transformer; the resonance circuit is connected with the output end of the transformer and used for reducing the square wave signal into a sine signal.
In another preferred example, the apparatus further comprises a transducer unit, the transducer unit comprises an ultrasonic probe, the ultrasonic transducer unit is connected with the output end of the resonance impedance matching unit, and the input end of the resonance impedance matching unit is connected with the resonance circuit of the power amplifier.
In another preferred example, the output end of the signal generator unit is connected to the input end of the power amplifier unit, the output end of the power generator unit is connected to the input end of the resonant impedance matching unit, and the output end of the resonant impedance matching unit is connected to the ultrasonic transducer unit.
In another preferred example, the main control unit is an ARM chip, and is configured to store and load a plurality of ultrasound stimulation parameters.
Drawings
FIG. 1 is a block diagram of the construction of an ultrasonic stimulation apparatus of the present invention;
Fig. 2 is a schematic diagram of a signal generator unit of the ultrasonic stimulation apparatus of the present invention;
FIG. 3 is a schematic view of a display control panel of the ultrasonic stimulation apparatus of the present invention;
FIG. 4 is a schematic diagram of the power supply system unit and voltage regulation unit of the ultrasonic stimulation apparatus of the present invention;
FIG. 5 is a schematic diagram of a power amplifier of the ultrasonic stimulation apparatus of the present invention;
FIG. 6 is a schematic illustration of a stimulation waveform of the ultrasonic stimulation apparatus of the present invention;
FIG. 7 is a schematic view of an external coordinating unit of the ultrasonic stimulation apparatus of the present invention;
FIG. 8 is a schematic illustration of an asynchronous trigger mode in an external coordination unit of the ultrasound stimulation apparatus of the present invention;
FIG. 9 is a schematic diagram of the closed loop regulation of the ultrasonic stimulation apparatus of the present invention with an external device;
FIG. 10 is a schematic representation of the operation of the upper computer unit of the ultrasonic stimulation apparatus of the present invention;
Fig. 11 is a top computer interface diagram of the inventive ultrasound stimulation apparatus.
in the drawings, the designations are as follows:
1-Master control Unit
2-Signal Generator Unit
21-DDS control unit
22-smoothing rectification unit
23-Linear amplification Unit
3-power amplifier unit
31-power amplifier
311-control circuit
312-signal modulation circuit
313-MOS tube driving circuit
314-MOS tube
315-transformer
316-resonant circuit
4-resonant impedance matching unit
5-display control panel unit
51-display panel unit
511-TFT display screen
512-LED lamp
52-control panel unit
521-push button
522-Rotary encoder
53-processor unit
6-Power supply System Unit
61-DC voltage stabilizing unit
62-Voltage conversion Unit
7-Voltage regulating Unit
8-external coordination unit
9-upper computer unit
10-ultrasonic transducer unit
Detailed Description
The inventor of the invention develops a portable double-channel transcranial ultrasonic stimulation device for nerve regulation and control for the first time through extensive and intensive research and a large number of screens, and the device adopts a circuit design with high integration level, so that the device realizes double-channel output of the ultrasonic stimulation device in a limited space, and can simultaneously output two paths of independent ultrasonic excitation signals to drive an ultrasonic probe to work. In addition, an external cooperative unit adopted by the device innovatively provides asynchronous triggering and synchronous triggering working modes, can lead or lag an ultrasonic excitation signal according to needs, outputs an external triggering signal, and is matched with external equipment such as an electroencephalogram or electromyogram system to realize more flexible ultrasonic stimulation. Meanwhile, an upper computer unit of the device can communicate with equipment through a USB, control of a computer end is achieved, the transcranial ultrasonic stimulation device is simple in work integration, flexible in control and rich in function, and the requirement for nerve regulation and control of various stimulation modes can be met.
In the following description, numerous technical details are set forth in order to provide a better understanding of the present application. However, it will be understood by those skilled in the art that the technical solutions claimed in the present application may be implemented without these technical details and with various changes and modifications based on the following embodiments.
The invention provides a portable double-channel transcranial ultrasonic stimulation device for nerve regulation, which is used for outputting an ultrasonic signal matched with an ultrasonic probe, and comprises: the device comprises a main control unit, a signal generator unit, a power amplifier unit, a resonant impedance matching unit, a display control panel unit and a power supply system unit;
The main control unit is configured to process information transfer among the units and process data of the units; the signal generator unit is used for receiving the control instruction transmitted by the main control unit and generating a required pulse signal; the power amplifier unit is used for modulating and amplifying the pulse signal from the signal generator unit; the resonance impedance matching unit is configured to match the power amplifier unit output impedance with the impedance of the ultrasonic probe while filtering the output signal of the power amplifier unit; the display control panel unit is used for displaying and inputting the operating parameters of the device; the power supply system unit is used for supplying power to the device;
The device comprises a first channel and a second channel which are independent of each other, wherein the first channel comprises a first ultrasonic excitation signal branch and a first external trigger signal branch which are connected with a main control unit; the second channel comprises a second ultrasonic excitation signal branch and a second external trigger signal branch which are connected with the main control unit;
The device also comprises an external coordination unit, wherein the external coordination unit is configured to be used for the coordination work of the transcranial ultrasonic stimulation device and other external equipment so as to generate or receive an external trigger signal; the working modes of the external cooperating unit include a synchronous trigger mode and an asynchronous trigger mode. The synchronous trigger mode refers to that in the same channel, the generation of the ultrasonic excitation signal sent to the ultrasonic probe in the corresponding ultrasonic excitation signal branch is synchronous with the generation of the external trigger signal sent outwards in the external trigger signal branch. The asynchronous trigger mode refers to that in the same channel, the generation of the ultrasonic excitation signal sent to the ultrasonic probe in the corresponding ultrasonic excitation signal branch circuit is asynchronous with the generation of the external trigger signal sent outwards in the external trigger signal branch circuit. Preferably, the external cooperative unit receives or sends the trigger signal through the main control unit to realize cooperative work of the device and the external other device, which includes synchronous triggering and asynchronous triggering. Preferably, when the ultrasonic stimulation device is used as a main control device, a starting signal is sent to the outside, and the external device is preferably a 64-lead brain electrical acquisition system; when the ultrasonic stimulation device does not act as a master control device, the ultrasonic stimulation device receives an external trigger signal.
Preferably, the first ultrasonic excitation signal branch and the second ultrasonic excitation signal branch each independently output synchronous or time-sequential ultrasonic excitation signals for driving the ultrasonic probe.
Preferably, the main control unit is a processor of the device, the ARM chip is adopted to receive and send control instructions of each unit, information transmission among the units is completed, data transmitted by each unit are analyzed and processed, operation parameters of the device are stored and loaded, and normal operation of the device is guaranteed. The storage unit reads and writes a flash cache of the ARM chip to complete storage and loading of the ultrasonic parameters.
Preferably, the signal generator unit adopts a DDS synthesis technology, receives a control command transmitted by the main control unit, and generates a required original pulse sinusoidal signal. Preferably, the signal generator unit comprises a DDS control unit, a filtering and rectifying unit, and a linear amplifying unit. The DDS control unit receives an instruction of the main control unit to generate an initial sinusoidal signal, the filtering rectification unit filters the initial sinusoidal signal to reduce noise interference, and the linear amplification unit is responsible for amplifying the amplitude of the initial sinusoidal signal.
Preferably, the device further comprises a voltage regulation unit, the voltage regulation unit is powered by the power supply system unit, and the voltage conversion module is used for generating different output voltages for supplying power to the power amplifier.
Preferably, the power amplifier unit further amplifies the output signal of the signal generator unit by using a resonant power amplifying circuit, and amplifies the input signal to different degrees under different supply voltages; and meanwhile, the modulation signal generated by the main control unit is received, and the signal is output after being modulated to generate the required high-voltage pulse signal. In the present invention, the power amplifier unit comprises two independent power amplifiers. As shown in fig. 5, the power amplifier includes a control circuit, a signal modulation circuit, a MOS transistor driving circuit, a MOS transistor, a transformer, and a resonant circuit. The control circuit is connected with the main control unit to modulate signals, is TTL level, and controls the power amplifier to be switched on or switched off by changing the TTL level; the signal modulation circuit is connected with the analog input signal and converts the signal into two paths of complementary square wave signals; the MOS tube driving circuit comprises two drivers, wherein the input end of each driver is connected with a square wave signal, and the output end of each driver is connected with an MOS tube to drive the MOS tube to work so as to improve the driving capability of the square wave signal; the MOS tube is connected with the transformer and the driver, and amplification of square wave signals is completed through the on-off of the MOS tube and the amplification of the transformer; the resonance circuit is connected with the output of the transformer and restores the square wave signal into a sine signal.
Preferably, the impedance matching unit adopts a scheme of a series resonance circuit, matches the output of the power amplifier unit with the impedance of the ultrasonic probe, makes the output be a sinusoidal pulse signal under a resonance condition, and ensures that the equipment works at maximum efficiency.
The output signal generated by the impedance matching unit to which the transducer unit is connected, outputs an ultrasonic signal, and preferably, the transducer unit comprises an ultrasonic probe.
Preferably, the power supply system unit generates different output voltages by adopting a scheme that the switching power supply and the voltage stabilizing chip are matched with each other, so as to supply power to all power utilization units in the equipment.
Preferably, the display control panel unit comprises a display panel unit and a control panel unit, wherein the display panel unit displays multiple stimulation parameters of the first ultrasonic excitation signal branch and the second ultrasonic excitation signal branch in the working process of the device in real time, and the multiple stimulation parameters are selected from the following group: an operating mode, a fundamental frequency F, a pulse duration TBD, a duty cycle DC, a number of acoustic pulse bursts NTB, a stimulation interval time ISI, a probe loading voltage Vpp, a spatial peak pulse mean intensity Isppa, an external trigger delay T, or a combination thereof.
Preferably, the display control panel unit is as shown in fig. 3, and includes a display panel unit, a control panel unit and a processor unit, wherein the display panel unit uses a TFT liquid crystal display and an LED lamp to complete the display of multiple parameters; the display panel unit can display multiple stimulation parameters of the first ultrasonic excitation signal branch and the second ultrasonic excitation signal branch in the working process of the equipment in real time, wherein the multiple stimulation parameters comprise a working mode, a fundamental frequency F, a pulse duration TBD (Tone-burst-duration), a duty cycle DC (duty cycle), a sound pulse group number NTB (number of Tone burst), a stimulation interval time ISI (Inter-stimulation interval), a probe loading voltage Vpp, a spatial peak pulse average Intensity Isppa (spatial-peak-average-Intensity), and an external trigger delay T. The control panel unit adopts keys and a rotary encoder to realize the control of multiple parameters, and the processor unit adopts an embedded chip to control the control panel unit and the display panel unit and is responsible for communicating with the main control unit. In the working process, the processor unit sends the key information to the main control unit, the main control unit processes the information and then sends an instruction to the processor unit, and the processor unit analyzes the instruction and then displays the instruction in the display panel unit.
Preferably, the device also comprises an upper computer unit, wherein the upper computer unit comprises a computer and is in communication connection with the main control unit.
Preferably, a plurality of parameters of the device are controlled at the computer terminal.
Preferably, the plurality of parameters is selected from the group consisting of: an ultrasonic stimulation signal center frequency, a pulse duration duty cycle DC, a number of acoustic pulse bursts NTB, a stimulation interval time ISI, an excitation pulse voltage Vpp, an asynchronous trigger time T, or a combination thereof.
preferably, the upper computer unit communicates with the main control unit in a USB or wireless mode.
preferably, the upper computer unit can receive information given by external equipment (such as electroencephalogram or electromyogram equipment), automatically adjust stimulation parameters, and realize closed-loop control of the transcranial ultrasonic stimulation device and the external equipment.
Preferably, the upper computer unit can receive information given by external equipment (such as electroencephalogram or electromyogram equipment, for example, a 64-lead electroencephalogram acquisition system), automatically adjust stimulation parameters, and realize closed-loop regulation and control of the transcranial ultrasonic stimulation device and the external equipment. As shown in fig. 8, during the stimulation process, the upper computer unit automatically adjusts multiple parameters of the ultrasonic stimulation according to information fed back by external devices (such as electroencephalogram or electromyogram devices, for example, a 64-lead electroencephalogram acquisition system) and according to the content set by the program, so as to realize the closed-loop control of the transcranial ultrasonic stimulation device and the external devices.
preferably, the upper computer unit writes a desktop control program by using a programming language at a computer end, the desktop control program automatically sends or receives information to the main control unit so as to control a plurality of parameters (a working mode, a fundamental frequency F, a pulse duration TBD, a duty ratio DC, a sound pulse group number NTB, a stimulation interval time ISI, a probe loading voltage Vpp, a spatial peak pulse average intensity Isppa and an external trigger delay T) of the system, and the upper computer unit and the main control unit communicate by using a USB data line.
Portable double-channel transcranial ultrasonic stimulation device for nerve regulation
The device comprises a main control unit, a signal generator unit, a voltage regulating unit, a power amplifier unit, a resonant impedance matching unit, a display control panel unit, a power supply system unit, a voltage regulating unit, an upper computer unit and an external coordination unit. The main control unit is a processor system of the device and is responsible for processing information transmission among all units and processing data of each unit to ensure normal operation of equipment. The signal generator unit receives the control instruction transmitted by the main control unit and generates the required pulse signal. The power amplifier unit receives the signal generated by the signal, modulates and amplifies the signal, and amplifies the input signal to different degrees under different power supply voltages; the impedance matching circuit matches the output of the power amplifier unit with the impedance of the ultrasonic probe through the resonance circuit so as to ensure that the equipment works at the maximum efficiency; the display control panel unit comprises a display panel unit and a control panel unit, the display panel unit displays multiple parameters in the operation process of the equipment through a display screen, and the control panel unit is responsible for controlling the multiple parameters of the equipment through keys; the external cooperation unit is responsible for the cooperation of the device and other external devices, and is used for generating or receiving an external trigger signal. The power supply system unit is responsible for supplying power to all the electricity consuming units in the device. The upper computer unit is communicated with the main control unit through a USB and controls the device at a computer end;
the device comprises a first channel and a second channel which are independent of each other, wherein the first channel comprises a first ultrasonic excitation signal branch and a first external trigger signal branch which are connected with a main control unit; the second channel comprises a second ultrasonic excitation signal branch and a second external trigger signal branch which are connected with the main control unit; the external coordination unit is configured to coordinate the transcranial ultrasonic stimulation device with other external equipment to generate or receive an external trigger signal; the working modes of the external cooperative unit comprise a synchronous trigger mode and an asynchronous trigger mode.
Working mode of nerve regulation portable double-channel transcranial ultrasonic stimulation device
The working mode of the device is divided into an independent output mode and a cooperative output mode;
in the independent output mode of the device: the first ultrasonic excitation signal branch and the second ultrasonic excitation signal branch are independent and do not interfere with each other, and both can drive the ultrasonic probe.
In a coordinated output mode of the device: the two are mutually related and work cooperatively. At the moment, the respective stimulation parameters of the first ultrasonic excitation signal branch and the second ultrasonic excitation signal branch are independent, the second ultrasonic excitation signal branch starts to work after the first ultrasonic excitation signal branch starts to work and the time is delayed for T milliseconds, and the size of T can be preset or controlled in real time through a program. Under the working mode, two paths of ultrasonic signals are output in a delayed mode, and the ultrasonic signal processing method can be used for researching the interaction relation among different brain regions in nerve regulation and control.
Mode of operation with external cooperating units
The portable double-channel transcranial ultrasonic stimulation device for nerve regulation can be synchronously triggered and asynchronously triggered in the working mode of the external cooperative unit, as shown in fig. 8.
In the synchronous trigger mode, in the same channel, the generation of the ultrasonic excitation signal sent to the ultrasonic probe in the corresponding ultrasonic excitation signal branch is synchronous with the generation of the external trigger signal sent outwards in the external trigger signal branch. That is to say, when the main control unit of the device sends an external trigger signal outwards, the trigger signal of the external trigger signal branch and the pulse excitation signal of the ultrasonic excitation signal branch are generated at the same time; when receiving an external trigger signal, the first channel and the second channel start to work immediately after receiving the trigger signal.
in the asynchronous trigger mode, in the same channel, the generation of the ultrasonic excitation signal sent to the ultrasonic probe in the corresponding ultrasonic excitation signal branch circuit and the generation of the external trigger signal sent to the outside in the external trigger signal branch circuit are asynchronous. That is, when the main control unit of the device sends an external trigger signal to the outside, the trigger signal of the first external trigger signal branch and/or the second external trigger signal branch leads or lags the pulse excitation signal of the first ultrasonic excitation signal branch and the second ultrasonic excitation signal branch; when receiving an external trigger signal, the first channel and the second channel start to operate after delaying for a certain time after receiving the trigger signal. The amount of time to advance or retard can be preset to a constant or can be programmed to do so in real time. That is, when the single channel sends the trigger signal to the outside, the trigger signal or the pulse excitation signal is output in a delayed manner through the delay action of the timer by calling the internal timer resource. Such that the trigger signal leads or lags the pulsed excitation signal of the respective channel. When each channel receives the trigger signal, the CPU detects the trigger signal and then triggers the timer to interrupt, and the timer outputs the pulse excitation signal after delaying for a period of time, so that the output lags behind the trigger signal to work.
The invention is further described below with reference to the accompanying drawings: the present embodiment is implemented on the premise of the technical solution of the present invention, and a detailed implementation manner and a specific operation process are given, but the protection scope of the present invention is not limited to the following embodiments.
example 1
The invention provides a portable two-channel transcranial ultrasonic stimulation device for nerve regulation, realizes real-time control of two-channel ultrasonic stimulation signals, is flexible to control and convenient to operate, and can meet nerve regulation requirements of various complex two-channel stimulation modes and closed-loop nerve regulation stimulation.
As shown in fig. 1, the apparatus includes: the ultrasonic diagnosis device comprises a main control unit 1, a signal generator unit 2, a power amplifier unit 3, an impedance matching unit 4, a display control panel unit 5, a power supply system unit 6, a voltage adjusting unit 7, an external cooperation unit 8, an upper computer unit 9 and an ultrasonic transducer unit 10. The main control unit 1 is an ARM chip and can store and load a plurality of ultrasonic stimulation parameters. The stimulation parameters of the last working moment can be kept unchanged every time the device is started.
fig. 2 is a schematic structural diagram of a signal generator unit 2, which includes: a DDS control unit 21, a filter rectification unit 22, and a linear amplification unit 23.
the specific implementation flow of the signal generator unit 2 is shown in fig. 2, the DDS control unit 21 receives the instruction of the main control unit 1, generates two sinusoidal signals, respectively outputs the sinusoidal signals to the two filtering and rectifying units 22, and respectively inputs the sinusoidal signals to the two linear units 23 for amplification after filtering. The filtering and rectifying unit 22 includes two filtering and rectifying circuits, and the linear amplifying unit 23 includes two linear amplifying circuits.
Fig. 3 is a schematic structural diagram of the display control panel unit 5, which includes a display panel unit 51, a control panel unit 52, and a processor unit 53.
The display panel unit 51 shown in fig. 3 is composed of a TFT display screen 511 and LED lamps 512. The LED lamp 512 is responsible for displaying the output status of the channel and the operation mode. The TFT display screen 511 displays the various ultrasound stimulation parameters as shown in fig. 5.
The control panel unit 52 shown in fig. 3 is composed of a key 521 and a rotary encoder 522. Wherein the key 521 is responsible for selecting various parameters (working mode, fundamental frequency F, pulse duration TBD, duty cycle DC, number of acoustic pulse groups NTB, stimulation interval time ISI, probe loading voltage Vpp, spatial peak pulse average strength Isppa and external trigger delay T) of the system, and the rotary encoder 522 is responsible for adjusting the size of the selected parameters.
The processor unit 53 of fig. 3 employs embedded chips to control the display panel unit 51 and the control panel unit 52 and is responsible for communication with the main control unit 1.
Fig. 3 shows a flow chart of a specific implementation of the display and control panel unit 5, in which the processor unit 53 is connected to the control panel unit 52 through an interrupt of a chip, and when the key 521 is pressed, the processor unit 53 receives a corresponding interrupt, processes the interrupt information, and sends the processed interrupt information to the display panel unit 51 and the main control unit 1. When the main control unit 1 sends an instruction to the display control panel unit 5, the processor unit 53 of the display control panel unit 5 sends corresponding information to the display panel unit 51 to display after receiving the instruction.
Preferably, the display control panel unit 5 and the main control unit 1 perform data transmission through a serial port.
Fig. 4 is a schematic structural diagram of the power supply system unit 6 and the voltage regulating unit 7. As shown in fig. 4, the power supply system unit 6 includes a dc voltage stabilization unit 61 and a voltage conversion unit 62. The power supply system unit 6 is specifically implemented such that the power supply unit 6 is connected to 220V ac power, and is primarily converted into the required 30V dc voltage through the dc voltage stabilizing unit 61, and different voltages are output through different voltage stabilizing circuits in the voltage converting unit 62 to supply power to each unit in the circuit.
As shown in fig. 4, the input end of the voltage regulating unit 7 is connected to the output end of the dc voltage stabilizing unit 61 in the power supply system unit 6, and is connected to the main control unit 1, and receives the control command from the main control unit 1 to generate different output voltages for supplying power to the power amplifier unit 3.
Fig. 5 is a schematic diagram of a power amplifier 31 in the power amplifier unit 3, which includes a control circuit 311, a signal modulation circuit 312, a MOS transistor driving circuit 313, a MOS transistor 314, a transformer 315, and a resonant circuit 316. The power amplifier 31 supply is controlled by the voltage regulation unit 7.
The control circuit 311 is connected to the main control unit 1, and the control circuit is responsible for controlling the power supply of the power amplifier 31 to be switched on and off, so that the main control unit controls the power amplifier to be switched on and off; the signal modulation circuit 312 receives the sinusoidal signal generated by the signal generator unit 2, and converts the signal into two complementary square wave signals; the MOS tube driving circuit 313 inputs and connects the square wave signal, outputs and connects the MOS tube 314, and drives the MOS tube 314 to work. Preferably, the MOS transistor 314 is a P-channel MOS transistor, and an output terminal thereof is connected to an input terminal of the transformer 315, and outputs a square wave signal after passing through the transformer 315; the resonant circuit 316 is connected to the output of the transformer 315 to reduce the square wave signal to a sinusoidal signal.
fig. 6 is a schematic diagram of the final output ultrasonic signal of the ultrasonic nerve stimulation apparatus, and the center frequency F, the pulse duration TBD, the duty ratio DC, the number of sound pulse groups NTB, the stimulation interval time ISI, the excitation pulse voltage Vpp, the spatial peak pulse average intensity Isppa, and other properties of the ultrasonic signal can be displayed and adjusted by the display control panel unit 5.
fig. 7 is a schematic diagram showing the output of the external cooperative unit 8 of the ultrasonic nerve stimulation device.
The external cooperative unit 8 is controlled by the main control unit 1 and the upper computer unit 9 (preferably, upper computer software) to receive or send a trigger signal, so as to realize cooperative work of the device and other external devices, and the working modes of the device include a synchronous trigger mode and an asynchronous trigger mode.
As shown in a diagram in fig. 7, which is a synchronous trigger operation mode, when a single channel sends a trigger signal to the outside, the trigger signal and the pulse excitation signal of each channel are generated at the same time. When receiving an external trigger signal, each channel starts to operate immediately after receiving the trigger signal.
As shown in b of fig. 7, which is an asynchronous trigger mode, when a single channel sends a trigger signal to the outside, the trigger signal leads or lags the time T of the pulse excitation signal of the respective channel. And after each channel receives the trigger signal, the channel starts to work after a certain time T lags behind.
The particular parameter T can be controlled by a display control panel or adjusted by an upper computer unit 9, preferably upper computer software.
Specifically, the working diagram of the asynchronous trigger mode is shown in fig. 8, and the specific implementation flow is as follows:
S1, starting;
S2, setting the trigger mode as asynchronous trigger mode;
s3, when the trigger mode is set to send out the leading trigger signal, the main control unit of the device sends out the trigger signal first, and outputs the excitation signal after the timer delays T time, thereby generating the leading trigger signal shown in b of fig. 7;
S4, when the trigger mode is set to send out the lag trigger signal, the main control unit of the device firstly outputs the excitation signal, and sends out the trigger signal after the timer delays T time, thereby generating the lag trigger signal shown in b of fig. 7;
S5, when the trigger mode is set to accept external trigger signal, the system detects the trigger signal and generates timer interrupt, and outputs excitation signal after time T is delayed by the timer;
And S6, ending.
Fig. 9 is a schematic diagram of the closed-loop control of the ultrasonic stimulation apparatus and an external device. As shown in the figure, in the process of stimulating the tested brain by the ultrasonic device, external equipment (such as myoelectric equipment and electroencephalogram equipment) collects various tested physiological indexes and sends the indexes to a computer, the computer analyzes data, judges whether the current stimulation parameters need to be changed or not according to results, and if the current stimulation parameters need to be changed, the computer sends a message to the upper computer unit 9 to modify the corresponding parameters.
Fig. 10 is a schematic diagram showing the operation of the upper computer unit 9 of the transcranial ultrasonic stimulation device. The work flow comprises the following steps:
S1: start of
S2: and selecting a corresponding serial port by the serial port equipment with the scanning surface connected with the upper computer.
S3: and setting the baud rate and starting communication.
S4: according to the requirements, the ultrasonic stimulation device can automatically or manually modify a plurality of parameters (working mode, fundamental frequency F, pulse duration TBD, duty ratio DC, acoustic pulse group number NTB, stimulation interval time ISI, probe loading voltage Vpp, spatial peak pulse average intensity Isppa and external trigger time delay T) in the upper computer.
S5: and when the parameters of the upper computer are modified, sending data to the lower computer and waiting for a return message of the lower computer.
s6: and after receiving the return confirmation message of the lower computer, confirming that the data is modified, and displaying in the display control panel.
s7: when the lower computer modifies the parameters through the display control panel, the upper computer receives the information sent by the lower computer and verifies the information.
S8: and after the information is confirmed to be correct, updating a plurality of items of parameter information on the interface.
In this embodiment, the upper computer unit is a desktop computer, a notebook computer, a tablet computer, or other computers capable of running a graphics operating system.
In this embodiment, the lower computer is the transcranial ultrasound stimulation device.
The parameters and their ranges that can be modified in this embodiment are, the ultrasonic stimulation signal center frequency F: 300 KHz-1.5 MHz, pulse duration TBD: 80ms to 4000ms, duty ratio DC: 2% -100%, the number of sound pulse groups NTB is 1-1000, the stimulation interval time ISI is 100 ms-50000 ms, the excitation pulse voltage Vpp: 100Vpp 600Vpp, asynchronous trigger time T: -1000ms to 1000 ms;
The communication between the upper computer and the lower computer in the embodiment is communicated through a USB data line
The interface of the upper computer unit in this example is shown in fig. 11.
The application of a portable dual-channel transcranial ultrasonic stimulation device for nerve regulation comprises the following steps.
S1: and starting.
s2: and when the power supply is switched on, the power supply system unit starts to work to supply power to each unit.
S3: and a plurality of stimulation parameters are set on the display control panel through the control panel unit and the control panel unit.
s4: and clicking a stimulation starting button, and sending the set parameters to the main control unit through the processor unit of the display control panel.
S5: the main control unit controls the output of each unit according to the information of the display control panel unit, judges whether the upper computer is connected or not, and forwards the information to the upper computer unit if the upper computer is connected.
S6: the device outputs to an ultrasonic transducer, which is actuated to begin generating an ultrasonic pulse signal.
The main advantages of the invention are as follows:
(a) The dual-channel output is provided, and the two channels can work independently or cooperatively.
(b) The system has an asynchronous trigger function and can realize early or late trigger output.
(c) The ultrasonic stimulation device has the functions of data storage and loading, can store multiple groups of ultrasonic stimulation parameters, and loads different stimulation parameters through the display control panel.
(d) The display control panel can display the working mode, the pulse center frequency F, the pulse duration TBD (Tone-burst-duration), the duty ratio DC (duty cycle), the number of sound pulse groups NTB (number of Tone burst), the stimulation interval ISI (Inter-stimulation interval), the probe loading voltage Vpp, the spatial-peak pulse-average Intensity Isppa (spatial-peak-average Intensity), the external trigger time T in real time, and the operation is more concise and clear.
(e) The device is provided with an upper computer unit, can control and display a plurality of parameters of the system on a computer, is convenient to control complex time sequence stimulation, and can adjust a plurality of stimulation parameters in real time, thereby being matched with other equipment systems to realize real-time closed-loop transcranial ultrasonic stimulation based on physiological states (such as the physiological states of electroencephalogram or myoelectricity detection).
(f) the device integrates all units of transcranial ultrasound into one case, and has the advantages of convenient operation, small volume and portability.
It is noted that, in the present patent application, relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, the use of the verb "comprise a" to define an element does not exclude the presence of another, same element in a process, method, article, or apparatus that comprises the element. In the present patent application, if it is mentioned that a certain action is executed according to a certain element, it means that the action is executed according to at least the element, and two cases are included: performing the action based only on the element, and performing the action based on the element and other elements. The expression of a plurality of, a plurality of and the like includes 2, 2 and more than 2, more than 2 and more than 2.
All documents mentioned in this application are to be considered as being incorporated in their entirety into the disclosure of this application so as to be subject to modification as necessary. Further, it is understood that various changes or modifications may be made to the present application by those skilled in the art after reading the above disclosure of the present application, and such equivalents are also within the scope of the present application as claimed.
Claims (10)
1. A portable dual channel transcranial ultrasound stimulation device for neuromodulation, the device for outputting an ultrasound signal matched to an ultrasound probe, comprising: the device comprises a main control unit, a signal generator unit, a power amplifier unit, a resonant impedance matching unit, a display control panel unit and a power supply system unit;
The main control unit is configured to process information transfer among the units and process data of the units; the signal generator unit is used for receiving the control instruction transmitted by the main control unit and generating a required pulse signal; the power amplifier unit is used for modulating and amplifying the pulse signal from the signal generator unit; the resonant impedance matching unit is configured to match the power amplifier unit output impedance with an impedance of an ultrasound probe while filtering an output signal of the power amplifier unit; the display control panel unit is used for displaying and inputting the operating parameters of the device; the power supply system unit is used for supplying power to the device;
The device comprises a first channel and a second channel which are independent of each other, wherein the first channel comprises a first ultrasonic excitation signal branch and a first external trigger signal branch which are connected with a main control unit; the second channel comprises a second ultrasonic excitation signal branch and a second external trigger signal branch which are connected with the main control unit;
The device further comprises an external coordination unit, wherein the external coordination unit is configured to be used for the coordination work of the transcranial ultrasonic stimulation device and external other equipment so as to generate or receive an external trigger signal; the working modes of the external cooperative unit comprise a synchronous trigger mode and an asynchronous trigger mode.
2. The apparatus according to claim 1, wherein the synchronous trigger mode is that the generation of the ultrasonic excitation signal transmitted to the ultrasonic probe in the corresponding ultrasonic excitation signal branch and the generation of the external trigger signal transmitted to the outside in the external trigger signal branch are synchronized in the same channel.
3. The apparatus of claim 1, wherein the asynchronous trigger mode refers to the generation of the ultrasonic excitation signal transmitted to the ultrasonic probe in its corresponding ultrasonic excitation signal branch and the generation of the external trigger signal transmitted outward in the external trigger signal branch being asynchronous in the same channel.
4. the apparatus of claim 1, wherein the first ultrasonic excitation signal branch and the second ultrasonic excitation signal branch each independently output a synchronized or timed ultrasonic excitation signal for driving the ultrasonic probe.
5. the apparatus of claim 1, further comprising a voltage regulation unit that is powered by a power supply system unit and that generates a different output voltage that is provided to the power amplifier.
6. The device of claim 1, further comprising an upper computer unit, wherein the upper computer unit comprises a computer, and the upper computer unit is in communication connection with the master control unit.
7. the apparatus of claim 1, wherein the signal generator unit comprises a signal source and an amplifying circuit, wherein the signal source is a direct digital frequency synthesizer (DDS) with an adjustable output frequency; the amplifying circuit amplifies and outputs the DDS output signal through a linear voltage amplifier.
8. The apparatus of claim 1, wherein the power amplifier unit has a first power amplifier and a second power amplifier independent from each other, the power amplifier has a modulation signal input and an analog signal input, the modulation signal input is connected with a modulation signal of the main control unit, the modulation signal is a TTL level, and the power amplifier is controlled to be turned on and off by changing a magnitude of the TTL level; the analog signal input is from the analog signal output by the signal generator unit.
9. The apparatus of claim 8, wherein the power amplifier comprises a control circuit, a signal modulation circuit, a MOS transistor drive circuit, a MOS transistor, a transformer, a resonant circuit;
The signal modulation circuit receives the analog signal output by the signal generator unit and converts the signal into two paths of complementary square wave signals; the MOS tube driving circuit comprises two drivers, wherein the input end of the MOS tube driving circuit is connected with a square wave signal, and the output end of the MOS tube driving circuit is connected with an MOS tube; the MOS tube is connected with the driver and the transformer, and amplification of square wave signals is completed through on-off of the MOS tube and amplification of the transformer; the resonance circuit is connected with the output end of the transformer and used for reducing the square wave signal into a sine signal.
10. The apparatus of claim 9, further comprising a transducer unit including an ultrasound probe, the ultrasound transducer unit connected to an output of the resonant impedance matching unit, and an input of the resonant impedance matching unit connected to a resonant circuit of the power amplifier.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910945471.2A CN110548233B (en) | 2019-09-30 | 2019-09-30 | Portable double-channel transcranial ultrasonic stimulation device for nerve regulation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910945471.2A CN110548233B (en) | 2019-09-30 | 2019-09-30 | Portable double-channel transcranial ultrasonic stimulation device for nerve regulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110548233A true CN110548233A (en) | 2019-12-10 |
| CN110548233B CN110548233B (en) | 2021-07-27 |
Family
ID=68742191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910945471.2A Active CN110548233B (en) | 2019-09-30 | 2019-09-30 | Portable double-channel transcranial ultrasonic stimulation device for nerve regulation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110548233B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111790067A (en) * | 2020-08-24 | 2020-10-20 | 中国人民解放军陆军军医大学第一附属医院 | Multi-frequency ultrasonic stimulation instrument |
| CN114432604A (en) * | 2022-02-18 | 2022-05-06 | 天津大学 | Angle-adjustable wearable dual-channel conduction device, ultrasonic regulation and control system and use method |
| CN114917495A (en) * | 2022-04-28 | 2022-08-19 | 燕山大学 | Multi-parameter adjustable signal source device for transcranial ultrasonic stimulation |
| WO2024108566A1 (en) * | 2022-11-25 | 2024-05-30 | 中国科学院深圳先进技术研究院 | Ultrasonic transducer, in-vivo transfection system, and use thereof |
Citations (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2088413U (en) * | 1991-03-10 | 1991-11-13 | 温州医学院 | Electronic stethoscope capable of selecting cardiac auscultation interval |
| CN102232856A (en) * | 2010-05-06 | 2011-11-09 | 高春平 | Double-frequency ultrasonic multi-dimensional focused cerebrovascular thrombolytic system |
| CN103285512A (en) * | 2013-06-09 | 2013-09-11 | 中国人民解放军第三军医大学第三附属医院 | Electric brain stimulator based on serial port output digital trigger signals and implementation method thereof |
| CN103751909A (en) * | 2014-01-23 | 2014-04-30 | 上海诺诚电气有限公司 | Real-time feedback intelligent electrical stimulation device and stimulation method thereof |
| CN203777523U (en) * | 2014-02-12 | 2014-08-20 | 绿谷（集团）有限公司 | Multichannel ultrasonic acupoint stimulation device |
| CN104606779A (en) * | 2015-01-06 | 2015-05-13 | 上海交通大学 | Multi-channel electric stimulator applicable to human body skin antennal nerve stimulation |
| CN104888347A (en) * | 2014-12-21 | 2015-09-09 | 徐志强 | Multi-channel nerve stimulation device and application thereof |
| WO2016046830A2 (en) * | 2014-09-28 | 2016-03-31 | Elminda Ltd. | Brain stimulation tool configuration |
| CN205198725U (en) * | 2015-12-03 | 2016-05-04 | 深圳先进技术研究院 | Supersound nerve stimulation equipment and system |
| CN106502410A (en) * | 2016-10-27 | 2017-03-15 | 天津大学 | Improve the transcranial electrical stimulation device of Mental imagery ability and method in brain-computer interface |
| US9735893B1 (en) * | 2016-07-21 | 2017-08-15 | Intel Corporation | Patch system for in-situ therapeutic treatment |
| CN206543179U (en) * | 2016-11-09 | 2017-10-10 | 工业和信息化部电信研究院 | Eeg signal acquisition system |
| CN107252525A (en) * | 2017-04-28 | 2017-10-17 | 上海交通大学 | A kind of multichannel electrical stimulation device based on EMG feedback |
| CN107362465A (en) * | 2017-07-06 | 2017-11-21 | 上海交通大学 | It is a kind of that the system synchronous with eeg recording is stimulated for human body TCD,transcranial Doppler |
| WO2018056733A1 (en) * | 2016-09-23 | 2018-03-29 | 기초과학연구원 | Brain stimulating device and use thereof |
| CN108144199A (en) * | 2017-12-22 | 2018-06-12 | 深圳先进技术研究院 | Device, method and system are motivated by ultrasound |
| CN110037654A (en) * | 2019-03-22 | 2019-07-23 | 同济大学 | A kind of noninvasive cerebral function imaging helmet and imaging method |
-
2019
- 2019-09-30 CN CN201910945471.2A patent/CN110548233B/en active Active
Patent Citations (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2088413U (en) * | 1991-03-10 | 1991-11-13 | 温州医学院 | Electronic stethoscope capable of selecting cardiac auscultation interval |
| CN102232856A (en) * | 2010-05-06 | 2011-11-09 | 高春平 | Double-frequency ultrasonic multi-dimensional focused cerebrovascular thrombolytic system |
| CN103285512A (en) * | 2013-06-09 | 2013-09-11 | 中国人民解放军第三军医大学第三附属医院 | Electric brain stimulator based on serial port output digital trigger signals and implementation method thereof |
| CN103751909A (en) * | 2014-01-23 | 2014-04-30 | 上海诺诚电气有限公司 | Real-time feedback intelligent electrical stimulation device and stimulation method thereof |
| CN203777523U (en) * | 2014-02-12 | 2014-08-20 | 绿谷（集团）有限公司 | Multichannel ultrasonic acupoint stimulation device |
| WO2016046830A2 (en) * | 2014-09-28 | 2016-03-31 | Elminda Ltd. | Brain stimulation tool configuration |
| CN104888347A (en) * | 2014-12-21 | 2015-09-09 | 徐志强 | Multi-channel nerve stimulation device and application thereof |
| CN104606779A (en) * | 2015-01-06 | 2015-05-13 | 上海交通大学 | Multi-channel electric stimulator applicable to human body skin antennal nerve stimulation |
| CN205198725U (en) * | 2015-12-03 | 2016-05-04 | 深圳先进技术研究院 | Supersound nerve stimulation equipment and system |
| US9735893B1 (en) * | 2016-07-21 | 2017-08-15 | Intel Corporation | Patch system for in-situ therapeutic treatment |
| WO2018056733A1 (en) * | 2016-09-23 | 2018-03-29 | 기초과학연구원 | Brain stimulating device and use thereof |
| CN106502410A (en) * | 2016-10-27 | 2017-03-15 | 天津大学 | Improve the transcranial electrical stimulation device of Mental imagery ability and method in brain-computer interface |
| CN206543179U (en) * | 2016-11-09 | 2017-10-10 | 工业和信息化部电信研究院 | Eeg signal acquisition system |
| CN107252525A (en) * | 2017-04-28 | 2017-10-17 | 上海交通大学 | A kind of multichannel electrical stimulation device based on EMG feedback |
| CN107362465A (en) * | 2017-07-06 | 2017-11-21 | 上海交通大学 | It is a kind of that the system synchronous with eeg recording is stimulated for human body TCD,transcranial Doppler |
| CN108144199A (en) * | 2017-12-22 | 2018-06-12 | 深圳先进技术研究院 | Device, method and system are motivated by ultrasound |
| CN110037654A (en) * | 2019-03-22 | 2019-07-23 | 同济大学 | A kind of noninvasive cerebral function imaging helmet and imaging method |
Non-Patent Citations (1)
| Title |
|---|
| 宁彬: "双心室绝对不应期电刺激对慢性心力衰竭兔心功能影响的研究", 《中国博士学位论文全文数据库 医药卫生科技辑》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111790067A (en) * | 2020-08-24 | 2020-10-20 | 中国人民解放军陆军军医大学第一附属医院 | Multi-frequency ultrasonic stimulation instrument |
| CN114432604A (en) * | 2022-02-18 | 2022-05-06 | 天津大学 | Angle-adjustable wearable dual-channel conduction device, ultrasonic regulation and control system and use method |
| CN114917495A (en) * | 2022-04-28 | 2022-08-19 | 燕山大学 | Multi-parameter adjustable signal source device for transcranial ultrasonic stimulation |
| CN114917495B (en) * | 2022-04-28 | 2023-02-24 | 燕山大学 | Multi-parameter adjustable signal source device for transcranial ultrasonic stimulation |
| WO2024108566A1 (en) * | 2022-11-25 | 2024-05-30 | 中国科学院深圳先进技术研究院 | Ultrasonic transducer, in-vivo transfection system, and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110548233B (en) | 2021-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110548233B (en) | Portable double-channel transcranial ultrasonic stimulation device for nerve regulation | |
| CN108744275A (en) | A kind of wearable transcutaneous electrical stimulation medical apparatus for treating menalgia | |
| CN103638598A (en) | Mobile terminal intelligent meridian physiotherapeutic instrument | |
| WO2007019491A3 (en) | Method and apparatus for producing therapeutic and diagnostic stimulation | |
| CN103949011A (en) | Portable wireless transcutaneous electric nerve stimulator | |
| CN104857640A (en) | Closed-loop type transcranial ultrasonic brain stimulation apparatus | |
| CN204601385U (en) | Mobile intelligent terminal is as the physiotherapeutic instruments of Core Control Platform Based | |
| CN109364371A (en) | A kind of reaction type animal nerve electrical stimulation device | |
| CN103638599A (en) | Implanted nerve electrical stimulation control method, device and system | |
| CN103479471B (en) | Intelligent amblyopic treatment instrument and control method thereof | |
| CN111317660A (en) | Myoelectricity detection electric acupuncture device and myoelectricity detection method | |
| CN109976199B (en) | Signal generating device and equipment with same | |
| CN114917495B (en) | Multi-parameter adjustable signal source device for transcranial ultrasonic stimulation | |
| CN103239350B (en) | Intelligent vibration therapeutic device based on multi-channel physiological information feedback | |
| CN103933674A (en) | Ultrasonic treatment equipment | |
| CN109876296A (en) | A kind of electrical acupuncture therapeutic equipment | |
| KR101417386B1 (en) | Apparatus for Magnetic field therapy for preventing or treating breast cancer | |
| CN1181900C (en) | Controlled pulsive DC electric field equipment for inducing and exciting human electroencephalogic waves in waking state of sleeping | |
| CN114949614A (en) | Frequency modulation signal generator for millimeter wave therapeutic apparatus | |
| CN107224670A (en) | A kind of low-frequency electrical stimulation pulse parameter regulation work station and control method | |
| CN110882004B (en) | Ultrasonic control and imaging device, method, server and storage medium | |
| CN203564406U (en) | Intelligent amblyopia therapeutic instrument | |
| JP2004267325A (en) | Interference low-frequency treatment device | |
| CN111097102A (en) | Wireless control multi-channel therapeutic apparatus | |
| CN212235629U (en) | Portable multichannel neuromuscular stimulation therapeutic instrument |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |