CN102397617A - Artificial thalamus reaction type brain electric therapeutic apparatus with wakening-promoting function - Google Patents
Artificial thalamus reaction type brain electric therapeutic apparatus with wakening-promoting function Download PDFInfo
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- CN102397617A CN102397617A CN2010102742173A CN201010274217A CN102397617A CN 102397617 A CN102397617 A CN 102397617A CN 2010102742173 A CN2010102742173 A CN 2010102742173A CN 201010274217 A CN201010274217 A CN 201010274217A CN 102397617 A CN102397617 A CN 102397617A
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Abstract
The invention relates to an artificial thalamus reaction type brain electric therapeutic apparatus with a wakening-promoting function, which is used for carrying out reaction type regulation aiming at different types of electroencephalograms of coma patients through establishing an artificial thalamus system. Found from clinical tests to small samples of patients in clinical, the artificial thalamus reaction type brain electric therapeutic apparatus has a remarkable improving function on the mind states of the coma patients.
Description
Technical field
The present invention relates to a kind of research and development with artificial thalamus reaction type brain electric therapeutic apparatus of the short effect of waking up; We utilize digital signaling system to set up artificial thalamus system in in-vitro simulated human body thalamus system; And carry out the reaction type adjusting according to the electroencephalogram that collects; And with this instrument application in the short treatment of waking up of stupor, this therapeutical effect also can be used for the short of special state comatose patient such as vegetative state and wakes up.Belong to field of medicaments.
Background technology
Stupor is meant because the impaired caused serious disturbance of consciousness of higher nervous center structure that the various causes of disease cause and functional activity (consciousness, sensation and motion).Present popular viewpoint is thought: cortex and diencephalon are the basic positions of keeping wakefulness, and they interact with reticular formation of brain stem on function.In view of brain stem ARAS and thalamus system importance to awakening, people's instinct consider that they are also most important to keeping consciousness.It is information integrated fast that Zeman thinks that consciousness depends on the thalamus cortex loop of turning back.Llin á s thinks that consciousness results from cortex, thalamus, the neuronic spontaneous discharge of the airtight loop of RF.Massimini thinks that consciousness depends on the ability of brain integrate information, depends on the efficient connection in thalamus cortex specific function zone, it is believed that brain stem carries out neuroregulation through ascending activating system to this system.Cerebral cortex will could stimulate to produce suitable reaction under the promptly appropriate lasting waking state of the excitement of medium level to external world.The research group of BL Negrao thinks that 40HZ can make brain electrical acti synchronous, is the precondition that consciousness exists, because the vibrations of thalamus 40Hz, different neural subgroups are kept synchronous discharge, so the vibrations of thalamus 40hz are suitable for keeping consciousness.And also have in one's early years square wave that scholar's research points out 120Hz to be best suited for for short the waking up of the patient of insulin induced coma.
Electroencephalogram and brain biological metabolism are closely related, are a kind of phenomenons that cerebral metabolism produces, and wherein any one link or a kind of composition destroy and all can take place unusually.Electroencephalogram slow wave frequency is parallel relation between cycle length and the disturbance of consciousness degree, and promptly disturbance of consciousness is heavy more, and the slow wave cycle, long more prognosis was poor more, and survival rate is low more.The very fast wave amplitude of ripple rate is higher, and prompting has prognosis preferably.
Summary of the invention
In view of the importance of thalamus for consciousness, we are on the basis of eeg recording appearance, and initiative proposition utilization digital signaling system is simulated the thalamus system of human body; The external square wave that gives 40-120Hz; Give the neuron electricity irritation, keep neuronic synchronous discharge, play the short effect of waking up.Electroencephalogram changes during stupor has multiplely, slow wave type stupor can be arranged, coma; β-stupor, triphasic wave, periodic wave; Smooth ripple etc.; The artificial thalamus reaction type brain electricity of our research and development is short wake up appearance can be according to the different wave of patient's eeg recording, reaction type is regulated, and uses the square wave of 40-120Hz frequency urge awake.
Description of drawings
1. when tracing electroencephalogram; On scalp, place earlier 10-21 electrode, the position be generally in (Ta or F7,8) before (Fp), volume (F) before the volume of the left and right sides, central area (C) (before and after the Rolandic fissure), top (P), pillow (O), the temporo, the temporo behind (T or T3), the temporo (T or T5), both sides ear-lobe (A1) and the crown just in the middle part of (top heart C)
2. the visible α (8-13Hz) of normal brain activity computer, β (13-30Hz), θ (4-7HZ), δ (＜4HZ) four kinds of waveforms.
3. when human body was gone into a coma, electroencephalogram changed.The short appearance of waking up of artificial thalamus reaction type brain electricity carries out reaction type adjusting with the 40-120Hz ripple to human body according to the EEG signals that record.
The specific embodiment
We select for use in October, 2009～2010 my section in year March to accept coma patient 22 examples after the serious symptom craniocerebral injury, male 15 examples, women 7 examples, age 18-56 year for medical treatment.Be divided into two groups at random: matched group 11 examples, male 8 examples, women 3 examples, mean age 33.23+10.22 year, GCS scoring 6.64 ± 1.56 was on average gone into a coma natural law 6.63+3.02 days; 11 examples are organized in treatment, male 7 examples, women 4 examples, and 36.45 ± 9.71 years old mean age, GCS divided 6.44 ± 1.49, the natural law 6.56 ± 1.64 days of on average going into a coma.Two groups of comparing difference nonsignificances.
Therapeutic Method: 1. matched group: matched group adopts the conventional method treatment, with adding XINGNAOJING 20ml and Cerebrolysin Vial 50ml, quiet, 1 time/day among the 5% glucose saline 250ml respectively.2. treatment group: on the basis of conventional method treatment, adopt acupuncture treatment.Under same position, identical conditions, to two groups of the 2nd detections, contrast stimulates the instant blood flow situation of change in front and back after the acupuncture.Giving reaction type eeg recording appearance every day stimulated 30 minutes, individual month of continued treatment, the situation such as Glasgow coma score (GCS), neurological functional recovery and language function of contrast therapy in the time of 3 months.Select asymmetric double to pulsed continuous wave, stimulate major parameter: pulsewidth 0.5ms ± 30%, output pulse frequency 40-120Hz.Patient's bilateral finger slight shrinkage get final product when stimulus intensity stimulated to observe, 30 minutes every days of stimulation time, lasting 30 days.Methods of marking should adopt Glasgow coma score (GCS) and the U.S.'s state-run health research institute's apoplexy scale (NIHSS) and (MRS).Continued treatment 3 months, the contrast therapy situation such as Glasgow coma score (GCS), neurological functional recovery and language function in the time of 3 months.Select square wave, stimulate major parameter: pulsewidth 0.5ms ± 30%, output pulse frequency 40～120Hz.
Table: three months state of an illness of treatment group and treatment of control group relatively
Annotate: * compares P＜0.05. with matched group
Claims (2)
1. one kind has the short artificial thalamus reaction type brain electric therapeutic apparatus of waking up and acting on.
2. according to claim 1, protect the design research and development power of this instrument, and the application aspect short the waking up of going into a coma.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104888346A (en) * | 2014-12-21 | 2015-09-09 | 徐志强 | Method and device for nerve stimulation for brain in coma |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101530647A (en) * | 2009-04-23 | 2009-09-16 | 哈尔滨奥博医疗器械有限公司 | Transcranial magnetoelectric depression therapeutic apparatus |
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2010
- 2010-09-07 CN CN2010102742173A patent/CN102397617A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530647A (en) * | 2009-04-23 | 2009-09-16 | 哈尔滨奥博医疗器械有限公司 | Transcranial magnetoelectric depression therapeutic apparatus |
Non-Patent Citations (2)
| Title |
|---|
| 林支付等: "丘脑的计算机三维重建及其临床意义", 《中国临床解剖学杂志》, vol. 18, no. 1, 31 December 2000 (2000-12-31), pages 39 - 41 * |
| 赵刚勇等: "微电脑促醒仪的研制", 《医疗设备信息》, vol. 18, no. 3, 31 December 2003 (2003-12-31), pages 20 - 22 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104888346A (en) * | 2014-12-21 | 2015-09-09 | 徐志强 | Method and device for nerve stimulation for brain in coma |
| CN108126274A (en) * | 2014-12-21 | 2018-06-08 | 徐志强 | The multi-channel nerve stimulating apparatus of impulse stimulation is carried out to depth stupor brain |
| CN108175939A (en) * | 2014-12-21 | 2018-06-19 | 徐志强 | Device is activated for carrying out the brain of impulse stimulation to brain death brain |
| CN108187228A (en) * | 2014-12-21 | 2018-06-22 | 徐志强 | The brain stimulation device of impulse stimulation is carried out to depth stupor brain |
| CN108175939B (en) * | 2014-12-21 | 2021-06-04 | 徐志强 | Brain activation device for pulse stimulation of the brain |
| CN108187228B (en) * | 2014-12-21 | 2022-04-05 | 徐志强 | Brain stimulation device for pulse stimulation of deep coma brain |
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Application publication date: 20120404 |