CN107029352B - Stimulation pulse amplitude adjusting module and implantable neural stimulation system with same - Google Patents
Stimulation pulse amplitude adjusting module and implantable neural stimulation system with same Download PDFInfo
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- 230000000638 stimulation Effects 0.000 title claims abstract description 106
- 230000001537 neural effect Effects 0.000 title claims description 4
- 230000003247 decreasing effect Effects 0.000 claims description 9
- 230000000694 effects Effects 0.000 abstract description 8
- 230000007383 nerve stimulation Effects 0.000 abstract description 3
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000008859 change Effects 0.000 description 11
- 210000004556 brain Anatomy 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
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- 230000006872 improvement Effects 0.000 description 4
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- 239000003814 drug Substances 0.000 description 2
- 210000004281 subthalamic nucleus Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
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- 229940079593 drug Drugs 0.000 description 1
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- 230000000630 rising effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36103—Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/375—Constructional arrangements, e.g. casings
Abstract
The invention discloses a stimulation pulse amplitude adjusting module and an implanted nerve stimulation system with the same, wherein the stimulation pulse amplitude adjusting module comprises an initial amplitude generating unit, an adjusting unit and a processing unit, and the initial amplitude generating unit is used for generating an initial amplitude of a stimulation pulse; the adjusting unit is used for generating an amplitude configuration value; the processing unit is used for superposing the initial amplitude value and the amplitude configuration value to generate a final amplitude value. The invention realizes effective regulation of the pulse amplitude through the regulating module, thereby improving the treatment effect and improving the treatment experience of patients.
Description
Technical Field
The invention relates to the field of implantable medical treatment, in particular to a stimulation pulse amplitude adjusting module and an implantable neural stimulation system with the same.
Background
Implantable medical systems, which are used in clinical medicine in recent years, generally include implantable neurostimulation systems (including deep brain stimulation system DBS, implantable cortical brain stimulation system CNS, implantable spinal cord electrical stimulation system SCS, implantable sacral nerve stimulation system SNS, implantable vagus nerve stimulation system VNS, etc.), implantable cardiac stimulation systems (commonly referred to as cardiac pacemaker), implantable drug infusion systems (IDDS), etc.
Implantable neurostimulation systems, as shown in fig. 1, generally include the following components: a plurality of stimulating electrode contacts 30 (here, left and right brain electrode contacts are taken as examples), electrode leads 33, extension leads 34, a pulse generator 35, and a programmer 36.
Taking deep brain stimulation system DBS as an example, the pulse generator 35 conducts electrical pulses to the STN (Subthalamic Nucleus) Nucleus of the brain through the extension lead 34, the electrode lead 33 and the stimulation electrode contact 30 for the purpose of treating parkinson's disease.
The programmable controller 36 is used to adjust various stimulation parameters of the pulse generator 35, including pulse amplitude, pulse width (i.e., pulse width), pulse frequency, etc.
In conjunction with fig. 2, a typical bi-directional pulsed stimulation waveform, i.e., with both positive and negative stimulation voltages, relative to a "zero volt reference line" voltage.
Wherein, what really plays a therapeutic role is the negative stimulation voltage.
Fig. 2 shows a constant-voltage pulse stimulation microscopic waveform, however, in practical applications, the pulse amplitude PA of the negative stimulation voltage is not constant.
In connection with the enlarged view of fig. 2, the negative pulse amplitude PA during a predetermined stimulation period PT assumes a trapezoidal shape over time, i.e. the pulse amplitude PA decreases, i.e. it is not true constant voltage stimulation at this time, which may lead to a poor treatment experience for the patient.
The above phenomenon is caused by the change of the charge on the capacitor in the implantable neurostimulation system, namely:
q ═ I Δ t ═ C Δ V, Δ V ═ I Δ t/C.
Wherein Q is the electric quantity on the capacitor; c is capacitance value of the capacitor; i is a stimulation current or a current value obtained by dividing a stimulation voltage by a resistor; Δ t is the time variation within a predetermined stimulation period PT, i.e., the pulse width PW; Δ V is the voltage change, i.e., the change in the pulse amplitude PA.
Therefore, the wider the pulse width PW, the larger the variation of the pulse amplitude PA, that is, the pulse amplitude PA decreases with the increase of the pulse width PW.
In addition, referring to fig. 3, a typical pulse stimulation macroscopic waveform is shown.
It can be seen that the change of the pulse amplitude PA is relatively abrupt when the stimulation is switched on and off, and the pulse amplitude PA exhibits steep rising and falling states at the time when the stimulation is switched on and off, so that the patient feels relatively uncomfortable, which also brings about poor treatment experience for the patient.
Disclosure of Invention
The invention aims to provide a stimulation pulse amplitude adjusting module and an implantable neurostimulation system with the same.
To achieve one of the above objects, an embodiment of the present invention provides an implantable neurostimulation pulse amplitude adjusting module, which comprises:
an initial amplitude generating unit for generating an initial amplitude of a stimulation pulse, the stimulation pulse including a positive-going stimulation pulse and a negative-going stimulation pulse;
an adjusting unit for generating an amplitude configuration value;
the processing unit is used for superposing the initial amplitude corresponding to the negative stimulation pulse and the amplitude configuration value to generate a final amplitude;
the adjusting unit comprises a microscopic adjusting unit, the microscopic adjusting unit is used for generating a microscopic amplitude configuration value, the processing unit superposes the initial amplitude and the microscopic amplitude configuration value in a preset stimulation period to generate a microscopic final amplitude, the microscopic final amplitude is an increasing amplitude, and the adjusting module is used for realizing constant-voltage stimulation.
As a further improvement of the embodiment of the present invention, the adjusting module further includes a control unit, the control unit is configured to generate a microscopic enable signal, and when the microscopic enable signal is at a high level, the microscopic adjusting unit generates the microscopic amplitude configuration value.
As a further improvement of an embodiment of the present invention, the adjusting unit includes a macro adjusting unit, the macro adjusting unit is configured to generate a macro amplitude configuration value, in a stimulation phase including a plurality of predetermined stimulation periods, the processing unit superimposes the initial amplitude value and the macro amplitude configuration value to generate a plurality of macro final amplitude values corresponding to the plurality of predetermined stimulation periods, and the plurality of macro final amplitude values are in a gradual change trend.
As a further refinement of an embodiment of the invention, the several macroscopic final amplitudes comprise an increasing trend and/or a decreasing trend.
As a further improvement of one embodiment of the present invention, the adjusting module further includes a control unit, and the control unit is configured to generate a macro enable signal, and when the macro enable signal is at a high level, the macro adjusting unit generates the macro amplitude configuration value.
To achieve one of the above objects, an embodiment of the present invention provides an implantable neurostimulation pulse amplitude adjusting module, which comprises:
an initial amplitude generating unit for generating an initial amplitude of the stimulation pulse;
a microscopic adjusting unit for generating microscopic amplitude configuration values;
a macro-tuning unit for generating a macro-amplitude configuration value;
the processing unit is used for superposing the initial amplitude and the microscopic amplitude configuration value in a preset stimulation period to generate a microscopic final amplitude, in a stimulation stage comprising a plurality of preset stimulation periods, the processing unit is used for superposing the microscopic final amplitude and the macroscopic amplitude configuration value to generate a plurality of macroscopic final amplitudes corresponding to the plurality of preset stimulation periods, the microscopic final amplitudes are incremental amplitudes, and the adjusting module is used for realizing constant-voltage stimulation.
As a further refinement of an embodiment of the invention, the several macroscopic final amplitudes comprise an increasing trend and/or a decreasing trend.
As a further improvement of the embodiment of the present invention, the adjusting module further includes a high frequency clock and a frequency dividing unit, the high frequency clock generates a high frequency division clock and a low frequency division clock after passing through the frequency dividing unit, the high frequency division clock is used for controlling the micro adjusting unit, and the low frequency division clock is used for controlling the initial amplitude generating unit and the macro adjusting unit.
In order to achieve one of the above objects, an embodiment of the present invention provides an implantable neurostimulation system, which comprises the implantable neurostimulation pulse amplitude adjusting module, a pulse generator and a stimulation electrode contact according to any one of the above technical solutions, wherein the pulse generator generates a stimulation pulse according to the final amplitude generated by the adjusting module, and the pulse generator outputs the stimulation pulse to the stimulation electrode contact.
Compared with the prior art, the invention has the beneficial effects that: according to the embodiment of the invention, the pulse amplitude is effectively adjusted through the adjusting module, so that the treatment effect is improved, and the treatment experience of a patient is improved.
Drawings
FIG. 1 is a schematic diagram of a prior art implantable neurostimulation system;
FIG. 2 is a microscopic view of a prior art bi-directional pulsed stimulation waveform;
FIG. 3 is a macroscopic view of a prior art bi-directional pulsed stimulation waveform;
FIG. 4 is a schematic diagram of a stimulation pulse amplitude adjustment module according to an embodiment of the invention;
FIG. 5 is a schematic diagram illustrating micro-modulation of the amplitude of a stimulation pulse in accordance with an embodiment of the present invention;
FIG. 6 is a schematic view of a micro-conditioning unit according to an embodiment of the present invention;
FIG. 7 is a schematic diagram illustrating macroscopic adjustment of the amplitude of stimulation pulses in accordance with an embodiment of the present invention;
FIG. 8 is a schematic diagram of several configurations of macroscopic modulation of the amplitude of the stimulation pulses according to an embodiment of the present invention;
fig. 9 is a schematic view of a macro-conditioning unit according to an embodiment of the present invention.
Detailed Description
The present invention will be described in detail below with reference to specific embodiments shown in the drawings. These embodiments are not intended to limit the present invention, and structural, methodological, or functional changes made by those skilled in the art according to these embodiments are included in the scope of the present invention.
One embodiment of the present invention provides an implantable neurostimulation system (see fig. 1).
Referring to fig. 4, the implantable neurostimulation system comprises a stimulation pulse amplitude adjustment module 100, a pulse generator (not shown) and a stimulation electrode contact (not shown).
Wherein the pulse generator generates a stimulation pulse according to the final amplitude (PA1 'and/or PA 2') generated by the adjustment module 100, and the pulse generator outputs the stimulation pulse to the stimulation electrode contacts.
Other descriptions of the implantable neurostimulation system (for example, the implantable neurostimulation system further comprises an electrode lead, an extension lead, a programmer and the like) can be referred to the description of fig. 1, and are not repeated herein.
In this embodiment, the stimulation pulse amplitude adjustment module 100 includes an initial amplitude generation unit 10, an adjustment unit 11, and a processing unit 12.
The initial amplitude generating unit 10 is used to generate an initial amplitude PA of the stimulation pulses.
The adjusting unit 11 is used to generate amplitude configuration values (PA1 and/or PA 2).
The processing unit 12 is configured to superimpose the initial amplitude PA with the amplitude configuration values (PA1 and/or PA2) to generate a final amplitude (PA1 'and/or PA 2').
Here, effective adjustment of the pulse amplitude can be realized through the adjusting module 100, so that the treatment effect is improved, and the treatment experience of the patient is improved.
In the present embodiment, the processing unit 12 may be an and gate unit.
In the present embodiment, the adjustment unit 11 includes a microscopic adjustment unit 11 a.
The microscopic adjusting unit 11a is used for generating microscopic amplitude configuration value PA1, and in conjunction with fig. 5, the processing unit 12 superimposes the initial amplitude PA and the microscopic amplitude configuration value PA1 to generate microscopic final amplitude PA 1' within a predetermined stimulation period PT.
The adjusting module 100 further includes a control unit 13, where the control unit 13 is configured to generate a Micro enable signal Micro _ EN, and when the Micro enable signal Micro _ EN is at a high level, the Micro adjusting unit 11a generates the Micro amplitude configuration value PA 1.
That is, by controlling the Micro enable signal Micro _ EN, it is ensured that the generation time of the Micro amplitude profile PA1 corresponds to the generation time of the initial amplitude PA within a predetermined stimulation period PT, and thus, the accuracy of superimposing the initial amplitude PA and the Micro amplitude profile PA1 can be achieved.
It should be noted that the initial amplitude PA, the microscopic amplitude profile PA1, and the microscopic final amplitude PA1 'are all preset amplitudes, such as a series of amplitude control numbers written in the pulse generator, and the initial amplitude PA, the microscopic amplitude profile PA1, and the microscopic final amplitude PA 1' are all pulse amplitudes of the negative stimulus.
Referring to waveform 1 in fig. 5, for example, the constant voltage stimulation is used, and the initial amplitude PA of the pulse amplitude is a constant amplitude.
Referring to waveform 2, the microscopic final amplitude PA1 'is obtained by superimposing the microscopic amplitude configuration value PA1, and the microscopic final amplitude PA 1' is an incremental amplitude.
Referring to waveform 3, when the pulse generator outputs the microscopic final amplitude PA 1', the actual output is the microscopic actual amplitude PA1 "as shown in waveform 3, and the microscopic actual amplitude PA 1" is a constant voltage amplitude, due to the effect of the change in the charge on the capacitance within the implantable neurostimulation system.
It can be understood that, referring to the description of the background art, the pulse amplitude actually output by the pulse generator will generate a gradual decrease effect due to the effect of the capacitance electric quantity change, the final actual output of the pulse generator of the present embodiment is the pulse amplitude corresponding to the microscopic final amplitude PA1 ', and the decrease effect of the amplitude due to the change of the capacitance electric quantity can be cancelled out by the increase trend of the microscopic final amplitude PA 1', so that the microscopic actual amplitude PA ″ actually output by the pulse generator is the constant voltage amplitude, thereby achieving the true constant voltage stimulation within the predetermined stimulation period PT, increasing the therapeutic effect, and reducing the side effect.
Of course, the microscopic actual amplitude PA "is not limited to a constant voltage amplitude, and for example, the microscopic amplitude configuration PA1 may be adjusted according to the actual condition of the patient, so as to realize any pulse amplitude, thereby further improving the flexibility of the treatment.
In this embodiment, referring to fig. 6, the micro adjustment unit 11a is a micro register, the micro register includes a plurality of micro register bits 111a (Microscopic Reg 1 to Microscopic Reg n), each micro register bit 111a may store a micro amplitude configuration value PA1, the micro amplitude configuration value PA1 is substantially a series of gradually changing amplitudes, and a duration occupied by the micro amplitude configuration value PA1 stored in the plurality of micro register bits 111a corresponds to a duration limited by one pulse width PW.
It is understood that when the processing unit 12 superimposes the initial amplitude PA and the microscopic amplitude configuration PA1 to generate the microscopic final amplitude PA1 ', the microscopic final amplitude PA1 ' is stepped, and when the number of the microscopic register bits 111a is large enough, the microscopic final amplitude PA1 ' is linearly changed.
In the present embodiment, the adjusting unit 11 further includes a macro adjusting unit 11 b.
Referring to fig. 4, the adjusting module 100 further includes a HIGH frequency CLOCK HIGH CLOCK and a frequency dividing unit 14.
The HIGH frequency CLOCK HIGH CLOCK generates a HIGH frequency CLOCK1 and a LOW frequency CLOCK LOW CLOCK1 after passing through the frequency dividing unit 14, the HIGH frequency CLOCK1 is used for controlling the micro adjusting unit 11a, and the LOW frequency CLOCK LOW CLOCK1 is used for controlling the initial amplitude generating unit 10 and the macro adjusting unit 11 b.
The frequency of the HIGH CLOCK1 is an integer multiple of the LOW CLOCK LOW 1, but not limited thereto.
Here, the HIGH frequency CLOCK HIGH CLOCK and the frequency dividing unit 14 are adopted, which has the following advantages: (1) the complexity and the cost of the system are reduced, one clock input is adopted, only one input pin and one clock crystal oscillator are needed, and the structure is simple; (2) ensuring that the HIGH frequency CLOCK HIGH 1 and the LOW frequency CLOCK LOW 1 are the same source CLOCK is very advantageous for accurate timing control.
In this embodiment, the macro adjustment unit 11b is configured to generate the macro amplitude configuration PA2, and with reference to fig. 7, in a stimulation phase including a plurality of predetermined stimulation periods PT, the processing unit 12 superimposes the initial amplitude PA and the macro amplitude configuration PA2 to generate a plurality of macro final amplitudes PA2 'corresponding to the plurality of predetermined stimulation periods PT, and the plurality of macro final amplitudes PA 2' are gradually changed.
The control unit 13 is further configured to generate a Macro enable signal Macro _ EN, and when the Macro enable signal Macro _ EN is at a high level, the Macro adjusting unit 11b generates the Macro amplitude configuration value PA 2.
That is, by controlling the Macro enable signal Macro _ EN, it is ensured that the generation time of the Macro amplitude profile PA2 corresponds to the generation time of the initial amplitudes PA of the predetermined stimulation periods PT in the stimulation phase, so that the accuracy of the superposition of the initial amplitudes PA and the Macro amplitude profiles PA2 can be achieved.
It should be noted that the initial amplitude PA, the macroscopic amplitude configuration PA2, and the macroscopic final amplitude PA2 'are all preset amplitudes, such as a series of numbers about amplitude control written in the pulse generator, and the initial amplitude PA, the macroscopic amplitude configuration PA2, and the macroscopic final amplitude PA 2' are all pulse amplitudes of the negative stimulus.
Referring to waveform 4 in fig. 7, the initial amplitude PA of the pulse amplitude is a constant amplitude, taking constant voltage stimulation as an example.
Referring to the waveform 5, the macroscopic amplitude configuration value PA2 is superimposed to obtain the macroscopic final amplitude PA2 ', and the macroscopic final amplitudes PA 2' within the predetermined stimulation periods PT are gradually changed, here, an increasing trend in a period of time and a decreasing trend in another period of time are taken as an example.
Referring to the waveform 6, when the micro-adjustment unit 11a does not perform amplitude adjustment, referring to the enlarged view, each of several macro actual amplitude values PA2 "actually output at this time is in a decreasing trend.
Referring to the waveform 7, when the micro-adjustment unit 11a performs amplitude adjustment, referring to the enlarged view, each of several macro actual amplitudes PA2 "actually output at this time is a constant voltage amplitude.
It can be understood that the pulse amplitude actually output by the pulse generator has a gradual change trend in macroscopical scale, and the gradual change trend includes an increasing trend and/or a decreasing trend through proper setting of the macroscopic amplitude configuration value PA 2.
In connection with fig. 8, the situation of the pulse amplitude actually output by the pulse generator on a macroscopic level is enumerated.
With reference to the waveform 8, at the starting and closing time of stimulation, the pulse amplitude respectively presents an increasing trend and a decreasing trend, while at the middle time of stimulation, the pulse amplitude is constant, thus realizing the slow increase of the pulse amplitude at the starting time of stimulation and the slow decrease at the closing time of stimulation, effectively improving the treatment experience of patients and improving the treatment quality.
Reference is made to waveform 9, which differs from waveform 8 in that the pulse amplitude exhibits an increasing trend only at the start of stimulation, and is constant at other times.
Reference is made to waveform 10, which differs from waveform 8 in that the pulse amplitude exhibits a decreasing trend only at the moment when stimulation is off, and is constant at other times.
Of course, the macroscopic situation of the pulse amplitude can also be in other forms, and can be determined according to the actual situation.
In this embodiment, referring to fig. 9, the macro adjusting unit 11b is a macro register, and the macro register includes a plurality of micro register bits 111b (macro Reg 1-macro Reg n), each of the macro register bits 111b may store a macro amplitude configuration value PA2, the macro amplitude configuration value PA2 is substantially a series of amplitudes distributed at intervals and gradually changed, a duration occupied by the macro amplitude configuration value PA2 stored in each of the macro register bits 111b corresponds to a duration defined by one pulse width PW, and a total duration occupied by the macro amplitude configuration value PA2 stored in the plurality of macro register bits 111b corresponds to a total duration defined by a plurality of interval pulse widths PW.
In the present embodiment, the micro-adjustment unit 11a and the macro-adjustment unit 11b may be adjusted individually or jointly, and may be specifically adjusted according to actual conditions.
When the micro-adjustment unit 11a and the macro-adjustment unit 11b perform adjustment together, in a predetermined stimulation period PT, the processing unit 12 superimposes the initial amplitude PA and the micro-amplitude configuration PA1 to generate a micro-final amplitude PA1 ', and in a stimulation phase including a plurality of predetermined stimulation periods PT, the processing unit 12 superimposes the micro-final amplitude PA1 ' and the macro-amplitude configuration PA2 to generate a plurality of macro-final amplitudes PA2 ' corresponding to the predetermined stimulation periods PT, at this time, the actually output pulse amplitudes are in a macro-gradual change trend and a micro-constant voltage trend.
It is understood that the adjustment processes of the micro-adjustment unit 11a and the macro-adjustment unit 11b have no definite precedence relationship.
It should be understood that although the present description refers to embodiments, not every embodiment contains only a single technical solution, and such description is for clarity only, and those skilled in the art should make the description as a whole, and the technical solutions in the embodiments can also be combined appropriately to form other embodiments understood by those skilled in the art.
The above-listed detailed description is only a specific description of a possible embodiment of the present invention, and they are not intended to limit the scope of the present invention, and equivalent embodiments or modifications made without departing from the technical spirit of the present invention should be included in the scope of the present invention.
Claims (9)
1. An implantable neurostimulation pulse amplitude adjustment module, comprising:
an initial amplitude generating unit for generating an initial amplitude of a stimulation pulse, the stimulation pulse including a positive-going stimulation pulse and a negative-going stimulation pulse;
an adjusting unit for generating an amplitude configuration value;
the processing unit is used for superposing the initial amplitude corresponding to the negative stimulation pulse and the amplitude configuration value to generate a final amplitude;
the adjusting unit comprises a microscopic adjusting unit, the microscopic adjusting unit is used for generating a microscopic amplitude configuration value, the processing unit superposes the initial amplitude and the microscopic amplitude configuration value in a preset stimulation period to generate a microscopic final amplitude, the microscopic final amplitude is an increasing amplitude, and the adjusting module is used for realizing constant-voltage stimulation.
2. The implantable neurostimulation pulse amplitude adjustment module according to claim 1, further comprising a control unit, wherein the control unit is used for generating a microscopic enable signal, and when the microscopic enable signal is at a high level, the microscopic adjustment unit generates the microscopic amplitude configuration value.
3. The implantable neurostimulation pulse amplitude adjustment module according to claim 1, wherein the adjustment unit comprises a macroscopic adjustment unit, the macroscopic adjustment unit is configured for generating a macroscopic amplitude configuration value, and the processing unit is configured for superimposing the initial amplitude value and the macroscopic amplitude configuration value to generate a plurality of macroscopic final amplitude values corresponding to a plurality of predetermined stimulation periods within a stimulation period comprising the plurality of predetermined stimulation periods, wherein the plurality of macroscopic final amplitude values have a gradual trend.
4. The implantable neurostimulation pulse amplitude adjustment module of claim 3, wherein the number of macroscopic final amplitudes comprises an increasing trend and/or a decreasing trend.
5. The implantable neural stimulation pulse amplitude adjustment module of claim 3, wherein the adjustment module further comprises a control unit configured to generate a macro enable signal, and wherein the macro adjustment unit generates the macro amplitude configuration value when the macro enable signal is at a high level.
6. An implantable neurostimulation pulse amplitude adjustment module, comprising:
an initial amplitude generating unit for generating an initial amplitude of the stimulation pulse;
a microscopic adjusting unit for generating microscopic amplitude configuration values;
a macro-tuning unit for generating a macro-amplitude configuration value;
the processing unit is used for superposing the initial amplitude and the microscopic amplitude configuration value in a preset stimulation period to generate a microscopic final amplitude, in a stimulation stage comprising a plurality of preset stimulation periods, the processing unit is used for superposing the microscopic final amplitude and the macroscopic amplitude configuration value to generate a plurality of macroscopic final amplitudes corresponding to the plurality of preset stimulation periods, the microscopic final amplitudes are incremental amplitudes, and the adjusting module is used for realizing constant-voltage stimulation.
7. The implantable neurostimulation pulse amplitude adjustment module of claim 6, wherein the number of macroscopic final amplitudes comprises an increasing trend and/or a decreasing trend.
8. The implantable neurostimulation pulse amplitude adjustment module according to claim 6, wherein the adjustment module further comprises a high-frequency clock and a frequency dividing unit, the high-frequency clock generates a high-frequency clock and a low-frequency clock after passing through the frequency dividing unit, the high-frequency clock is used for controlling the micro-adjustment unit, and the low-frequency clock is used for controlling the initial amplitude generation unit and the macro-adjustment unit.
9. An implantable neurostimulation system comprising the implantable neurostimulation pulse amplitude modulation module of any of claims 1-8, a pulse generator and a stimulation electrode contact, wherein the pulse generator generates stimulation pulses according to the final amplitude generated by the modulation module, and the pulse generator outputs the stimulation pulses to the stimulation electrode contact.
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| US5018522A (en) * | 1987-10-26 | 1991-05-28 | Medtronic, Inc. | Ramped waveform non-invasive pacemaker |
| US7359751B1 (en) * | 2004-05-05 | 2008-04-15 | Advanced Neuromodulation Systems, Inc. | Clinician programmer for use with trial stimulator |
| US8457734B2 (en) * | 2006-08-29 | 2013-06-04 | Cardiac Pacemakers, Inc. | System and method for neural stimulation |
| US9259571B2 (en) * | 2009-10-21 | 2016-02-16 | Medtronic, Inc. | Electrical stimulation therapy using decaying current pulses |
| CN104485926B (en) * | 2014-12-12 | 2017-09-19 | 杭州爱司米医疗器械有限公司 | A kind of overshot waveform generating system treated for micro-current and its application method |
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