CN109481844A - Implantable nerve stimulation apparatus with multiple-frequency-mode - Google Patents
Implantable nerve stimulation apparatus with multiple-frequency-mode Download PDFInfo
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- CN109481844A CN109481844A CN201811613512.XA CN201811613512A CN109481844A CN 109481844 A CN109481844 A CN 109481844A CN 201811613512 A CN201811613512 A CN 201811613512A CN 109481844 A CN109481844 A CN 109481844A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36125—Details of circuitry or electric components
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/36167—Timing, e.g. stimulation onset
- A61N1/36171—Frequency
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- Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Electrotherapy Devices (AREA)
Abstract
The present invention provides a kind of implantable nerve stimulation apparatus with multiple-frequency-mode, including control circuit, for determining frequency mode, the frequency mode includes independent frequency mode and same frequency pattern, and multiple and different pulse frequencies is provided under the independent frequency mode, provides unique pulse frequency under the same frequency pattern；Signal output apparatus, for exporting multiple groups pulse signal according to the plurality of different pulse frequency under the independent frequency mode, wherein the pulse frequency of the pulse signal of different groups is not identical, multiple groups pulse signal is exported according to unique pulse frequency under the same frequency pattern, wherein the pulse frequency of each group pulse signal is identical.
Description
Technical field
The present invention relates to implantable medical device fields, and in particular to a kind of implantable nerve thorn with multiple-frequency-mode
Swash equipment.
Background technique
Embedded nerve stimulator generally has multiple stimulation contacts, can export the boost pulse of multiple groups parameter combination,
Every group of boost pulse can set different stimulation contact combinations, and multiple positions are generated with different stimulus signals to realize,
Multiple and different positions are namely stimulated simultaneously.
Different therapies has the stimulation location demand of different numbers in clinical application, and stimulation location quantity may be 2,4
It is a, 6 it is even more.By taking lesions located in deep brain device as an example, two stimulation locations of left and right brain, or referred to as two are generally at least needed
A stimulation channels.In most cases, the frequency of different stimulated position (such as left and right brain of brain deep electricity thorn) needs consistent,
The output frequency of i.e. different groups boost pulses is identical.
With going deep into for clinical research, there are indications that different stimulated position uses different frequency of stimulation in some cases
Different effects may be generated.And a sequential control circuit is only set in existing implantable medical device, Sequential output
The boost pulse of different parameters cannot achieve while export the different boost pulse of multiple groups frequency.
Summary of the invention
In view of this, the present invention provides a kind of implantable nerve stimulation apparatus with multiple-frequency-mode, comprising:
Control circuit, for determining frequency mode, the frequency mode includes independent frequency mode and same frequency pattern,
Multiple and different pulse frequencies is provided under the independent frequency mode, unique pulse is provided under the same frequency pattern
Frequency；
Signal output apparatus is more for being exported under the independent frequency mode according to the plurality of different pulse frequency
Group pulse signal, wherein the pulse frequency of the pulse signal of different groups is not identical, under the same frequency pattern according to
Unique pulse frequency exports multiple groups pulse signal, and wherein the pulse frequency of each group pulse signal is identical.
Optionally, the control circuit includes:
Multiple frequency registers are respectively used to store different pulse frequencies；
Multiple time series stereodata circuits are respectively used to provide pulse frequency according to the different frequency registers.
Optionally, signal output apparatus includes:
Multiple stimulus signal output modules, the pulse frequency provided respectively according to the different time series stereodata circuits
Multiple groups stimulus signal is exported by corresponding electrode.
Optionally, the control circuit selectes a time series stereodata circuit under the same frequency pattern, and
Select a frequency register；Selected time series stereodata circuit provides unique pulse frequency according to selected frequency register
Rate.
Optionally, signal output apparatus includes:
Multiple stimulus signal output modules, the unique pulse frequency provided according to selected time series stereodata circuit are logical
Cross corresponding electrode output multiple groups stimulus signal.
Optionally, the control circuit also provides for pulse parameter, and multiple groups arteries and veins is provided under the independent frequency mode
Rush parameter；
Each pulse signal in each group pulse signal is arranged according to the multiple groups pulse parameter for the signal output apparatus.
Optionally, the control circuit includes:
Multiple pulse parameter registers are respectively used to store the pulse parameter of the multiple groups pulse signal；
Multiple time series stereodata circuits are respectively used to that each group pulse signal is arranged according to different pulse parameter registers
In each pulse signal.
Optionally, the control circuit provides multiple groups pulse parameter under the same frequency pattern；
Each pulse signal in each group pulse signal is arranged according to the multiple groups pulse parameter for the signal output apparatus.
Optionally, the control circuit includes:
Multiple pulse parameter registers are respectively used to store the pulse parameter of the multiple groups pulse signal；
Multiple time series stereodata circuits select a time series stereodata circuit, choosing under the same frequency pattern
Fixed time series stereodata circuit is used for according to each pulse in different pulse parameter register setting each group pulse signals
Signal.
Optionally, under the independent frequency mode, the output time of the pulse signal of difference group is not identical.
The implantable nerve stimulation apparatus provided according to embodiments of the present invention, control circuit can determine frequency mode,
Multiple and different pulse frequencies is provided under independent frequency mode, unique pulse frequency is provided under same frequency pattern, so that
Signal output apparatus can export the different pulse signal of multiple groups frequency or export the consistent pulse signal of multiple groups frequency.
Thus it is compatible with independent frequency mode and same frequency pattern, meets different clinical demands.
Detailed description of the invention
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art
Embodiment or attached drawing needed to be used in the description of the prior art be briefly described, it should be apparent that, it is described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, is also possible to obtain other drawings based on these drawings.
Fig. 1 is implantable nerve stimulation apparatus structural schematic diagram provided in an embodiment of the present invention；
Fig. 2 is the structural schematic diagram of the multiconductor stimulation circuit in the embodiment of the present invention under independent frequency mode；
Fig. 3 is the schematic diagram of two group pulse signals in the embodiment of the present invention；
Fig. 4 is the structural schematic diagram of the multiconductor stimulation circuit in the embodiment of the present invention under same frequency pattern.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation
Example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill
Personnel's every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that term " first ", is used for description purposes only " second ", and cannot
It is interpreted as indication or suggestion relative importance.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " connected " " connects
Connect " it shall be understood in a broad sense, for example, it may be being fixedly connected, it may be a detachable connection, or be integrally connected；It can be machine
Tool connection, is also possible to be electrically connected；It can be directly connected, can also can also be two indirectly connected through an intermediary
Connection inside element can be wireless connection, be also possible to wired connection.For the ordinary skill in the art,
The concrete meaning of above-mentioned term in the present invention can be understood with concrete condition.
As long as in addition, the non-structure each other of technical characteristic involved in invention described below different embodiments
It can be combined with each other at conflict.
The embodiment of the present invention provides a kind of implantable nerve stimulation apparatus with multiple-frequency-mode, specifically can be brain depth
Portion's egersimeter or spinal stimulator etc..As shown in Figure 1, the equipment includes telecommunication circuit 11, electric power management circuit 12, micro-control
The components such as device 13 and multiconductor stimulation circuit 14 processed, wherein telecommunication circuit 11 can be wirelessly connected with external device, receive setting
Instruction；Microcontroller 13 is used to be configured multiconductor stimulation circuit 14 according to setting instruction.
Wherein multiconductor stimulation circuit 14 includes control circuit 141 and signal output apparatus 142, signal output apparatus 142
N electrode is connected, stimulus signal (voltage/current) is issued by electrode and realizes therapy.In the present embodiment, user can be used
External device sends frequency mode instruction, and implantable nerve stimulation apparatus is made to work under independent frequency mode or in same frequency
It works under rate mode.
Control circuit 141, when being determined as independent frequency mode, provides multiple and different pulses for determining frequency mode
Frequency.Pulse frequency under independent frequency mode at least there are two, when practical application, can be set according to the grouping of electrode.?
N electrode is divided into 2 groups in the present embodiment, and under independent frequency mode, control circuit 141 can provide two different pulse frequencies
Rate f1 and f2.In other embodiments, the grouping of electrode can be at least 2, one with more than two, alternative pulse frequency quantity N
Kind is Preferable scheme is that N is equal to the number of packet of electrode；When being determined as same frequency pattern, control circuit 141 provide one
A pulse frequency f1 or f2.
Signal output apparatus 142 is for exporting multiple groups pulse according to multiple and different pulse frequencies under independent frequency mode
Signal, wherein the pulse frequency of the pulse signal of different groups is not identical.In the present embodiment, signal exports under independent frequency mode
Circuit 142 will pass through electrode 1 ... electrode n/2 (first group of electrode) and export the first group pulse signal, frequency f1；Pass through electrode
N/2+1 ... electrode n (second group of electrode) exports the second group pulse signal, frequency f2.First group pulse signal and second group
The frequency of pulse signal is independent, and can be consistent with the pulse signal frequency in group.
Signal output apparatus 142 will also pass through electrode 1 ... electrode n/2 (first group of electrode) output under same frequency pattern
First group pulse signal exports the second group pulse signal by electrode n/2+1 ... electrode n (second group of electrode).Under this mode
The frequency of this two group pulses signal is identical, such as frequency is f1 or f2.
The implantable nerve stimulation apparatus provided according to embodiments of the present invention, control circuit can determine frequency mode,
Multiple and different pulse frequencies is provided under independent frequency mode, unique pulse frequency is provided under same frequency pattern, so that
Signal output apparatus can export the different pulse signal of multiple groups frequency or export the consistent pulse signal of multiple groups frequency.
Thus it is compatible with independent frequency mode and same frequency pattern, meets different clinical demands.
In a specific embodiment, control circuit 141 includes the 1410, first frequency of frequency mode register as indicated with 2
Rate register 1411, second frequency register 1412, the first time series stereodata circuit 1413 and the second time series stereodata electricity
Road 1414.
Wherein frequency mode register 1410 is used to set the rate-adaptive pacemaker mode of different pulse groups；
First frequency register 1411 is used for storage pulse for storage pulse frequency values f1, second frequency register 1412
Frequency values f2.
When being set as independent frequency mode by frequency mode register 1410, first frequency register 1411 is corresponded to
First time series stereodata circuit 1413, second frequency register 1412 correspond to the second time series stereodata circuit 1414.
Signal output apparatus 142 includes the first stimulus signal output module 1421 and the second stimulus signal output module
1422.First stimulus signal output module, 1421 connection electrode 1 ... electrode 2/n (first group of electrode), the second stimulus signal are defeated
1422 connection electrode 2/n+1 ... electrode n (second group of electrode) of module out.
Under independent frequency mode, the first stimulus signal output module 1421 corresponds to the first time series stereodata circuit
1413, the second stimulus signal output module 1422 corresponds to the second time series stereodata circuit 1414.
As shown in figure 3, the first time series stereodata circuit 1413 makes the first stimulus signal output module 1421 export first
Group pulse AP1-AP2-AP3-AP1-AP2-AP3 ..., can be and export at equal intervals, and frequency is f1 (adjacent pulse AP1, adjacent
AP2, adjacent AP3 between time interval T1 inverse)；Second time series stereodata circuit 1414 makes the second stimulus signal
Output module 1422 exports the second group pulse BP1-BP2-BP1-BP2 ..., can be and exports at equal intervals, and frequency is that f2 is (adjacent
The inverse of time interval T2 between pulse BP1, adjacent BP2).
In the present embodiment, the first stimulus signal output module 1421 and the second stimulus signal output module 1422 export
Pulse frequency is mutually indepedent, but output pulse signal when difference.
In a preferred embodiment, control circuit 141 also provides for pulse parameter.Control circuit 141 is in independence
Multiple groups pulse parameter, such as 2,4,6,8 group pulse parameters are provided under frequency mode.Signal output apparatus 142 is according to multiple groups pulse
Each pulse signal in parameter setting each group pulse signal.
In a specific embodiment, control circuit 141 further includes multiple pulse parameter registers, is respectively used to store
The pulse parameter of multiple groups pulse signal, pulse parameter may include pulse polarity, amplitude and width etc..As indicated with 2, in the present embodiment
There are pulse 1-3 parameter register 1431 (for storing the parameter of the first group pulse) and pulse 4-6 parameter register 1432 (to be used for
Store the parameter of the second group pulse).
First time series stereodata circuit 1413 is according to first group of arteries and veins of parameter setting in pulse 1-3 parameter register 1431
Punching；Second time series stereodata circuit 1414 sets the second group pulse according to pulse 4-6 parameter register 1432.It is achieved in
A set of pulses and the second group pulse frequency are mutually indepedent, and can export the boost pulse of multiple groups parameter combination respectively.
Implantable nerve stimulation apparatus provided by the invention can also be with the identical multiple groups pulse signal of output frequency.It ties below
It closes Fig. 4 and introduces the working method under same frequency pattern.
Under same frequency pattern, a time series stereodata circuit is selected, and select a frequency register.It is selected
Time series stereodata circuit provide unique pulse frequency according to selected frequency register.Multiple stimulus signal output modules
Multiple groups stimulation letter is exported by corresponding electrode all in accordance with unique pulse frequency that selected time series stereodata circuit provides
Number.
Specifically, first frequency register 1411, the first stimulus signal output module 1421 and the output of the second stimulus signal
Module 1422 corresponds to the first time series stereodata circuit 1413, and the second time series stereodata circuit 1414 and second frequency are posted
The closing of storage 1412 does not have to.Two group pulses output is controlled by the first time series stereodata circuit 1413, can be exported at equal intervals
Pulse signal.The frequency of two group pulses is unanimously f1, to realize the identical frequency stimulation at two positions.
Under same frequency pattern, control circuit 141 also can provide multiple groups pulse parameter, such as 2,4,6,8 group pulses ginseng
Number.Each pulse signal in each group pulse signal is arranged according to multiple groups pulse parameter for signal output apparatus 142.
In a specific embodiment, control circuit includes multiple pulse parameter registers, is respectively used to storage multiple groups
The pulse parameter of pulse signal.Under same frequency pattern, all pulse parameter registers all correspond to selected timing and patrol
Control circuit is collected, is the first time series stereodata circuit 1413 in the present embodiment.First 1413, time series stereodata circuit
According to each pulse signal in different pulse parameter register setting each group pulse signals.
The implantable nerve stimulation apparatus provided according to embodiments of the present invention, control circuit can be under same frequency patterns
A selected time series stereodata circuit provides unique pulse frequency, so that signal output apparatus is according to unique pulse frequency
The identical pulse signal of multiple groups frequency, compatible independent frequency mode and same frequency pattern are exported, different clinical demands is met.
It should be understood by those skilled in the art that, the embodiment of the present invention can provide as method, system or computer program
Product.Therefore, complete hardware embodiment, complete software embodiment or reality combining software and hardware aspects can be used in the present invention
Apply the form of example.Moreover, it wherein includes the computer of computer usable program code that the present invention, which can be used in one or more,
The computer program implemented in usable storage medium (including but not limited to magnetic disk storage, CD-ROM, optical memory etc.) produces
The form of product.
The present invention be referring to according to the method for the embodiment of the present invention, the process of equipment (system) and computer program product
Figure and/or block diagram describe.It should be understood that every one stream in flowchart and/or the block diagram can be realized by computer program instructions
The combination of process and/or box in journey and/or box and flowchart and/or the block diagram.It can provide these computer programs
Instruct the microcontroller of general purpose computer, special purpose computer, Embedded Processor or other programmable data processing devices with
A machine is generated, so that generating use by the instruction that computer or the microcontroller of other programmable data processing devices execute
In the dress for realizing the function of specifying in one or more flows of the flowchart and/or one or more blocks of the block diagram
It sets.
These computer program instructions, which may also be stored in, is able to guide computer or other programmable data processing devices with spy
Determine in the computer-readable memory that mode works, so that it includes referring to that instruction stored in the computer readable memory, which generates,
Enable the manufacture of device, the command device realize in one box of one or more flows of the flowchart and/or block diagram or
The function of being specified in multiple boxes.
These computer program instructions also can be loaded onto a computer or other programmable data processing device, so that counting
Series of operation steps are executed on calculation machine or other programmable devices to generate computer implemented processing, thus in computer or
The instruction executed on other programmable devices is provided for realizing in one or more flows of the flowchart and/or block diagram one
The step of function of being specified in a box or multiple boxes.
Obviously, the above embodiments are merely examples for clarifying the description, and does not limit the embodiments.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or
It changes.There is no necessity and possibility to exhaust all the enbodiments.And it is extended from this it is obvious variation or
It changes still within the protection scope of the invention.
Claims (10)
1. a kind of implantable nerve stimulation apparatus with multiple-frequency-mode characterized by comprising
Control circuit, for determining frequency mode, the frequency mode includes independent frequency mode and same frequency pattern, in institute
It states and multiple and different pulse frequencies is provided under independent frequency mode, unique pulse frequency is provided under the same frequency pattern
Rate；
Signal output apparatus, for exporting multiple groups arteries and veins according to the plurality of different pulse frequency under the independent frequency mode
Signal is rushed, wherein the pulse frequency of the pulse signal of different groups is not identical, according to described unique under the same frequency pattern
Pulse frequency export multiple groups pulse signal, wherein the pulse frequency of each group pulse signal is identical.
2. implantable nerve stimulation apparatus according to claim 1, which is characterized in that the control circuit includes:
Multiple frequency registers are respectively used to store different pulse frequencies；
Multiple time series stereodata circuits are respectively used to provide pulse frequency according to the different frequency registers.
3. implantable nerve stimulation apparatus according to claim 2, which is characterized in that signal output apparatus includes:
Multiple stimulus signal output modules pass through according to the pulse frequency that the different time series stereodata circuits provides respectively
Corresponding electrode exports multiple groups stimulus signal.
4. implantable nerve stimulation apparatus according to claim 2, which is characterized in that the control circuit is described identical
A time series stereodata circuit is selected under frequency mode, and selectes a frequency register；Selected time series stereodata
Circuit provides unique pulse frequency according to selected frequency register.
5. implantable nerve stimulation apparatus according to claim 4, which is characterized in that signal output apparatus includes:
Multiple stimulus signal output modules pass through phase according to unique pulse frequency that selected time series stereodata circuit provides
The electrode output multiple groups stimulus signal answered.
6. implantable nerve stimulation apparatus according to claim 1, which is characterized in that the control circuit also provides for
Pulse parameter provides multiple groups pulse parameter under the independent frequency mode；
Each pulse signal in each group pulse signal is arranged according to the multiple groups pulse parameter for the signal output apparatus.
7. implantable nerve stimulation apparatus according to claim 6, which is characterized in that the control circuit includes:
Multiple pulse parameter registers are respectively used to store the pulse parameter of the multiple groups pulse signal；
Multiple time series stereodata circuits are respectively used to according in different pulse parameter register setting each group pulse signals
Each pulse signal.
8. implantable nerve stimulation apparatus according to claim 6, which is characterized in that the control circuit is described identical
Multiple groups pulse parameter is provided under frequency mode；
Each pulse signal in each group pulse signal is arranged according to the multiple groups pulse parameter for the signal output apparatus.
9. implantable nerve stimulation apparatus according to claim 8, which is characterized in that the control circuit includes:
Multiple pulse parameter registers are respectively used to store the pulse parameter of the multiple groups pulse signal；
Multiple time series stereodata circuits select a time series stereodata circuit under the same frequency pattern, selected
Time series stereodata circuit is used for according to each pulse signal in different pulse parameter register setting each group pulse signals.
10. implantable nerve stimulation apparatus according to claim 1 to 9, which is characterized in that in the independence
Under frequency mode, the output time of the pulse signal of difference group is not identical.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811613512.XA CN109481844B (en) | 2018-12-27 | 2018-12-27 | Implantable neural stimulation device with multiple frequency modes |
| PCT/CN2019/100391 WO2020134112A1 (en) | 2018-12-27 | 2019-08-13 | Implantable nerve stimulation device having multiple frequency modes |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811613512.XA CN109481844B (en) | 2018-12-27 | 2018-12-27 | Implantable neural stimulation device with multiple frequency modes |
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| CN110141784A (en) * | 2019-05-28 | 2019-08-20 | 清华大学 | Implantable medical device and its impulse stimulation method |
| CN110772715A (en) * | 2019-09-16 | 2020-02-11 | 清华大学 | Implantable neural stimulation device and pulse frequency setting method thereof |
| CN110975141A (en) * | 2019-09-16 | 2020-04-10 | 清华大学 | Implantable neurostimulation device |
| WO2020134112A1 (en) * | 2018-12-27 | 2020-07-02 | 清华大学 | Implantable nerve stimulation device having multiple frequency modes |
| CN111420276A (en) * | 2020-03-23 | 2020-07-17 | 清华大学 | Implanted nerve stimulation equipment and system with frequency conversion function |
| CN113426008A (en) * | 2021-05-07 | 2021-09-24 | 未来穿戴技术有限公司 | Massage control method, massage device, and computer-readable storage medium |
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| WO2020134112A1 (en) | 2020-07-02 |
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