CN110141784A - Implantable medical device and its impulse stimulation method - Google Patents
Implantable medical device and its impulse stimulation method Download PDFInfo
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- CN110141784A CN110141784A CN201910451377.1A CN201910451377A CN110141784A CN 110141784 A CN110141784 A CN 110141784A CN 201910451377 A CN201910451377 A CN 201910451377A CN 110141784 A CN110141784 A CN 110141784A
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- 238000000034 method Methods 0.000 title claims abstract description 25
- 230000000638 stimulation Effects 0.000 title claims abstract description 20
- 230000000630 rising effect Effects 0.000 claims description 16
- 238000004891 communication Methods 0.000 claims description 3
- 210000001367 artery Anatomy 0.000 claims description 2
- 210000003462 vein Anatomy 0.000 claims description 2
- 238000010586 diagram Methods 0.000 description 11
- 238000001727 in vivo Methods 0.000 description 8
- 238000004590 computer program Methods 0.000 description 7
- 230000006870 function Effects 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 210000004556 brain Anatomy 0.000 description 3
- 210000000278 spinal cord Anatomy 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007383 nerve stimulation Effects 0.000 description 1
- 230000004007 neuromodulation Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000001515 vagal effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36053—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36062—Spinal stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36125—Details of circuitry or electric components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
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- Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Electrotherapy Devices (AREA)
Abstract
The present invention provides a kind of implantable medical device and its impulse stimulation method, and the implantable medical device has at least two channels for being used for output pulse signal, the method includes obtain be used to indicate different group pulse signals between phase difference offset information；Determined at least two time-count cycles according to the offset information, all the sum of described time-count cycle is the pulse period；The different channels is controlled respectively according to the pulse period output pulse signal, wherein the length of at least two time-count cycle is used to determine the phase difference of different interchannel pulse signals.
Description
Technical field
The present invention relates to field of medical device, and in particular to a kind of implantable medical device and its impulse stimulation method.
Background technique
With the continuous variation of clinical application demand, the function of the impulse generator in implantable medical device is constantly increasing
By force.Impulse generator usually has multiple signal output channels, can stimulate multiple positions.But different channels
Frequency of stimulation be it is fixed, impulse phase is fixed.
It is defeated to control two fixed time-count cycle when implantation equipment uses timer by taking two stimulation locations as an example
Channel generates pulse out, such as stimulating starting point of the first passage of first position n-th of time-count cycle to generate rising edge,
For stimulating starting point of the second channel of second position in (n+1)th time-count cycle to generate rising edge, therefore frequency of stimulation f=1/
(2* time-count cycle), the pulse phase difference in two channels is fixed as 180 °.
With going deep into for clinical research, there are indications that different stimulated position can using different phase differences in some cases
It can generate different effects.And frequency of stimulation can only be adjusted in existing implantable medical device, it cannot achieve to phase difference
It is configured.
Summary of the invention
In view of this, the embodiment of the present invention provides a kind of impulse stimulation method of implantable medical device, the implanted
Medical Devices have at least two channels for being used for output pulse signal, which comprises
Obtain the offset information of phase difference between being used to indicate different group pulse signals；
Determined at least two time-count cycles according to the offset information, all the sum of described time-count cycle is the pulse period；
The different channels is controlled respectively according to the pulse period output pulse signal, wherein at least two meter
When the period length be used to determine the phase differences of different interchannel pulse signals.
Optionally, the range of the phase difference be [0 °, 360 °).
Optionally, the time-count cycle is two, the phase difference between the offset information indicates different group pulse signals
When for 180 degree, two time-count cycles are equal；When the offset information indicates that the phase difference between different group pulse signals differs
When 180 degree, two time-count cycles are unequal.
Optionally, for two output pulse signals time-count cycle of switching.
Optionally, there are two the channels for being used for output pulse signal for the implantable medical device tool；For each pulse
In the period, the different channel of the control is respectively according to the pulse period output pulse signal, comprising:
It enabled for the first time-count cycle, makes the starting point of the first time-count cycle of rising edge of a pulse of first passage, failing edge exists
In first time-count cycle；
Switched for the second time-count cycle, make the starting point of the second time-count cycle of rising edge of a pulse of second channel, failing edge exists
In second time-count cycle.
Correspondingly, the present invention also provides a kind of implantable medical devices, comprising: at least one processor；And with it is described
The memory of at least one processor communication connection；Wherein, the memory is stored with and can be executed by one processor
Instruction, described instruction are executed by least one described processor, so that at least one described processor executes such as claim 1-5
Any one of described in impulse stimulation method.
The present invention also provides a kind of implantable medical device, the channel for being used for output pulse signal at least two should
Equipment further include:
Setting unit obtains the offset information of phase difference between being used to indicate different group pulse signals；
Computing unit, for determining at least two time-count cycles according to the offset information, all the time-count cycles it
With for the pulse period；
Control unit, for controlling the different channels respectively according to the pulse period output pulse signal, wherein
The length of at least two time-count cycle is used to determine the phase difference of different interchannel pulse signals.
Optionally, the range of the phase difference be [0 °, 360 °).
Optionally, the time-count cycle is two, the phase difference between the offset information indicates different group pulse signals
When for 180 degree, two time-count cycles are equal；When the offset information indicates that the phase difference between different group pulse signals differs
When 180 degree, two time-count cycles are unequal.
Optionally, described control unit, which alternately switches, controls different channel output pulses two time-count cycles
Signal；
There are two the channels for being used for output pulse signal for the implantable medical device tool；For each pulse period, institute
It states control unit and enabled for the first time-count cycle, make the starting point of the first time-count cycle of rising edge of a pulse of first passage, failing edge
Within first time-count cycle；Switched for the second time-count cycle, makes the second time-count cycle of rising edge of a pulse of second channel
Starting point, failing edge is within second time-count cycle.
The implantable medical device and its impulse stimulation method provided according to the present invention allows user to provide phase difference and believes
Breath, determines multiple time-count cycles according to the information by equipment, and according to multiple output multi-channel time-count cycle pulse signals, make difference
Phase difference output adjustable multiplex pulse signal in channel meets clinically diversified treatment it is possible thereby to realize different therapies
Method demand.
Detailed description of the invention
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art
Embodiment or attached drawing needed to be used in the description of the prior art be briefly described, it should be apparent that, it is described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, is also possible to obtain other drawings based on these drawings.
Fig. 1 is the structural schematic diagram of the Implanted medical system in the embodiment of the present invention；
Fig. 2 is a kind of waveform diagram of pulse signal in the embodiment of the present invention；
Fig. 3 is another waveform diagram of pulse signal in the embodiment of the present invention；
Fig. 4 is the third waveform diagram of pulse signal in the embodiment of the present invention；
Fig. 5 is the structural schematic diagram of the implantable medical device in the embodiment of the present invention.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation
Example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill
Personnel's every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that term " first ", " second " are used for description purposes only, and cannot
It is interpreted as indication or suggestion relative importance.In addition, technology involved in invention described below different embodiments
Feature can be combined with each other as long as they do not conflict with each other.
Fig. 1 shows a kind of Implanted medical system, specifically can be with DBS (deep brain stimulation, brain deep thorn
Swash), VNS (vagusneve stimulation, vagal stimulation), SCS (Spinalcord stimulation, spinal cord electricity
Stimulation) and the charging such as SNM (Sacral Neuromodulation, sacral nerve stimulation system) and non-charge prepd.The system packet
In-vivo device 1 and external device 2 are included, wherein external device 2 is equipped with interworking function unit 21, external control unit 22 and leads in vitro
Believe unit 23；In-vivo device 1 is equipped with internal control unit 11, intra-body communication unit 12 and multiple signal output channels.It is produced with DBS
For product, which is equipped with first passage 13 and the two channels of second channel 14.These channels are for exporting pulse letter
Number, they can be implanted the different parts of brain respectively.
The present invention provides a kind of impulse stimulation methods, for controlling above-mentioned multiple signal output channels output pulse letters
Number, this method can be by external control unit 22 or control unit 11 executes in vivo.This method comprises the following steps:
S1 obtains the offset information of phase difference between being used to indicate different group pulse signals.Offset information can be phase difference
Value, unit be degree；It is also possible to time value, unit is millisecond or microsecond.This information can be set by user, such as with
Offset information can be arranged by the interworking function unit 21 of external device 2 in family.
S2 determines that multiple time-count cycles, the sum of whole time-count cycles are the pulse period according to offset information.Preferably at one
Embodiment in, using two time-count cycle T1 and T2, pulse period T=T1+T2.T1 and T2 can be it is equal or unequal,
It can be specifically calculated according to offset information, or inquire to obtain using the mode tabled look-up.Such as it can preset
Phase difference value, and these phase difference values are set and respectively correspond different multiple time-count cycles, it, can when user provides offset information
To inquire corresponding multiple time-count cycles.
S3 controls different channels respectively according to pulse period output pulse signal, and the length of time-count cycle is for determining
The phase difference of different interchannel pulse signals.The two-way letter that the waveform referring to shown in Fig. 2, first passage 13 and second channel 14 export
Number pulse period be T, and second channel fall behind first passage phase differenceAre as follows:First passage 13 falls behind the phase difference of second channel 14Are as follows:Therefore phase difference depend on two time-count cycle T1 and T2 length.Preferably at one
Embodiment in, the range of phase difference be [0 °, 360 °), allow user provide correspond to this range offset information, Yong Huke
To input any number within the scope of this, suitable multiple time-count cycles are determined by step S2, and embody in this step
Corresponding phase difference out.
As a special case, the waveform referring to shown in Fig. 3, when T1 is equal with T2, the pulse signal phase in the two channels
Difference is 180 °.
The impulse stimulation method provided according to embodiments of the present invention, allow user provide phase information, by equipment according to
The information determines multiple time-count cycles, and according to multiple output multi-channel time-count cycle pulse signals, makes different channel output phases
The adjustable multiplex pulse signal of difference, is achieved in different therapies, meets clinically diversified therapy demand.
In a preferred embodiment, pulse signal is generated by the way of alternately switching two time-count cycles.Fig. 4 shows
The pulse signal in multiple periods is gone out, time-count cycle, T1 and T2 were alternately switched, so that second channel falls behind the in each period
The phase difference in one channel isThe phase difference of the backward second channel of first passage is in each period
Further, there is not high level in synchronization in two channels.Specifically, for each pulse period, first
The rising edge of a pulse in channel be first time-count cycle T1 starting point, failing edge is in the first time-count cycle T1, and second channel is in T1
It is interior there is no rising edge and failing edge；After switching for the second time-count cycle, the rising edge of a pulse of second channel was the second time-count cycle
Starting point, failing edge is within the second time-count cycle, and first passage is in T2 without rising edge and failing edge.
The embodiment of the present invention also provides a kind of implantable medical device, can be above-mentioned in-vivo device or external device,
It includes setting unit 51, computing unit 52, control unit 53 that the equipment as shown in Figure 5, which includes the equipment,.
The acquisition of setting unit 51 is used to indicate the offset information of phase difference between different group pulse signals, specifically can refer to above-mentioned
Step S1.If external device, then offset information can be directly obtained and interacting with user；If in-vivo device, then may be used
To obtain offset information and being communicated with external device.
Computing unit 52 is used to determine that at least two time-count cycles, the sum of whole time-count cycles are pulse according to offset information
Period.Specifically it can refer to above-mentioned steps S2, details are not described herein again.
Control unit 53 is for controlling different channels respectively according to pulse period output pulse signal, wherein time-count cycle
Length be used to determine the phase differences of different interchannel pulse signals, specifically can refer to above-mentioned steps S3.If in-vivo device, then
Each channel output pulse signal can be directly controlled；If external device, then can by communicated with in-vivo device to
It sends these time-count cycles, executes pulse output action by in-vivo device.
The implantable medical device provided according to embodiments of the present invention allows user to provide phase information, by equipment root
Multiple time-count cycles are determined according to the information, and according to multiple output multi-channel time-count cycle pulse signals, make different channel output phasies
The adjustable multiplex pulse signal of potential difference is achieved in different therapies, meets clinically diversified therapy demand.
In a preferred embodiment, the range of phase difference be [0 °, 360 °).
In a preferred embodiment, time-count cycle is two, between offset information indicates different group pulse signals
When phase difference is 180 degree, two time-count cycles are equal；When offset information indicates that the phase difference between different group pulse signals is not equal to
When 180 degree, two time-count cycles are unequal.
In a preferred embodiment, implantable medical device alternately switch two time-count cycle output pulse signal.
Further, for each pulse period, control unit enabled for the first time-count cycle first, made the arteries and veins of first passage
The starting point that rising edge was the first time-count cycle is rushed, failing edge is within the first time-count cycle；Switched for the second time-count cycle later, makes
The rising edge of a pulse in two channels is the starting point of the second time-count cycle, and failing edge is within the second time-count cycle.
It should be understood by those skilled in the art that, the embodiment of the present invention can provide as method, system or computer program
Product.Therefore, complete hardware embodiment, complete software embodiment or reality combining software and hardware aspects can be used in the present invention
Apply the form of example.Moreover, it wherein includes the computer of computer usable program code that the present invention, which can be used in one or more,
The computer program implemented in usable storage medium (including but not limited to magnetic disk storage, CD-ROM, optical memory etc.) produces
The form of product.
The present invention be referring to according to the method for the embodiment of the present invention, the process of equipment (system) and computer program product
Figure and/or block diagram describe.It should be understood that every one stream in flowchart and/or the block diagram can be realized by computer program instructions
The combination of process and/or box in journey and/or box and flowchart and/or the block diagram.It can provide these computer programs
Instruct the processor of general purpose computer, special purpose computer, Embedded Processor or other programmable data processing devices to produce
A raw machine, so that being generated by the instruction that computer or the processor of other programmable data processing devices execute for real
The device for the function of being specified in present one or more flows of the flowchart and/or one or more blocks of the block diagram.
These computer program instructions, which may also be stored in, is able to guide computer or other programmable data processing devices with spy
Determine in the computer-readable memory that mode works, so that it includes referring to that instruction stored in the computer readable memory, which generates,
Enable the manufacture of device, the command device realize in one box of one or more flows of the flowchart and/or block diagram or
The function of being specified in multiple boxes.
These computer program instructions also can be loaded onto a computer or other programmable data processing device, so that counting
Series of operation steps are executed on calculation machine or other programmable devices to generate computer implemented processing, thus in computer or
The instruction executed on other programmable devices is provided for realizing in one or more flows of the flowchart and/or block diagram one
The step of function of being specified in a box or multiple boxes.
Obviously, the above embodiments are merely examples for clarifying the description, and does not limit the embodiments.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or
It changes.There is no necessity and possibility to exhaust all the enbodiments.And it is extended from this it is obvious variation or
It changes still within the protection scope of the invention.
Claims (10)
1. a kind of impulse stimulation method of implantable medical device, the implantable medical device has at least two to be used to export
The channel of pulse signal, which is characterized in that the described method includes:
Obtain the offset information of phase difference between being used to indicate different group pulse signals；
Determined at least two time-count cycles according to the offset information, all the sum of described time-count cycle is the pulse period；
The different channels is controlled respectively according to the pulse period output pulse signal, wherein at least two timing is all
The length of phase is used to determine the phase difference of different interchannel pulse signals.
2. the method according to claim 1, wherein the range of the phase difference be [0 °, 360 °).
3. according to method described in claim 1, which is characterized in that the time-count cycle is two, when the offset information indicates
When phase difference between different group pulse signals is 180 degree, two time-count cycles are equal；When the offset information indicates difference
When phase difference between group pulse signal is not equal to 180 degree, two time-count cycles are unequal.
4. the method stated according to claim 3, which is characterized in that controlling the different channels respectively according to the pulse period
During output pulse signal, alternately switch two output pulse signals time-count cycle.
5. according to the method described in claim 4, it is characterized in that, for exporting arteries and veins there are two implantable medical device tools
Rush the channel of signal；For each pulse period, the different channel of the control is exported according to the pulse period respectively
Pulse signal, comprising:
It enabled for the first time-count cycle, makes the starting point of the first time-count cycle of rising edge of a pulse of first passage, failing edge is described
In first time-count cycle；
Switched for the second time-count cycle, makes the starting point of the second time-count cycle of rising edge of a pulse of second channel, failing edge is described
In second time-count cycle.
6. a kind of implantable medical device characterized by comprising at least one processor；And with described at least one
Manage the memory of device communication connection；Wherein, the memory is stored with the instruction that can be executed by one processor, the finger
It enables and being executed by least one described processor, so that at least one described processor is executed such as any one of claim 1-5
The impulse stimulation method.
7. a kind of implantable medical device, the channel for being used for output pulse signal at least two, which is characterized in that also wrap
It includes:
Setting unit obtains the offset information of phase difference between being used to indicate different group pulse signals；
Computing unit, for determining at least two time-count cycles according to the offset information, all the sum of described time-count cycle is
Pulse period；
Control unit, for controlling the different channels respectively according to the pulse period output pulse signal, wherein described
The length of at least two time-count cycles is used to determine the phase difference of different interchannel pulse signals.
8. equipment according to claim 7, which is characterized in that the range of the phase difference be [0 °, 360 °).
9. according to equipment as claimed in claim 7, which is characterized in that the time-count cycle is two, when the offset information indicates
When phase difference between different group pulse signals is 180 degree, two time-count cycles are equal；When the offset information indicates difference
When phase difference between group pulse signal is not equal to 180 degree, two time-count cycles are unequal.
10. the equipment stated according to claim 9, which is characterized in that described control unit alternately control time-count cycle of switching two
Make the different channel output pulse signals；
There are two the channels for being used for output pulse signal for the implantable medical device tool；For each pulse period, the control
Unit processed enabled for the first time-count cycle, made the starting point of the first time-count cycle of rising edge of a pulse of first passage, failing edge is in institute
It states in the first time-count cycle；Switched for the second time-count cycle, make the starting point of the second time-count cycle of rising edge of a pulse of second channel,
Failing edge is within second time-count cycle.
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| CN201910451377.1A CN110141784A (en) | 2019-05-28 | 2019-05-28 | Implantable medical device and its impulse stimulation method |
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| CN201910451377.1A CN110141784A (en) | 2019-05-28 | 2019-05-28 | Implantable medical device and its impulse stimulation method |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02285810A (en) * | 1989-04-27 | 1990-11-26 | Mitsubishi Electric Corp | Phase difference detection device |
| CN1431486A (en) * | 1994-12-16 | 2003-07-23 | 东京瓦斯株式会社 | Electromagnetic wave checking method for duct system |
| CN104548342A (en) * | 2014-12-31 | 2015-04-29 | 清华大学 | Implantable electric pulse stimulation system |
| US20150223710A1 (en) * | 2014-02-07 | 2015-08-13 | Medtronic, Inc. | Devices and Methods for Sensing Physiological Signals During Stimulation Therapy |
| CN109481844A (en) * | 2018-12-27 | 2019-03-19 | 清华大学 | Implantable nerve stimulation apparatus with multiple-frequency-mode |
-
2019
- 2019-05-28 CN CN201910451377.1A patent/CN110141784A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02285810A (en) * | 1989-04-27 | 1990-11-26 | Mitsubishi Electric Corp | Phase difference detection device |
| CN1431486A (en) * | 1994-12-16 | 2003-07-23 | 东京瓦斯株式会社 | Electromagnetic wave checking method for duct system |
| US20150223710A1 (en) * | 2014-02-07 | 2015-08-13 | Medtronic, Inc. | Devices and Methods for Sensing Physiological Signals During Stimulation Therapy |
| CN104548342A (en) * | 2014-12-31 | 2015-04-29 | 清华大学 | Implantable electric pulse stimulation system |
| CN106139396A (en) * | 2014-12-31 | 2016-11-23 | 清华大学 | A kind of implanted electric pulse stimulation system |
| CN109481844A (en) * | 2018-12-27 | 2019-03-19 | 清华大学 | Implantable nerve stimulation apparatus with multiple-frequency-mode |
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