CN111840803B - Variable frequency magnetic stimulation system combining preset frequency and bioelectric feedback - Google Patents
Variable frequency magnetic stimulation system combining preset frequency and bioelectric feedback Download PDFInfo
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- 230000000638 stimulation Effects 0.000 title claims abstract description 112
- 210000005036 nerve Anatomy 0.000 claims abstract description 59
- 238000000605 extraction Methods 0.000 claims abstract description 19
- 238000000034 method Methods 0.000 claims description 6
- 238000001228 spectrum Methods 0.000 claims description 6
- 238000012886 linear function Methods 0.000 claims description 5
- 230000008859 change Effects 0.000 claims description 3
- 230000009466 transformation Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 210000002569 neuron Anatomy 0.000 abstract description 4
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000010355 oscillation Effects 0.000 description 11
- 210000004556 brain Anatomy 0.000 description 10
- 230000001105 regulatory effect Effects 0.000 description 5
- 230000003925 brain function Effects 0.000 description 4
- 230000033001 locomotion Effects 0.000 description 4
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- 230000001054 cortical effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000033764 rhythmic process Effects 0.000 description 2
- 238000011491 transcranial magnetic stimulation Methods 0.000 description 2
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- 238000001311 chemical methods and process Methods 0.000 description 1
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- 230000009123 feedback regulation Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 238000013548 repetitive transcranial magnetic stimulation Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
Abstract
The frequency conversion magnetic stimulation system combining preset frequency and bioelectric feedback is provided with a nerve electric signal acquisition module and a frequency extraction module, wherein the nerve electric signal acquisition module is used for acquiring nerve electric signals of organisms, the frequency extraction module is used for extracting a nerve electric signal main frequency sequence, the magnetic stimulator host is connected with a coil used for outputting magnetic stimulation to the organisms, the feedback control module is connected with a frequency preset module used for presetting the magnetic stimulation repetition frequency, the output end of the frequency preset module is respectively connected with the input ends of the magnetic stimulator host and the feedback control module, the input end of the feedback control module is also connected with the output end of the frequency extraction module, the output end of the feedback control module is connected with the input end of the magnetic stimulator host and is used for inputting a frequency control signal generated by combining the preset magnetic stimulation repetition frequency and the nerve electric signal main frequency sequence, and the input end of the magnetic stimulator host is also connected with a stimulation intensity and pulse number setting module. The invention can regulate and control the neuron activity more effectively.
Description
Technical Field
The invention relates to a variable frequency magnetic stimulation system. In particular to a variable frequency magnetic stimulation system combining preset frequency and bioelectric feedback.
Background
Repeated transcranial magnetic stimulation (repetitive transcranial magnetic stimulation, rTMS) is a brain stimulation technique widely used in the study of brain function, brain network, brain circuit, etc.
The repetition frequency is an important parameter for rTMS brain studies. It is generally believed that high frequency rTMS is used to predispose to cortical excitability and low frequency rTMS is used to inhibit cortical excitability. In practical studies, repeated stimulation is usually performed at a predetermined frequency according to the observed stimulation effect or the results of studies in the existing literature. The oscillation frequency of the brain ganglion is usually 1-100Hz, and usually, repeated stimulation at a preset frequency can only form resonance with nerve oscillation in a specific frequency band, but cannot form comprehensive resonance with nerve oscillation at a stimulation target point. Brain function is typically formed by the oscillation of multiple rhythms together. Therefore, when conducting transcranial magnetic stimulation brain function research, repeated stimulation with preset frequency does not consider the nerve oscillation of the stimulation target point, and all nerve oscillations of the stimulation target point which are not completely related to brain functions can not form resonance, so that the stimulation effect has a certain limitation.
Thus, the repetition of magnetic stimulation at a preset frequency does not form an overall resonance with the neural oscillations at the stimulation target. The invention provides a magnetic stimulation device and a magnetic stimulation method combining preset frequency and bioelectric feedback.
Disclosure of Invention
The invention aims to solve the technical problem of providing a variable frequency magnetic stimulation system which can form more fitting resonance with nerve oscillation at a target point and can more effectively regulate and control neuron activity and combine preset frequency and bioelectric feedback.
The technical scheme adopted by the invention is as follows: a variable frequency magnetic stimulation system combining preset frequency and bioelectric feedback, comprising: the device comprises a nerve electric signal acquisition module, a frequency extraction module, a magnetic stimulator host, a frequency preset module, a feedback control module, a frequency setting module and a stimulation intensity and pulse number setting module, wherein the nerve electric signal acquisition module is used for acquiring nerve electric signals of organisms, the frequency extraction module is used for extracting a nerve electric signal main frequency sequence, the magnetic stimulator host is connected with the frequency extraction module is used for extracting the nerve electric signal main frequency sequence, the magnetic stimulator host is connected with the coil used for outputting magnetic stimulation to the organisms, the feedback control module is further arranged, the frequency preset module is used for presetting the magnetic stimulation repetition frequency, the output of the frequency preset module is respectively connected with the input ends of the magnetic stimulator host and the feedback control module, the output end of the feedback control module is further connected with the output end of the frequency extraction module, and the output end of the feedback control module is connected with the input end of the magnetic stimulator host and is used for inputting frequency control signals generated by combining the preset magnetic stimulation repetition frequency and the nerve electric signal main frequency sequence to the magnetic stimulator host.
The frequency preset module is composed of a first programmable controller and has three working modes: respectively, for a preset fixed repetition frequency f 1 (t)＝F 0 Presetting a repetition frequency f which varies with a linear function 2 (t) =k×t and the preset varies with the step functionRepetition frequency f of the chemical process 3 (t)＝{F 1 ,F 2 F3, … }, wherein F 0 For a fixed repetition frequency, k is the rate of change of frequency, k>0，F 1 ,F 2 F3, … is a step repetition frequency, and the frequency preset module operates as follows:
(5.1) setting the total duration of the stimulation sequence as h, n stimulation segments in total, wherein n is more than 2, and the duration of each stimulation segment is m, and m=h/n;
(5.2) setting a preset frequency sequence x= { X0, X1..xn }, as a repetition frequency sequence of the magnetic stimulus, for a first operation mode, the preset frequency sequence x= { F0, …, F0}, for a second operation mode, the preset frequency sequence x= { F2 (m), F2 (2*m), …, F2 (n X m) }, for a third operation mode, the preset frequency sequence x= { F1, F2, …, fn };
(5.3) outputting the repetition frequency sequence X and each stimulation segment duration m to the magnetic stimulator host.
The frequency extraction module is composed of a second programmable controller and is used for segmenting the acquired nerve electric signals, carrying out Fourier transform on each segment of nerve electric signals to obtain a spectrum curve of each segment of nerve electric signals, extracting the frequency corresponding to the maximum energy value in the spectrum curve to obtain a main frequency sequence of the nerve electric signals at a biological magnetic stimulation target point, and marking the main frequency sequence as Y= { Y 0 ,y 1 ,...y n }。
The feedback control module is composed of a third programmable controller and is used for giving a feedback frequency sequence by combining a preset frequency and a nerve electric signal main frequency sequence, and the feedback control module comprises the following steps:
(4.1) calculating the square root of the difference between the preset frequency sequence X and the main frequency sequence Y of the nerve electric signal at the biological magnetic stimulation target point;
(4.2) judging whether the square root of the difference value of the main frequency sequence Y of the nerve electric signal at the preset frequency sequence X and the biological magnetic stimulation target point is smaller than 1Hz, if yes, calculating to obtain a feedback frequency sequence F= (X+Y)/2, outputting the feedback frequency sequence F to a main machine of the magnetic stimulator, continuously receiving signals of a frequency extraction module and a frequency preset module, and returning to the step (4.1); otherwise, the feedback frequency sequence F is not output, and the magnetic stimulation is stopped.
The time-varying repetition frequency based on the time-frequency characteristics of the bioelectric signals preset by the frequency preset module is the bioelectric signal frequency at other positions except for the bioelectric magnetic stimulation target points or the bioelectric signal frequency of other organisms.
According to the variable-frequency magnetic stimulation system combining the preset frequency and the bioelectric feedback, the main frequency of the nerve electric signal at the stimulation target point is used for feedback regulation and control of the preset frequency, the repetition frequency combining the preset frequency and the bioelectric feedback is formed, magnetic stimulation is performed on the target point, more fitting resonance can be formed by the magnetic stimulation on the nerve oscillation at the target point, neuron activity can be regulated and controlled more effectively, a new scheme is provided for setting the repetition frequency of rTMS, and a new thought is provided for the rTMS to be used for brain stimulation.
Drawings
FIG. 1 is a block diagram of a variable frequency magnetic stimulation system combining preset frequency and bioelectric feedback in accordance with the present invention;
fig. 2 is a schematic diagram of the operation mode of the feedback control module according to the present invention.
In the figure
1: organism 2: nerve electric signal acquisition module
3: frequency extraction module 4: feedback control module
5: frequency presetting module 6: magnetic stimulator host
7: coil 8: stimulation intensity and pulse number setting module
Detailed Description
A variable frequency magnetic stimulation system according to the present invention, which combines a preset frequency and bioelectric feedback, will be described in detail with reference to the following examples and accompanying drawings.
As shown in fig. 1, a variable frequency magnetic stimulation system combining preset frequency and bioelectric feedback according to the present invention includes: the device comprises a nerve electric signal acquisition module 2, a frequency extraction module 3, a magnetic stimulator host 6, a coil 7, a feedback control module 4, a frequency preset module 5, a magnetic stimulator host 6 and a pulse number setting module 8, wherein the nerve electric signal acquisition module 2 is used for acquiring nerve electric signals of an organism 1, the frequency extraction module 3 is used for extracting a nerve electric signal main frequency sequence, the magnetic stimulator host 6 is connected with the coil 7 is used for outputting magnetic stimulation to the organism 1, the feedback control module 4 is further arranged, the frequency preset module 5 is used for presetting the magnetic stimulation repetition frequency, the output of the frequency preset module 5 is respectively connected with the input ends of the magnetic stimulator host 6 and the feedback control module 4, the output end of the feedback control module 4 is also connected with the output end of the frequency extraction module 3, and the output end of the feedback control module 4 is connected with the input end of the magnetic stimulator host 6 and is used for inputting frequency control signals generated by combining the preset magnetic stimulation repetition frequency and the nerve electric signal main frequency sequence.
In the variable frequency magnetic stimulation system combining the preset frequency and the bioelectric feedback, the stimulation intensity and pulse number setting module 8 is used for outputting the stimulation intensity and the pulse number to the magnetic stimulator host 6, the magnetic stimulator host 6 outputs the received preset frequency sequence or feedback frequency sequence, the duration of each stimulation section, the stimulation intensity and the pulse number to the coil 7, the coil 7 is used for generating magnetic stimulation and acting on a magnetic stimulation target point of the organism 1, and the nerve electric signal acquisition module 2 is used for acquiring nerve electric signals on the magnetic stimulation target point of the organism after the organism receives the magnetic stimulation.
According to the method, firstly, magnetic stimulation is implemented according to the preset frequency and the duration of each stimulation section, then, bioelectric signals at a magnetic stimulation target point of an organism 1 are collected, a feedback frequency sequence is given by combining the preset frequency and a main frequency sequence of the bioelectric signals at the stimulation target point, and magnetic stimulation based on the feedback frequency sequence is output again. When the nerve oscillation is regulated and controlled according to the preset frequency, the preset frequency is finely regulated according to the nerve electric signal at the target point of the organism 1, so that a better stimulation effect is achieved.
The frequency preset module 5 of the invention is composed of a first programmable controller and has three working modes: respectively for presetting a fixed repetition frequency f 1 (t)＝F 0 Presetting a repetition frequency f which varies with a linear function 2 (t) =k×t, and preset repetition frequency f varying with the step function 3 (t)＝{F 1 ,F 2 F3, … }, wherein F 0 For a fixed repetition frequency, k is the rate of change of frequency, k>0，F 1 ,F 2 F3, … is a step repetition frequency, and the frequency presetting module 5 performs the following steps:
(5.1) setting the total duration of the stimulation sequence as h, n stimulation segments in total, wherein n is more than 2, and the duration of each stimulation segment is m, and m=h/n;
(5.2) setting a preset frequency sequence x= { X0, X1..xn }, as a repetition frequency sequence of the magnetic stimulus, for a first operation mode, the preset frequency sequence x= { F0, …, F0}, for a second operation mode, the preset frequency sequence x= { F2 (m), F2 (2*m), …, F2 (n X m) }, for a third operation mode, the preset frequency sequence x= { F1, F2, …, fn };
(5.3) outputting the repetition frequency sequence X and each stimulation segment duration m to the magnetic stimulator host 6.
For the first working mode of the frequency preset module 5, the frequency is consistent with the existing repetition frequency magnetic stimulation, namely, the fixed repetition frequency is set for magnetic stimulation, 10s is taken as the total duration of a stimulation sequence, 2s is taken as the duration of each stimulation section, the fixed repetition frequency is set to be 5Hz, and the preset frequency sequence output by the first working mode is {5,5,5,5,5}; for the second working mode of the frequency preset module 5, a frequency sequence changing with time is generated according to a linear function to serve as a repetition frequency of magnetic stimulation, the repetition frequency is the magnetic stimulation changing with time, the repetition frequency is increased with time by taking a unitary linear function f (t) =0.5t as an example, the repetition frequency is increased with time, 10s is taken as the total duration of the stimulation sequence, the repetition frequency is increased from 0Hz to 5Hz, 2s is taken as the duration of each stimulation segment to form 5 time segments, the repetition frequency corresponding to the end time point of each time segment is taken as the repetition frequency of the time segment, and the output preset frequency sequence is {1,2,3,4,5}; for the third working mode of the frequency preset module 5, a frequency sequence changing with time is generated according to a step function to serve as the repetition frequency of magnetic stimulation, 1Hz is used as a frequency step, 2s is used as the duration of each stimulation segment, 6s is used as the total duration of the stimulation sequence, and the generated repetition frequency is { F } 1 ＝1Hz，0<t<＝2；F 2 ＝2Hz,2<t<＝4；F 3 ＝3Hz,4<t<=6 }, the output predetermined frequency sequence is {1,2,3}.
For the third working mode, the setting can also be carried out according to the empirical value of the time-frequency characteristic of the biological nerve electric signal. For example, the Alpha rhythm is dominant (8-13 Hz) in the period of eye-closure wakefulness, so that the repetition frequency of this period can be set to 8-13Hz in the form of a gradient function. In addition, according to the research target, the empirical values of the time-frequency characteristics of the nerve electric signals at other positions except the magnetic stimulation target point of the organism 1 can be selected for setting, or the empirical values of the time-frequency characteristics of the nerve electric signals of other organisms can be selected for setting.
The frequency extraction module 3 of the invention is composed of a second programmable controller, and is used for segmenting the collected nerve electric signals, carrying out Fourier transform on each segment of nerve electric signals to obtain a spectrum curve of each segment of nerve electric signals, extracting the frequency corresponding to the maximum energy value in the spectrum curve to obtain a main frequency sequence of the nerve electric signals at a biological magnetic stimulation target point, and recording as Y= { Y 0 ,y 1 ,...y n }。
As shown in fig. 2, the feedback control module 4 of the present invention is formed by a third programmable controller, and is configured to combine a preset frequency and a main frequency sequence of a nerve electric signal to give a feedback frequency sequence, and includes the following steps:
(4.1) calculating the square root of the difference between the preset frequency sequence X and the main frequency sequence Y of the nerve electric signal at the biological magnetic stimulation target point;
(4.2) judging whether the square root of the difference value of the main frequency sequence Y of the nerve electric signal at the preset frequency sequence X and the biological magnetic stimulation target point is smaller than 1Hz, if yes, calculating to obtain a feedback frequency sequence F= (X+Y)/2, outputting the feedback frequency sequence F to the magnetic stimulator host 6, continuously receiving signals of the frequency extraction module 3 and the frequency preset module 5, and returning to the step (4.1); otherwise, the feedback frequency sequence F is not output, and the magnetic stimulation is stopped.
The first programmable controller, the second programmable controller and the third programmable controller have the same structure and can all adopt XILINX companyFPGA board, model: ULTRASCALE+ fFZ3B or AX7020. According to the method, an algorithm is written, the algorithm is converted into an assembly language which can be identified by the FPGA, the assembly language is written into a program memory ROM of the FPGA, and a program is executed. The nerve electric signal acquisition module 2 can adopt a model of a Neuroscan brain electric amplifier or a BiosemiActiveTwo brain electric amplifier. The magnetic stimulator host 6 may be a quick type Magtim 2 Or Magpro magnetic stimulator from magventuri corporation.
The following gives examples:
setting the preset frequency as high-frequency stimulation of 5Hz, and performing repeated magnetic stimulation through a magnetic stimulator host, wherein the stimulation target is a movement area C4 on the right side of the human brain; after the stimulation is finished, acquiring an electroencephalogram signal at the C4 of the motion area, extracting a main frequency sequence, calculating the difference root mean square of the main frequency sequence at the C4 of the motion area and the preset frequency, giving out a control signal whether to continue iteration or not according to whether the difference root mean square is smaller than 1Hz, taking the average value of the preset frequency and the main frequency sequence at the C4 of the motion area as the repetition frequency of the next magnetic stimulation when the difference root mean square is not smaller than 1Hz, continuing to perform the repeated magnetic stimulation, and stopping the magnetic stimulation when the difference root mean square is smaller than 1Hz, thereby realizing the magnetic stimulation combining the preset frequency and bioelectricity feedback.
The nerve electric signal main frequency at the stimulation target point is used for feeding back, regulating and controlling the preset frequency, forming the repetition frequency combining the preset frequency and bioelectric feedback, performing magnetic stimulation on the target point, forming more fitting resonance with nerve oscillation at the target point, more effectively regulating and controlling neuron activity, providing a new scheme for setting the rTMS repetition frequency, and providing a new thought, device and method for using the rTMS for brain stimulation.
Although the preferred embodiments of the present invention have been described above with reference to the accompanying drawings, the present invention is not limited to the above-described embodiments, which are merely illustrative, and not restrictive.
Those skilled in the art, having the benefit of this disclosure, may make numerous forms without departing from the spirit of the invention and the scope of the claims.
Claims (4)
1. A variable frequency magnetic stimulation system combining preset frequency and bioelectric feedback, comprising: the device comprises a nerve electric signal acquisition module (2) which is connected and used for acquiring nerve electric signals of an organism (1), a frequency extraction module (3) which is used for extracting a nerve electric signal main frequency sequence, a magnetic stimulator host (6) which is connected and used for outputting magnetic stimulation to the organism (1), a feedback control module (4) and a frequency preset module (5) which is used for presetting the magnetic stimulation repetition frequency, wherein the output of the frequency preset module (5) is respectively connected with the magnetic stimulator host (6) and the input end of the feedback control module (4), the input end of the feedback control module (4) is also connected with the output end of the frequency extraction module (3), and the output end of the feedback control module (4) is connected with the input end of the magnetic stimulator host (6) and is used for inputting frequency control signals which are generated by combining the preset magnetic stimulation repetition frequency and the nerve electric signal main frequency sequence to the magnetic stimulator host (6), and the input end of the magnetic stimulator host (6) is also connected with a stimulation intensity and pulse number setting module (8);
the feedback control module (4) is composed of a third programmable controller and is used for giving a feedback frequency sequence by combining a preset frequency and a main frequency sequence of the nerve electric signal, and the method comprises the following steps of:
(4.1) calculating the root mean square of the difference between the preset frequency sequence X and the main frequency sequence Y of the nerve electric signal at the biological magnetic stimulation target point;
(4.2) judging whether the root mean square of the difference value of the preset frequency sequence X and the main frequency sequence Y of the nerve electric signal at the biological magnetic stimulation target point is smaller than 1Hz, when the root mean square of the difference value is not smaller than 1Hz, calculating to obtain a feedback frequency sequence F= (X+Y)/2, outputting the feedback frequency sequence F to a magnetic stimulator host (6), continuously receiving signals of a frequency extraction module (3) and a frequency preset module (5), and returning to the step (4.1); when the root mean square of the difference is smaller than 1Hz, the feedback frequency sequence F is not output, and the magnetic stimulation is stopped.
2. The variable frequency magnetic stimulation system combining preset frequency and bioelectric feedback according to claim 1, characterized in that the frequency preset module (5) is composed of a first programmable controller and has three working modes: respectively, for a preset fixed repetition frequency f 1 (t)=F 0 Presetting a repetition frequency f which varies with a linear function 2 (t) =k×t and preset repetition frequency f varying with the step function 3 (t)={F 1 , F 2 ,F 3 … }, wherein F 0 For a fixed repetition frequency, k is the rate of change of frequency, k>0，F 1 , F 2 , F 3 … are step repetition frequencies, and the frequency presetting module (5) operates the following steps:
(5.1) setting the total duration of the stimulation sequence as h, n stimulation segments in total, wherein n is more than 2, and the duration of each stimulation segment is m, and m=h/n;
(5.2) setting a preset frequency sequence x= { X0, X1..xn }, as a repetition frequency sequence of the magnetic stimulus, for a first operation mode, the preset frequency sequence x= { F0, …, F0}, for a second operation mode, the preset frequency sequence x= { F2 (m), F2 (2*m), …, F2 (n X m) }, for a third operation mode, the preset frequency sequence x= { F1, F2, …, fn };
(5.3) outputting the repetition frequency sequence X and each stimulation segment duration m to the magnetic stimulator host (6).
3. The variable frequency magnetic stimulation system combining preset frequency and bioelectric feedback according to claim 1, characterized in that the frequency extraction module (3) is composed of a second programmable controller, and is used for segmenting the collected nerve electric signals, performing fourier transformation on each segment of nerve electric signals to obtain a spectrum curve of each segment of nerve electric signals, extracting the frequency corresponding to the maximum energy value in the spectrum curve, and obtaining a main frequency sequence of the nerve electric signals at a biological magnetic stimulation target point, which is denoted as y= { Y 0 ,y 1 ,...y n }。
4. A variable frequency magnetic stimulation system according to claim 2, characterized in that the time-varying repetition frequency based on the time-frequency characteristics of bioelectric signals preset by the frequency preset module (5) is the frequency of bioelectric signals at other positions except for the target point of the magnetic stimulation of the organism (1) or the frequency of bioelectric signals of other organisms.
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| JP2000254239A (en) * | 1999-03-08 | 2000-09-19 | Apollo Mec:Kk | Magnetic therapeutic equipment |
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| CN106310526A (en) * | 2015-07-10 | 2017-01-11 | 张五二 | Brain wave resonance instrument |
| CN110755749A (en) * | 2019-08-17 | 2020-02-07 | 中国医学科学院生物医学工程研究所 | Method for establishing transcranial magnetic stimulation target and repetition frequency |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US10420953B2 (en) * | 2016-08-27 | 2019-09-24 | Wave Neuroscience, Inc. | RTMS pulse frequency optimization |
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| US6266556B1 (en) * | 1998-04-27 | 2001-07-24 | Beth Israel Deaconess Medical Center, Inc. | Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation |
| JP2000254239A (en) * | 1999-03-08 | 2000-09-19 | Apollo Mec:Kk | Magnetic therapeutic equipment |
| CN106310526A (en) * | 2015-07-10 | 2017-01-11 | 张五二 | Brain wave resonance instrument |
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