CN115887857A - Multi-physical-factor stimulation nerve regulation and control device and method combining biofeedback - Google Patents
Multi-physical-factor stimulation nerve regulation and control device and method combining biofeedback Download PDFInfo
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Abstract
The invention discloses a multi-physical factor stimulation nerve regulation and control device and method combined with biofeedback, which comprises the following steps: the system comprises a system operation unit, a system control unit and a system function unit, wherein the system function unit comprises a multi-physical-factor stimulation wearable device, the system control unit comprises a controller, a multi-physical-factor generator, a signal processing module and a stimulation paradigm and parameter control module, biological feedback quantitative electroencephalogram detection is carried out during stimulation, before stimulation and/or after stimulation, and electroencephalogram signal characteristic parameters and a physical stimulation system are fused to form closed-loop feedback so as to guide rhythm regulation and control of multi-physical-factor multi-modal stimulation. Through the mode, the multi-physical factor stimulation nerve regulation and control device and method combined with biofeedback can perform time-frequency-space multi-dimensional nerve regulation and control on deep brain nuclei and shallow cerebral cortex in a sound, light and electricity multi-physical factor stimulation combination mode, and the curative effect and safety of nerve regulation and control are improved by combining biofeedback.
Description
Technical Field
The invention relates to the technical field of nerve regulation, in particular to a multi-physical-factor stimulation nerve regulation device and method combined with biofeedback.
Background
The clinical manifestations of the dysfunction of nerve and cognition are many, including tinnitus, deafness, insomnia, anxiety, depression, vertigo, schizophrenia, nerve fatigue, hyperactivity, self-imposed, memory decline, reaction retardation and dementia. Most disorders due to neurological and cognitive dysfunction involve objective physiological and subjective psychological interactions with multiple deep brain central nuclei and multiple shallow brain cortex, and often one disorder is accompanied by multiple other disorders, such as tinnitus sleep anxiety syndrome and vertigo depression cognitive syndrome.
The nerve and cognitive dysfunction usually involves the cross influence of objective physiology and subjective psychology, lacks effective medicines, and clinically, non-invasive single physical factor stimulation intervention treatment can be adopted, such as transcranial electrical stimulation of cortex, transcranial near infrared light stimulation of cortex or acoustic stimulation of auditory canals, and the stimulation is converted into electrophysiological signals through cochlea to stimulate deep brain central nuclei and the like, so the nerve and cognitive dysfunction is clinically accepted due to the safety and certain curative effect on a certain single disease and the addition of various nerve and psychological subjective evaluation scales.
For example, patent application No. 202210841852.8 discloses a wearable brain cognitive detection and regulation wireless closed-loop device and method, which comprises an electroencephalogram detection module and an alternating current stimulation current regulation and control module.
Patent application No. 202210746805.5 discloses a multi-mode deep electroencephalogram stimulation precise nerve regulation and control system and method, which adopt synchronous and asynchronous working modes of invasive implantation type electrical stimulation, electroencephalogram acquisition and filter processing.
A closed loop adaptive transcranial electrical stimulation apparatus and method including only modulation of a single transcranial electrical stimulation is disclosed in application No. 202210945498.3.
The patent with the application number of 201210303152.X discloses a traditional Chinese and western medicine combined physiotherapy equipment system for deafness and tinnitus, which comprises a pure-tone audiometric acoustic impedance instrument, a red light treatment instrument and a sound spectrum resonance treatment instrument which are separately and independently operated, wherein the pure-tone audiometric acoustic impedance instrument is a common pure-tone audiometer for detecting hearing loss; the red light therapeutic instrument adopts a red visible light wave band with the wavelength of 600-700 nm as a main component to irradiate; the acoustic spectrum resonance therapeutic apparatus is a sound, heat, electric and magnetic micro massager for ear, and combines traditional Chinese medicine fumigation and acupuncture for physical therapy; these traditional physiotherapy devices are only the fine massage of the surface of the ear, and can neither stimulate the deep brain nuclei nor the cortex of the multiple brain regions; the equipment system is a simple superposition of traditional Chinese medicine physiotherapy means, and cannot be combined with electroencephalogram (EEG) detection to evaluate the objective curative effect.
In fact, due to the difficulty of simultaneously and effectively stimulating multiple targets distributed in multiple levels and positions of a brain neural network by single physical factor stimulation and the lack of real-time objective detection and evaluation of physical stimulation intervention treatment effects, the treatment effects of covering the range of neurological and cognitive dysfunction symptoms and intractable syndromes are limited, and particularly the treatment effects on tinnitus, sleep anxiety syndrome and vertigo, depression and cognitive syndrome are poor.
In order to improve the curative effect, the stimulation of nerve regulation by multiple physical factors can be considered, but the comprehensive control of transcranial electrical stimulation cortex, transcranial near-infrared light stimulation cortex and acoustic stimulation central nucleus is involved, and at present, no device or method suitable for clinical service can be used for simultaneously carrying out controllable and adjustable sound, light and electric combined stimulation on a patient so as to treat various nerve and cognitive dysfunction diseases; and the participation degree of the patient in the treatment is low, the curative effect perception is weak and untimely, the cognitive psychological regulation of the patient is not facilitated, and the popularization and the application of the multi-physical-factor stimulation technology are limited. In addition, compared with the single physical factor stimulation neural regulation, the influence of the multi-physical factor stimulation neural regulation process and the brain endogenous oscillation is more complicated, the brain nerves are easy to break, the safety range of external physical stimulation intervention can be borne, and improvement is needed.
Disclosure of Invention
The invention mainly solves the technical problem of providing a multi-physical factor nerve stimulation regulation and control device and method combined with biofeedback, and the device and method are combined with biofeedback to carry out comprehensive regulation and control on a sound, light and electricity multi-physical factor integrated time-frequency-space multi-dimensional nerve stimulation regulation and control paradigm and stimulation parameters, so that the nerve regulation and control curative effect and safety are improved.
In order to solve the technical problems, the invention adopts a technical scheme that: there is provided a multi-physical factor stimulatory neuromodulation device incorporating biofeedback, comprising: the system comprises a system operation unit, a system control unit and a system function unit, wherein the system function unit comprises a wearable device stimulated by multiple physical factors, the wearable device stimulated by multiple physical factors comprises a deep brain central nucleus module stimulated by acoustics through an ear canal, a transcranial near infrared light stimulation shallow cerebral cortex module, a transcranial electric stimulation shallow cerebral cortex module and a biological feedback signal acquisition electrode, the system control unit comprises a controller, a multiple physical factor generator, a signal processing module, a stimulation paradigm and parameter control module, the multiple physical factor generator comprises a light stimulation signal generator, an acoustic stimulation signal generator and an electric stimulation signal generator, the signal processing module comprises an acoustic signal regulation and control processing module, a light stimulation signal regulation and amplification processing module, an electric signal stabilization and current limitation processing module and a biological feedback signal acquisition amplifier and sensor module, continuous signal waveform processing and/intermittent signal pulse processing are carried out on physical factor signals according to physical factor characteristics and physical stimulation intervention treatment requirements, the stimulation paradigm and parameter control module comprises a light stimulation signal output module, an acoustic stimulation signal output module and an electric stimulation signal output module, an infrared light stimulation signal output module and a near infrared light stimulation signal output module which are connected with the multiple physical factor generator, the acoustic stimulation signal generator, the light stimulation signal generator, the optical stimulation signal generation and the optical stimulation signal output module in series connection with the light stimulation signal output module or the light stimulation signal output module, the system comprises an acoustic stimulation signal output module, an electrical stimulation signal generator, an electrical signal stabilizing and current limiting processing module, an electrical stimulation signal output module, a transcranial electrical stimulation shallow cerebral cortex module, a biofeedback signal acquisition electrode, a biofeedback signal acquisition amplifier and a sensor module, wherein the acoustic stimulation signal output module is connected with the deep brain central nucleus module acoustically stimulated through an ear canal in a wired or wireless mode, the electrical stimulation signal generator, the electrical signal stabilizing and current limiting processing module are sequentially connected with the electrical stimulation signal output module in series, the electrical stimulation signal output module is connected with the transcranial electrical stimulation shallow cerebral cortex module in a wired or wireless mode, the biofeedback signal acquisition electrode is connected with the biofeedback signal acquisition amplifier and the sensor module in a wired or wireless mode, the biofeedback signal acquisition amplifier and the sensor module are connected with a controller, a system operation unit is connected with a system control unit in a wireless or wired mode, and the system operation unit is connected with a system function unit in a wireless or wired mode.
In a preferred embodiment of the invention, the ear canal acoustic stimulation deep brain central nucleus module adopts an earphone, the transcranial near infrared light stimulation shallow cortex module adopts an LED lamp cap, and the transcranial electrical stimulation shallow cortex module adopts an electrical stimulation electrode.
In a preferred embodiment of the invention, a brain-computer interface is arranged in the system operation unit.
In a preferred embodiment of the invention, the electric brain stimulator further comprises an electrode cap, and the transcranial near infrared light stimulation shallow cerebral cortex module, the transcranial electric stimulation shallow cerebral cortex module and the biofeedback signal acquisition electrode are arranged on the electrode cap.
In a preferred embodiment of the present invention, the system operation unit is one or more of a computer, a smart phone and a smart television.
In a preferred embodiment of the present invention, the system operating unit further comprises a remote controller, which communicates with the system control unit and the system function unit in a wireless manner.
In a preferred embodiment of the present invention, the controller includes a master control MCU and a slave control MCU connected to each other, the master control MCU is respectively connected to the acoustic stimulation signal generator, the optical stimulation signal generator, the electrical stimulation signal generator and the system operation unit to provide currents with required parameters, and the slave control MCU is respectively connected to the electrical stimulation signal generator, the biofeedback signal acquisition amplifier and the sensor module to improve the stability and fidelity of the waveform of the micro constant current signal output by the high-precision resistor network in the electrical stimulation loop.
In order to solve the technical problems, the invention adopts a technical scheme that: a multi-physical factor stimulation nerve regulation method combined with biofeedback is provided, which comprises the following steps:
implementing time-frequency-space multi-dimensional regulation of single physical factor stimulation and/or multi-physical factor stimulation combination of sound, light and electric stimulation, and performing acoustic stimulation deep brain central nucleus nerve regulation, transcranial near infrared light stimulation shallow cortical brain nerve regulation and transcranial electric stimulation shallow cortical brain nerve regulation;
wherein, the acoustic stimulation deep brain central nucleus nerve regulation: acoustic stimulation signals are transmitted into the auditory meatus through an earphone, converted into electrical stimulation signals through a cochlea and transmitted to a deep brain stimulation central nucleus along an auditory pathway;
the transcranial near-infrared light stimulates the nerve regulation of the superficial cerebral cortex: near infrared light is emitted by the LED lamp holder to stimulate the cortex of the superficial brain region;
transcranial electrical stimulation shallow cortical nerve modulation: micro-current is sent out through an electrical stimulation electrode to stimulate the cortex of the superficial brain region;
performing biofeedback quantitative electroencephalogram detection during, before and/or after stimulation: the electroencephalogram signals are collected in real time through a biofeedback signal collecting electrode, electroencephalogram signal processing is carried out, electroencephalogram signal cross influence of multiple brain areas is analyzed, inquiry and patient information recorded by a neural and psychological scale are combined, the combined stimulation curative effect of multiple physical factors is comprehensively evaluated, and time-frequency-space multi-dimensional stimulation paradigm adjustment and stimulation parameter optimization are guided, wherein the adjustment and the stimulation parameter optimization comprise one or more combinations of sound, light and electrical stimulation intervention sequence, time, waveform, intermittence and intensity parameters, and spatial position selection and alternative transformation among multiple light stimulation lamp heads and/or multiple electrical stimulation electrodes;
processing the electroencephalogram signals: the method comprises the steps that an input biofeedback electroencephalogram signal is amplified, decoded and analyzed through a biofeedback signal acquisition amplifier and a sensor module, electroencephalogram feedback characteristic parameters of treatment effects and treatment times related to a time-frequency space stimulation mode and/or stimulation parameters are obtained, and the electroencephalogram feedback characteristic parameters comprise one or more combinations of electroencephalogram waveforms, brain endogenous oscillation frequency, power spectral density, neural network space topology, related brain neural network statistical attribute parameters and evaluation indexes, so that objective quantitative evaluation is conducted on the stimulation curative effects of multiple physical factors, the pathogenesis of nerve and cognitive dysfunction is analyzed, and the cross influence of objective physiology and subjective psychology between deep brain central nuclei and shallow brain cortex is quantitatively analyzed;
through biofeedback quantitative electroencephalogram detection, the intracerebral oscillation frequency is detected, accurate time sequence logic control and time-frequency-space combined algorithm analysis of intracerebral oscillation and acousto-optic electric stimulation are depicted, and electroencephalogram signal characteristic parameters and a physical stimulation system are fused to form closed-loop feedback so as to guide the rhythm regulation and control of multi-physical-factor multi-modal stimulation;
controlling crosstalk influence between sound, light and electric stimulation signals and electroencephalogram signals collected by a biofeedback electrode within a set acceptable range through a sound, light and electric combined time-frequency-space multi-dimensional stimulation paradigm and regulation and control of stimulation parameters;
the time-frequency-space multi-dimensional regulation of the multi-physical factor stimulation combination comprises one or more combinations of time regulation, frequency regulation and space regulation, wherein the time regulation comprises synchronization, asynchrony and interval of each physical factor stimulation combination; the frequency regulation comprises the matching of the stimulation signal rhythm of each physical factor and the brain endogenous oscillation; the spatial regulation and control comprises acoustic stimulation of multiple central nuclei of deep brain (hypothalamus, thalamus, hippocampus, amygdala and the like), transcranial near-infrared light stimulation of shallow cerebral cortex and/or electric stimulation of shallow cerebral cortex (multi-electrode and multi-LED lamp holder distribution) and associated spatial change control constructed in a three-dimensional cranial nerve network.
In a preferred embodiment of the present invention, the method further comprises the following steps: the method mainly uses acoustic stimulation to regulate deep brain central nucleus nerve, and uses transcranial near infrared light to stimulate shallow cortical nerve regulation and transcranial electrical stimulation to regulate shallow cortical nerve to assist in the intervention of multiple physical factors for non-invasive nerve regulation and treatment of nerve and cognitive dysfunction, so as to form a multiple physical factor combined stimulation scheme, and partially or completely cover the brain functional region in the brain neural network, which is associated with multiple diseases of nerve and cognitive dysfunction.
In a preferred embodiment of the present invention, the method further comprises: implementing individual multi-course accurate multi-physical factor combined stimulation therapy, strengthening multi-physical factor stimulation cooperative regulation function targets, and mobilizing the specificity of electrophysiological signal transmission and filtration of a neural channel and the plasticity and memory function of a neural network, so as to enhance the effectiveness, real-time performance, accuracy and controllability of the time-frequency space-stimulated paradigm neural regulation therapy;
using the system operation unit, according to the electrical signal loss and/or electrical signal disorder occurrence position and/or transmission path found by the individual nerve and cognitive dysfunction disease big data: according to electroencephalogram detection and analysis data, and the sequence, the severity and urgency of multi-disease individualized stimulation treatment and the requirement of treatment period, a time-frequency-space multi-dimensional stimulation paradigm regulation and control algorithm of multi-physical-factor sound, light and electricity combination is formulated, one or more combinations of stimulation parameters and stimulation paradigm modes influencing treatment effects, including sound, light and electric stimulation signal generation and processing, stimulation parameters, electroencephalogram signal processing and analysis, an acousto-optic electric stimulation combination mode, a near-infrared light LED lamp holder position, an electric stimulation electrode position and an electroencephalogram electrode position are controlled in a wired or wireless connection mode, and then the regulation and control process is iterated circularly through patient feedback and/or electroencephalogram detection and analysis in stimulation treatment until an individualized time-frequency-space multi-dimensional stimulation neural regulation and control paradigm with satisfactory treatment effect and a corresponding stimulation parameter optimization combination are found and stored in a patient person, so that the regulation and recovery treatment can be conveniently carried out in a repeated and multi-file treatment process.
The invention has the beneficial effects that: the invention provides a multi-physical factor stimulation nerve regulation and control device and method combining biofeedback, which are used for carrying out time-frequency-space multi-dimensional nerve regulation and control on sound, light and electricity multi-physical factor stimulation combination of deep brain nuclei and shallow brain cortex, and adjusting and optimizing a stimulation paradigm and stimulation parameters by combining objective biofeedback qualitative and quantitative electroencephalogram detection and analysis so as to improve the curative effect and safety of nerve regulation and control and cover more physical intervention treatments of nerve and cognitive dysfunction diseases.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments are briefly introduced below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without inventive efforts, wherein:
FIG. 1 is a schematic diagram of the multi-physical factor neural stimulation device and method of the present invention;
FIG. 2 is a schematic diagram of the operation of a multi-physical factor stimulation neuromodulation device in combination with biofeedback according to the present invention;
FIG. 3 is a time-frequency-space multidimensional stimulation paradigm and stimulation parameter control flow design in a multi-physical factor stimulation neural control method in combination with biofeedback according to the present invention;
figure 4 is a neural and cognitive functional compartmentalization-transcranial light, electrical stimulation shallow cortical target location design.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
Referring to fig. 1 to 4, an embodiment of the present invention includes:
the multi-physical factor stimulation neuromodulation apparatus combining biofeedback as shown in fig. 1 and 2, comprising: the system operation unit is connected with the system control unit in a wireless or wired mode, and stimulation parameters are intelligently controlled. The system operation unit is connected with the system function unit in a wireless or wired mode, adopts one or more of a computer, a smart phone and a smart television, and is flexible to select.
In this embodiment, a brain-computer interface is disposed in the system operation unit, and the stimulation paradigm of the system function unit can be intelligently controlled through the brain-computer interface. In addition, the system operation unit also comprises a remote controller which is communicated with the system control unit and the system function unit in a wireless mode, so that a patient or a technician can conveniently respond and remotely control in the regulation and control process.
The system functional unit comprises a multi-physical-factor stimulation wearable device, the multi-physical-factor stimulation wearable device comprises a deep brain central nucleus module acoustically stimulated through an ear canal, a transcranial near infrared light stimulation shallow cerebral cortex module, a transcranial electrical stimulation shallow cerebral cortex module and a biofeedback signal acquisition electrode, in the embodiment, the transcranial near infrared light stimulation shallow cerebral cortex module adopts an LED lamp holder, the deep brain central nucleus module acoustically stimulated through the ear canal adopts an earphone, and the transcranial electrical stimulation shallow cerebral cortex module adopts an electrical stimulation electrode.
In order to be convenient to wear, the transcranial near-infrared light stimulation superficial cerebral cortex module, the transcranial electrical stimulation superficial cerebral cortex module and the biological feedback signal acquisition electrode are arranged on the electrode cap, the electrode cap is divided into areas according to 52 brain functional areas, and the transcranial near-infrared light stimulation superficial cerebral cortex module, the transcranial electrical stimulation superficial cerebral cortex module and the biological feedback signal acquisition electrode are arranged in the brain functional areas associated with nervous and cognitive disorders.
In addition, the wearable equipment for stimulating by multiple physical factors can be also provided with a battery power supply and a microcomputer, an individualized sound, light and electricity combined stimulation treatment scheme and stimulation parameters stored by a host are transmitted to the microcomputer with a storage function, the microcomputer transmits stimulation signals to an earphone for acoustic stimulation, a near infrared light stimulation LED lamp cap and an electrical stimulation electrode to form complete sound, light and electricity treatment and mobile electroencephalogram acquisition equipment, the wearable equipment is convenient for patients to carry out multi-course treatment rehabilitation at home, treatment implementation records and electroencephalogram feedback information are transmitted to a system operation unit, and a specialist can conveniently regulate and control in time.
The system control unit comprises a controller, a multi-physical factor generator, a signal processing module, a stimulation normal form and parameter control module, the multi-physical factor generator comprises a light stimulation signal generator, an acoustic stimulation signal generator and an electrical stimulation signal generator, and the controller is respectively connected with the multi-physical factor generator, the signal processing module and the stimulation normal form and parameter control module and controls light, sound and electrical stimulation signals.
The signal processing module comprises an acoustic signal regulation and control processing module, a light stimulation signal regulation and control amplification processing module, an electric signal stabilization current-limiting processing module, a biofeedback signal acquisition amplifier and a sensor module, and continuous signal waveform processing and/or intermittent signal pulse processing are carried out on the physical factor signal according to the physical factor characteristic and the physical stimulation intervention treatment requirement.
In this embodiment, the stimulation paradigm and parameter control module includes a light stimulation signal output module, an acoustic stimulation signal output module and an electrical stimulation signal output module, the light stimulation signal generator, the light stimulation signal regulation and amplification processing module and the light stimulation signal output module are sequentially connected in series, the light stimulation signal output module is connected with the transcranial near-infrared light stimulation superficial cortex module in a wired or wireless manner, and the transcranial near-infrared light stimulation superficial cortex module is used for emitting near-infrared light to perform transcranial near-infrared light stimulation on the cortex of the brain functional region.
Transcranial infrared light stimulation parameters: the light wavelength is 700-1000nm, and the optical power density is 30-60 mW/cm 2 10-50mW/cm in normal light state 2 The pulse flicker state of 10Hz and 40Hz reaches 40-150mW/cm 2 The optical power of (a); 4-16 channels, each channel is not lower than 2 near-infrared LED lamp sets of 700-1000nm, and the current is 100 mA/lamp set.
As shown in fig. 2, the acoustic stimulation signal generator, the acoustic signal conditioning and processing module and the acoustic stimulation signal output module are sequentially connected in series, the acoustic stimulation signal output module is connected with the module for acoustically stimulating the central nucleus of the deep brain through the auditory canal in a wired or wireless manner, and the module for acoustically stimulating the central nucleus of the deep brain through the auditory canal produces sound to stimulate the central nucleus through the auditory canal.
Acoustic stimulation parameters include hearing: -10dB HL-120dB HL, 25Hz-20000 Hz; masking noise: 100 Hz-10000Hz, 0dB HL-110 dB HL; the number of channels on each ear side is 4-12; the audio signals of each channel comprise pure tone, pulse pure tone, gaussian noise, speech noise, twitter tone, uniform noise and the like.
In the embodiment, the electrical stimulation signal generator, the electrical signal stabilization current-limiting processing module and the electrical stimulation signal output module are sequentially connected in series, the electrical stimulation signal output module is connected with the transcranial electrical stimulation shallow cerebral cortex module in a wired or wireless mode, and micro current is emitted through the transcranial electrical stimulation shallow cerebral cortex module to perform transcranial electrical stimulation on the cortex of the brain functional region.
Transcranial electrical stimulation parameters include: the current is from-3 mA to 3mA, the pulse frequency is 0-200Hz, and the number of channels is not less than 2.
The biofeedback signal acquisition electrode is connected with the biofeedback signal acquisition amplifier and the sensor module in a wired or wireless mode, and the biofeedback signal acquisition amplifier and the sensor module are connected with the controller to carry out electroencephalogram detection. In addition, the electrical stimulation signal output module is connected with the controller and used for monitoring the output electrical stimulation signals.
The electroencephalogram detection parameters comprise: the sampling rate is 1.6-2.4kHz, the input noise is not more than 1 mu Vp-p, and the input impedance is not less than 400M omega; the synchronous precision of the stimulation regulation and control equipment and the electroencephalogram detection equipment is not more than 1.5ms.
In this embodiment, the controller includes a master control MCU and a slave control MCU connected to each other, the master control MCU is respectively connected to the acoustic stimulation signal generator, the optical stimulation signal generator, the electrical stimulation signal generator, and the system operation unit, and provides a current with a required parameter, and supplies a specific power supply required for signal generation to the multi-physical factor generator, so as to control a stable current parameter required by the multi-physical factor generator. The main control MCU adopts a low-power consumption CMOS microcontroller based on AVR, has an enhanced RISC system structure, realizes the throughput close to MHz1MIPS by quickly executing a plurality of instructions in a single clock period, and has low power consumption and ultra-fast processing speed.
And the slave control MCU is respectively connected with the electrical stimulation signal generator, the biological feedback signal acquisition amplifier and the sensor module. The transcranial direct current stimulation needs to adopt high-precision resistors to form a resistor network to output a tiny constant current source, and the added slave control MCU is used for ensuring the stability and fidelity of real-time output waveforms of the resistor network.
As shown in fig. 3, a method for stimulating nerve regulation by multiple physical factors in combination with biofeedback includes the following steps:
implementing time-frequency-space multi-dimensional regulation of single physical factor stimulation and/or multi-physical factor stimulation combination of sound, light and electric stimulation, and performing acoustic stimulation deep brain central nucleus nerve regulation, transcranial near infrared light stimulation shallow cortical brain nerve regulation and transcranial electric stimulation shallow cortical brain nerve regulation;
wherein, the acoustic stimulation deep brain central nucleus nerve regulation: acoustic stimulation signals are transmitted into the auditory meatus through an earphone, converted into electrical stimulation signals through a cochlea and transmitted to a deep brain stimulation central nucleus along an auditory pathway;
the transcranial near-infrared light stimulates the nerve regulation of the superficial cerebral cortex: near infrared light is emitted by the LED lamp holder to stimulate the cortex of the superficial cerebral region;
transcranial electrical stimulation shallow cortical nerve modulation: micro-current is sent out through an electrical stimulation electrode to stimulate the cortex of the superficial brain region;
the method mainly uses acoustic stimulation to regulate deep brain central nucleus nerve, and uses transcranial near infrared light to stimulate shallow cortical nerve regulation and transcranial electrical stimulation to regulate shallow cortical nerve to assist in the intervention of multiple physical factors for non-invasive nerve regulation and treatment of nerve and cognitive dysfunction, so as to form a multiple physical factor combined stimulation scheme, and partially or completely cover the brain functional region in the brain neural network, which is associated with multiple diseases of nerve and cognitive dysfunction.
Performing biofeedback quantitative electroencephalogram detection during, before and/or after stimulation: collecting electroencephalogram signals in real time through a biofeedback signal collecting electrode, processing the electroencephalogram signals, analyzing the cross influence of the electroencephalogram signals of multiple brain areas, comprehensively evaluating the combined stimulation curative effect of multiple physical factors by combining patient information recorded by inquiry and a neural and psychological scale, and guiding the adjustment of a time-frequency-space multi-dimensional stimulation paradigm and the optimization of stimulation parameters, wherein the adjustment of the time-frequency-space multi-dimensional stimulation paradigm and the optimization of the stimulation parameters comprise one or more of sound, light, electrical stimulation intervention sequence, time, waveform, intermittence and intensity parameters, and the selection and the alternate transformation of spatial positions among multiple light stimulation lamp holders and/or multiple electrical stimulation electrodes;
processing the electroencephalogram signals: the method comprises the steps that an input biofeedback electroencephalogram signal is amplified, decoded and analyzed through a biofeedback signal acquisition amplifier and a sensor module, electroencephalogram feedback characteristic parameters of treatment effects and treatment times related to a time-frequency space stimulation mode and/or stimulation parameters are obtained, and the electroencephalogram feedback characteristic parameters comprise one or more combinations of electroencephalogram waveforms, brain endogenous oscillation frequency, power spectral density, neural network space topology, related brain neural network statistical attribute parameters and evaluation indexes, so that objective quantitative evaluation is conducted on the stimulation curative effects of multiple physical factors, the pathogenesis of nerve and cognitive dysfunction is analyzed, and the cross influence of objective physiology and subjective psychology between deep brain central nuclei and shallow brain cortex is quantitatively analyzed;
through biofeedback quantitative electroencephalogram detection, the intracerebral oscillation frequency is detected, accurate time sequence logic control and time-frequency-space joint algorithm analysis of intracerebral oscillation and acousto-optic electric stimulation are depicted, and electroencephalogram signal characteristic parameters and a physical stimulation system are fused to form closed-loop feedback so as to guide rhythm regulation and control of multi-physical-factor multi-modal stimulation;
through the regulation and control of a time-frequency-space multi-dimensional stimulation paradigm of sound, light and electricity combination and stimulation parameters, the crosstalk influence between sound, light and electric stimulation signals and electroencephalogram signals collected by a biofeedback electrode is controlled within a set acceptable range, such as less than 5%;
the time-frequency-space multi-dimensional regulation and control of the multi-physical-factor stimulation combination comprises one or more combinations of time regulation and control, frequency regulation and control and space regulation and control, wherein the time regulation and control comprises synchronization, asynchronization and interval of each physical-factor stimulation combination; the frequency regulation comprises the matching of the stimulation signal rhythm of each physical factor and the brain endogenous oscillation; the spatial regulation and control comprises acoustic stimulation of a plurality of central nuclei of deep brain (hypothalamus, thalamus, hippocampus, amygdala and the like), transcranial near-infrared light stimulation of shallow cerebral cortex and/or electrical stimulation of shallow cerebral cortex (multi-electrode and multi-LED lamp head distribution) and associated spatial variation control constructed in a three-dimensional cranial nerve network;
implementing individual multi-course accurate multi-physical factor combined stimulation therapy, strengthening multi-physical factor stimulation cooperative regulation function targets, and mobilizing the specificity of electrophysiological signal transmission and filtration of a neural channel and the plasticity and memory function of a neural network, so as to enhance the effectiveness, real-time performance, accuracy and controllability of time-frequency space-stimulation paradigm nerve regulation therapy;
using the system operating unit, the locations and/or transmission pathways of the electrical signal deletions and/or electrical signal disorders found from the individualized neurological and cognitive dysfunction disorder big data: according to the electroencephalogram detection and analysis data, the sequence, the severity and urgency of multi-disease individualized stimulation treatment and the treatment period requirements of the multi-disease individualized stimulation treatment, a time-frequency-space multi-dimensional stimulation paradigm regulation and a stimulation parameter interactive regulation algorithm of multi-physical-factor sound, light and electricity combination are formulated, one or more combinations of stimulation parameters and stimulation paradigm modes influencing treatment effects, including sound, light and electric stimulation signal generation and processing, stimulation parameters, electroencephalogram signal processing and analysis, an acousto-optic electric stimulation combination mode, a near infrared light LED lamp holder position, an electric stimulation electrode position and an electroencephalogram electrode position are controlled in a wired or wireless connection mode, and the regulation and control process is iterated through patient feedback and/or electroencephalogram detection and analysis in stimulation treatment until the individualized time-frequency-space multi-dimensional stimulation neural regulation and control paradigm with satisfactory treatment effects and the corresponding stimulation parameter optimization combination are found and stored in a patient person, so that the individual multi-file rehabilitation treatment and multi-course rehabilitation can be called conveniently.
Example (b):
patients with tinnitus, sleep anxiety syndrome, age 52 and female, complain about tinnitus for three years, continuous cicada sound, poor sleep, dysphoria and inability to concentrate on work;
and (3) detection:
hearing threshold detection starts from 4000Hz-35 dB and hearing drops to 8000 Hz-65 dB, tinnitus detection tinnitus dominant frequency is 4000Hz, tinnitus loudness is 60dB HL (belongs to moderate and severe hearing loss), an international tinnitus severity scale THI is adopted for evaluation for 72 points (belongs to severe tinnitus grade 4 and 58-76 points), a Pittsburgh sleep quality index PSQI scale is adopted for evaluation for 7 points (the index is more than or equal to 5 indicates that sleep quality problems exist), and anxiety is evaluated from an SAS number scale for 70 points (the index is more than or equal to 70 indicates severe);
the preparation of a multi-physical factor stimulation scheme:
adopting 8 channels at each ear side and three frequency points of 3800Hz, 4000Hz and 4200Hz, formulating amplitude modulation and Gaussian noise composite sound within the range of 55dB to 65dB, superposing background relaxing sound waves of 3Hz to 6Hz, flattening 10 percent of wave crest and waveform processing of 1S to 5S waveform intermittence, and forming an individualized acoustic stimulation scheme;
in the neural and cognitive function cortical network-transcranial photoelectric stimulation superficial cortex target point design (overlook) of fig. 4, four positions of Pz, cz, F8 and Fp1 are selected to be subjected to transcranial infrared light stimulation;
selecting four positions of P3, T6, T4 and FP2 to do transcranial direct current stimulation;
transcranial infrared light stimulation parameters include: the light wavelength is 700-900nm, and the optical power density is 30-60 mW/cm 2 10-50mW/cm in normal light state 2 The pulse flicker state of 10Hz and 40Hz reaches 40-150mW/cm 2 The optical power of (a); 4-8 channels, 2 LED lamp groups per channel, and 100 mA/lamp group current; transcranial electrical stimulation parameters include: the current is-3 mA to 3mA, the pulse frequency is 80-160Hz, and 2 channels are adopted.
Stimulating for 10 minutes by sound, light and electricity synchronously in a stimulating sequence, reducing the volume of the single sound stimulation by 20 percent for stimulating for 5 minutes, alternately stimulating for 5 minutes by light and electricity combination, and reducing the intensity of the sound, light and electricity synchronously by 10 percent for stimulating for 10 minutes;
and (3) comparing the curative effects: a single acoustic stimulus can improve tinnitus by about 60%, sleep by about 20%, anxiety by about 10%; single transcranial direct current stimulation can improve tinnitus by about 15%, and sleep and anxiety are both less than 10%; single transcranial infrared light stimulation can improve tinnitus, sleep and anxiety by less than 10%; through combined stimulation of sound, light and electricity, the tinnitus can be improved by more than 80%, and the sleep and anxiety can be improved by more than 60%, so that the effect is obvious.
In conclusion, the multi-physical factor nerve stimulation regulation and control device and method combining biofeedback provided by the invention can be used for performing time-frequency-space multi-dimensional stimulation of multiple physical factors, realizing nerve regulation and biological feedback, fusing the characteristic parameters of electroencephalogram signals and a physical stimulation system to form closed-loop feedback, limiting stimulation in the range which brain nerves can bear, and ensuring operation safety while improving curative effect.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, or direct or indirect applications in other related fields, which are made by the contents of the present specification, are included in the scope of the present invention.
Claims (10)
1. A multi-physical-factor stimulatory neuromodulation device that incorporates biofeedback, comprising: the system comprises a system operation unit, a system control unit and a system function unit, wherein the system function unit comprises a wearable device stimulated by multiple physical factors, the wearable device stimulated by multiple physical factors comprises a deep brain central nucleus module acoustically stimulated by auditory meatus, a transcranial near infrared light stimulation shallow brain cortex module, a transcranial electrical stimulation shallow brain cortex module and a biological feedback signal acquisition electrode, the system control unit comprises a controller, a multiple physical factor generator, a signal processing module and a stimulation paradigm and parameter control module, the multiple physical factor generator comprises a light stimulation signal generator, an acoustic stimulation signal generator and an electrical stimulation signal generator, the signal processing module comprises an acoustic signal regulation and control processing module, a light stimulation signal regulation and amplification processing module, an electrical signal stabilization current-limiting processing module and a biological feedback signal acquisition amplifier and sensor module, according to the physical factor characteristics and the physical stimulation intervention treatment requirements, continuous signal waveform processing and/or intermittent signal pulse processing are carried out on physical factor signals, the stimulation paradigm and parameter control module comprises a light stimulation signal output module, an acoustic stimulation signal output module and an electric stimulation signal output module, the controller is respectively connected with a multi-physical factor generator, a signal processing module and a stimulation paradigm and parameter control module, the light stimulation signal generator, the light stimulation signal regulation and amplification processing module and the light stimulation signal output module are sequentially connected in series, the light stimulation signal output module is connected with the transcranial near infrared light stimulation superficial cerebral cortex module in a wired or wireless mode, the acoustic stimulation signal generator, the acoustic signal regulation and processing module and the acoustic stimulation signal output module are sequentially connected in series, the system comprises an acoustic stimulation signal output module, an electrical stimulation signal generator, an electrical signal stabilizing and current limiting processing module, an electrical stimulation signal output module, a transcranial electrical stimulation shallow cerebral cortex module, a biofeedback signal acquisition electrode, a biofeedback signal acquisition amplifier and a sensor module, wherein the acoustic stimulation signal output module is connected with the deep brain central nucleus module acoustically stimulated through an ear canal in a wired or wireless mode, the electrical stimulation signal generator, the electrical signal stabilizing and current limiting processing module are sequentially connected with the electrical stimulation signal output module in series, the electrical stimulation signal output module is connected with the transcranial electrical stimulation shallow cerebral cortex module in a wired or wireless mode, the biofeedback signal acquisition electrode is connected with the biofeedback signal acquisition amplifier and the sensor module in a wired or wireless mode, the biofeedback signal acquisition amplifier and the sensor module are connected with a controller, a system operation unit is connected with a system control unit in a wireless or wired mode, and the system operation unit is connected with a system function unit in a wireless or wired mode.
2. The biofeedback-combined multi-physical factor stimulation neuromodulation device as claimed in claim 1, wherein the ear canal acoustic stimulation deep brain central nucleus module employs an earphone, the transcranial near infrared light stimulation shallow cortex module employs an LED lamp cap, and the transcranial electrical stimulation shallow cortex module employs an electrical stimulation electrode.
3. The device for regulating nerve stimulation by multiple physical factors combined with biofeedback according to claim 1, wherein a brain-computer interface is provided in the system operation unit.
4. The biofeedback-combined multi-physical-factor stimulation nerve regulation device as claimed in claim 1, further comprising an electrode cap, wherein the transcranial near infrared light stimulation superficial cerebral cortex module, the transcranial electrical stimulation superficial cerebral cortex module and the biofeedback signal acquisition electrode are arranged on the electrode cap.
5. The device for regulating and controlling nerve stimulation by multiple physical factors combined with biofeedback according to claim 1, wherein the system operation unit is one or more of a computer, a smart phone and a smart television.
6. The apparatus as claimed in claim 5, wherein the system operation unit further comprises a remote controller for communicating with the system control unit and the system function unit in a wireless manner.
7. The multi-physical-factor nerve stimulation regulation and control device combining biofeedback of claim 1, wherein the controller comprises a master control MCU and a slave control MCU which are connected, the master control MCU is respectively connected with an acoustic stimulation signal generator, an optical stimulation signal generator, an electrical stimulation signal generator and a system operation unit to provide currents with required parameters, and the slave control MCU is respectively connected with the electrical stimulation signal generator, a biofeedback signal acquisition amplifier and a sensor module to improve stability and fidelity of waveforms of micro constant current signals output by a high-precision resistance network in an electrical stimulation loop.
8. A multi-physical-factor nerve stimulation and control method combined with biofeedback adopts the multi-physical-factor nerve stimulation and control device combined with biofeedback of any one of claims 1 to 7, and is characterized by comprising the following steps:
the multi-physical factor stimulation respectively adopts one level or a combination of a plurality of levels in three levels of signal processing methods:
the first level is the modulation of the frequency, amplitude and phase angle of the single-channel continuous signal;
the second level is a multi-channel synthesis of continuous signals and/or pulse signals;
the third level is that each physical stimulation signal is respectively input into a waveform generator, the waveform generator generates a certain waveform according to a demand instruction, and a stimulation signal with a given waveform is output;
implementing time-frequency-space multi-dimensional regulation of single physical factor stimulation and/or multi-physical factor stimulation combination of sound, light and electric stimulation, and performing acoustic stimulation deep brain central nucleus nerve regulation, transcranial near infrared light stimulation shallow cortical brain nerve regulation and transcranial electric stimulation shallow cortical brain nerve regulation;
wherein, acoustically stimulating deep brain central nucleus nerve regulation: acoustic stimulation signals are transmitted into the auditory meatus through an earphone, converted into electrical stimulation signals through a cochlea and transmitted to a deep brain stimulation central nucleus along an auditory pathway;
the transcranial near infrared light stimulates the nerve regulation of the superficial cerebral cortex: near infrared light is emitted by the LED lamp holder to stimulate the cortex of the superficial brain region;
transcranial electrical stimulation shallow cortical nerve modulation: micro-current is sent out through an electrical stimulation electrode to stimulate the cortex of the superficial brain region;
performing biofeedback quantitative electroencephalogram detection during, before and/or after stimulation: collecting electroencephalogram signals in real time through a biofeedback signal collecting electrode, processing the electroencephalogram signals, analyzing the cross influence of the electroencephalogram signals of multiple brain areas, comprehensively evaluating the combined stimulation curative effect of multiple physical factors by combining patient information recorded by inquiry and a neural and psychological scale, and guiding the adjustment of a time-frequency-space multi-dimensional stimulation paradigm and the optimization of stimulation parameters, wherein the adjustment of the time-frequency-space multi-dimensional stimulation paradigm and the optimization of the stimulation parameters comprise one or more of sound, light, electrical stimulation intervention sequence, time, waveform, intermittence and intensity parameters, and the selection and the alternate transformation of spatial positions among multiple light stimulation lamp holders and/or multiple electrical stimulation electrodes;
processing the electroencephalogram signals: the method comprises the steps that an input biofeedback electroencephalogram signal is amplified, decoded and analyzed through a biofeedback signal acquisition amplifier and a sensor module, electroencephalogram feedback characteristic parameters related to treatment effects and treatment times and time-frequency space stimulation modes and/or stimulation parameters are obtained, and the electroencephalogram feedback characteristic parameters comprise one or more combinations of electroencephalogram waveforms, brain endogenous oscillation frequency, power spectral density, neural network space topology, related cerebral neural network statistical attribute parameters and evaluation indexes, so that objective quantitative evaluation is performed on the stimulation effects of multiple physical factors, the pathogenesis of nerve and cognitive dysfunction is analyzed, and the cross influence of objective physiology and subjective psychology between deep brain central nuclei and shallow brain cortex is quantitatively analyzed;
through biofeedback quantitative electroencephalogram detection, the intracerebral oscillation frequency is detected, accurate time sequence logic control and time-frequency-space combined algorithm analysis of intracerebral oscillation and acousto-optic electric stimulation are depicted, and electroencephalogram signal characteristic parameters and a physical stimulation system are fused to form closed-loop feedback so as to guide the rhythm regulation and control of multi-physical-factor multi-modal stimulation;
controlling the crosstalk influence between sound, light and electric stimulation signals and electroencephalogram signals collected by a biofeedback electrode within a set acceptable range through the regulation and control of a sound, light and electric combined time-frequency-space multi-dimensional stimulation paradigm and stimulation parameters;
the time-frequency-space multi-dimensional regulation and control of the multi-physical-factor stimulation combination comprises one or more of time regulation and control, frequency regulation and control and space regulation and control, wherein the time regulation and control comprises synchronization, asynchronization and interval of the physical-factor stimulation combination, the frequency regulation and control comprises matching or isolation of the stimulation signal rhythm of each physical factor and brain endogenous oscillation, and the space regulation and control comprises acoustic stimulation of a plurality of central nuclei of the deep brain, transcranial near infrared light stimulation of a plurality of superficial cerebral cortex and/or transcranial electrical stimulation of a plurality of superficial cerebral cortex and associated space change control constructed in a three-dimensional cranial nerve network.
9. The method of claim 8, further comprising the steps of: the method mainly performs acoustic stimulation on deep brain central nucleus nerve regulation and control, and performs nerve and cognitive dysfunction multi-physical factor intervention non-invasive nerve regulation and control treatment with transcranial near infrared light stimulation on shallow cortical nerve regulation and control and transcranial electrical stimulation on shallow cortical nerve regulation and control as assistance to form a multi-physical factor combined stimulation scheme, and partially or completely covers a brain functional region associated with multiple diseases of nerve and cognitive dysfunction in a brain neural network.
10. The method of claim 8, further comprising: implementing individual multi-course accurate multi-physical factor combined stimulation therapy, strengthening multi-physical factor stimulation cooperative regulation function targets, and mobilizing the specificity of electrophysiological signal transmission and filtration of a neural channel and the plasticity and memory function of a neural network, so as to enhance the effectiveness, real-time performance, accuracy and controllability of the time-frequency space-stimulated paradigm neural regulation therapy;
using the system operation unit, according to the electrical signal loss and/or electrical signal disorder occurrence position and/or transmission path found by the individual nerve and cognitive dysfunction disease big data: according to electroencephalogram detection and analysis data, and the sequence, the severity and urgency of multi-disease individualized stimulation treatment and the requirement of treatment period, a time-frequency-space multi-dimensional stimulation paradigm regulation and control algorithm of multi-physical-factor sound, light and electricity combination is formulated, one or more combinations of stimulation parameters and stimulation paradigm modes influencing treatment effects, including sound, light and electric stimulation signal generation and processing, stimulation parameters, electroencephalogram signal processing and analysis, an acousto-optic electric stimulation combination mode, a near-infrared light LED lamp holder position, an electric stimulation electrode position and an electroencephalogram electrode position are controlled in a wired or wireless connection mode, and then the regulation and control process is iterated circularly through patient feedback and/or electroencephalogram detection and analysis in stimulation treatment until an individualized time-frequency-space multi-dimensional stimulation neural regulation and control paradigm with satisfactory treatment effect and a corresponding stimulation parameter optimization combination are found and stored in a patient person, so that the regulation and recovery treatment can be conveniently carried out in a repeated and multi-file treatment process.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116492597A (en) * | 2023-06-28 | 2023-07-28 | 南昌大学第一附属医院 | Peripheral-central nerve regulation and control device and storage medium |
| CN117281994A (en) * | 2023-11-14 | 2023-12-26 | 北京理工大学 | Closed-loop time interference acousto-electric regulation system and method based on acoustic stimulation navigation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116492597A (en) * | 2023-06-28 | 2023-07-28 | 南昌大学第一附属医院 | Peripheral-central nerve regulation and control device and storage medium |
| CN116492597B (en) * | 2023-06-28 | 2023-11-24 | 南昌大学第一附属医院 | Peripheral-central nerve regulation and control device and storage medium |
| CN117281994A (en) * | 2023-11-14 | 2023-12-26 | 北京理工大学 | Closed-loop time interference acousto-electric regulation system and method based on acoustic stimulation navigation |
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