CN102457252A - Dual channel pulse generator and implantable electrical stimulation system - Google Patents
Dual channel pulse generator and implantable electrical stimulation system Download PDFInfo
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- CN102457252A CN102457252A CN2010105172792A CN201010517279A CN102457252A CN 102457252 A CN102457252 A CN 102457252A CN 2010105172792 A CN2010105172792 A CN 2010105172792A CN 201010517279 A CN201010517279 A CN 201010517279A CN 102457252 A CN102457252 A CN 102457252A
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- 230000000638 stimulation Effects 0.000 title claims abstract description 62
- 230000009977 dual effect Effects 0.000 title abstract 4
- 210000004556 brain Anatomy 0.000 claims abstract description 11
- 238000004088 simulation Methods 0.000 claims abstract description 6
- 238000004891 communication Methods 0.000 claims description 37
- 230000003278 mimic effect Effects 0.000 claims description 24
- 210000005036 nerve Anatomy 0.000 claims description 15
- 230000000747 cardiac effect Effects 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 210000000278 spinal cord Anatomy 0.000 claims description 3
- 210000001186 vagus nerve Anatomy 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 230000001537 neural effect Effects 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 abstract description 2
- 230000005540 biological transmission Effects 0.000 description 5
- 238000002513 implantation Methods 0.000 description 5
- 239000007943 implant Substances 0.000 description 4
- 230000004007 neuromodulation Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 2
- 208000035126 Facies Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000006870 function Effects 0.000 description 1
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- 230000000630 rising effect Effects 0.000 description 1
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Abstract
The invention discloses a dual channel pulse generator that comprises a microprocessor module and a dual channel electrical stimulation circuit module. The microprocessor module is used for receiving a regulation and control command emitted by an external program controller and transmitting the regulation and control command to the electrical stimulation circuit module. And the electrical stimulation circuit module includes a first stimulation pulse output channel and a second simulation pulse output channel, wherein the two stimulation pulse output channels are capable of realizing independent regulation and control output respectively. Compared with the prior art, the technology employed in the invention enables an electrical stimulation digital-analog mixing chip to carry out processing on a regulation and control command sent by an external program controller; and a first stimulation pulse output channel and a second stimulation pulse output channel are used to realize independent regulation and control output; therefore, a doctor can independently carry out regulation and control on stimulation output of two channels of a dual channel pulse generator, wherein the stimulation output includes frequencies, pulse widths, amplitudes and stimulation modes and the like, so that neural regulation and control of left and right sides of a brain of a patient can reach an optimal effect.
Description
Technical field
The present invention relates to implantable medical devices, especially the pulse generator and the implantation type electric stimulation system of the independent adjustable output of binary channels.
Background technology
In the prior art, implantation type electric stimulation system and implanted delivery system have obtained application more and more widely as treatment or prophylactic a kind of means.Implantation type electric stimulation system generally includes implantable cardiac electric stimulation (being commonly called as cardiac pacemaker) and implantable nerve electric stimulation, mainly comprises the pulse generator, electrode and the external control device that implant.Wherein, Pulse generator is connected with electrode; Thereby the burst transmissions that pulse generator produced is arrived electrode, and the pulse signal that pulse generator produces transfers to heart by electrode or electrostimulation is carried out at specific neural position, thereby makes function of human body return to the state of normal operation.
Known implantable nerve electric stimulation mainly comprises pulse generator, electrode, extension wire and external control device usually.Wherein, pulse generator is connected with extension wire, extension wire and then be connected to electrode again, thereby with burst transmissions that pulse generator produced to electrode, so that nerve is carried out electrostimulation.
Implanted binary channels pulse generator is meant that pulse generator has two-way and stimulates output respectively the brain left and right sides to be stimulated, and realizes result of treatment.The frequency of stimulation of two passages of binary channels pulse generator of the prior art must be identical; Can't regulate and control respectively; Research shows that the brain left and right sides uses the stimulus modality effect of same frequency undesirable; Therefore how to realize the binary channels pulse generator all stimulation parameters (comprising frequency, pulsewidth, amplitude and stimulus modality) but all independent regulation control, making the neuromodulation of the brain left and right sides reach optimal effectiveness is problem demanding prompt solution.
Summary of the invention
To the deficiency that exists in the prior art, the technical problem that the present invention will solve provides a kind of two passages that can the paired pulses generator and realizes the binary channels pulse generator and the implantation type electric stimulation system of independent regulation control respectively.
According to technical scheme provided by the present invention; A kind of binary channels pulse generator; Comprise microprocessor module and binary channels electrical stimulation circuit module; Said microprocessor module is used to receive the regulation and control order that vitro program controlled device sends and sends said electrical stimulation circuit module to, and said electrical stimulation circuit module comprises the first boost pulse output channel and the second boost pulse output channel that can distinguish independent regulation and control output.
Preferably, said binary channels electrical stimulation circuit module is a binary channels electrostimulation digital-to-analogue hybrid chip.
Preferably, the said regulation and control of independence respectively output comprises frequency, pulsewidth, amplitude, the stimulus modality of boost pulse.
Preferably, described microprocessor module comprises CPU, memory, first communication module;
Said electrostimulation digital-to-analogue hybrid chip comprises second communication module that is connected with said first communication module through communication bus;
The said first boost pulse output channel comprises first passage register-stored module, first passage digital pulse generator, first passage mimic pulse generator, the first passage output control module that is connected successively with said second communication module;
The said second boost pulse output channel comprises second channel register-stored module, second channel digital pulse generator, second channel mimic pulse generator, the second channel output control module that is connected successively with said second communication module.
Preferably, said electrostimulation digital-to-analogue hybrid chip comprises that being used to produce independent regulatable numeral stimulates the digital circuit blocks of adjustment signal output to stimulate adjustment signal to convert the analog module of simulation stimulus signal output into above-mentioned numeral with being used for;
Said digital circuit blocks comprises described second communication module; First passage register-stored module that is connected with said second communication module and second channel register-stored module; Be connected with said first passage register-stored module and be used to produce the first passage assigned frequency; Pulsewidth; The first passage digital pulse generator of amplitude and stimulus modality; Be connected with said second channel register-stored module and be used to produce the second channel assigned frequency; Pulsewidth; The second channel digital pulse generator of amplitude and stimulus modality;
Said analog module comprises the first passage mimic pulse generator that is connected with said first passage digital pulse generator, the second channel mimic pulse generator that is connected with said second channel digital pulse generator, the first passage output control module that is connected with said first passage mimic pulse generator, the second channel output control module that is connected with said second channel mimic pulse generator.
Preferably, the stimulus modality of described appointment is the continued stimulus pattern, bunch sends out stimulus modality, a kind of in stimulus modality, motion stimulus modality, the soft stimulus modality regularly.
The invention provides a kind of implantable nerve electric stimulation that comprises aforesaid binary channels pulse generator.
Preferably, said implantable nerve electric stimulation is a kind of in implanted brain deep electric stimulation, implanted cortex electric stimulation, implanted spinal cord stimulation trial system, implanted sacral nerve electric stimulation or the implanted vagus nerve electric stimulation.
The present invention also provides a kind of implantable cardiac pacing system and implantable cardiac conversion defibrillation system, comprises aforesaid binary channels pulse generator, and two of the paired pulses generator passages carry out independent regulation control respectively.
Advantage compared with prior art of the present invention is: because electrostimulation digital-to-analogue hybrid chip of the present invention comprises the first boost pulse output channel and the second boost pulse output channel that can distinguish independent regulation and control output; Make electrostimulation digital-to-analogue hybrid chip to handle to the regulation and control order of the transmission of vitro program controlled device; Realize independently regulation and control output through the first boost pulse output channel and the second boost pulse output channel respectively; Realize that the doctor can be independent adjustable to the stimulation output (frequency, pulsewidth, amplitude and stimulus modality) of two passages of binary channels pulse generator, make the neuromodulation of patient's brain left and right sides reach optimal effectiveness.
Description of drawings
Accompanying drawing 1 is module principle figure of the present invention;
Accompanying drawing 2 is the module principle figure of pulse generator of the present invention;
Accompanying drawing 3 is the module principle figure of microprocessor chip of the present invention and electrostimulation digital-to-analogue hybrid chip.
Wherein:
1, pulse generator; 11, microprocessor chip; 111, first communication module; 12, electrostimulation digital-to-analogue hybrid chip; 121, second communication module; 122, first passage register-stored module; 123, first passage digital pulse generator; 124, first passage mimic pulse generator; 125, first passage output control module; 126, second channel register-stored module; 127, second channel digital pulse generator; 128, second channel mimic pulse generator; 129, second channel output control module; 13, wireless communication module; 14, power supply; 15, the first boost pulse output channel; 16, the second boost pulse output channel; 17, digital circuit blocks; 18, analog module; 2, electrode; 3, vitro program controlled device.
Embodiment
Below in conjunction with accompanying drawing the present invention is done further detailed explanation:
With reference to Fig. 1, the independent regulatable implantable nerve electric stimulation of a kind of binary channels comprises pulse generator 1, electrode 2, vitro program controlled device 3 in the implant patient body.Pulse generator 1 is electrically connected with electrode 2, thereby the burst transmissions that pulse generator 1 is produced is arrived electrode 2, so that neuronal target is carried out electrostimulation, reaches the effect of treatment.Vitro program controlled device 3 can communicate through solenoid or wireless communication module with pulse generator 1, thus the various output parameters of regulating impulse generator 1.
With reference to Fig. 2; With the independent regulatable implanted brain of binary channels deep electric stimulation is example; Comprise binary channels pulse generator 1 in the facies sternocostalis hypodermis of implant patient, implant the electrode 2 that is connected with pulse generator 1 in brain deep, electrical stimulation circuit module, the wireless communication module 13 that pulse generator 1 comprises microprocessor module, be connected with microprocessor module and be the power supply 14 of above-mentioned module for power supply.
Said microprocessor module is used to receive the regulation and control order that vitro program controlled device sends and sends said electrical stimulation circuit module to, and said electrical stimulation circuit module comprises the first boost pulse output channel 15 and the second boost pulse output channel 16 that can distinguish independent regulation and control output.In this execution mode, said microprocessor module is a microprocessor chip 11, and said binary channels electrical stimulation circuit module is a binary channels electrostimulation digital-to-analogue hybrid chip 12.
The output that the first boost pulse output channel 15 and the second boost pulse output channel 16 can independently be regulated and control respectively comprises frequency, pulsewidth, amplitude, the stimulus modality of boost pulse.The output parameter of the first boost pulse output channel 15 and the second boost pulse output channel 16 can be identical also can be different.
With reference to Fig. 3, described microprocessor module comprises CPU, memory, first communication module 111, and said electrostimulation digital-to-analogue hybrid chip 12 comprises second communication module 121 that is connected with said first communication module 111 through communication bus.
The said first boost pulse output channel 15 comprises first passage register-stored module 122, first passage digital pulse generator 123, first passage mimic pulse generator 124, the first passage output control module 125 that is connected successively with said second communication module 121.
The said second boost pulse output channel 16 comprises second channel register-stored module 126, second channel digital pulse generator 127, second channel mimic pulse generator 128, the second channel output control module 129 that is connected successively with said second communication module 121.
First communication module 111 is the SPI sending module in this execution mode, and second communication module 121 is the SPI receiver module, and the SPI sending module is connected through spi bus with the SPI receiver module and is used for the serial both-way communication.In all the other execution modes, can use other bus communication modes to realize the communication of microprocessor chip 11 and electrostimulation digital-to-analogue hybrid chip 12.
Said electrostimulation digital-to-analogue hybrid chip 12 comprises that being used to produce independent regulatable numeral stimulates the digital circuit blocks 17 of adjustment signal output to stimulate adjustment signal to convert the analog module 18 of simulation stimulus signal output into above-mentioned numeral with being used for.
Said digital circuit blocks 17 comprises described second communication module 121; The first passage register-stored module 122 and the second channel register-stored module 126 that are connected with said second communication module 121; Be connected with said first passage register-stored module 122 and be used to produce the first passage assigned frequency; Pulsewidth; The first passage digital pulse generator 123 of amplitude and stimulus modality; Be connected with said second channel register-stored module 126 and be used to produce the second channel assigned frequency; Pulsewidth; The second channel digital pulse generator 127 of amplitude and stimulus modality;
Said analog module 18 comprises the first passage mimic pulse generator 124 that is connected with said first passage digital pulse generator 123, the second channel mimic pulse generator 128 that is connected with said second channel digital pulse generator 127, the first passage output control module 125 that is connected with said first passage mimic pulse generator 124, the second channel output control module 129 that is connected with said second channel mimic pulse generator 128.
The stimulus modality of described appointment is the continued stimulus pattern, bunch send out stimulus modality, a kind of in stimulus modality, motion stimulus modality, the soft stimulus modality regularly.Said timing stimulus modality is meant the opening and closing state that can in the time interval of program setting, have stimulation programs in the circulation nerve stimulator; Soft stimulus modality is meant can soft unlatching and soft stopping; Promptly allow the value of the slow rising of pulse amplitude when stimulating, when stimulation is closed, allow pulse amplitude slowly to be reduced to 0 up to the permission of program setting when opening.
The invention provides a kind of implantable nerve electric stimulation that comprises the independent regulatable pulse generator of aforesaid binary channels.Different said implantable nerve electric stimulation according to the treatment disease can be a kind of in implanted brain deep electric stimulation, implanted cortex electric stimulation, implanted spinal cord stimulation trial system, implanted sacral nerve electric stimulation or the implanted vagus nerve electric stimulation.
The present invention also provides a kind of implantable cardiac pacing system and implantable cardiac conversion defibrillation system, comprises aforesaid binary channels pulse generator, and two of the paired pulses generator passages carry out independent regulation control respectively.
But use the pulse generator of the independent independent regulation control of binary channels of the present invention output; The doctor can will regulate and control order input microprocessor chip 11 through wireless communication module 13 through vitro program controlled device and handle; Get into second communication module 121 by first communication module 111 through spi bus, be stored in first passage register-stored module 122 and second channel register-stored module 126 then respectively.
First passage register-stored module 122 sends first passage regulation and control order to first passage digital pulse generator 123 and is used for producing the independent regulatable digital adjustment signal output that stimulates; First passage digital pulse generator 123 stimulates adjustment signal to send first passage mimic pulse generator 124 to numeral to convert the simulation stimulus signal into, and first passage mimic pulse generator 124 will be simulated stimulus signal and sent 125 outputs of first passage output control module to and stimulate.
Likewise; Second channel register-stored module 126 sends second channel regulation and control order to second channel digital pulse generator 127 and is used for producing the independent regulatable digital adjustment signal output that stimulates; Second channel digital pulse generator 127 stimulates adjustment signal to send second channel mimic pulse generator 128 to numeral to convert the simulation stimulus signal into, and second channel mimic pulse generator 128 will be simulated stimulus signal and sent 129 outputs of second channel output control module to and stimulate.
Compared with prior art; Electrostimulation digital-to-analogue hybrid chip 12 of the present invention comprises the first boost pulse output channel 15 and the second boost pulse output channel 16 that can distinguish independent regulation and control output; Make electrostimulation digital-to-analogue hybrid chip 12 to handle to the regulation and control order of the transmission of vitro program controlled device; Realize independently regulation and control output through the first boost pulse output channel 15 and the second boost pulse output channel 16 respectively; Realize that the doctor can export all can independently to regulate and control to stimulation such as frequency, pulsewidth, amplitude and stimulus modality of two passages of binary channels pulse generator, makes the neuromodulation of patient's brain left and right sides reach optimal effectiveness.
The present invention also can have other various embodiments; Under the situation that does not deviate from spirit of the present invention and essence; Those skilled in the art can make various corresponding changes and distortion according to the present invention, but these corresponding changes and distortion all should belong to the scope of claim protection of the present invention.
Claims (10)
1. binary channels pulse generator; It is characterized in that: comprise microprocessor module and binary channels electrical stimulation circuit module; Said microprocessor module is used to receive the regulation and control order that vitro program controlled device sends and sends said electrical stimulation circuit module to, and said electrical stimulation circuit module comprises the first boost pulse output channel and the second boost pulse output channel that can distinguish independent regulation and control output.
2. binary channels pulse generator according to claim 1 is characterized in that: said binary channels electrical stimulation circuit module is a binary channels electrostimulation digital-to-analogue hybrid chip.
3. binary channels pulse generator according to claim 2 is characterized in that: the said regulation and control of independence respectively output comprises frequency, pulsewidth, amplitude, the stimulus modality of boost pulse.
4. according to claim 2 or 3 described binary channels pulse generators, it is characterized in that: described microprocessor module comprises CPU, memory, first communication module;
Said electrostimulation digital-to-analogue hybrid chip comprises second communication module that is connected with said first communication module through communication bus;
The said first boost pulse output channel comprises first passage register-stored module, first passage digital pulse generator, first passage mimic pulse generator, the first passage output control module that is connected successively with said second communication module;
The said second boost pulse output channel comprises second channel register-stored module, second channel digital pulse generator, second channel mimic pulse generator, the second channel output control module that is connected successively with said second communication module.
5. binary channels pulse generator according to claim 4 is characterized in that:
Said electrostimulation digital-to-analogue hybrid chip comprises that being used to produce independent regulatable numeral stimulates the digital circuit blocks of adjustment signal output to stimulate adjustment signal to convert the analog module of simulation stimulus signal output into above-mentioned numeral with being used for;
Said digital circuit blocks comprises described second communication module; First passage register-stored module that is connected with said second communication module and second channel register-stored module; Be connected with said first passage register-stored module and be used to produce the first passage assigned frequency; Pulsewidth; The first passage digital pulse generator of amplitude and stimulus modality; Be connected with said second channel register-stored module and be used to produce the second channel assigned frequency; Pulsewidth; The second channel digital pulse generator of amplitude and stimulus modality;
Said analog module comprises the first passage mimic pulse generator that is connected with said first passage digital pulse generator, the second channel mimic pulse generator that is connected with said second channel digital pulse generator, the first passage output control module that is connected with said first passage mimic pulse generator, the second channel output control module that is connected with said second channel mimic pulse generator.
6. binary channels pulse generator according to claim 5 is characterized in that: the stimulus modality of described appointment is the continued stimulus pattern, bunch send out stimulus modality, a kind of in stimulus modality, motion stimulus modality, the soft stimulus modality regularly.
7. an implantable nerve electric stimulation is characterized in that: comprise arbitrary described binary channels pulse generator in the claim 1 to 6.
8. implantable nerve electric stimulation according to claim 7 is characterized in that: said implantable nerve electric stimulation is a kind of in implanted brain deep electric stimulation, implanted cortex electric stimulation, implanted spinal cord stimulation trial system, implanted sacral nerve electric stimulation or the implanted vagus nerve electric stimulation.
9. an implantable cardiac pacing system is characterized in that: comprise arbitrary described binary channels pulse generator in the claim 1 to 6.
10. an implantable cardiac conversion defibrillation system is characterized in that: comprise arbitrary described binary channels pulse generator in the claim 1 to 6.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010517279.2A CN102457252B (en) | 2010-10-25 | 2010-10-25 | Dual channel pulse generator and implantable electrical stimulation system |
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| CN201010517279.2A CN102457252B (en) | 2010-10-25 | 2010-10-25 | Dual channel pulse generator and implantable electrical stimulation system |
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| CN102457252A true CN102457252A (en) | 2012-05-16 |
| CN102457252B CN102457252B (en) | 2015-01-21 |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102931951A (en) * | 2012-11-09 | 2013-02-13 | 天津大学 | Multi-channel differential pulse generator using metal-oxide-semiconductor (MOS) tube and method for controlling generator |
| CN102931950A (en) * | 2012-11-09 | 2013-02-13 | 天津大学 | Multi-channel differential motion pulse generator with three-state gate and control method thereof |
| WO2017215256A1 (en) * | 2016-06-12 | 2017-12-21 | 上海市儿童医院 | Implantable double-channel vagus nerve stimulation device |
| CN109481844A (en) * | 2018-12-27 | 2019-03-19 | 清华大学 | Implantable nerve stimulation apparatus with multiple-frequency-mode |
| CN111298292A (en) * | 2020-03-20 | 2020-06-19 | 北京航空航天大学 | Implanted diaphragm pacemaker |
| CN111420277A (en) * | 2020-04-09 | 2020-07-17 | 北京品驰医疗设备有限公司 | Implantable neurostimulation device |
| WO2023011492A1 (en) * | 2021-08-03 | 2023-02-09 | 苏州景昱医疗器械有限公司 | Implantable stimulator and stimulation system |
| US11691008B2 (en) | 2017-09-25 | 2023-07-04 | Samsung Electronics Co., Ltd. | Neuromimetic stimulating apparatus and method |
| WO2023124617A1 (en) * | 2021-12-30 | 2023-07-06 | 苏州景昱医疗器械有限公司 | Implantable stimulation system |
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| CN86103049A (en) * | 1985-04-02 | 1986-10-08 | 莱兰斯坦福初级大学评议会 | Multi-channel implantable neural stimulator |
| US20030195591A1 (en) * | 1996-06-07 | 2003-10-16 | Jay Law | Multiprogrammable tissue stimulator and method |
| CN101648053A (en) * | 2009-09-03 | 2010-02-17 | 清华大学 | Double-channel embedded nerve stimulator |
| CN201871123U (en) * | 2010-10-25 | 2011-06-22 | 鼎迈医疗科技(苏州)有限公司 | Two-channel pulse generator and implantable electrical stimulation system |
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2010
- 2010-10-25 CN CN201010517279.2A patent/CN102457252B/en not_active Withdrawn - After Issue
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN86103049A (en) * | 1985-04-02 | 1986-10-08 | 莱兰斯坦福初级大学评议会 | Multi-channel implantable neural stimulator |
| US20030195591A1 (en) * | 1996-06-07 | 2003-10-16 | Jay Law | Multiprogrammable tissue stimulator and method |
| CN101648053A (en) * | 2009-09-03 | 2010-02-17 | 清华大学 | Double-channel embedded nerve stimulator |
| CN201871123U (en) * | 2010-10-25 | 2011-06-22 | 鼎迈医疗科技(苏州)有限公司 | Two-channel pulse generator and implantable electrical stimulation system |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102931951A (en) * | 2012-11-09 | 2013-02-13 | 天津大学 | Multi-channel differential pulse generator using metal-oxide-semiconductor (MOS) tube and method for controlling generator |
| CN102931950A (en) * | 2012-11-09 | 2013-02-13 | 天津大学 | Multi-channel differential motion pulse generator with three-state gate and control method thereof |
| CN102931951B (en) * | 2012-11-09 | 2015-01-28 | 天津大学 | Multi-channel differential pulse generator using metal-oxide-semiconductor (MOS) tube and method for controlling generator |
| CN102931950B (en) * | 2012-11-09 | 2015-10-28 | 天津大学 | A kind of multichannel difference pulse generator and control method thereof adopting triple gate |
| WO2017215256A1 (en) * | 2016-06-12 | 2017-12-21 | 上海市儿童医院 | Implantable double-channel vagus nerve stimulation device |
| US11691008B2 (en) | 2017-09-25 | 2023-07-04 | Samsung Electronics Co., Ltd. | Neuromimetic stimulating apparatus and method |
| CN109481844A (en) * | 2018-12-27 | 2019-03-19 | 清华大学 | Implantable nerve stimulation apparatus with multiple-frequency-mode |
| CN111298292A (en) * | 2020-03-20 | 2020-06-19 | 北京航空航天大学 | Implanted diaphragm pacemaker |
| CN111420277A (en) * | 2020-04-09 | 2020-07-17 | 北京品驰医疗设备有限公司 | Implantable neurostimulation device |
| WO2023011492A1 (en) * | 2021-08-03 | 2023-02-09 | 苏州景昱医疗器械有限公司 | Implantable stimulator and stimulation system |
| WO2023124617A1 (en) * | 2021-12-30 | 2023-07-06 | 苏州景昱医疗器械有限公司 | Implantable stimulation system |
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| CN102457252B (en) | 2015-01-21 |
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