CN104856898A - Toothpaste containing fructus viticis composition - Google Patents
Toothpaste containing fructus viticis composition Download PDFInfo
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- CN104856898A CN104856898A CN201510233881.6A CN201510233881A CN104856898A CN 104856898 A CN104856898 A CN 104856898A CN 201510233881 A CN201510233881 A CN 201510233881A CN 104856898 A CN104856898 A CN 104856898A
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- fructus viticis
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Abstract
The invention discloses toothpaste containing a fructus viticis composition, which comprises a basic material composition and a functional composition, wherein the basic material composition comprises humectants, abrasive, foaming agent, essence, thickening agent, sweetening agent and water, the functional composition is chaste tree extracts, and the percentage by weight of the functional composition is 0.01%-5%. The toothpaste containing the fructus viticis composition uses fructus viticis extracts as a functional component to add into toothpaste for the first time, clearly determines effective radio of the fructus viticis extracts and other base components in the toothpaste, and supplies effective adding range simultaneously. The toothpaste containing a fructus viticis composition has the obvious effects of antibiosis, antiphlogosis and pain stopping, and can thoroughly relieve the oral problems of red and swollen gums, pain and bleeding and the like.
Description
Technical field
The present invention relates to a kind of toothpaste, belong to oral care product technical field, specifically relate to a kind of toothpaste containing Fructus Viticis composition.
Background technology
Gingival swelling and pain refers to around teeth swelling and aching of gum pain, also has patient to be described as tooth meat and swells and ache.Cause the reason of gingival swelling and pain mainly patient inherently suffer from gingivitis or periodontitis, Abwehrkraft des Koepers decline, dry weather in addition, the food of pungent stimulation of taking food or tonic, will cause original chronic inflammatory disease acute attack, occur gingival swelling and pain symptom.
Fructus Viticis is the dry mature fruit of Verbenaceae Vitex rotundifolia or wild pepper.Its cold nature, bitter in the mouth is pungent, has dispelling wind and heat pathogens, effect of the clear sharp head, can be used for anemopyretic cold headache, gingival swelling and pain, the diseases such as the many tears of conjunctival congestion.
Modern pharmacology shows, containing multiple bioactive ingredients in Fructus Viticis, mainly contain flavone compound (casticin, Artemisia flavin), volatile oil (camphene, pinene), aminoacid (γ-aminobutyric acid), phenolic acids (vanillic acid) etc.Have antibacterial, antiinflammatory, analgesic effect, also have eliminating phlegm and relieving asthma, antitumor, prophylaxis of cancer, improve microcirculation simultaneously, effect of antioxidation, slow down aging.
At present, the relevant report not yet finding to be applied to by Fructus Viticis in toothpaste investigated by patent documentation.
Summary of the invention
The object of the present invention is to provide a kind of toothpaste containing Fructus Viticis composition, in toothpaste, with the addition of Fructus Viticis extract, there is antibacterial, antiinflammatory, analgesic effect, fundamentally can alleviate red swelling of gingiva, pain, the oral problem such as hemorrhage.
Technical scheme of the present invention is as follows:
A kind of toothpaste containing Fructus Viticis composition, comprise base ingredients and functional component, described base ingredients comprises wetting agent, abrasive, foaming agent, essence, thickening agent, sweeting agent and water, described functional component is Fructus Viticis extract, and its percentage by weight is account for toothpaste total amount 0.01% ~ 5%.
The present invention contains the toothpaste of Fructus Viticis composition, and described Fructus Viticis extract can be the crystalline thing of Fructus Viticis extracting solution, quintessence oil, extract powder or extract, and addition can be 0.02% ~ 2%, and in Fructus Viticis extract, characteristic component is casticin.
The present invention contains the toothpaste of Fructus Viticis composition, described base ingredients and functional component percentage by weight as follows:
Described wetting agent is one or more the mixture in sorbitol, glycerol, Polyethylene Glycol, propylene glycol;
Described abrasive is one or more the mixture in silicon dioxide, calcite, calcium hydrogen phosphate;
Described foaming agent is one or more the mixture in sodium lauryl sulfate, cocamido propyl betaine, sodium N-lauroyl sarcosinate;
Described thickening agent is one or more the mixture in xanthan gum, carrageenin, cellulose gum, hydroxyethyl-cellulose;
Described sweeting agent is one or more the mixture in saccharin sodium, sucralose, stevioside.
The present invention contains the toothpaste of Fructus Viticis composition, and described Fructus Viticis extracting solution its preparation method is as follows:
1) pulverizing of the Viticis Fructus of drying is weighed, add by solid-to-liquid ratio 1:10 the ethanol that volume fraction is 70%;
2) under 85 DEG C of conditions, water-bath reflux, extract, 3 times, each 4 hours, merges 3 extracting solution, obtains crude extract;
3) by crude extract concentrating under reduced pressure, reclaim ethanol, obtain suspension, centrifugal, filter, obtain Fructus Viticis extracting solution.
In addition, the invention allows for a kind of toothpaste containing Fructus Viticis composition, its preparation method is as follows:
1) abrasive, thickening agent are dropped into filler bin, stir;
2) sweeting agent, functional component, wetting agent and water are added in premixing tank, after fully dissolving, suck Manufacturing medicine extract machine;
3) suck in Manufacturing medicine extract machine by material in filler bin, rapid stirring is to even;
4) suck in Manufacturing medicine extract machine by foaming agent, vacuum rapid stirring is to even;
5) suck essence, vacuum rapid stirring is to evenly, degassed, fill after standing a period of time.
The present invention has the following advantages and Advantageous Effects:
1) Fructus Viticis extract adds in toothpaste as functional component by the present invention first, and specify that Fructus Viticis extract in toothpaste with effective proportioning of each base ingredients, give effective interpolation scope simultaneously.
2) what prepared by the present invention has antibacterial, antiinflammatory significantly, analgesic effect containing the toothpaste of Fructus Viticis composition, fundamentally can alleviate red swelling of gingiva, pain, the oral problem such as hemorrhage.
Detailed description of the invention
To be further elaborated the present invention by concrete preferred embodiment below, but the present invention is not limited in following embodiment.
A kind of toothpaste containing Fructus Viticis composition of the present invention, comprise base ingredients and functional component, described base ingredients comprises wetting agent, abrasive, foaming agent, essence, thickening agent, sweeting agent and water, described functional component is Fructus Viticis extract, its percentage by weight is account for toothpaste total amount 0.01% ~ 5%, is preferably 0.02% ~ 2%.Fructus Viticis extract wherein can be the crystalline thing of Fructus Viticis extracting solution, quintessence oil, extract powder or extract, and in Fructus Viticis extract, characteristic component is casticin, and usable highly effective liquid chromatography characterizes and obtains.
Functional component in its raw material of tooth paste product below in embodiment all adopts Fructus Viticis extracting solution, and described its process of preparing of Fructus Viticis extracting solution is:
1) pulverizing of the Viticis Fructus of drying is weighed, add by solid-to-liquid ratio 1:10 the ethanol that volume fraction is 70%;
2) under 85 DEG C of conditions, water-bath reflux, extract, 3 times, each 4 hours, merges 3 extracting solution, obtains crude extract;
3) by crude extract concentrating under reduced pressure, reclaim ethanol, obtain suspension, centrifugal, filter, obtain Fructus Viticis extracting solution.
embodiment 1
A toothpaste containing Fructus Viticis composition, its each weight percentages of components is as follows:
The above-mentioned toothpaste its preparation method containing Fructus Viticis composition is as follows:
1) cellulose gum is dropped into filler bin together with silicon dioxide, stir;
2) saccharin sodium, sorbitol, glycerol, Fructus Viticis extracting solution and water are added in premixing tank, suck in Manufacturing medicine extract machine after fully dissolving;
3) suck in Manufacturing medicine extract machine by material in powder storehouse, rapid stirring is to even;
4) suck in Manufacturing medicine extract machine by sodium lauryl sulfate, vacuum rapid stirring is to even;
5) slowly suck essence, vacuum rapid stirring is to evenly, degassed, fill after standing a period of time.
embodiment 2
A toothpaste containing Fructus Viticis composition, its each weight percentages of components is as follows:
The above-mentioned toothpaste its preparation method containing Fructus Viticis composition is as follows:
1) cellulose gum, carrageenin, calcite are dropped into filler bin together, stir;
2) saccharin sodium, sucralose, sorbitol, glycerol, Fructus Viticis extract and water are added in premixing tank, suck in Manufacturing medicine extract machine after fully dissolving;
3) suck in Manufacturing medicine extract machine by material in powder storehouse, rapid stirring is to even;
4) suck in Manufacturing medicine extract machine by sodium lauryl sulfate, vacuum rapid stirring is to even;
5) slowly suck essence, vacuum rapid stirring is to evenly, degassed, fill after standing a period of time.
embodiment 3
A toothpaste containing Fructus Viticis composition, its each weight percentages of components is as follows:
The above-mentioned toothpaste its preparation method containing Fructus Viticis composition is as follows:
1) cellulose gum is dropped into filler bin together with calcium hydrogen phosphate, stir;
2) saccharin sodium, sorbitol, glycerol, Polyethylene Glycol, Fructus Viticis extract and water are added in premixing tank, suck in Manufacturing medicine extract machine after fully dissolving;
3) suck in Manufacturing medicine extract machine by material in powder storehouse, rapid stirring is to even;
4) suck in Manufacturing medicine extract machine by sodium lauryl sulfate, vacuum rapid stirring is to even;
5) slowly suck essence, vacuum rapid stirring is to evenly, degassed, fill after standing a period of time.
effect test example
Below be respectively toothpaste extracorporeal bacteria inhibitor test, anti-inflammation test effect test example that the present invention contains Fructus Viticis composition, its result is as shown in table 1 below.
Toothpaste A: containing high dose Fructus Viticis extract;
Toothpaste B: containing low dosage Fructus Viticis extract;
Toothpaste C: blank, does not add any medicine.
1, extracorporeal bacteria inhibitor test
1) test strain
Prevotella intermedia (Prevotella intermedia) (ATCC 25611), Candida albicans (Candida albicans) (ATCC 10231), Streptococcus mutans (Streptococcus mutans) (ATCC25175), by Guangdong Microbes Inst, DSMZ provides.
2) test method
With reference to the evaluation methodology of QB/T 2738-2012 daily chemical products antibacterial bacteriostatic effect, test concentrations: 1:1 (m/v), testing time: 10min.
3) result of the test
The toothpaste extracorporeal bacteria inhibitor test result of table 1 containing Fructus Viticis composition
Can be found out by extracorporeal bacteria inhibitor test, toothpaste containing Fructus Viticis composition prepared by the present invention all has stronger inhibitory action to common bacterium Prevotella intermedia, Candida albicans, the Streptococcus mutans of curing the disease in oral cavity, and along with the increase of Fructus Viticis extract addition, fungistatic effect strengthens.
2, anti-inflammation test
1) experimental animal
Kunming (KM) mice 60, male and female half and half, SPF level, is provided by Traditional Chinese Medicine University Of Guangzhou's Experimental Animal Center, and adaptability raises 3 days afterwards for test.
2) test method
Mice is divided into 3 groups at random, is respectively toothpaste A group, toothpaste B group, toothpaste C group, weighs, depilation.Often organize and give through dermal application respectively, smear dosage at every turn: 6g/kg, smear 2 every day, continuous 4 days.Drip in mouse right ear two sides by 100ul dimethylbenzene after last smears toothpaste 0.5h, left ear is not coated with in contrast.Put to death animal after causing scorching 0.5h, cut two ears along auricle baseline, diameter 9mm disk is laid at the same position of ears, analytical balance precise weighing, using the difference of left and right ear weight as swelling, and more each group difference.
3) result of the test, as shown in table 2 below:
The toothpaste anti-inflammation test result of table 2 containing Fructus Viticis composition
| Test sample | Number of animals (only) | Dosage (g/kg) | Swelling (mg) |
| Toothpaste A | 20 | 6 | 5.28±1.22 |
| Toothpaste B | 20 | 6 | 8.93±1.35 |
| Toothpaste C | 20 | 6 | 10.87±1.16 |
Table 2 result shows, test toothpaste A, B more all have significant difference (P < 0.01) with blank toothpaste C, illustrate that the toothpaste that the present invention contains Fructus Viticis composition has obvious antiinflammatory action, can effectively alleviate red swelling of gingiva pain.
The above, it is only preferred embodiment of the present invention, not any pro forma restriction is done to the present invention, therefore everyly do not depart from technical solution of the present invention content, the any simple modification done above embodiment according to technical spirit of the present invention, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.
Claims (6)
1. the toothpaste containing Fructus Viticis composition, comprise base ingredients and functional component, it is characterized in that: described base ingredients comprises wetting agent, abrasive, foaming agent, essence, thickening agent, sweeting agent and water, described functional component is Fructus Viticis extract, and its percentage by weight is account for toothpaste total amount 0.01% ~ 5%.
2. the toothpaste containing Fructus Viticis composition according to claim 1, it is characterized in that: described Fructus Viticis extract is the crystalline thing of Fructus Viticis extracting solution, quintessence oil, extract powder or extract, addition can be 0.02% ~ 2%, and in Fructus Viticis extract, characteristic component is casticin.
3. the toothpaste containing Fructus Viticis composition according to claim 1, is characterized in that: it comprises each raw material components of following percentage by weight:
4. the toothpaste containing Fructus Viticis composition according to claim 3, is characterized in that: described wetting agent is one or more the mixture in sorbitol, glycerol, Polyethylene Glycol, propylene glycol;
Described abrasive is one or more the mixture in silicon dioxide, calcite, calcium hydrogen phosphate;
Described foaming agent is one or more the mixture in sodium lauryl sulfate, cocamido propyl betaine, sodium N-lauroyl sarcosinate;
Described thickening agent is one or more the mixture in xanthan gum, carrageenin, cellulose gum, hydroxyethyl-cellulose;
Described sweeting agent is one or more the mixture in saccharin sodium, sucralose, stevioside.
5. the toothpaste containing Fructus Viticis composition according to claim 3, is characterized in that: described Fructus Viticis extracting solution its preparation method is as follows:
1) pulverizing of the Viticis Fructus of drying is weighed, add by solid-to-liquid ratio 1:10 the ethanol that volume fraction is 70%;
2) under 85 DEG C of conditions, water-bath reflux, extract, 3 times, each 4 hours, merges 3 extracting solution, obtains crude extract;
3) by crude extract concentrating under reduced pressure, reclaim ethanol, obtain suspension, centrifugal, filter, obtain Fructus Viticis extracting solution.
6. the preparation method of the toothpaste containing Fructus Viticis composition according to any one of Claims 1 to 5, is characterized in that comprising the following steps:
1) abrasive, thickening agent are dropped into filler bin, stir;
2) sweeting agent, functional component, wetting agent and water are added in premixing tank, after fully dissolving, suck Manufacturing medicine extract machine;
3) suck in Manufacturing medicine extract machine by material in filler bin, rapid stirring is to even;
4) suck in Manufacturing medicine extract machine by foaming agent, vacuum rapid stirring is to even;
5) suck essence, vacuum rapid stirring is to evenly, degassed, fill after standing a period of time.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510233881.6A CN104856898B (en) | 2015-05-08 | 2015-05-08 | A kind of toothpaste containing wild pepper subconstiuent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510233881.6A CN104856898B (en) | 2015-05-08 | 2015-05-08 | A kind of toothpaste containing wild pepper subconstiuent |
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| CN104856898A true CN104856898A (en) | 2015-08-26 |
| CN104856898B CN104856898B (en) | 2017-09-29 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596260A (en) * | 2016-01-29 | 2016-05-25 | 海南宇星日用化工股份有限公司 | Coconut toothpaste |
| CN107468603A (en) * | 2017-07-16 | 2017-12-15 | 何家平 | A kind of children's Chinese herbal toothpaste |
| KR20190041800A (en) * | 2017-10-13 | 2019-04-23 | 주식회사 엘지생활건강 | Composition for prevention or treatment of oral disease comprising Casticin |
| CN109771414A (en) * | 2019-03-15 | 2019-05-21 | 苏州大学附属第二医院 | A kind of pharmaceutical composition for treating haemorrhagic shock |
| CN114404498A (en) * | 2022-02-22 | 2022-04-29 | 江西农业大学 | Application of traditional Chinese medicine fructus viticis ethanol extract in preparation of antibacterial drugs |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11154470B1 (en) * | 2020-07-31 | 2021-10-26 | vVardis AG | Anti-inflammatory and senolytic dental care product with tooth whitening characteristics |
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| CN1066584A (en) * | 1991-03-12 | 1992-12-02 | 王乃昭 | Multipurpose tooth paste |
| CN1899261A (en) * | 2006-07-26 | 2007-01-24 | 广州立白企业集团有限公司 | Composition and its use in oral nursing |
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Patent Citations (3)
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| CN1066584A (en) * | 1991-03-12 | 1992-12-02 | 王乃昭 | Multipurpose tooth paste |
| CN1899261A (en) * | 2006-07-26 | 2007-01-24 | 广州立白企业集团有限公司 | Composition and its use in oral nursing |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596260A (en) * | 2016-01-29 | 2016-05-25 | 海南宇星日用化工股份有限公司 | Coconut toothpaste |
| CN107468603A (en) * | 2017-07-16 | 2017-12-15 | 何家平 | A kind of children's Chinese herbal toothpaste |
| KR20190041800A (en) * | 2017-10-13 | 2019-04-23 | 주식회사 엘지생활건강 | Composition for prevention or treatment of oral disease comprising Casticin |
| KR102485968B1 (en) * | 2017-10-13 | 2023-01-06 | 주식회사 엘지생활건강 | Composition for prevention or treatment of oral disease comprising Casticin |
| CN109771414A (en) * | 2019-03-15 | 2019-05-21 | 苏州大学附属第二医院 | A kind of pharmaceutical composition for treating haemorrhagic shock |
| CN109771414B (en) * | 2019-03-15 | 2021-04-20 | 苏州大学附属第二医院 | Pharmaceutical composition for treating hemorrhagic shock |
| CN114404498A (en) * | 2022-02-22 | 2022-04-29 | 江西农业大学 | Application of traditional Chinese medicine fructus viticis ethanol extract in preparation of antibacterial drugs |
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| CN104856898B (en) | 2017-09-29 |
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