CN104856898B - A kind of toothpaste containing wild pepper subconstiuent - Google Patents
A kind of toothpaste containing wild pepper subconstiuent Download PDFInfo
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- CN104856898B CN104856898B CN201510233881.6A CN201510233881A CN104856898B CN 104856898 B CN104856898 B CN 104856898B CN 201510233881 A CN201510233881 A CN 201510233881A CN 104856898 B CN104856898 B CN 104856898B
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Abstract
The invention discloses a kind of toothpaste containing wild pepper subconstiuent, include base ingredients and functional component, base ingredients include NMF, abrasive, foaming agent, essence, thickener, sweetener and water, and functional component is Fructus Viticis extract, and percentage by weight is 0.01%~5%.The present invention is added to Fructus Viticis extract as functional component in toothpaste first, and specify that effective proportioning of the Fructus Viticis extract with other each base ingredients in toothpaste, while giving effective addition scope.Toothpaste containing wild pepper subconstiuent prepared by the present invention has significant antibacterial, anti-inflammatory, analgesic effect, can fundamentally mitigate the oral problems such as gum redness, pain, bleeding.
Description
Technical field
The present invention relates to a kind of toothpaste, belong to oral care product technical field, be specifically related to one kind and contain fructus viticis
The toothpaste of composition.
Background technology
Swelling and aching of gum refers to tooth surrounding gum swelling pain, also has patient to be described as tooth meat and swells and ache.Cause swelling and aching of gum
The reason for be mainly patient and inherently suffer from gingivitis or periodontitis, Abwehrkraft des Koepers declines, and dry weather in addition is fed pungent
The food or tonic of stimulation, may result in original chronic inflammation acute attack, swelling and aching of gum symptom occur.
Fructus viticis is Verbenaceae Vitex rotundifolia or the dry mature fruit of wild pepper.Its cold nature, it is bitterly, have
The effect of dispelling wind and heat from the body, head clearing, available for anemopyretic cold headache, swelling and aching of gum, the disease such as many tears of hot eyes.
Modern pharmacology shows, multiple biological activities composition is contained in fructus viticis, mainly there is flavone compound (pale reddish brown Vitex negundo var cannabifolia
Element, wormwood artemisia flavine), volatile oil (amphene, firpene), amino acid (γ-aminobutyric acid), phenolic acid class (vanillic acid) etc..With antibacterial,
Anti-inflammatory, analgesic effect, while also having eliminating phlegm and relieving asthma, antitumor, pre- anti-cancer improves microcirculation, anti-oxidant, anti-aging
Effect.
At present, patent document investigation not yet finds the relevant report being applied to fructus viticis in toothpaste.
The content of the invention
It is an object of the invention to provide a kind of toothpaste containing wild pepper subconstiuent, fructus viticis extraction is with the addition of in toothpaste
Thing, with antibacterial, anti-inflammatory, analgesic effect, can fundamentally mitigate the oral problems such as gum redness, pain, bleeding.
Technical scheme is as follows：
A kind of toothpaste containing wild pepper subconstiuent, comprising base ingredients and functional component, the base ingredients include moisturizing
Agent, abrasive, foaming agent, essence, thickener, sweetener and water, the functional component are Fructus Viticis extract, its weight hundred
Divide than being to account for the 0.01%~5% of toothpaste total amount.
Toothpaste of the invention containing wild pepper subconstiuent, the Fructus Viticis extract can be fructus viticis extract solution, essential oil, carry
Thing powder or the crystalline thing of extract are taken, addition can be 0.02%~2%, and characteristic component is pale reddish brown male in Fructus Viticis extract
Jing Su.
Toothpaste of the invention containing wild pepper subconstiuent, base ingredients and the functional component percentage by weight is as follows：
The NMF is mixture more than one or both of sorbierite, glycerine, polyethylene glycol, propane diols；
The abrasive is mixture more than one or both of silica, calcite, calcium monohydrogen phosphate；
The foaming agent is one in laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, sodium N-lauroyl sarcosinate
Plant or two or more mixtures；
The thickener is more than one or both of xanthans, carrageenan, cellulose gum, hydroxyethyl cellulose
Mixture；
The sweetener is mixture more than one or both of saccharin sodium, Sucralose, steviol glycoside.
Toothpaste of the invention containing wild pepper subconstiuent, the fructus viticis extract solution its preparation method is as follows：
1) dry Viticis Fructus is crushed and weighed, by solid-to-liquid ratio 1：10 add the ethanol that volume fraction is 70%；
2) under the conditions of 85 DEG C, water-bath refluxing extraction 3 times 4 hours every time, merges No. 3 extract solutions, obtains crude extract；
3) crude extract is concentrated under reduced pressure, reclaims ethanol, obtain suspension, centrifuged, filtering produces fructus viticis extract solution.
In addition, the invention also provides a kind of toothpaste containing wild pepper subconstiuent, its preparation method is as follows：
1) abrasive, thickener are put into filler bin, stirred；
2) sweetener, functional component, NMF and water are added in premixing tank, fully sucks Manufacturing medicine extract machine after dissolving；
3) material in filler bin is sucked in Manufacturing medicine extract machine, be quickly stirred until homogeneous；
4) foaming agent is sucked in Manufacturing medicine extract machine, vacuum is quickly stirred until homogeneous；
5) essence is sucked, vacuum is quickly stirred until homogeneous, deaerated, stood filling after a period of time.
The present invention has advantages below and advantageous effects：
1) present invention is added to Fructus Viticis extract as functional component in toothpaste first, and specify that fructus viticis is extracted
Effective proportioning of the thing in toothpaste with each base ingredients, while giving effective addition scope.
2) toothpaste containing wild pepper subconstiuent prepared by the present invention has significant antibacterial, anti-inflammatory, analgesic effect, can be from root
Mitigate the oral problems such as gum redness, pain, bleeding in sheet.
Embodiment
The present invention will be further elaborated by specific preferred embodiment below, but the present invention be not limited in
Under embodiment.
A kind of toothpaste containing wild pepper subconstiuent of the present invention, comprising base ingredients and functional component, the base ingredients bag
Containing NMF, abrasive, foaming agent, essence, thickener, sweetener and water, the functional component is Fructus Viticis extract, and its is heavy
It is account for toothpaste total amount 0.01%~5%, preferably 0.02%~2% to measure percentage.Fructus Viticis extract therein can be
Characteristic component is pale reddish brown Vitex negundo var cannabifolia in fructus viticis extract solution, essential oil, extract powder or the crystalline thing of extract, Fructus Viticis extract
Element, usable highly effective liquid chromatography is characterized and obtained.
The functional component in tooth paste product its raw material in example below uses fructus viticis extract solution, the fructus viticis
Its process of preparing of extract solution is：
1) dry Viticis Fructus is crushed and weighed, by solid-to-liquid ratio 1:10 add the ethanol that volume fraction is 70%；
2) under the conditions of 85 DEG C, water-bath refluxing extraction 3 times 4 hours every time, merges No. 3 extract solutions, obtains crude extract；
3) crude extract is concentrated under reduced pressure, reclaims ethanol, obtain suspension, centrifuged, filtering produces fructus viticis extract solution.
Embodiment 1
A kind of toothpaste containing wild pepper subconstiuent, its each component percentage by weight is as follows：
The above-mentioned toothpaste its preparation method containing wild pepper subconstiuent is as follows：
1) cellulose gum is put into filler bin together with silica, stirred；
2) saccharin sodium, sorbierite, glycerine, fructus viticis extract solution and water are added in premixing tank, fully sucks system after dissolving
In cream machine；
3) material in powder cabin is sucked in Manufacturing medicine extract machine, be quickly stirred until homogeneous；
4) laruyl alcohol sodium sulfovinate is sucked in Manufacturing medicine extract machine, vacuum is quickly stirred until homogeneous；
5) essence is slowly sucked, vacuum is quickly stirred until homogeneous, deaerated, stood filling after a period of time.
Embodiment 2
A kind of toothpaste containing wild pepper subconstiuent, its each component percentage by weight is as follows：
The above-mentioned toothpaste its preparation method containing wild pepper subconstiuent is as follows：
1) cellulose gum, carrageenan, calcite are put into filler bin together, stirred；
2) saccharin sodium, Sucralose, sorbierite, glycerine, Fructus Viticis extract and water are added in premixing tank, fully dissolving
Afterwards in suction Manufacturing medicine extract machine；
3) material in powder cabin is sucked in Manufacturing medicine extract machine, be quickly stirred until homogeneous；
4) laruyl alcohol sodium sulfovinate is sucked in Manufacturing medicine extract machine, vacuum is quickly stirred until homogeneous；
5) essence is slowly sucked, vacuum is quickly stirred until homogeneous, deaerated, stood filling after a period of time.
Embodiment 3
A kind of toothpaste containing wild pepper subconstiuent, its each component percentage by weight is as follows：
The above-mentioned toothpaste its preparation method containing wild pepper subconstiuent is as follows：
1) cellulose gum is put into filler bin together with calcium monohydrogen phosphate, stirred；
2) saccharin sodium, sorbierite, glycerine, polyethylene glycol, Fructus Viticis extract and water are added in premixing tank, fully dissolving
Afterwards in suction Manufacturing medicine extract machine；
3) material in powder cabin is sucked in Manufacturing medicine extract machine, be quickly stirred until homogeneous；
4) laruyl alcohol sodium sulfovinate is sucked in Manufacturing medicine extract machine, vacuum is quickly stirred until homogeneous；
5) essence is slowly sucked, vacuum is quickly stirred until homogeneous, deaerated, stood filling after a period of time.
Effete test embodiment
It is individually below the toothpaste extracorporeal bacteria inhibitor test of the invention containing wild pepper subconstiuent, anti-inflammation test effete test embodiment,
Its result is as shown in table 1 below.
Toothpaste A：Fructus Viticis extract containing high dose；
Toothpaste B：Fructus Viticis extract containing low dosage；
Toothpaste C：Blank control, is not added with any medicine.
1st, extracorporeal bacteria inhibitor test
1) test strain
Prevotella intermedia (Prevotella intermedia) (ATCC 25611), Candida albicans (Candida
Albicans) (ATCC 10231), Streptococcus mutans (Streptococcus mutans) (ATCC25175), by Guangdong Province
DSMZ of institute of microbiology provides.
2) test method
With reference to the evaluation method of QB/T 2738-2012 daily chemical products antibacterial bacteriostatic effects, test concentrations：1:1 (m/v), is surveyed
The examination time：10min.
3) result of the test
Toothpaste extracorporeal bacteria inhibitor test result of the table 1 containing wild pepper subconstiuent
By extracorporeal bacteria inhibitor test as can be seen that the toothpaste containing wild pepper subconstiuent for preparing of the present invention is common to oral cavity controls
Germ Prevotella intermedia, Candida albicans, Streptococcus mutans are respectively provided with stronger inhibitory action, and with Fructus Viticis extract
The increase of addition, fungistatic effect enhancing.
2nd, anti-inflammation test
1) experimental animal
Kunming (KM) mouse 60, male and female half and half, SPF grades, by Traditional Chinese Medicine University Of Guangzhou, Experimental Animal Center is provided, and is adapted to
Property raise 3 days after for experiment.
2) test method
Mouse is randomly divided into 3 groups, respectively toothpaste A groups, toothpaste B groups, toothpaste C groups, weighed, lost hair or feathers.Every group passes through respectively
Dermal application is given, and dosage is smeared every time：6g/kg, is smeared 2 times, continuous 4 days daily.Last is smeared 100ul after toothpaste 0.5h
Dimethylbenzene is dripped in mouse right ear two sides, and left ear is not applied as control.Animal is put to death after causing inflammation 0.5h, two are cut along auricle baseline
Diameter 9mm disks are laid at ear, the same position of ears, assay balance precise weighing, using the difference of left and right ear weight as swelling, than
More each group difference.
3) result of the test, it is as shown in table 2 below：
Toothpaste anti-inflammation test result of the table 2 containing wild pepper subconstiuent
| Test sample | Number of animals (only) | Dosage (g/kg) | Swelling (mg) |
| Toothpaste A | 20 | 6 | 5.28±1.22 |
| Toothpaste B | 20 | 6 | 8.93±1.35 |
| Toothpaste C | 20 | 6 | 10.87±1.16 |
The result of table 2 shows that test toothpaste A, B are compared with blank toothpaste C significant difference (P ＜ 0.01), illustrates this
Toothpaste of the invention containing wild pepper subconstiuent has obvious antiinflammatory action, can effectively alleviate gum congestion and swelling pain.
The above described is only a preferred embodiment of the present invention, any formal limitation not is made to the present invention, therefore
It is every without departing from technical solution of the present invention content, what the technical spirit according to the present invention was made to above example any simply repaiies
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.
Claims (3)
1. a kind of toothpaste containing wild pepper subconstiuent, it is characterised in that：It is each raw material components group by following percentage by weight
Into：
State fructus viticis extract solution its preparation method as follows：
1) dry Viticis Fructus is crushed and weighed, by solid-to-liquid ratio 1:10 add the ethanol that volume fraction is 70%；
2) under the conditions of 85 DEG C, water-bath refluxing extraction 3 times 4 hours every time, merges No. 3 extract solutions, obtains crude extract；
3) crude extract is concentrated under reduced pressure, reclaims ethanol, obtain suspension, centrifuged, filtering produces fructus viticis extract solution；
Water surplus.
2. the toothpaste according to claim 1 containing wild pepper subconstiuent, it is characterised in that：The NMF be sorbierite,
Mixture more than one or both of glycerine, polyethylene glycol, propane diols；
The abrasive is mixture more than one or both of silica, calcite, calcium monohydrogen phosphate；
The foaming agent be laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, sodium N-lauroyl sarcosinate in one kind or
Two or more mixtures；
The thickener is mixing more than one or both of xanthans, carrageenan, cellulose gum, hydroxyethyl cellulose
Thing；
The sweetener is mixture more than one or both of saccharin sodium, Sucralose, steviol glycoside.
3. the preparation method of the toothpaste containing wild pepper subconstiuent described in claim 1 or 2, it is characterised in that including following step
Suddenly：
1) abrasive, thickener are put into filler bin, stirred；
2) sweetener, functional component, NMF and water are added in premixing tank, fully sucks Manufacturing medicine extract machine after dissolving；
3) material in filler bin is sucked in Manufacturing medicine extract machine, be quickly stirred until homogeneous；
4) foaming agent is sucked in Manufacturing medicine extract machine, vacuum is quickly stirred until homogeneous；
5) essence is sucked, vacuum is quickly stirred until homogeneous, deaerated, stood filling after a period of time.
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| CN201510233881.6A CN104856898B (en) | 2015-05-08 | 2015-05-08 | A kind of toothpaste containing wild pepper subconstiuent |
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| CN104856898B true CN104856898B (en) | 2017-09-29 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022023523A1 (en) * | 2020-07-31 | 2022-02-03 | vVardis AG | Anti-inflammatory and senolytic dental care product with tooth whitening characteristics |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596260A (en) * | 2016-01-29 | 2016-05-25 | 海南宇星日用化工股份有限公司 | Coconut toothpaste |
| CN107468603A (en) * | 2017-07-16 | 2017-12-15 | 何家平 | A kind of children's Chinese herbal toothpaste |
| KR102485968B1 (en) * | 2017-10-13 | 2023-01-06 | 주식회사 엘지생활건강 | Composition for prevention or treatment of oral disease comprising Casticin |
| CN109771414B (en) * | 2019-03-15 | 2021-04-20 | 苏州大学附属第二医院 | Pharmaceutical composition for treating hemorrhagic shock |
| CN114404498A (en) * | 2022-02-22 | 2022-04-29 | 江西农业大学 | Application of traditional Chinese medicine fructus viticis ethanol extract in preparation of antibacterial drugs |
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| CN1066584A (en) * | 1991-03-12 | 1992-12-02 | 王乃昭 | Multipurpose tooth paste |
| CN1899261A (en) * | 2006-07-26 | 2007-01-24 | 广州立白企业集团有限公司 | Composition and its use in oral nursing |
| CN103505567A (en) * | 2012-06-17 | 2014-01-15 | 刘国慧 | Medicament for treating periodontitis |
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2015
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066584A (en) * | 1991-03-12 | 1992-12-02 | 王乃昭 | Multipurpose tooth paste |
| CN1899261A (en) * | 2006-07-26 | 2007-01-24 | 广州立白企业集团有限公司 | Composition and its use in oral nursing |
| CN103505567A (en) * | 2012-06-17 | 2014-01-15 | 刘国慧 | Medicament for treating periodontitis |
Non-Patent Citations (1)
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| 蔓荆子有效提取物抗肿瘤作用研究进展;胡晓楠 等;《现代肿瘤医学》;20140228;第22卷(第2期);472-475 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022023523A1 (en) * | 2020-07-31 | 2022-02-03 | vVardis AG | Anti-inflammatory and senolytic dental care product with tooth whitening characteristics |
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| CN104856898A (en) | 2015-08-26 |
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