CN103462841B - Toothpaste containing saussurea involucrate component - Google Patents
Toothpaste containing saussurea involucrate component Download PDFInfo
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- CN103462841B CN103462841B CN201310404181.XA CN201310404181A CN103462841B CN 103462841 B CN103462841 B CN 103462841B CN 201310404181 A CN201310404181 A CN 201310404181A CN 103462841 B CN103462841 B CN 103462841B
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Abstract
The invention discloses toothpaste containing a saussurea involucrate component. The toothpaste contains the following raw material components by weight percentage: 20%-60% of a moisturizing agent, 0.5%-2% of a binder, 0.1%-0.3% of a sweetener, 1%-3% of a foaming agent, 0.8%-1.5% of a flavoring agent, 20%-50% of an abradant, 0.2%-2.0% of a medicinal component, 0.01%-0.1% of a stabilizer and 10%-30% of water, wherein the medicinal component is a saussurea involucrate extract. According to the toothpaste, the saussurea involucrate which is taken as an antibacterial and anti-inflammatory component is added into the toothpaste for the first time, and the stabilizer for effectively stabilizing the medicinal component is provided. After the active component is added into the toothpaste, the antibacterial and anti-inflammatory capabilities of the toothpaste are obviously improved, and the toothpaste can effectively alleviate the oral health problems such as swelling and aching of gum and gum bleeding caused by oral diseases such as periodontitis and gingivitis.
Description
Technical field
The invention belongs to daily chemical products field, relate to a kind of toothpaste, especially a kind of toothpaste containing Herba Saussureae Involueratae composition.
Background technology
The adult of China 90% has oral problem in various degree, the medical statistics data of specialty find along with the change (numb, peppery, boiling hot) of dietary habit and the increase of operating pressure, and the oral problem such as oral ulcer, gingival swelling and pain, hemorrhage, atrophy spreads just fast.These oral cavities " minor issue ", although be not enough to hospital, greatly perplexed the emotion of people, have been thereby produced the consumption demand for oral problem.Intraoral Periodontal Supporting Tissue is subject to local excitation simultaneously, as tartar, food impaction, ill fitting prosthesis etc., it is excessive that the uneven and incorrect method for brushing teeth of long-term mechanical stimulus, denture makes part dental articulation power bear, and chemicals, burn, hypovitaminosis C, oral cavity bacterium growth etc. cause the oral cavity commonly encountered diseases such as gingivitis, periodontitis and alveolar abscess.
Herba Saussureae Involueratae is Chinese exclusive rare plant in the world, passes on from one to another " Herba Saussureae Involueratae " and can control all kinds of diseases and ailments, separate hundred poison, not only can building body, and is the miraculous cure of conditioning skin and losing.
Herba Saussureae Involueratae belongs to Compositae (Compositae) Cynara scolymus L (Cyhara cardunculus.) race (Trib.Cynareae Less.) phoenix hair Chrysanthemum (SaussureaDC.) plant, and China Herba Saussureae Involueratae is mainly distributed in the plateau refrigerant latitudes of more than 4000m, as Xinjiang, Gansu, Sichuan, Yunnan and Tibet etc.In the middle of numerous Herba Saussureae Involueratae, take Herba Saussureae Involueratae as certified products, its functional component content, medical value are the highest.
Main component flavone in Herba Saussureae Involueratae and glycoside thereof are strong sterilization components, and have stronger broad-spectrum antibacterial action, are especially better than antibacterial to fungus inhibitory action, are natural antibiotics.
According to the retrieval, not yet find Herba Saussureae Involueratae to be applied to the pertinent literature on toothpaste and patent.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of anti-inflammation be provided, alleviate gingival swelling and pain, the toothpaste containing Herba Saussureae Involueratae of oral problem such as treatment gingival hemorrhage etc.
The object of the invention is to be achieved through the following technical solutions:
A kind of toothpaste containing Herba Saussureae Involueratae composition, comprise base material, medicinal ingredient and stabilizing agent, the component of described base material comprises grinding agent, wetting agent, foaming agent, binding agent, flavouring agent, sweeting agent, stabilizing agent and water, medicinal ingredient is Herba Saussureae Involueratae extract, percentage by weight is 0.2%-2.0%, with the addition of the stabilizing agent of described medicinal ingredient simultaneously, account for the 5%-8% of medicinal ingredient, this medicinal ingredient content of drug effect components under the effect of stabilizing agent is stablized.
The present invention contains the toothpaste of Herba Saussureae Involueratae composition, and each component and the medicinal ingredient percentage by weight of described base material are as follows:
The present invention contains the toothpaste of Herba Saussureae Involueratae composition, and described wetting agent is one or more the mixture in glycerol, sorbitol, propylene glycol.
The present invention contains the toothpaste of Herba Saussureae Involueratae composition, and described binding agent is one or more the mixture in carboxymethyl cellulose, hydroxyethyl-cellulose, xanthan gum, carrageenan.
The present invention contains the toothpaste of Herba Saussureae Involueratae composition, and described foaming agent is one or more the mixture in sodium lauryl sulfate, sodium N-lauroyl sarcosinate.
The present invention contains the toothpaste of Herba Saussureae Involueratae composition, and described grinding agent is one or more the mixture in calcite, calcium hydrogen phosphate, silicon dioxide.
The present invention contains the toothpaste of Herba Saussureae Involueratae composition, and described stabilizing agent is ascorbic acid or citric acid or both mixture.
The present invention contains the toothpaste of Herba Saussureae Involueratae composition, and the preparation method of described Herba Saussureae Involueratae extract is as follows:
The Herba Saussureae Involueratae of drying is made powder, add 70% alcoholic solution by weight the ratio for 1:15, under 80 DEG C of conditions, then heat soak extraction twice, each extraction 1 hour, merge extracted twice liquid, obtain crude extract, crude extract concentrating under reduced pressure is reclaimed ethanol, obtains suspension, by suspension low temperature (4 DEG C) leave standstill 16 hours centrifugal, supernatant is with diatomaceous earth as filter aid, and buchner funnel sucking filtration, obtains Herba Saussureae Involueratae extract.
Advantage of the present invention and good effect are:
Herba Saussureae Involueratae adds in toothpaste as anti-inflammation composition by the present invention first, proves that its fungistatic effect obviously strengthens by experiment, specify that Herba Saussureae Involueratae in toothpaste with base material effective proportioning of each composition, give effective interpolation scope simultaneously.Can find out all there is stronger bacteriostasis containing Herba Saussureae Involueratae toothpaste to staphylococcus aureus, escherichia coli, porphyromonas gingivalis, Prevotella intermedia, bacterium actinomycetem comitans by the extracorporeal bacteria inhibitor test result of the toothpaste containing Herba Saussureae Involueratae medicinal ingredient.
Detailed description of the invention
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
The present invention contains the toothpaste of Herba Saussureae Involueratae composition, comprise grinding agent, wetting agent, foaming agent, binding agent, flavouring agent, sweeting agent, stabilizing agent and water, medicinal ingredient is wherein Herba Saussureae Involueratae extract, percentage by weight is the 0.2%-2.0% accounting for toothpaste gross weight, and stabiliser content is wherein the 5%-8% accounting for medicinal ingredient; This medicinal ingredient content of drug effect components under the effect of stabilizing agent is stablized.
The preparation method of above-mentioned Herba Saussureae Involueratae extract is as follows:
The Herba Saussureae Involueratae of drying is made powder, add 70% alcoholic solution by weight the ratio for 1:15, under 80 DEG C of conditions, then heat soak extraction twice, each extraction 1 hour, merge extracted twice liquid, obtain crude extract, crude extract concentrating under reduced pressure is reclaimed ethanol, obtains suspension, by suspension low temperature (4 DEG C) leave standstill 16 hours centrifugal, supernatant is with diatomaceous earth as filter aid, and buchner funnel sucking filtration, obtains Herba Saussureae Involueratae extract.
embodiment 1
Containing the toothpaste of Herba Saussureae Involueratae, its constituent and percentage by weight as follows:
Wherein mentioned component also available following composition or not write exactly but the identical similar or analogous components of effect conventional in toothpaste preparation field replaces;
Grinding agent: calcite, calcium hydrogen phosphate, silicon dioxide or analog;
Wetting agent: glycerol, sorbitol, propylene glycol or analog;
Foaming agent: sodium lauryl sulfate, sodium N-lauroyl sarcosinate or analog;
Binding agent: carboxymethyl cellulose, hydroxyethyl-cellulose, xanthan gum, carrageenan or analog.
The preparation method of the toothpaste containing Herba Saussureae Involueratae is:
By the sorbitol after above-mentioned metering, propylene glycol, squeeze into main frame (full-automatic three-in-one Manufacturing medicine extract machine) and start machinery and stir;
(2) stir through too small liquid tank after the saccharin sodium after above-mentioned metering, Herba Saussureae Involueratae extract, ascorbic acid is water-soluble, then squeeze in main frame, start the machine and stir;
(3) the carboxymethyl cellulose after above-mentioned metering and part of silica are stirred, then squeeze into main frame, carry out strong stirring 10 minutes;
(4) the silicon dioxide of the sodium lauryl sulfate after above-mentioned metering and remaining part is stirred and squeeze into main frame, strong stirring 30 minutes;
(5) the essence after above-mentioned metering is squeezed into main frame, then stir and obtain mastic in degassed 15 minutes.
embodiment 2
Containing the toothpaste of Herba Saussureae Involueratae, its constituent and percentage by weight as follows:
Its preparation method is with embodiment 1.
Wherein mentioned component also available following composition or not write exactly but the identical similar or analogous components of effect conventional in toothpaste preparation field replaces;
Grinding agent: calcite, calcium hydrogen phosphate, silicon dioxide or analog;
Wetting agent: glycerol, sorbitol, propylene glycol or analog;
Foaming agent: sodium lauryl sulfate, sodium N-lauroyl sarcosinate or analog;
Binding agent: carboxymethyl cellulose, hydroxyethyl-cellulose, xanthan gum, carrageenan or analog.
embodiment 3
Containing the toothpaste of Herba Saussureae Involueratae, its constituent and percentage by weight as follows:
Its preparation method is with embodiment 1.
Wherein mentioned component also available following composition or not write exactly but the identical similar or analogous components of effect conventional in toothpaste preparation field replaces;
Grinding agent: calcite, calcium hydrogen phosphate, silicon dioxide or analog;
Wetting agent: glycerol, sorbitol, propylene glycol or analog;
Foaming agent: sodium lauryl sulfate, sodium N-lauroyl sarcosinate or analog;
Binding agent: carboxymethyl cellulose, hydroxyethyl-cellulose, xanthan gum, carrageenan or analog.
embodiment 4
Containing the toothpaste of Herba Saussureae Involueratae, its constituent and percentage by weight as follows:
Its preparation method is with embodiment 1.
Wherein mentioned component also available following composition or not write exactly but the identical similar or analogous components of effect conventional in toothpaste preparation field replaces;
Grinding agent: calcite, calcium hydrogen phosphate, silicon dioxide or analog;
Wetting agent: glycerol, sorbitol, propylene glycol or analog;
Foaming agent: sodium lauryl sulfate, sodium N-lauroyl sarcosinate or analog;
Binding agent: carboxymethyl cellulose, hydroxyethyl-cellulose, xanthan gum, carrageenan or analog.
effect test example
Below be respectively the effect experimental example of the present invention containing determination of total flavonoids in Herba Saussureae Involueratae toothpaste antibacterial experiment in vitro and toothpaste.
1, containing Herba Saussureae Involueratae toothpaste antibacterial experiment in vitro
1) activation of strain: respectively by the streak inoculation of each strain bacterium on specific solid medium 37 DEG C cultivate 24 hours, to choose in single colony inoculation to specific fluid medium 37 DEG C and cultivate 20 hours.
2) bacteriostatic test: get each strain culturing bacterium liquid 1ml of 20 hours, add respectively in 50-60 DEG C of 100ml solid medium, shake up and be down flat plate, rear stainless steel tube punching (aperture is 8mm) to be solidified, in hole, add the toothpaste solution of dilution, added sample size with not overfolw hole outward for degree.Control wells adds normal saline.Cultivate after 24 hours, measure its inhibition zone diameter for 37 DEG C.
Table 1 is containing Herba Saussureae Involueratae toothpaste antibacterial experiment in vitro result
Annotation: aperture is 8mm
As can be seen from above-mentioned table 1, toothpaste prepared by the present invention significantly improves the anti-inflammation ability of toothpaste after adding this effective ingredient Herba Saussureae Involueratae, effectively can treat the oral problem such as gingival swelling and pain, gingival hemorrhage that the oral disease such as periodontitis, gingivitis causes.
2, determination of total flavonoids in toothpaste
1) get toothpaste content and be about 5g, accurately weighed, put in 250ml tool plug conical flask, add methanol and be about 100ml, airtight, jolting is about 1min, makes lotion of toothpaste in methanol, be fragmented into fragment shape, supersound extraction 10min in Ultrasound Instrument, by extracting solution filter paper filtering in 150ml conical flask, in water-bath, boil off methanol, when amount of solution is less than 25ml in conical flask, solution is transferred in 25ml volumetric flask, methanol constant volume.
2) get 10ml extracting solution, put in 25ml volumetric flask, add purified water 2ml, add NaNO
2solution (5%) 1.0ml, jolting, leaves standstill 6min, adds Al (NO
3)
3solution (10%) 1.0ml, jolting, leaves standstill 6min, adds NaOH solution (4%) 10ml, shake up, add purified water standardize solution, leaves standstill 15min, as test liquid, gets methanol 10ml simultaneously, determine placebo solution with legal system.Solution measures absorbance under ultraviolet spectrophotometer 500nm wavelength, carries out assay calculating with absorbance, quality.
Cubage formula:
X%=（82.558*A-0.1755）*25/(M*10000)
X: general flavone content
A: absorbance
M: sample weighing (g)
Determination of total flavonoids result in table 2 toothpaste
| Formulation of tooth-paste is numbered | Total flavones (%) |
| 1#(is not containing stabilizing agent) | 0.0056 |
| 1#(is containing stabilizing agent 1) | 0.0072 |
| 1#(is containing stabilizing agent 2) | 0.0081 |
| 2#(is not containing stabilizing agent) | 0.0118 |
| 2#(is containing stabilizing agent 1) | 0.0153 |
| 2#(is containing stabilizing agent 2) | 0.0164 |
As can be seen from above-mentioned table 2, the present invention adds the stability that stabilizing agent improves content of drug effect components.By confirming the interpretation of result of Herba Saussureae Involueratae determination of total flavonoids in toothpaste, the Herba Saussureae Involueratae toothpaste content of drug effect components containing stabilizing agent is more stable.
The above, it is only preferred embodiment of the present invention, not any pro forma restriction is done to the present invention, therefore everyly do not depart from technical solution of the present invention content, the any simple modification done above embodiment according to technical spirit of the present invention, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.
Claims (4)
1. the toothpaste containing Herba Saussureae Involueratae composition, comprise base material, medicinal ingredient and stabilizing agent, the component of described base material comprises grinding agent, wetting agent, foaming agent, binding agent, flavouring agent, sweeting agent and water, it is characterized in that: the medicinal ingredient of interpolation is Herba Saussureae Involueratae extract, percentage by weight is the 0.2%-2.0% accounting for toothpaste gross weight, with the addition of the stabilizing agent of described medicinal ingredient simultaneously;
The preparation method of described Herba Saussureae Involueratae extract is as follows:
The Herba Saussureae Involueratae of drying is made powder, ratio by weight 1:15 adds 70% alcoholic solution, then under 80 DEG C of conditions, heats soak extraction twice, each extraction 1 hour, merge extracted twice liquid, obtain crude extract, crude extract concentrating under reduced pressure is reclaimed ethanol, obtains suspension, by suspension low temperature 4 DEG C leave standstill 16 hours centrifugal, supernatant is with diatomaceous earth as filter aid, and buchner funnel sucking filtration, obtains Herba Saussureae Involueratae extract;
Each component of described base material and medicinal ingredient, stabilizing agent percentage by weight are as follows:
2. the toothpaste containing Herba Saussureae Involueratae composition according to claim 1, is characterized in that: described wetting agent is one or more the mixture in glycerol, sorbitol, propylene glycol.
3. the toothpaste containing Herba Saussureae Involueratae composition according to claim 1, is characterized in that: described binding agent is one or more the mixture in carboxymethyl cellulose, hydroxyethyl-cellulose, xanthan gum, carrageenan.
4. the toothpaste containing Herba Saussureae Involueratae composition according to claim 1, is characterized in that: described foaming agent is one or both the mixture in sodium lauryl sulfate, sodium N-lauroyl sarcosinate.
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| CN103462841B true CN103462841B (en) | 2015-06-10 |
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| CN105411959A (en) * | 2015-12-30 | 2016-03-23 | 刘操 | Healthcare toothpaste containing traditional Chinese herbals and preparation method thereof |
| CN107822920A (en) * | 2017-10-23 | 2018-03-23 | 广州市西瑶玉池科技有限公司 | A kind of inflammation-diminishing toothpaste of the mineral element containing the tremolite |
| CN111700835B (en) * | 2020-07-22 | 2021-04-16 | 三椒口腔健康股份有限公司 | Toothpaste containing snow lotus herb and preparation method thereof |
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| CN1392128A (en) * | 2002-07-18 | 2003-01-22 | 中山大学 | Process for preparing extract containing hypericin and flavon compounds |
| CN101897656A (en) * | 2010-07-13 | 2010-12-01 | 大连普瑞康生物技术有限公司 | Application of Saussurea involucrata culture as new raw material in daily chemicals |
| CN102579305A (en) * | 2012-03-29 | 2012-07-18 | 安徽两面针·芳草日化有限公司 | Natural medicine toothpaste with saussurea involucrata as major material |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102772340A (en) * | 2012-08-20 | 2012-11-14 | 青海阿如拉藏医药研究开发有限公司 | Tibetan saussurea toothpaste and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1392128A (en) * | 2002-07-18 | 2003-01-22 | 中山大学 | Process for preparing extract containing hypericin and flavon compounds |
| CN101897656A (en) * | 2010-07-13 | 2010-12-01 | 大连普瑞康生物技术有限公司 | Application of Saussurea involucrata culture as new raw material in daily chemicals |
| CN102579305A (en) * | 2012-03-29 | 2012-07-18 | 安徽两面针·芳草日化有限公司 | Natural medicine toothpaste with saussurea involucrata as major material |
Non-Patent Citations (2)
| Title |
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| 南果梨黄酮液稳定性研究;刘延吉等;《食品与生物技术学报》;20100731;第29卷(第4期);第558-561页 * |
| 罗明生等.硅藻土.《中国药用辅料》.化学工业出版社,2006,(第1版), * |
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