CN103462841A - Toothpaste containing saussurea involucrate component - Google Patents
Toothpaste containing saussurea involucrate component Download PDFInfo
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- CN103462841A CN103462841A CN201310404181XA CN201310404181A CN103462841A CN 103462841 A CN103462841 A CN 103462841A CN 201310404181X A CN201310404181X A CN 201310404181XA CN 201310404181 A CN201310404181 A CN 201310404181A CN 103462841 A CN103462841 A CN 103462841A
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Abstract
The invention discloses toothpaste containing a saussurea involucrate component. The toothpaste contains the following raw material components by weight percentage: 20%-60% of a moisturizing agent, 0.5%-2% of a binder, 0.1%-0.3% of a sweetener, 1%-3% of a foaming agent, 0.8%-1.5% of a flavoring agent, 20%-50% of an abradant, 0.2%-2.0% of a medicinal component, 0.01%-0.1% of a stabilizer and 10%-30% of water, wherein the medicinal component is a saussurea involucrate extract. According to the toothpaste, the saussurea involucrate which is taken as an antibacterial and anti-inflammatory component is added into the toothpaste for the first time, and the stabilizer for effectively stabilizing the medicinal component is provided. After the active component is added into the toothpaste, the antibacterial and anti-inflammatory capabilities of the toothpaste are obviously improved, and the toothpaste can effectively alleviate the oral health problems such as swelling and aching of gum and gum bleeding caused by oral diseases such as periodontitis and gingivitis.
Description
Technical field
The invention belongs to the daily chemical products field, relate to a kind of toothpaste, especially a kind of toothpaste that contains the Herba Saussureae Involueratae composition.
Background technology
The adult of China 90% has oral problem in various degree, the medical statistics data of specialty find along with the change (numb, peppery, boiling hot) of dietary habit and the increase of operating pressure, and the oral problem such as oral ulcer, gingival swelling and pain, hemorrhage, atrophy spread just fast.People's emotion, although be not enough to hospital, has greatly been perplexed in these oral cavities " minor issue ", has produced thus the consumption demand for oral problem.Intraoral periodontal support tissue is subject to local excitation simultaneously, as tartar, food impaction, bad dummy etc., long-term mechanical stimulus, denture is uneven and incorrect method for brushing teeth makes part dental articulation power burden excessive, and chemicals, burn, hypovitaminosis C, oral cavity bacterium growth etc. cause the oral cavity commonly encountered diseases such as gingivitis, periodontitis and alveolar abscess.
Herba Saussureae Involueratae is Chinese exclusive rare plant in the world, passes on from one to another " Herba Saussureae Involueratae " and can control all kinds of diseases and ailments, separate hundred poison, not only can building body, and be the miraculous cure of conditioning skin and losing.
Herba Saussureae Involueratae belongs to Compositae (Compositae) Cynara scolymus L (Cyhara cardunculus.) family (Trib.Cynareae Less.) phoenix hair Chrysanthemum (Saussurea DC.) plant, and China Herba Saussureae Involueratae mainly is distributed in the above plateau refrigerant latitudes of 4000m, as Xinjiang, Gansu, Sichuan, Yunnan and Tibet etc.In the middle of numerous Herba Saussureae Involueratae, take Herba Saussureae Involueratae as certified products, its functional component content, medical value are the highest.
Main component flavone and glycoside thereof in Herba Saussureae Involueratae, be strong sterilization component, and have stronger broad-spectrum antibacterial action, especially the fungus inhibitory action is better than to antibacterial, is natural antibiotics.
According to the retrieval, not yet find Herba Saussureae Involueratae is applied to pertinent literature and the patent on toothpaste.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of anti-inflammation is provided, alleviates gingival swelling and pain, the toothpaste that contains Herba Saussureae Involueratae of the oral problem such as treatment gingival hemorrhage.
The objective of the invention is to be achieved through the following technical solutions:
A kind of toothpaste that contains the Herba Saussureae Involueratae composition, comprise base material, medicinal ingredient and stabilizing agent, the component of described base material comprises grinding agent, wetting agent, foaming agent, binding agent, flavouring agent, sweeting agent, stabilizing agent and water, medicinal ingredient is the Herba Saussureae Involueratae extract, percentage by weight is 0.2%-2.0%, added the stabilizing agent of described medicinal ingredient simultaneously, accounted for the 5%-8% of medicinal ingredient, this medicinal ingredient content of drug effect components under the effect of stabilizing agent is stable.
The toothpaste that the present invention contains the Herba Saussureae Involueratae composition, each component and the medicinal ingredient percentage by weight of described base material are as follows:
The toothpaste that the present invention contains the Herba Saussureae Involueratae composition, described wetting agent is one or more the mixture in glycerol, sorbitol, propylene glycol.
The toothpaste that the present invention contains the Herba Saussureae Involueratae composition, described binding agent is one or more the mixture in carboxymethyl cellulose, hydroxyethyl-cellulose, xanthan gum, carrageenan.
The toothpaste that the present invention contains the Herba Saussureae Involueratae composition, described foaming agent is one or more the mixture in sodium lauryl sulfate, sodium N-lauroyl sarcosinate.
The toothpaste that the present invention contains the Herba Saussureae Involueratae composition, described grinding agent is one or more the mixture in calcite, calcium hydrogen phosphate, silicon dioxide.
The toothpaste that the present invention contains the Herba Saussureae Involueratae composition, described stabilizing agent is ascorbic acid or citric acid or both mixture.
The toothpaste that the present invention contains the Herba Saussureae Involueratae composition, the preparation method of described Herba Saussureae Involueratae extract is as follows:
Dry Herba Saussureae Involueratae is made to powder, by weight for the ratio of 1:15 adds 70% alcoholic solution, then under 80 ℃ of conditions, add heat soaking and extract twice, extract 1 hour at every turn, merge extracted twice liquid, obtain crude extract, the crude extract concentrating under reduced pressure is reclaimed to ethanol, obtain suspension, standing 16 hours of suspension low temperature (4 ℃) is centrifugal, supernatant is made filter aid with kieselguhr, and the buchner funnel sucking filtration, obtain Herba Saussureae Involueratae extract.
Advantage of the present invention and good effect are:
The present invention adds Herba Saussureae Involueratae in toothpaste to as the anti-inflammation composition first, proves that by experiment its fungistatic effect obviously strengthens, clear and definite Herba Saussureae Involueratae in toothpaste with effective proportioning of each composition of base material, provided effective interpolation scope simultaneously.Extracorporeal bacteria inhibitor test result by the toothpaste containing the Herba Saussureae Involueratae medicinal ingredient can find out, containing Herba Saussureae Involueratae toothpaste, staphylococcus aureus, escherichia coli, porphyromonas gingivalis, middle general Salmonella, bacterium actinomycetem comitans are all had to stronger bacteriostasis.
The specific embodiment
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
The toothpaste that the present invention contains the Herba Saussureae Involueratae composition, comprise grinding agent, wetting agent, foaming agent, binding agent, flavouring agent, sweeting agent, stabilizing agent and water, medicinal ingredient wherein is the Herba Saussureae Involueratae extract, percentage by weight is the 0.2%-2.0% that accounts for the toothpaste gross weight, and stabiliser content wherein is the 5%-8% that accounts for medicinal ingredient; This medicinal ingredient content of drug effect components under the effect of stabilizing agent is stable.
The preparation method of above-mentioned Herba Saussureae Involueratae extract is as follows:
Dry Herba Saussureae Involueratae is made to powder, by weight for the ratio of 1:15 adds 70% alcoholic solution, then under 80 ℃ of conditions, add heat soaking and extract twice, extract 1 hour at every turn, merge extracted twice liquid, obtain crude extract, the crude extract concentrating under reduced pressure is reclaimed to ethanol, obtain suspension, standing 16 hours of suspension low temperature (4 ℃) is centrifugal, supernatant is made filter aid with kieselguhr, and the buchner funnel sucking filtration, obtain Herba Saussureae Involueratae extract.
embodiment 1
A kind of toothpaste that contains Herba Saussureae Involueratae, its constituent and percentage by weight are as follows:
Wherein mentioned component also available following each composition or do not write exactly but in the toothpaste preparation field the identical similar or analogous components of effect commonly used replace;
Grinding agent: calcite, calcium hydrogen phosphate, silicon dioxide or analog;
Wetting agent: glycerol, sorbitol, propylene glycol or analog;
Foaming agent: sodium lauryl sulfate, sodium N-lauroyl sarcosinate or analog;
Binding agent: carboxymethyl cellulose, hydroxyethyl-cellulose, xanthan gum, carrageenan or analog.
The preparation method of the toothpaste that contains Herba Saussureae Involueratae is:
By the sorbitol after above-mentioned metering, propylene glycol, squeeze into main frame (full-automatic three-in-one Manufacturing medicine extract machine) and start machinery and stir;
By the saccharin sodium after above-mentioned metering, Herba Saussureae Involueratae extract, ascorbic acid is water-soluble by too small liquid tank, stirs, and then squeezes in main frame, start the machine and stir;
(3) the carboxymethyl cellulose after above-mentioned metering and part silicon dioxide are stirred, then squeeze into main frame, carry out strong stirring 10 minutes;
(4) the silicon dioxide of the sodium lauryl sulfate after above-mentioned metering and remaining part is stirred and squeezes into main frame, strong stirring 30 minutes;
(5) the essence after above-mentioned metering is squeezed into to main frame, then stir and within degassed 15 minutes, obtain mastic.
embodiment 2
A kind of toothpaste that contains Herba Saussureae Involueratae, its constituent and percentage by weight are as follows:
Its preparation method is with embodiment 1.
Wherein mentioned component also available following each composition or do not write exactly but in the toothpaste preparation field the identical similar or analogous components of effect commonly used replace;
Grinding agent: calcite, calcium hydrogen phosphate, silicon dioxide or analog;
Wetting agent: glycerol, sorbitol, propylene glycol or analog;
Foaming agent: sodium lauryl sulfate, sodium N-lauroyl sarcosinate or analog;
Binding agent: carboxymethyl cellulose, hydroxyethyl-cellulose, xanthan gum, carrageenan or analog.
embodiment 3
A kind of toothpaste that contains Herba Saussureae Involueratae, its constituent and percentage by weight are as follows:
Its preparation method is with embodiment 1.
Wherein mentioned component also available following each composition or do not write exactly but in the toothpaste preparation field the identical similar or analogous components of effect commonly used replace;
Grinding agent: calcite, calcium hydrogen phosphate, silicon dioxide or analog;
Wetting agent: glycerol, sorbitol, propylene glycol or analog;
Foaming agent: sodium lauryl sulfate, sodium N-lauroyl sarcosinate or analog;
Binding agent: carboxymethyl cellulose, hydroxyethyl-cellulose, xanthan gum, carrageenan or analog.
embodiment 4
A kind of toothpaste that contains Herba Saussureae Involueratae, its constituent and percentage by weight are as follows:
Its preparation method is with embodiment 1.
Wherein mentioned component also available following each composition or do not write exactly but in the toothpaste preparation field the identical similar or analogous components of effect commonly used replace;
Grinding agent: calcite, calcium hydrogen phosphate, silicon dioxide or analog;
Wetting agent: glycerol, sorbitol, propylene glycol or analog;
Foaming agent: sodium lauryl sulfate, sodium N-lauroyl sarcosinate or analog;
Binding agent: carboxymethyl cellulose, hydroxyethyl-cellulose, xanthan gum, carrageenan or analog.
the effect test example
Below be respectively the effect experimental example of the present invention containing determination of total flavonoids in the outer bacteriostatic experiment of Herba Saussureae Involueratae toothpaste body and toothpaste.
1, containing the outer bacteriostatic experiment of Herba Saussureae Involueratae toothpaste body
1) activation of strain: respectively by each strain bacterium streak inoculation on specific solid medium 37 ℃ cultivate 24 hours, choose single colony inoculation in specific fluid medium 37 ℃ cultivate 20 hours.
2) bacteriostatic test: get each strain culturing bacterium liquid 1ml of 20 hours, add respectively in 50-60 ℃ of 100ml solid medium, shake up and be down flat plate, after solidifying with stainless steel tube punching (aperture is 8mm), the toothpaste solution that adds dilution in hole, institute adds sample size and take not overfolw hole outward for spending.Control wells adds normal saline.Cultivate after 24 hours, measure its inhibition zone diameter for 37 ℃.
Table 1 is containing the outer bacteriostatic experiment result of Herba Saussureae Involueratae toothpaste body
Annotation: aperture is 8mm
By above-mentioned table 1, can be found out, toothpaste prepared by the present invention adds after this effective ingredient Herba Saussureae Involueratae the anti-inflammation ability that has obviously improved toothpaste, can effectively treat the oral problem such as gingival swelling and pain that the oral diseases such as periodontitis, gingivitis cause, gingival hemorrhage.
2, determination of total flavonoids in toothpaste
1) get the about 5g of toothpaste content, accurately weighed, put in 250ml tool plug conical flask, add the about 100ml of methanol, airtight, the about 1min of jolting, make lotion of toothpaste be fragmented into the fragment shape in methanol, supersound extraction 10min in Ultrasound Instrument, by extracting solution with filter paper filtering to the 150ml conical flask, boil off methanol in water-bath, when amount of solution is less than 25ml in conical flask, solution is transferred in the 25ml volumetric flask to methanol constant volume.
2) get the 10ml extracting solution, put in the 25ml volumetric flask, add purified water 2ml, add NaNO
2solution (5%) 1.0ml, jolting, standing 6min, add Al (NO
3)
3solution (10%) 1.0ml, jolting, standing 6min, add NaOH solution (4%) 10ml, shakes up, and adds the purified water standardize solution, and standing 15min as test liquid, gets methanol 10ml simultaneously, with legal system, determines blank solution.Solution is measured absorbance under ultraviolet spectrophotometer 500nm wavelength, with absorbance, quality, carries out assay calculating.
The cubage formula:
X%=(82.558*A-0.1755)*25/(M*10000)
X: general flavone content
A: absorbance
M: sample weighing (g)
Determination of total flavonoids result in table 2 toothpaste
The formulation of tooth-paste numbering | Total flavones (%) |
1#(is not containing stabilizing agent) | 0.0056 |
1#(is containing stabilizing agent 1) | 0.0072 |
1#(is containing stabilizing agent 2) | 0.0081 |
2#(is not containing stabilizing agent) | 0.0118 |
2#(is containing stabilizing agent 1) | 0.0153 |
2#(is containing stabilizing agent 2) | 0.0164 |
By above-mentioned table 2, can be found out, the present invention adds the stability that stabilizing agent has improved content of drug effect components.By the interpretation of result to Herba Saussureae Involueratae determination of total flavonoids in toothpaste, confirm, the Herba Saussureae Involueratae toothpaste content of drug effect components that contains stabilizing agent is more stable.
The above, it is only preferred embodiment of the present invention, not the present invention is done to any pro forma restriction, do not break away from the technical solution of the present invention content therefore every, any simple modification, equivalent variations and the modification above embodiment done according to technical spirit of the present invention, all still belong in the scope of technical solution of the present invention.
Claims (8)
1. a toothpaste that contains the Herba Saussureae Involueratae composition, comprise base material, medicinal ingredient and stabilizing agent, the component of described base material comprises grinding agent, wetting agent, foaming agent, binding agent, flavouring agent, sweeting agent and water, it is characterized in that: the medicinal ingredient of interpolation is the Herba Saussureae Involueratae extract, percentage by weight is the 0.2%--2.0% that accounts for the toothpaste gross weight, add the stabilizing agent of described medicinal ingredient simultaneously, accounted for the 5%-8% of medicinal ingredient.
3. the toothpaste that contains the Herba Saussureae Involueratae composition according to claim 1 and 2 is characterized in that: described wetting agent is one or more the mixture in glycerol, sorbitol, propylene glycol.
4. the toothpaste that contains the Herba Saussureae Involueratae composition according to claim 1 and 2 is characterized in that: described binding agent is one or more the mixture in carboxymethyl cellulose, hydroxyethyl-cellulose, xanthan gum, carrageenan.
5. the toothpaste that contains the Herba Saussureae Involueratae composition according to claim 1 and 2 is characterized in that: described foaming agent is one or more the mixture in sodium lauryl sulfate, sodium N-lauroyl sarcosinate.
6. the toothpaste that contains the Herba Saussureae Involueratae composition according to claim 1 and 2 is characterized in that: described grinding agent is one or more the mixture in calcite, calcium hydrogen phosphate, silicon dioxide.
7. the toothpaste that contains the Herba Saussureae Involueratae composition according to claim 1 and 2, it is characterized in that: described stabilizing agent is ascorbic acid or citric acid or both mixture.
8. the toothpaste that contains the Herba Saussureae Involueratae composition according to claim 1 and 2, it is characterized in that: the preparation method of described Herba Saussureae Involueratae extract is as follows:
Dry Herba Saussureae Involueratae is made to powder, ratio by weight 1:15 adds 70% alcoholic solution, then under 80 ℃ of conditions, adds heat soaking and extracts twice, extracts 1 hour at every turn, merge extracted twice liquid, obtain crude extract, the crude extract concentrating under reduced pressure is reclaimed to ethanol, obtain suspension, standing 16 hours of suspension low temperature (4 ℃) is centrifugal, supernatant is made filter aid with kieselguhr, and the buchner funnel sucking filtration, obtain Herba Saussureae Involueratae extract.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105411959A (en) * | 2015-12-30 | 2016-03-23 | 刘操 | Healthcare toothpaste containing traditional Chinese herbals and preparation method thereof |
CN107822920A (en) * | 2017-10-23 | 2018-03-23 | 广州市西瑶玉池科技有限公司 | A kind of inflammation-diminishing toothpaste of the mineral element containing the tremolite |
CN111700835A (en) * | 2020-07-22 | 2020-09-25 | 三椒口腔健康股份有限公司 | Toothpaste containing snow lotus herb and preparation method thereof |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105411959A (en) * | 2015-12-30 | 2016-03-23 | 刘操 | Healthcare toothpaste containing traditional Chinese herbals and preparation method thereof |
CN107822920A (en) * | 2017-10-23 | 2018-03-23 | 广州市西瑶玉池科技有限公司 | A kind of inflammation-diminishing toothpaste of the mineral element containing the tremolite |
CN111700835A (en) * | 2020-07-22 | 2020-09-25 | 三椒口腔健康股份有限公司 | Toothpaste containing snow lotus herb and preparation method thereof |
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