CN102078275A - Shuanghuanglian mouthwash and preparation method thereof - Google Patents
Shuanghuanglian mouthwash and preparation method thereof Download PDFInfo
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Abstract
The invention provides Shuanghuanglian mouthwash and a preparation method thereof. The Shuanghuanglian mouthwash is prepared from 1-50g of honeysuckle flower (lonicera confusa), 0.1-15g of weeping forsythia, 0.1-15g of baical skullcap root, 0.01-1g of menthol crystal, 30-90ml of glycerol, 1-50g of xylitol, 1-20ml of ethanol, 0.05-0.5g of potassium sorbate and 0.01-10ml of essence in proportion by weight. The Shuanghuanglian mouthwash is prepared by taking the honeysuckle flower (lonicera confusa), the baical skullcap root and the weeping forsythia as main raw materials and adding other raw and auxiliary materials, wherein the baical skullcap root, the honeysuckle flower (lonicera confusa) and the weeping forsythia are respectively extracted and concentrated to obtain the extracts. For the Shuanghuanglian mouthwash and the preparation method thereof, a Shuanghuanglian classic formula of the Chinese medicine is applied, and particularly, an extraction process is optimized on the basis of the Shuanghuanglianclassic formula of the Chinese medicine, wherein the PH value of an alcoholic solution is regulated in a process for extracting the honeysuckle flower (lonicera confusa) extract and the weeping forsythia extract with the method provided by the invention; thus, the obtained Shuanghuanglian mouthwash has the advantages of high yield, fewer impurities, good taste and clear solution, has a good effect of keeping oral health and can effectively kill oral pathogenic bacteria and various harmful bacteria and viruses, including coronavirus and avian influenza virus. Compared with common gargles made of pure Chinese medicines or western medicines in the market, the Shuanghuanglian mouthwash provided by the invention is convenient to prepare and difficult to precipitate after long-term storage, has the advantages of good stability, safety and effectiveness and is an ideal preparation for daily oral care. The preparation method is applicable to industrial production.
Description
Technical field
What the present invention relates to is a kind of personal-care supplies, specifically a kind of rinse water.The present invention also relates to a kind of preparation method of rinse water.
Background technology
That Flos Lonicerae (Flos Lonicerae, Flos Lonicerae) has is antibacterial, antiviral, antiinflammatory, analgesic, regulate effect such as immunity; Fructus Forsythiae has effects such as antiinflammatory, antibiotic, antiviral, analgesic, analgesia, antiendotoxin; Effects such as that Radix Scutellariae has is antibiotic, antifungal, antiviral, antiinflammatory antiallergic action.Flos Lonicerae (Flos Lonicerae, Flos Lonicerae), Fructus Forsythiae, Radix Scutellariae share and are the classical Chinese medicine prescription, are the Chinese medicine compound that Chinese Pharmacopoeia version in 2010 is recorded.Its chemical constituent is clear, has the effect of relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, heat-clearing and toxic substances removing; The classical prescription of the SHUANGHUANLIAN of Chinese medicine is applied to the maintenance oral health effect that can reach good in the rinse water.
Summary of the invention
The object of the present invention is to provide a kind of mouth care that is used for, can keep oral cavity cleaning, comfortable, the prevention oral disease the SHUANGHUANLIAN rinse water.The present invention also aims to provide a kind of preparation method of SHUANGHUANLIAN rinse water.
The object of the present invention is achieved like this:
Contain among the every 1000ml of SHUANGHUANLIAN rinse water of the present invention:
Flos Lonicerae (Flos Lonicerae, Flos Lonicerae) 1-50g
Fructus Forsythiae 0.1-15g
Radix Scutellariae 0.1-15g
Xylitol 1-50g
Mentholum 0.01-1g
Glycerol 30-90ml
Ethanol 1-20ml
Potassium sorbate 0.05-0.5g
Essence 0.01-10ml
The preparation method of SHUANGHUANLIAN rinse water of the present invention is:
A kind of preparation method of SHUANGHUANLIAN rinse water, it is characterized in that: Radix Scutellariae decocts with water three times, first, secondary each 2 hours, 1 hour for the third time, collecting decoction, filter, filtrate concentrates and add hydrochloric acid solution in the time of 70-80 ℃ regulates pH value to 1.0～3.0, and insulation 1h left standstill 12 hours, filter, precipitation adds 8～10 times of water gagings, regulates pH value to 6.0～8.0 with sodium hydroxide solution, adds ethanol again and makes and contain the alcohol amount and reach 40～60%, stirring makes dissolving, filter, filtrate is regulated pH value to 1.0～2.0,50 ℃ insulation 1 hour with hydrochloric acid solution, left standstill 10 hours, filter, it is 6.0～8.0 that precipitation is washed till pH value with ethanol, reclaims ethanol and obtains Radix Scutellariae extractum, drying under reduced pressure is ground into fine powder.
Flos Lonicerae (Flos Lonicerae, Flos Lonicerae) adds water temperature soak 30 minutes after, decoct secondary, each 2 hours, collecting decoction filtered, it is 1.20～1.25 clear paste that filtrate is concentrated into 70～80 ℃ relative density, slowly add ethanol after the cooling and make and contain alcohol amount and reach 60～80%, fully stir, left standstill 12 hours, the leaching supernatant, regulate pH value to 6.0～8.0 with sodium hydroxide solution, it is an amount of that residue adds 75% ethanol, stirs evenly, left standstill 12 hours, filter, merge ethanol liquid, reclaim ethanol and obtain Flos Lonicerae (Flos Lonicerae, Flos Lonicerae) extractum, drying under reduced pressure is ground into fine powder.
After Fructus Forsythiae adds water temperature and soaks 30 minutes, decoct secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filters, and it is 1.20～1.25 clear paste that filtrate is concentrated into 70～80 ℃ relative density, slowly adding ethanol after the cooling makes and contains alcohol amount and reach 60～80%,, fully stir, left standstill 12 hours, the leaching supernatant, regulate pH value to 6.0～8.0 with sodium hydroxide solution, it is an amount of that residue adds 75% ethanol, stirs evenly, left standstill 12 hours, filter, merge ethanol liquid, reclaim ethanol and obtain Fructus Forsythiae extractum, drying under reduced pressure is ground into fine powder.
Getting Mentholum 0.01-1g is dissolved in the ethanol, Radix Scutellariae extract is dissolved in the 5%-40%NaOH solution, in addition extracting honeysuckle (Flos Lonicerae, Flos Lonicerae) extract, Fructus Forsythiae extract, xylitol 1-50g, potassium sorbate 0.05-0.5g, after adding an amount of purified water dissolving, add glycerol 30-90ml, essence 0.01-10ml, Radix Scutellariae extract aqueous slkali and Mentholum alcoholic solution, to full dose, filter with purified water, embedding, packing.
The invention provides a kind of rinse water preparation and preparation method thereof, transfer pH value according to Flos Lonicerae (Flos Lonicerae, Flos Lonicerae) extract, Fructus Forsythiae extract that method of the present invention obtains in leaching process in alcoholic solution, make the yield height, impurity is low, mouthfeel is good, the solution clarification; The SHUANGHUANLIAN rinse water that obtains more adds xylitol, effectively prevents decayed tooth, can play good maintenance oral health effect, cooperates natural mint flavored simultaneously, makes breath freshening, and is healthy pleasant.Be the desirable preparation that is used for daily mouth care, its preparation method adapts to suitability for industrialized production.
The present invention has optimized extraction process on the basis of the classical prescription of Chinese medicine SHUANGHUANLIAN, obtained the better product of performance.Experiment shows that SHUANGHUANLIAN has the effect of anti-sars, anti-avian influenza and anti-H1N1 influenza, compare with the visible common collutory in present market, the described SHUANGHUANLIAN rinse water preparation of the present patent application is convenient, and storage for a long time is difficult for separating out precipitation, good stability, preparation safety, effective.
Experiment shows that the SHUANGHUANLIAN composing prescription preparation has certain prevention and inhibitory action to coronavirus through China Sickness Prevention Control Center Virus Disease Prevention Control Institute; Experimental results show that through Harbin Medical University: the SHUANGHUANLIAN composing prescription preparation has to a certain degree sterilization and bacteriostasis to antibacterials such as staphylococcus aureus, Staphylococcus albus, Staphylococcus citreus, group B streptococcus, bacillus pyocyaneus and Bacillus proteus, Bacillus typhi, and can effectively kill and suppress coronavirus and bird flu virus; Experiment shows that the SHUANGHUANLIAN composing prescription preparation reaches 94.37% to the killing rate of bird flu virus through Harbin Veterinary Medicine Inst., China Academy of Agriculture.
The present invention has the following advantages:
1. can keep oral hygiene, often using has nursing role preferably to periodontitis, gingivitis, gingival hemorrhage, and human body is not had injury, is ideal dental care product.
2. multiple oral problem there are pain relieving, antiinflammatory effect.Have no side effect no pain.Simple and easy to do, produce easily.
3. to have preparation technology simpler in the present invention, characteristics such as the products made thereby color and luster is light, stability is strong, free from extraneous odour, mouthfeel is good and antibacterial and anti-inflammation functions is obvious.
4. has wide accommodation, advantage such as cleaning action is remarkable.Its preparation is simple, and cost is low, is worthy to be popularized.
5. the present invention has no side effect, its antibacterial action obviously is better than mouth care medical instruments commonly used, and has heat clearing away, detoxifcation, reducing swelling and alleviating pain, effect such as convergence granulation promoting etc., excellent to the patient's of stomatitis, gingivitis, oral ulcer, traumatic mucosal injury mouth care effect.
6. this rinse water collection like product advantage, it is not enough separately to overcome it, the energy deodorization and sterilization is removed oral cavity detritus and abnormal flavour, increases a mouthful perfume, its low price, not need during use to collude right temporarily, Anti-dental injury tooth, dental bed and be easy to carry, with need with usefulness, both be fit to grade places consumption, and be easy to ordinary populace again and accept.
7. this rinse water is for the assisted care of the oral diseases such as periodontal disease of non-systemic infection, have that consumption is little, expense is low, side effect is little, easy to use, cleaning effect good, has the clinical practice meaning; In this preparation, add relevant auxiliary materials such as correctives, make the rinse water mouthfeel little sweet, nice and cool, easily be accepted.
Effect of the present invention is verified by following test:
The inspection of semifinished product: the evaluation of baicalin: up to specification, PH6.8
Product inspection: the evaluation of baicalin: up to specification, PH6.9
The specific embodiment
For example the present invention is done in more detail below and describes:
Embodiment 1
(1) prescription
Flos Lonicerae (Flos Lonicerae, Flos Lonicerae) 10g
Fructus Forsythiae 8g
Radix Scutellariae 5g
Xylitol 30g
Mentholum 0.1g
Glycerol 50ml
Ethanol 5ml
Potassium sorbate 0.2g,
Essence 0.1ml
Purified water adds to 1000ml
(2) preparation technology
A kind of preparation method of SHUANGHUANLIAN rinse water, it is characterized in that: Radix Scutellariae decocts with water three times, first, secondary each 2 hours, 1 hour for the third time, collecting decoction, filter, filtrate concentrates and add hydrochloric acid solution in the time of 70-80 ℃ regulates pH value to 1.0～3.0, and insulation 1h left standstill 12 hours, filter, precipitation adds 8～10 times of water gagings, regulates pH value to 6.0～8.0 with sodium hydroxide solution, adds ethanol again and makes and contain the alcohol amount and reach 40～60%, stirring makes dissolving, filter, filtrate is regulated pH value to 1.0～2.0,50 ℃ insulation 1 hour with hydrochloric acid solution, left standstill 10 hours, filter, it is 6.0～8.0 that precipitation is washed till pH value with ethanol, reclaims ethanol and obtains Radix Scutellariae extractum, drying under reduced pressure is ground into fine powder;
Flos Lonicerae (Flos Lonicerae, Flos Lonicerae) adds water temperature soak 30 minutes after, decoct secondary, each 2 hours, collecting decoction filtered, it is 1.20～1.25 clear paste that filtrate is concentrated into 70～80 ℃ relative density, slowly add ethanol after the cooling and make and contain alcohol amount and reach 60～80%, fully stir, left standstill 12 hours, the leaching supernatant, regulate pH value to 6.0～8.0 with sodium hydroxide solution, it is an amount of that residue adds 75% ethanol, stirs evenly, left standstill 12 hours, filter, merge ethanol liquid, reclaim ethanol and obtain Flos Lonicerae (Flos Lonicerae, Flos Lonicerae) extractum, drying under reduced pressure is ground into fine powder;
After Fructus Forsythiae adds water temperature and soaks 30 minutes, decoct secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filters, and it is 1.20～1.25 clear paste that filtrate is concentrated into 70～80 ℃ relative density, slowly adding ethanol after the cooling makes and contains alcohol amount and reach 60～80%,, fully stir, left standstill 12 hours, the leaching supernatant, regulate pH value to 6.0～8.0 with sodium hydroxide solution, it is an amount of that residue adds 75% ethanol, stirs evenly, left standstill 12 hours, filter, merge ethanol liquid, reclaim ethanol and obtain Fructus Forsythiae extractum, drying under reduced pressure is ground into fine powder.
Getting Mentholum is dissolved in the ethanol, Radix Scutellariae extract is dissolved in the 5%-40%NaOH solution, in addition extracting honeysuckle (Flos Lonicerae, Flos Lonicerae) extract, Fructus Forsythiae extract, xylitol, potassium sorbate, after adding an amount of purified water dissolving, add glycerol, essence, Radix Scutellariae extract aqueous slkali and Mentholum alcoholic solution, to full dose, filter with purified water, embedding, packing.
The inspection of semifinished product: the evaluation of baicalin: up to specification; PH6.8
Product inspection: the evaluation of baicalin: up to specification, pH6.9
Embodiment 2
(1) prescription
Flos Lonicerae (Flos Lonicerae, Flos Lonicerae) 5g
Fructus Forsythiae 10g
Radix Scutellariae 4g
Xylitol 10g
Mentholum 0.3g
Glycerol 30ml
Ethanol 10ml
Potassium sorbate 0.3g
Essence 0.2ml
Purified water adds to 1000ml
(2) preparation technology
A kind of preparation method of SHUANGHUANLIAN rinse water, it is characterized in that: Radix Scutellariae decocts with water three times, first, secondary each 2 hours, 1 hour for the third time, collecting decoction, filter, filtrate concentrates and add hydrochloric acid solution in the time of 70-80 ℃ regulates pH value to 1.0～3.0, and insulation 1h left standstill 12 hours, filter, precipitation adds 8～10 times of water gagings, regulates pH value to 6.0～8.0 with sodium hydroxide solution, adds ethanol again and makes and contain the alcohol amount and reach 40～60%, stirring makes dissolving, filter, filtrate is regulated pH value to 1.0～2.0,50 ℃ insulation 1 hour with hydrochloric acid solution, left standstill 10 hours, filter, it is 6.0～8.0 that precipitation is washed till pH value with ethanol, reclaims ethanol and obtains Radix Scutellariae extractum, drying under reduced pressure is ground into fine powder;
Flos Lonicerae (Flos Lonicerae, Flos Lonicerae) adds water temperature soak 30 minutes after, decoct secondary, each 2 hours, collecting decoction filtered, it is 1.20～1.25 clear paste that filtrate is concentrated into 70～80 ℃ relative density, slowly add ethanol after the cooling and make and contain alcohol amount and reach 60～80%, fully stir, left standstill 12 hours, the leaching supernatant, regulate pH value to 6.0～8.0 with sodium hydroxide solution, it is an amount of that residue adds 75% ethanol, stirs evenly, left standstill 12 hours, filter, merge ethanol liquid, reclaim ethanol and obtain Flos Lonicerae (Flos Lonicerae, Flos Lonicerae) extractum, drying under reduced pressure is ground into fine powder;
After Fructus Forsythiae adds water temperature and soaks 30 minutes, decoct secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filters, and it is 1.20～1.25 clear paste that filtrate is concentrated into 70～80 ℃ relative density, slowly adding ethanol after the cooling makes and contains alcohol amount and reach 60～80%,, fully stir, left standstill 12 hours, the leaching supernatant, regulate pH value to 6.0～8.0 with sodium hydroxide solution, it is an amount of that residue adds 75% ethanol, stirs evenly, left standstill 12 hours, filter, merge ethanol liquid, reclaim ethanol and obtain Fructus Forsythiae extractum, drying under reduced pressure is ground into fine powder.
Getting Mentholum is dissolved in the ethanol, Radix Scutellariae extract is dissolved in the 5%-40%NaOH solution, in addition extracting honeysuckle (Flos Lonicerae, Flos Lonicerae) extract, Fructus Forsythiae extract, xylitol, potassium sorbate, after adding an amount of purified water dissolving, add glycerol, essence, Radix Scutellariae extract aqueous slkali and Mentholum alcoholic solution, to full dose, filter with purified water, embedding, packing.
The inspection of semifinished product: the evaluation of baicalin: up to specification; PH6.4
Product inspection: the evaluation of baicalin: up to specification, pH6.3
Embodiment 3
(1) prescription
Flos Lonicerae (Flos Lonicerae, Flos Lonicerae) 20g
Fructus Forsythiae 5g
Radix Scutellariae 10g
Xylitol 15g
Mentholum 0.05g
Glycerol 90ml
Ethanol 3ml
Potassium sorbate 0.2g,
Essence 0.2ml
Purified water adds to 1000ml
(2) preparation technology
A kind of preparation method of SHUANGHUANLIAN rinse water, it is characterized in that: Radix Scutellariae decocts with water three times, first, secondary each 2 hours, 1 hour for the third time, collecting decoction, filter, filtrate concentrates and add hydrochloric acid solution in the time of 70-80 ℃ regulates pH value to 1.0～3.0, and insulation 1h left standstill 12 hours, filter, precipitation adds 8～10 times of water gagings, regulates pH value to 6.0～8.0 with sodium hydroxide solution, adds ethanol again and makes and contain the alcohol amount and reach 40～60%, stirring makes dissolving, filter, filtrate is regulated pH value to 1.0～2.0,50 ℃ insulation 1 hour with hydrochloric acid solution, left standstill 10 hours, filter, it is 6.0～8.0 that precipitation is washed till pH value with ethanol, reclaims ethanol and obtains Radix Scutellariae extractum, drying under reduced pressure is ground into fine powder;
Flos Lonicerae (Flos Lonicerae, Flos Lonicerae) adds water temperature soak 30 minutes after, decoct secondary, each 2 hours, collecting decoction filtered, it is 1.20～1.25 clear paste that filtrate is concentrated into 70～80 ℃ relative density, slowly add ethanol after the cooling and make and contain alcohol amount and reach 60～80%, fully stir, left standstill 12 hours, the leaching supernatant, regulate pH value to 6.0～8.0 with sodium hydroxide solution, it is an amount of that residue adds 75% ethanol, stirs evenly, left standstill 12 hours, filter, merge ethanol liquid, reclaim ethanol and obtain Flos Lonicerae (Flos Lonicerae, Flos Lonicerae) extractum, drying under reduced pressure is ground into fine powder;
After Fructus Forsythiae adds water temperature and soaks 30 minutes, decoct secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filters, and it is 1.20～1.25 clear paste that filtrate is concentrated into 70～80 ℃ relative density, slowly adding ethanol after the cooling makes and contains alcohol amount and reach 60～80%,, fully stir, left standstill 12 hours, the leaching supernatant, regulate pH value to 6.0～8.0 with sodium hydroxide solution, it is an amount of that residue adds 75% ethanol, stirs evenly, left standstill 12 hours, filter, merge ethanol liquid, reclaim ethanol and obtain Fructus Forsythiae extractum, drying under reduced pressure is ground into fine powder.
Getting Mentholum is dissolved in the ethanol, Radix Scutellariae extract is dissolved in the 5%-40%NaOH solution, in addition extracting honeysuckle (Flos Lonicerae, Flos Lonicerae) extract, Fructus Forsythiae extract, xylitol, potassium sorbate, after adding an amount of purified water dissolving, add glycerol, essence, Radix Scutellariae extract aqueous slkali and Mentholum alcoholic solution, to full dose, filter with purified water, embedding, packing.
The inspection of semifinished product: the evaluation of baicalin: up to specification; PH6.7
Product inspection: the evaluation of baicalin: up to specification, pH6.8
The present invention is that the classical prescription of a kind of SHUANGHUANLIAN with Chinese medicine is applied to rinse water preparation wherein and preparation method thereof, obtaining the SHUANGHUANLIAN rinse water according to method of the present invention and can play good maintenance oral health effect, is the desirable preparation that is used for daily mouth care.SHUANGHUANLIAN rinse water preparation method adapts to suitability for industrialized production.Easy to use according to the product that method of the present invention obtains, curative effect is more definite, and quality is more stable.
Claims (2)
1. a SHUANGHUANLIAN rinse water is characterized in that: contain Flos Lonicerae (Flos Lonicerae, Flos Lonicerae) 1-50g, Fructus Forsythiae 0.1-15g, Radix Scutellariae 0.1-15g, Mentholum 0.01-1g, glycerol 30-90ml, xylitol 1-50g, ethanol 1-20ml, potassium sorbate 0.05-0.5g and essence 0.01-10ml among every 1000ml.
2. the preparation method of a SHUANGHUANLIAN rinse water, it is characterized in that: Radix Scutellariae decocts with water three times, first, secondary each 2 hours, 1 hour for the third time, collecting decoction, filter, filtrate concentrates and add hydrochloric acid solution in the time of 70-80 ℃ regulates pH value to 1.0～3.0, and insulation 1h left standstill 12 hours, filter, precipitation adds 8～10 times of water gagings, regulates pH value to 6.0～8.0 with sodium hydroxide solution, adds ethanol again and makes and contain the alcohol amount and reach 40～60%, stirring makes dissolving, filter, filtrate is regulated pH value to 1.0～2.0,50 ℃ insulation 1 hour with hydrochloric acid solution, left standstill 10 hours, filter, it is 6.0～8.0 that precipitation is washed till pH value with ethanol, reclaims ethanol and obtains Radix Scutellariae extractum, drying under reduced pressure is ground into fine powder.
Flos Lonicerae (Flos Lonicerae, Flos Lonicerae) adds water temperature soak 30 minutes after, decoct secondary, each 2 hours, collecting decoction filtered, it is 1.20～1.25 clear paste that filtrate is concentrated into 70～80 ℃ relative density, slowly add ethanol after the cooling and make and contain alcohol amount and reach 60～80%, fully stir, left standstill 12 hours, the leaching supernatant, regulate pH value to 6.0～8.0 with sodium hydroxide solution, it is an amount of that residue adds 75% ethanol, stirs evenly, left standstill 12 hours, filter, merge ethanol liquid, reclaim ethanol and obtain Flos Lonicerae (Flos Lonicerae, Flos Lonicerae) extractum, drying under reduced pressure is ground into fine powder.
After Fructus Forsythiae adds water temperature and soaks 30 minutes, decoct secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filters, and it is 1.20～1.25 clear paste that filtrate is concentrated into 70～80 ℃ relative density, slowly adding ethanol after the cooling makes and contains alcohol amount and reach 60～80%,, fully stir, left standstill 12 hours, the leaching supernatant, regulate pH value to 6.0～8.0 with sodium hydroxide solution, it is an amount of that residue adds 75% ethanol, stirs evenly, left standstill 12 hours, filter, merge ethanol liquid, reclaim ethanol and obtain Fructus Forsythiae extractum, drying under reduced pressure is ground into fine powder.
Getting Mentholum 0.01-1g is dissolved in the ethanol, Radix Scutellariae extract is dissolved in the 5%-40%NaOH solution, in addition extracting honeysuckle (Flos Lonicerae, Flos Lonicerae) extract, Fructus Forsythiae extract, xylitol 1-50g, potassium sorbate 0.05-0.5g, after adding an amount of purified water dissolving, add glycerol 30-90ml, essence 0.01-10ml, Radix Scutellariae extract aqueous slkali and Mentholum alcoholic solution, to full dose, filter with purified water, embedding, packing.
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Cited By (8)
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| CN103230441A (en) * | 2013-04-08 | 2013-08-07 | 周有财 | Medicine composition, preparation thereof, and application thereof |
| CN103446027A (en) * | 2013-09-18 | 2013-12-18 | 重庆市中药研究院 | Preparation method for largeflower-like honeysuckle flower leaf gargle |
| CN103751054A (en) * | 2014-01-04 | 2014-04-30 | 左权县桐峪镇嘉百岁农民专业合作社 | Forsythia suspense leaf gargle and preparation method thereof |
| CN105078845A (en) * | 2015-09-21 | 2015-11-25 | 张艳 | Mouthwash containing paeonia ostii and trollius chinensis bunge |
| CN105919892A (en) * | 2016-06-21 | 2016-09-07 | 广西大学 | Hazelnut flavor mouth wash and preparation method thereof |
| CN107049874A (en) * | 2017-05-23 | 2017-08-18 | 许备占 | Sunset abelmoschus flower mouthwash |
| CN107648136A (en) * | 2017-09-28 | 2018-02-02 | 杨功平 | Nurse the mouthwash in oral cavity and preparation method thereof |
| CN113197886A (en) * | 2020-01-31 | 2021-08-03 | 中国科学院上海药物研究所 | Application of Shuanghuanglian preparation in resisting virus infection |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230441A (en) * | 2013-04-08 | 2013-08-07 | 周有财 | Medicine composition, preparation thereof, and application thereof |
| CN103446027A (en) * | 2013-09-18 | 2013-12-18 | 重庆市中药研究院 | Preparation method for largeflower-like honeysuckle flower leaf gargle |
| CN103446027B (en) * | 2013-09-18 | 2015-04-08 | 重庆市中药研究院 | Preparation method for largeflower-like honeysuckle flower leaf gargle |
| CN103751054A (en) * | 2014-01-04 | 2014-04-30 | 左权县桐峪镇嘉百岁农民专业合作社 | Forsythia suspense leaf gargle and preparation method thereof |
| CN105078845A (en) * | 2015-09-21 | 2015-11-25 | 张艳 | Mouthwash containing paeonia ostii and trollius chinensis bunge |
| CN105919892A (en) * | 2016-06-21 | 2016-09-07 | 广西大学 | Hazelnut flavor mouth wash and preparation method thereof |
| CN107049874A (en) * | 2017-05-23 | 2017-08-18 | 许备占 | Sunset abelmoschus flower mouthwash |
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Application publication date: 20110601 |