CN104853782A - Dna抗体构建体及其使用方法 - Google Patents

Dna抗体构建体及其使用方法 Download PDF

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Publication number
CN104853782A
CN104853782A CN201380065674.3A CN201380065674A CN104853782A CN 104853782 A CN104853782 A CN 104853782A CN 201380065674 A CN201380065674 A CN 201380065674A CN 104853782 A CN104853782 A CN 104853782A
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China
Prior art keywords
acid sequence
nucleic acid
recombinant nucleic
env
subject
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Pending
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CN201380065674.3A
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English (en)
Chinese (zh)
Inventor
大卫·B·韦纳
卡鲁皮亚·穆苏马尼
尼兰詹·萨尔德赛
塞利克·夫林盖
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University of Pennsylvania Penn
Inovio Pharmaceuticals Inc
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University of Pennsylvania Penn
Inovio Pharmaceuticals Inc
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Publication of CN104853782A publication Critical patent/CN104853782A/zh
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/116—Togaviridae (F); Matonaviridae (F); Flaviviridae (F)
    • A—HUMAN NECESSITIES
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    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • C07K16/1145—Env proteins, e.g. gp41, gp110/120, gp160, V3, principal neutralising domain [PND] or CD4-binding site
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN201380065674.3A 2012-12-13 2013-12-13 Dna抗体构建体及其使用方法 Pending CN104853782A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261737094P 2012-12-13 2012-12-13
US61/737,094 2012-12-13
US201361881376P 2013-09-23 2013-09-23
US61/881,376 2013-09-23
US201361896646P 2013-10-28 2013-10-28
US61/896,646 2013-10-28
PCT/US2013/075137 WO2014093894A2 (en) 2012-12-13 2013-12-13 Dna antibody constructs and method of using same

Publications (1)

Publication Number Publication Date
CN104853782A true CN104853782A (zh) 2015-08-19

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CN201380065674.3A Pending CN104853782A (zh) 2012-12-13 2013-12-13 Dna抗体构建体及其使用方法

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US (4) US9994629B2 (https=)
EP (1) EP2931318A4 (https=)
JP (6) JP6898060B2 (https=)
KR (4) KR20230156146A (https=)
CN (1) CN104853782A (https=)
AU (7) AU2013358944B2 (https=)
BR (2) BR112015013700A8 (https=)
CA (1) CA2889723A1 (https=)
EA (1) EA201591131A1 (https=)
HK (1) HK1213481A1 (https=)
MX (4) MX2015007575A (https=)
MY (1) MY175708A (https=)
SG (1) SG10202002718RA (https=)
WO (1) WO2014093894A2 (https=)
ZA (1) ZA201503583B (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107427566A (zh) * 2014-12-01 2017-12-01 宾夕法尼亚大学理事会 Dna抗体构建体及其使用方法
CN109789224A (zh) * 2016-05-05 2019-05-21 宾夕法尼亚大学理事会 靶向il-6和cd126的dna单克隆抗体
CN109890407A (zh) * 2016-03-21 2019-06-14 大卫·B·韦纳 Dna抗体构建体和其使用方法
CN110167584A (zh) * 2016-11-07 2019-08-23 威斯塔解剖学和生物学研究所 用于针对莱姆病的dna抗体构建体
CN110325546A (zh) * 2016-05-05 2019-10-11 宾夕法尼亚大学理事会 靶向流感病毒的dna单克隆抗体

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* Cited by examiner, † Cited by third party
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WO2015089492A2 (en) 2013-12-13 2015-06-18 The Trustees Of The University Of Pennsylvania Dna antibody constructs and method of using same
WO2014093894A2 (en) * 2012-12-13 2014-06-19 The Trustees Of The University Of Pennsylvania Dna antibody constructs and method of using same
KR20230145241A (ko) * 2014-10-01 2023-10-17 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 항원 및 어쥬번트로서 인터류킨-21을 갖는 백신
RS62437B1 (sr) 2015-10-25 2021-11-30 Sanofi Sa Trispecifični i/ili trivalentni vezujući proteini za prevenciju ili lečenje hiv infekcije
US20180363000A1 (en) * 2015-12-14 2018-12-20 The Trustees Of The University Of Pennsylvania Aav-anti pcsk9 antibody constructs and uses thereof
LT3443006T (lt) 2016-04-13 2023-10-25 Sanofi Trispecifiniai ir (arba) trivalenčiai rišantieji baltymai
EA201892522A1 (ru) * 2016-05-05 2019-05-31 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Днк-моноклональные антитела, нацеленные на молекулы контрольных точек
SG11201809778TA (en) 2016-05-05 2018-12-28 Univ Pennsylvania Dna antibody constructs for use against pseudomonas aeruginosa
BR112019005378A2 (pt) * 2016-09-19 2019-08-27 The Trustees Of The University Of Pennsylvania molécula de ácido nucleico, composição, e, métodos para prevenir ou tratar uma doença e para induzir uma resposta imune
TW202300515A (zh) 2016-10-20 2023-01-01 法商賽諾菲公司 抗ｃｈｉｋｖ抗體及其用途
US11370830B2 (en) 2017-04-07 2022-06-28 The Rockefeller University Neutralizing antibodies that bind to the zika virus domain III envelope region
WO2018217681A1 (en) * 2017-05-22 2018-11-29 National Cheng Kung University Anti-dengue virus antibody, pharmaceutical composition comprising the same, and uses thereof
WO2019067671A1 (en) * 2017-09-27 2019-04-04 David Weiner DNA ANTIBODY CONSTRUCTS FOR USE IN CORONAVIRUS RESPIRATORY SYNDROME OF THE MIDDLE EAST
WO2019152602A1 (en) * 2018-01-31 2019-08-08 The Wistar Institute Of Anatomy And Biology Structurally modified flavivirus dmabs
US11613576B2 (en) 2019-04-09 2023-03-28 Sanofi Trispecific binding proteins, methods, and uses thereof
US12606612B2 (en) 2019-07-31 2026-04-21 The Wistar Institute Of Anatomy And Biology Multivalent DNA antibody constructs and use thereof
KR20220128607A (ko) 2019-09-18 2022-09-21 인터갈락틱 테라퓨틱스, 인크. 합성 dna 벡터 및 사용 방법
SE544001C2 (en) * 2020-03-17 2021-10-26 Xbrane Biopharma Ab Novel combination of tis sequences, signal peptide sequences and nucleic acid sequences encoding heavy and light chains of an antibody
SE544000C2 (en) * 2020-03-17 2021-10-26 Xbrane Biopharma Ab Novel combination of tis sequence, signal peptide sequence and nucleic acid sequence encoding a recombinant protein
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