SG11201809778TA - Dna antibody constructs for use against pseudomonas aeruginosa - Google Patents
Dna antibody constructs for use against pseudomonas aeruginosaInfo
- Publication number
- SG11201809778TA SG11201809778TA SG11201809778TA SG11201809778TA SG11201809778TA SG 11201809778T A SG11201809778T A SG 11201809778TA SG 11201809778T A SG11201809778T A SG 11201809778TA SG 11201809778T A SG11201809778T A SG 11201809778TA SG 11201809778T A SG11201809778T A SG 11201809778TA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- pseudomonas aeruginosa
- pct
- subject
- dna
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111011111111111111 01011E10 III 011111111011111101111101111111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/193101 Al 09 November 2017 (09.11.2017) WIP0 I PCT (51) International Patent Classification: (74) Agent: NGUYEN, Quang, D.; Riverside Law, LLP, Glen- A61K 39/40 (2006.01) C07K 16/12 (2006.01) hardie Corporate Center, 1285 Drummers Lane, Suite 202, C07K 16/00 (2006.01) Wayne, PA 19087 (US). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/US2017/031449 kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 05 May 2017 (05.05.2017) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (26) Publication Language: English KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (30) Priority Data: PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 62/332,363 05 May 2016 (05.05.2016) US SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors; and (71) Applicants: WEINER, David [US/US]; 717 Beacom (84) Designated States (unless otherwise indicated, for every Lane, Merion, PA 19066 (US). PATEL, Ami [US/US]; 1 kind of regional protection available): ARIPO (BW, GH, Rainey Court, Philadelphia, PA 19103 (US). YAN, Man GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, — [US/US]; 503 Sheffield Drive, Wallingford, PA 19086 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (US). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = = _ _ (54) Title: DNA ANTIBODY CONSTRUCTS FOR USE AGAINST PSEUDOMONAS AERUGINOSA = A = = = oni L, » li.dvy Liog Chain Chain .. , .. Optimization and = Bisi., it, SW111011r:P optina7ation mutt ,.. i into DNA — 1,4,R bt/ftt Chain = t.nctional IgG = = .... tA ' = 14t Exp fes s i o . A qcrarnhly A Secretion = 11131111114 IgGi = < = +.. = D b enters systemic 'isolation; binds to Pseudornones aeruyinose 11 15 % 1\" 1-1 V 0 1-1 01 en 1-1 Figure 1A ---- (57) : Disclosed herein are mono and bispecific DNA antibodies (DMAbs) targeting Pseudomonas aeruginosa. Also disclosed IN ,1 herein is a method of generating a synthetic antibody in a subject by administering the DMAbs to the subject. The disclosure also 0 provides a method of preventing and/or treating Pseudomonas aeruginosa infection in a subject using said composition and method \" of generation. [Continued on next page] WO 2017/193101 Al MIDEDIMOIMMIIMMEMOMEMIOMMIRHIMEMOIMIE TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt amendments (Rule 48.2(h)) of — with sequence listing part of description (Rule 5.2(a))
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662332363P | 2016-05-05 | 2016-05-05 | |
PCT/US2017/031449 WO2017193101A1 (en) | 2016-05-05 | 2017-05-05 | Dna antibody constructs for use against pseudomonas aeruginosa |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201809778TA true SG11201809778TA (en) | 2018-12-28 |
Family
ID=60203552
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201809778TA SG11201809778TA (en) | 2016-05-05 | 2017-05-05 | Dna antibody constructs for use against pseudomonas aeruginosa |
SG10202011016WA SG10202011016WA (en) | 2016-05-05 | 2017-05-05 | Dna antibody constructs for use against pseudomonas aeruginosa |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202011016WA SG10202011016WA (en) | 2016-05-05 | 2017-05-05 | Dna antibody constructs for use against pseudomonas aeruginosa |
Country Status (12)
Country | Link |
---|---|
US (1) | US20190153076A1 (en) |
EP (1) | EP3452090A4 (en) |
JP (2) | JP2019520085A (en) |
KR (2) | KR20230093338A (en) |
CN (1) | CN110072554A (en) |
AU (1) | AU2017261374A1 (en) |
BR (1) | BR112018072716A2 (en) |
CA (1) | CA3023094A1 (en) |
EA (1) | EA201892525A1 (en) |
MX (1) | MX2018013525A (en) |
SG (2) | SG11201809778TA (en) |
WO (1) | WO2017193101A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX349886B (en) | 2011-06-10 | 2017-08-17 | Medimmune Llc | Anti-pseudomonas psl binding molecules and uses thereof. |
HUE050985T2 (en) * | 2011-11-07 | 2021-01-28 | Medimmune Ltd | Combination therapies using anti- pseudomonas psl and pcrv binding molecules |
MX2020008062A (en) * | 2018-01-31 | 2020-12-03 | Wistar Inst | Nucleic acid antibody constructs for use against respiratory syncytial virus. |
AU2020322031A1 (en) * | 2019-07-31 | 2022-03-10 | The Wistar Institute Of Anatomy And Biology | Multivalent DNA antibody constructs and use thereof |
AU2020323601A1 (en) * | 2019-07-31 | 2022-03-03 | The Wistar Institute Of Anatomy And Biology | Multivalent DNA antibody constructs and use thereof |
WO2021244421A1 (en) * | 2020-06-01 | 2021-12-09 | Staidson (Beijing) Biopharmaceuticals Co., Ltd. | Antibodies specifically recognizing pseudomonas pcrv and uses thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG186017A1 (en) * | 2007-11-30 | 2012-12-28 | Kalobios Pharmaceuticals Inc | Antibodies to the pcrv antigen of pseudomonas aeruginosa |
MX349886B (en) * | 2011-06-10 | 2017-08-17 | Medimmune Llc | Anti-pseudomonas psl binding molecules and uses thereof. |
JP6159724B2 (en) * | 2011-08-23 | 2017-07-05 | ロシュ グリクアート アーゲー | Bispecific antibodies and tumor antigens specific for T cell activating antigens and methods of use |
WO2013036914A1 (en) * | 2011-09-08 | 2013-03-14 | University Of Florida Research Foundation, Inc. | Materials and methods for modulating immune responses |
HUE050985T2 (en) * | 2011-11-07 | 2021-01-28 | Medimmune Ltd | Combination therapies using anti- pseudomonas psl and pcrv binding molecules |
EP2776061B1 (en) * | 2011-11-07 | 2019-08-14 | MedImmune, LLC | Multispecific and multivalent binding proteins and uses thereof |
US10072098B2 (en) * | 2012-03-02 | 2018-09-11 | Ablynx N.V. | Pseudomonas aeruginosa PCRV binding single variable domain antibodies |
MX2015005719A (en) * | 2012-11-06 | 2016-01-12 | Medimmune Llc | Combination therapies using anti-pseudomonas psl and pcrv binding molecules. |
AU2013358944B2 (en) * | 2012-12-13 | 2016-08-18 | Inovio Pharmaceuticals, Inc. | DNA antibody constructs and method of using same |
EP3080159A4 (en) * | 2013-12-13 | 2017-08-02 | The Trustees Of The University Of Pennsylvania | Dna antibody constructs and method of using same |
US20170183397A1 (en) * | 2014-05-05 | 2017-06-29 | Medimmune, Llc | Multi-specific anti-pseudomonas psl and pcrv binding molecules and uses thereof |
TWI719938B (en) * | 2014-06-19 | 2021-03-01 | 美商麥迪紐有限責任公司 | Treatment of polybacterial infections |
-
2017
- 2017-05-05 WO PCT/US2017/031449 patent/WO2017193101A1/en unknown
- 2017-05-05 EP EP17793526.9A patent/EP3452090A4/en active Pending
- 2017-05-05 JP JP2019510582A patent/JP2019520085A/en active Pending
- 2017-05-05 BR BR112018072716-4A patent/BR112018072716A2/en unknown
- 2017-05-05 CA CA3023094A patent/CA3023094A1/en active Pending
- 2017-05-05 AU AU2017261374A patent/AU2017261374A1/en active Pending
- 2017-05-05 KR KR1020237019235A patent/KR20230093338A/en not_active Application Discontinuation
- 2017-05-05 MX MX2018013525A patent/MX2018013525A/en unknown
- 2017-05-05 EA EA201892525A patent/EA201892525A1/en unknown
- 2017-05-05 SG SG11201809778TA patent/SG11201809778TA/en unknown
- 2017-05-05 US US16/098,908 patent/US20190153076A1/en active Pending
- 2017-05-05 CN CN201780042016.0A patent/CN110072554A/en active Pending
- 2017-05-05 SG SG10202011016WA patent/SG10202011016WA/en unknown
- 2017-05-05 KR KR1020187035163A patent/KR20190025826A/en not_active IP Right Cessation
-
2023
- 2023-01-13 JP JP2023003954A patent/JP2023058497A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20230093338A (en) | 2023-06-27 |
CA3023094A1 (en) | 2017-11-09 |
KR20190025826A (en) | 2019-03-12 |
MX2018013525A (en) | 2019-06-10 |
EA201892525A1 (en) | 2019-04-30 |
SG10202011016WA (en) | 2020-12-30 |
JP2023058497A (en) | 2023-04-25 |
BR112018072716A2 (en) | 2019-02-19 |
WO2017193101A1 (en) | 2017-11-09 |
EP3452090A4 (en) | 2019-12-18 |
EP3452090A1 (en) | 2019-03-13 |
JP2019520085A (en) | 2019-07-18 |
CN110072554A (en) | 2019-07-30 |
US20190153076A1 (en) | 2019-05-23 |
AU2017261374A1 (en) | 2018-12-20 |
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