CN104812360A - 用于牙釉质增强和增白的矿物酶复合物、口腔卫生组合物和牙膏 - Google Patents
用于牙釉质增强和增白的矿物酶复合物、口腔卫生组合物和牙膏 Download PDFInfo
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- CN104812360A CN104812360A CN201380044236.9A CN201380044236A CN104812360A CN 104812360 A CN104812360 A CN 104812360A CN 201380044236 A CN201380044236 A CN 201380044236A CN 104812360 A CN104812360 A CN 104812360A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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RU2012135577/15A RU2494725C1 (ru) | 2012-08-20 | 2012-08-20 | Минерально-ферментативный комплекс для укрепления и отбеливания эмали зубов, композиция для гигиены полости рта и зубная паста |
RU2012135577 | 2012-08-20 | ||
PCT/RU2013/000716 WO2014031035A1 (fr) | 2012-08-20 | 2013-08-19 | Complexe de minéraux et ferments pour le renforcement et le blanchissement de l'émail dentaire, composition pour l'hygiène buccale et pâte dentifrice |
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CN104812360A true CN104812360A (zh) | 2015-07-29 |
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CN201380044236.9A Pending CN104812360A (zh) | 2012-08-20 | 2013-08-19 | 用于牙釉质增强和增白的矿物酶复合物、口腔卫生组合物和牙膏 |
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US (1) | US20150190329A1 (fr) |
EP (1) | EP2902008B1 (fr) |
CN (1) | CN104812360A (fr) |
CA (1) | CA2882558C (fr) |
EA (1) | EA024261B1 (fr) |
ES (1) | ES2723923T3 (fr) |
HK (1) | HK1212907A1 (fr) |
IN (1) | IN2015DN02235A (fr) |
RU (1) | RU2494725C1 (fr) |
SG (1) | SG11201501290QA (fr) |
TR (1) | TR201902383T4 (fr) |
UA (1) | UA113772C2 (fr) |
WO (1) | WO2014031035A1 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
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EP4234039A1 (fr) | 2015-12-31 | 2023-08-30 | Colgate-Palmolive Company | Composition de soins personnels comprenant de la taurine, de l'arginine et de la glycine |
EA027690B1 (ru) * | 2016-03-14 | 2017-08-31 | Общество С Ограниченной Ответственностью "Сплат-Косметика" (Ооо "Сплат-Косметика") | Минерально-растительный комплекс для удаления зубного налета, композиция для гигиены полости рта и зубная паста |
RU2675257C1 (ru) * | 2018-01-09 | 2018-12-18 | Федеральное государственное бюджетное учреждение науки Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук | Лечебно-профилактическая зубная паста |
JP2023110105A (ja) * | 2020-05-01 | 2023-08-09 | 株式会社トレスバイオ研究所 | 口腔用組成物 |
CN112274478A (zh) * | 2020-12-21 | 2021-01-29 | 广东微笑科技有限公司 | 一种含精氨酸护龈牙膏及其制备方法 |
CN112870115B (zh) * | 2021-02-25 | 2023-04-14 | 中国热带农业科学院热带作物品种资源研究所 | 一种中老年人专效的南药复方牙膏及其制备方法 |
CN113509394A (zh) * | 2021-07-14 | 2021-10-19 | 上海市第十人民医院 | 一种矿化甘油凝胶、制备方法及应用 |
CN114469750B (zh) * | 2022-01-28 | 2024-07-02 | 陕西师范大学 | 一种用于治疗牙敏感以及促进牙釉质外延生长的矿化材料及其应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1244386A (zh) * | 1998-08-07 | 2000-02-16 | 青木秀希 | 口腔清洁剂组成物及牙膏、牙粉组成物 |
WO2001064175A1 (fr) * | 2000-03-01 | 2001-09-07 | Lucas Huybrechts | Produits de blanchiment des dents et procedures associees |
JP2007308429A (ja) * | 2006-05-19 | 2007-11-29 | Lion Corp | 歯牙美白用組成物 |
EP2095724A1 (fr) * | 2008-02-27 | 2009-09-02 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Matériaux composites non cariogènes améliorés et leurs processus de préparation |
CN101692998A (zh) * | 2009-10-22 | 2010-04-14 | 浙江大学 | 一种含葡萄籽原花青素提取物的牙膏及应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3666627A (en) * | 1968-10-14 | 1972-05-30 | Corning Glass Works | Method of stabilizing enzymes |
JPH0228563B2 (ja) * | 1986-04-22 | 1990-06-25 | Dental Chem Co Ltd | Hamigakisoseibutsu |
RU2060030C1 (ru) | 1990-02-14 | 1996-05-20 | Научная фирма "Биосиб" | Зубная паста |
EP0709452A1 (fr) * | 1994-10-27 | 1996-05-01 | The Procter & Gamble Company | Compositions de nettoyage contenant des xylanases |
RU2131723C1 (ru) * | 1997-08-05 | 1999-06-20 | Открытое акционерное общество косметическое объединение "Свобода" | Лечебно-профилактическая композиция для обработки зубов |
US6652841B1 (en) * | 2002-08-28 | 2003-11-25 | Colgate Palmolive Company | Antiplaque enzyme containing dual component composition |
US20050271601A1 (en) * | 2004-06-02 | 2005-12-08 | Nebojsa Milanovich | Anti-staining antibacterial dentifrice |
US20060140881A1 (en) * | 2004-12-22 | 2006-06-29 | Guofeng Xu | Oral care compositions containing flavonoids and flavans |
FR2915386B1 (fr) * | 2007-04-24 | 2009-08-21 | Pierre Fabre Medicament Sa | Utilisation d'un extrait aqueux de pepins de raisin en association avec au moins un sel de fluor contre la formation ou l'accumulation du biofilm dentaire et les compositions comprenant cette association |
RU2355420C2 (ru) | 2007-06-29 | 2009-05-20 | Леонид Леонидович Клопотенко | Зубная паста, содержащая лактулозу, бетаин, хондроитин сульфат и ферменты: папаин, лизоцим, рибонуклеазу и лидазу |
RU2381021C2 (ru) * | 2007-11-12 | 2010-02-10 | Леонид Леонидович Клопотенко | Зубная паста, содержащая липосомы |
RU2355380C1 (ru) | 2008-01-11 | 2009-05-20 | Сергей Владимирович Сирак | Зубной эликсир для профилактики и лечения начальных форм кариеса зубов |
RU2416391C1 (ru) * | 2009-09-03 | 2011-04-20 | Общество с ограниченной ответственностью "СПЛАТ-КОСМЕТИКА" | Композиция для ухода за полостью рта |
JP2011162491A (ja) * | 2010-02-10 | 2011-08-25 | Ezaki Glico Co Ltd | 乾燥麹抽出物及びこれを用いた口腔用組成物 |
-
2012
- 2012-08-20 RU RU2012135577/15A patent/RU2494725C1/ru active
-
2013
- 2013-08-19 ES ES13830900T patent/ES2723923T3/es active Active
- 2013-08-19 EA EA201500145A patent/EA024261B1/ru unknown
- 2013-08-19 UA UAA201502464A patent/UA113772C2/uk unknown
- 2013-08-19 CA CA2882558A patent/CA2882558C/fr active Active
- 2013-08-19 WO PCT/RU2013/000716 patent/WO2014031035A1/fr active Application Filing
- 2013-08-19 IN IN2235DEN2015 patent/IN2015DN02235A/en unknown
- 2013-08-19 TR TR2019/02383T patent/TR201902383T4/tr unknown
- 2013-08-19 EP EP13830900.0A patent/EP2902008B1/fr active Active
- 2013-08-19 CN CN201380044236.9A patent/CN104812360A/zh active Pending
- 2013-08-19 SG SG11201501290QA patent/SG11201501290QA/en unknown
- 2013-08-19 US US14/422,985 patent/US20150190329A1/en not_active Abandoned
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2016
- 2016-01-28 HK HK16100925.2A patent/HK1212907A1/zh unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1244386A (zh) * | 1998-08-07 | 2000-02-16 | 青木秀希 | 口腔清洁剂组成物及牙膏、牙粉组成物 |
WO2001064175A1 (fr) * | 2000-03-01 | 2001-09-07 | Lucas Huybrechts | Produits de blanchiment des dents et procedures associees |
JP2007308429A (ja) * | 2006-05-19 | 2007-11-29 | Lion Corp | 歯牙美白用組成物 |
EP2095724A1 (fr) * | 2008-02-27 | 2009-09-02 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Matériaux composites non cariogènes améliorés et leurs processus de préparation |
CN101692998A (zh) * | 2009-10-22 | 2010-04-14 | 浙江大学 | 一种含葡萄籽原花青素提取物的牙膏及应用 |
Non-Patent Citations (1)
Title |
---|
童忠良等: "《无机抗菌新材料与技术》", 31 July 2006, 化学工业出版社 * |
Also Published As
Publication number | Publication date |
---|---|
EA024261B1 (ru) | 2016-08-31 |
EA201500145A1 (ru) | 2015-06-30 |
EP2902008A4 (fr) | 2016-05-18 |
IN2015DN02235A (fr) | 2015-08-21 |
UA113772C2 (xx) | 2017-03-10 |
SG11201501290QA (en) | 2015-04-29 |
CA2882558A1 (fr) | 2014-02-27 |
EP2902008A1 (fr) | 2015-08-05 |
HK1212907A1 (zh) | 2016-06-24 |
CA2882558C (fr) | 2020-07-07 |
US20150190329A1 (en) | 2015-07-09 |
ES2723923T3 (es) | 2019-09-03 |
WO2014031035A1 (fr) | 2014-02-27 |
TR201902383T4 (tr) | 2019-03-21 |
EP2902008B1 (fr) | 2019-02-13 |
RU2494725C1 (ru) | 2013-10-10 |
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