CN104784345A - Traditional Chinese medicine preparation for treating cervical erosion and cervical hypertrophy - Google Patents
Traditional Chinese medicine preparation for treating cervical erosion and cervical hypertrophy Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine preparation for treating cervical erosion and cervical hypertrophy. The traditional Chinese medicine preparation is prepared from the following traditional Chinese medicine raw materials according to a certain weight ratio: dayflower, golden cypress, polygonum aviculare, ramie roots, rehmanniae vaporata, solanum vine, lotus stamen, gorgon fruits, radix angelicae, and astragalus membranaceus. The traditional Chinese medicine preparation disclosed by the invention takes effects both inside and outside; tonification and purgation are carried out simultaneously; all the drugs not only take effects respectively but also are affected with each other; found from clinical tests, for treating cervical erosion and cervical hypertrophy, the traditional Chinese medicine preparation disclosed by the invention has a high cure rate and an overall effective rate; and simultaneously, the traditional Chinese medicine preparation is also capable of obviously increasing the living quality and physical conditions of patients and is free from side effects.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the treatment of cervical erosion and merging cervical hypertrophy.
Background technology
In recent years, due to constantly carrying out of census operations, find that chronic cervicitis is commonly encountered diseases, the frequently-occurring disease of Status of Married Child-bearing aged Women, active treatment cervicitis is significant to prevention cervical cancer.Cervical erosion refers to a visible red area around cervical orifice, smooth surface or in graininess, mamillary.Cervical hypertrophy refers to cervical tissue congestion and edema, and body of gland and interstitial proliferation, make cervical hypertrophy, finally due to fibrous connective tissue hypertrophy, makes cervix uteri hardening.So-called cervical erosion, cervical hypertrophy all belong to chronic cervicitis, and both are often accompanied.
Cervical erosion merges loose, in traditional therapeutic scheme, many employings microwave coagulation, loop electrosurgical excision procedure (LEEP) is treated, but physical trauma Sex therapy is in second day after operation, vaginal secretions increases, even there is a large amount of watery liquid to discharge, about continuing January, and have hemorrhage on a small quantity during decrustation in about 10 days after surgery, time serious, amount of bleeding even exceeds menstrual blood volume, is sometimes ignored by patient and causes danger.And (4 ~ 8 weeks) require to forbid bath in a tub, sexual life during wound healing.Several aspect has had a strong impact on the quality of life of patient in this process above.Clinical middle while also discovery part accept microwave coagulation, laser, electric ring cuts the patient for the treatment of, and after treatment, cervical tissue is hardening, pale, matt, and it changes women's cervical tissue and creates larger impact, is not suitable for not producing women.
Suppository and lotion are generally suitable for slight cervicitis, and have shortcomings, foreign body sensation is had as suppository is detained vagina overlong time, acting surface is little cannot cover affected part comprehensively, local drug concentration greatly easily injures mucosa and causes vaginal hemorrhage, repeatedly use the Drug resistance of easily cultivating harmful bacteria, cause multiple infection.The protection mucosa of vagina itself easily washed off by lotion, and destruction vagina natural environment and bacterium colony balance make external strain more easily invade vagina.
Primary disease belongs to the traditional Chinese medical science " leukorrheal diseases ", " married woman's stomachache " category.Think that the Etiological of primary disease is that " damp " is for suffering from.But damp has inside and outside other.Endogenous cause of ill is many because of spleen, Liver and kidney function imbalance, as diet should not injure taste, and dysfunction of the spleen in transportation, interior unboiled water wets; Or feelings will is not understood, stagnation of liver-QI insult spleen, the wet bet of folder; Or strain is impairment of the kidney, consume vital essence, gasify weak, water wets cohesion.These all can cause under water wets and walk uterus, contamination cervix uteri.Exopathogenic factor many because of health preserving after puerperal, menstrual period, Therapeutic Abortion careless, experience cold-damp, damp and hot heresy, stain hinders cervix uteri, and see with cervical hypertrophy with rotten to the corn be the chronic cervicitis of main elephant.Therefore select a convenience, safety, effective Therapeutic Method seems especially important.
Summary of the invention
The object of this invention is to provide a kind of cervical erosion for the treatment of and merge the Chinese medicine preparation of cervical hypertrophy, it is a kind of pure Chinese medicinal preparation, has toxic and side effects little, and medicine source is wide, cost is low, curative effect is high, the feature such as not to recur more.
For solving the problem, the present invention adopts following technical scheme:
Treat the Chinese medicine preparation that cervical erosion merges cervical hypertrophy, it is prepared from by certain weight by following traditional Chinese medicine raw: Herba Commelinae, Cortex Phellodendri, Herba Polygoni Avicularis, Radix Boehmeriae, Radix Rehmanniae Preparata, Herba Solani Lyrati, Stamen Nelumbinis, Semen Euryales, the Radix Angelicae Dahuricae, the Radix Astragali.
Wherein, preferably, treat the Chinese medicine preparation that cervical erosion merges cervical hypertrophy, it is characterized in that described Chinese medicine preparation is prepared from by the raw material of Chinese medicine of following weight: Herba Commelinae 35-45 part, Cortex Phellodendri 13-18 Fen, Herba Polygoni Avicularis 25-30 part, Radix Boehmeriae 13-18 part, Radix Rehmanniae Preparata 9-15 part, Herba Solani Lyrati 11-16 part, Stamen Nelumbinis 8-13 part, Semen Euryales 13-18 part, Radix Angelicae Dahuricae 6-10 part, Radix Astragali 11-16 part.
The preferred version optimized be: a kind of cervical erosion for the treatment of merges the Chinese medicine preparation of cervical hypertrophy, is characterised in that described Chinese medicine preparation is prepared from by the raw material of Chinese medicine of following weight: Herba Commelinae 35 parts, Cortex Phellodendri 15 Fen, Herba Polygoni Avicularis 30 parts, Radix Boehmeriae 15 parts, 10 parts, Radix Rehmanniae Preparata, Herba Solani Lyrati 12 parts, Stamen Nelumbinis 10 parts, Semen Euryales 13 parts, the Radix Angelicae Dahuricae 7 parts, the Radix Astragali 12 parts; Or a kind of Chinese medicine preparation for the treatment of cervical erosion and merging cervical hypertrophy, be characterised in that described Chinese medicine preparation is prepared from by the raw material of Chinese medicine of following weight: Herba Commelinae 40 parts, Cortex Phellodendri 16 Fen, Herba Polygoni Avicularis 25 parts, Radix Boehmeriae 15 parts, 15 parts, Radix Rehmanniae Preparata, Herba Solani Lyrati 15 parts, Stamen Nelumbinis 12 parts, Semen Euryales 15 parts, the Radix Angelicae Dahuricae 9 parts, the Radix Astragali 16 parts.
With Cortex Phellodendri heat clearing and damp drying, detoxification sore treatment in side, Herba Commelinae heat-clearing and toxic substances removing, inducing diuresis to remove edema; Herba Solani Lyrati clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, 5 in order to play heat-clearing and toxic substances removing, inducing diuresis to remove edema; Yi Herba Polygoni Avicularis inducing diuresis for treating stranguria syndrome, killing parasites for relieving itching, Radix Boehmeriae clearing away heat and promoting diuresis, removing toxic substances; 5 in order to dampness removing; With Radix Rehmanniae Preparata nourishing YIN and supplementing blood, invigorating the liver and kidney; With Stamen Nelumbinis astringency inducing leukorrhagia stopping; With Semen Euryales supplementing the kidney to control the nocturnal, damp eliminating leukorrhagia stopping; With Radix Astragali invigorating the spleen and replenishing QI, expelling pus and promoting granulation; Sensible with the Radix Angelicae Dahuricae, tying-in.We based on heat clearing away, removing dampness is auxiliary, nourishing the liver and kidney, and taste simultaneously, astringency inducing leukorrhagia stopping, inside and outside taking into account, reinforcing and reducing are with executing, and all medicines both played drug effect separately, acted on each other again, Be very effective.
In the present invention, the pharmaceutical research present situation of each medicine is as follows:
Herba Commelinae: sweet, light, cold.Return lung, stomach, small intestine meridian.Function cures mainly: heat-clearing and toxic substances removing, inducing diuresis to remove edema.For anemopyretic cold, hyperpyrexia, laryngopharynx swelling and pain, edema oliguria, the puckery pain of pyretic stranguria, carbuncle furunculosis.
Cortex Phellodendri: bitter, cold.Return kidney, urinary bladder channel.Function cures mainly: heat clearing and damp drying, and pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
Herba Polygoni Avicularis: bitter, is slightly cold.Return urinary bladder channel.Function cures mainly: inducing diuresis for treating stranguria syndrome, and parasite killing is antipruritic.For bladder pyretic stranguria, oliguria with reddish urine, drenches the puckery pain of drop, skin eczema, pudendal pruritus leukorrhagia.
Radix Boehmeriae: cold in nature, sweet in the mouth.Function cures mainly: clearing away heat and promoting diuresis, antiabortive hemostasis, removing toxic substances.Swell and ache for cold, fever, measles hyperpyrexia, urinary tract infection, oedema due to nephritis, anemia of pregnant woman's stomachache, frequent fetal movement, threatened abortion, traumatic injury, fracture, skin infection, hemorrhage.
Herba Solani Lyrati: sweet in the mouth; Bitter; Cold in nature; Mild toxicity.Return liver; Gallbladder; Kidney channel.Function cures mainly: clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.Main jaundice due to damp-heat; Cholecystitis; Cholelithiasis; Oedema due to nephritis; Rheumatic arthritis; Women's damp-heat vaginal discharge; Infantile hyperpyrexia is frightened jerks; Carbuncle scrofula; Eczema pruritus; Herpes zoster.
Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.
Stamen Nelumbinis: sweet, puckery is flat.GUIXIN, kidney channel.Function cures mainly: reinforcing the kindey to control nocturnal emission.For emission and spermatorrhea, leukorrhagia, frequent micturition.
Semen Euryales: sweet, puckery is flat.Return spleen, kidney channel.Function cures mainly: supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, damp eliminating leukorrhagia stopping.For emission, enuresis frequent micturition, insufficiency of the spleen chronic diarrhea, nebulousurine, leukorrhagia.
The Radix Angelicae Dahuricae: pungent, temperature.Return stomach, large intestine, lung meridian.Function cures mainly: loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.For headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.
The Radix Astragali: sweet, temperature.Return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Chinese medicine preparation of the present invention extracting method conveniently such as water extraction, alcohol extracting method, decoction and alcohol sedimentation technique etc. can extract the active component of medicinal raw material, add pharmaceutically acceptable carrier or/and adjuvant, as starch, dextrin, microcrystalline cellulose, amylum pregelatinisatum, magnesium stearate, micropowder silica gel, sucrose, carboxymethyl starch sodium, hydroxypropyl emthylcellulose, vegetable oil, lecithin, Polyethylene Glycol, propylene glycol, ethyl hydroxybenzoate etc., make peroral dosage form suitable on pharmaceutics, as granule, tablet, capsule, oral liquid, soft capsule, drop pill, water pill etc.
Chinese medicine preparation of the present invention can adopt but be not limited to following methods: by Herba Commelinae, Cortex Phellodendri, Herba Polygoni Avicularis, Radix Boehmeriae, Radix Rehmanniae Preparata, Herba Solani Lyrati, Stamen Nelumbinis, Semen Euryales, the Radix Angelicae Dahuricae, the Radix Astragali is soaked, decoct twice, first time decocts 2-3 hour, amount of water is 5-8 times of decocting herbs total weight parts, second time decocts 1-2 hour, amount of water is 4-6 times of decocting herbs total weight parts, collecting decoction, filter, filtrate reduced in volume, adding ethanol to concentration is 50%, in 0 DEG C of cold preservation 12 hours, filter, filtrate recycling ethanol, concentrate to obtain thick paste, dry, pulverize, add auxiliary materials and mixing, make dosage form suitable on pharmaceutics, as granule, tablet, capsule, oral liquid, soft capsule, drop pill, water pill etc.Preferably make capsule.
The usage and dosage of capsule of the present invention: every day services once sooner or later, each 3-4 grain, every 0.4g.
By pharmacological experiment embodiment 8, Chinese medicine preparation of the present invention is on the impact of cervicitis rat model: known Traditional Chinese medicine preparation capsule of the present invention has certain improvement result to vagina cervicitis rat model, vagina cervix uteri organ index is reduced, and cervical epithelial tissue ulcer squama degree, cervix uteri inflammatory infiltration and congestion and edema can be reduced, especially reduce cervical epithelial tissue ulcer squama degree and cervix uteri congestion and edema, this does not obviously observe in FUKE QIANJIN PIAN group.
Known by clinical observation test example 9: Chinese medicine preparation of the present invention is controlled cervical erosion and merged cervical hypertrophy, its cure rate and overall efficiency are all apparently higher than matched group (traditional western medical treatment), simultaneously at the mobility of patient, life feeling, Wb by, Family Functions and the scoring of daily life situation, observation group all apparently higher than matched group, and has no side effect.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
Prescription: Herba Commelinae 35 parts, Cortex Phellodendri 15 Fen, Herba Polygoni Avicularis 30 parts, Radix Boehmeriae 15 parts, 10 parts, Radix Rehmanniae Preparata, Herba Solani Lyrati 12 parts, Stamen Nelumbinis 10 parts, Semen Euryales 13 parts, the Radix Angelicae Dahuricae 7 parts, the Radix Astragali 12 parts.
Preparation method: Herba Commelinae, Cortex Phellodendri, Herba Polygoni Avicularis, Radix Boehmeriae, Radix Rehmanniae Preparata, Herba Solani Lyrati, Stamen Nelumbinis, Semen Euryales, the Radix Angelicae Dahuricae, the Radix Astragali are soaked, decoct twice, first time decocts 2-3 hour, amount of water is 5-8 times of decocting herbs total weight parts, and second time decocts 1-2 hour, and amount of water is 4-6 times of decocting herbs total weight parts, collecting decoction, filter, filtrate reduced in volume, adding ethanol to concentration is 50%, in 0 DEG C of cold preservation 12 hours, filter, filtrate recycling ethanol, concentrate to obtain thick paste, dry, pulverize, add auxiliary materials and mixing, make capsule.
Embodiment 2
Prescription: Herba Commelinae 40 parts, Cortex Phellodendri 16 Fen, Herba Polygoni Avicularis 25 parts, Radix Boehmeriae 15 parts, 15 parts, Radix Rehmanniae Preparata, Herba Solani Lyrati 15 parts, Stamen Nelumbinis 12 parts, Semen Euryales 15 parts, the Radix Angelicae Dahuricae 9 parts, the Radix Astragali 16 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 3
Prescription: Herba Commelinae 35 parts, Cortex Phellodendri 13 Fen, Herba Polygoni Avicularis 25 parts, Radix Boehmeriae 13 parts, 9 parts, Radix Rehmanniae Preparata, Herba Solani Lyrati 16 parts, Stamen Nelumbinis 8 parts, Semen Euryales 18 parts, the Radix Angelicae Dahuricae 8 parts, the Radix Astragali 11 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 4
Prescription: Herba Commelinae 45 parts, Cortex Phellodendri 18 Fen, Herba Polygoni Avicularis 30 parts, Radix Boehmeriae 18 parts, 15 parts, Radix Rehmanniae Preparata, Herba Solani Lyrati 16 parts, Stamen Nelumbinis 13 parts, Semen Euryales 18 parts, the Radix Angelicae Dahuricae 10 parts, the Radix Astragali 16 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 5
Prescription: Herba Commelinae 40 parts, Cortex Phellodendri 15 Fen, Herba Polygoni Avicularis 27 parts, Radix Boehmeriae 13 parts, 12 parts, Radix Rehmanniae Preparata, Herba Solani Lyrati 15 parts, Stamen Nelumbinis 11 parts, Semen Euryales 16 parts, the Radix Angelicae Dahuricae 8 parts, the Radix Astragali 14 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 6
Prescription: Herba Commelinae 35 parts, Cortex Phellodendri 18 Fen, Herba Polygoni Avicularis 27 parts, Radix Boehmeriae 17 parts, 15 parts, Radix Rehmanniae Preparata, Herba Solani Lyrati 11 parts, Stamen Nelumbinis 10 parts, Semen Euryales 18 parts, the Radix Angelicae Dahuricae 8 parts, the Radix Astragali 14 parts.
Preparation method: by Herba Commelinae, Cortex Phellodendri, Herba Polygoni Avicularis, Radix Boehmeriae, Radix Rehmanniae Preparata, Herba Solani Lyrati, Stamen Nelumbinis, Semen Euryales, the Radix Angelicae Dahuricae, the Radix Astragali is soaked, decoct twice, first time decocts 2-3 hour, amount of water is 5-8 times of decocting herbs total weight parts, second time decocts 1-2 hour, amount of water is 4-6 times of decocting herbs total weight parts, collecting decoction, filter, filtrate reduced in volume, adding ethanol to concentration is 50%, in 0 DEG C of cold preservation 12 hours, filter, filtrate recycling ethanol, concentrate to obtain thick paste, dry, pulverize, add auxiliary materials and mixing, granule is made by this area conventional method.
Embodiment 7
Prescription: Herba Commelinae 40 parts, Cortex Phellodendri 15 Fen, Herba Polygoni Avicularis 27 parts, Radix Boehmeriae 18 parts, 12 parts, Radix Rehmanniae Preparata, Herba Solani Lyrati 12 parts, Stamen Nelumbinis 10 parts, Semen Euryales 15 parts, the Radix Angelicae Dahuricae 8 parts, the Radix Astragali 13 parts.
Preparation method: Herba Commelinae, Cortex Phellodendri, Herba Polygoni Avicularis, Radix Boehmeriae, Radix Rehmanniae Preparata, Herba Solani Lyrati, Stamen Nelumbinis, Semen Euryales, the Radix Angelicae Dahuricae, the Radix Astragali are soaked, decoct twice, first time decocts 2-3 hour, amount of water is 5-8 times of decocting herbs total weight parts, second time decocts 1-2 hour, and amount of water is 4-6 times of decocting herbs total weight parts, collecting decoction, filter, filtrate reduced in volume, adding ethanol to concentration was 50%, in 0 DEG C of cold preservation 12 hours, filter, filtrate recycling ethanol, concentrates to obtain thick paste, dry, pulverize, make tablet by this area conventional method.
Embodiment 8 Chinese medicine preparation of the present invention is on the impact of cervicitis rat model
1. experimental animal: SD rat, female, unpregnancy, SPF level, body weight 200 ± 15g.Be purchased from Beijing Vital River Experimental Animals Technology Co., Ltd..
2. medicine and reagent: Traditional Chinese medicine preparation capsule prepared by the embodiment of the present invention 1, every 0.4g, is equivalent to crude drug 1.32g.FUKE QIANJIN PIAN, 0.32g/ sheet, Zhuzhou Qianjin Pharmacy Co., Ltd produces; Estradiol benzoate injection, hydrocortisone injection; Hydroxybenzene mucilage (get phenol 5m1 during configuration, tragakanta 1g, glycerol 4ml, adding distil water, to 20m1, is made into the Hydroxybenzene mucilage of 25%).
3. modeling: get female rats 70, after adaptability feeds one week, gets 10 at random for sham operated rats, remains 60 for modeling.Rat pre-operative anxiety, lumbar injection 10% chloral hydrate (300mg/kg) is anaesthetized, and lies on the back fixing, lower abdominal surgery position unhairing, routine disinfection.In the bottom of midline abdominal, cut off lcm and indulge opening, find ovary, extract bilateral ovaries.Postoperative muscle injection penicillin is protected from infection.2d rises and does vaginal smear examination, continuous 3d, has no vagina epithelium keratinocyte under microscope, shows that rat is in diestrus, shows that ovary has been extractd completely.Postoperative 4d start subcutaneous injection estradiol benzoate injection 2mg/kg and hydrogenation can injection pine 60mg/kg, object causes false rutting period and general immunity hypofunction, once a day, continuous 3d, postoperative 7d, connect mouse stomach syringe needle with sterilizing syringe, extract Hydroxybenzene mucilage 0.1mL, inject in vagina cervix uteri, original position stops 1 ~ 2min, prevents overflow.Once a day, totally 3 times.
4. grouping and administration: successful for modeling rat is divided into 5 groups at random, often organize 10, i.e. model control group, FUKE QIANJIN PIAN group (3.6g crude drug/kg), the large, medium and small dosage group of Traditional Chinese medicine preparation capsule of the present invention (2.64g crude drug/kg, 1.32g crude drug/kg, 0.66g crude drug/kg), once a day, administration volume is that 20m1/kg body weight calculates, sham operated rats and model control group gavage equal-volume deionized water, successive administration 7d.
5. observation index:
Vagina cervix uteri organ index: get vagina and weigh to subangle place, uterus tissue, calculates vagina and cervix uteri organ index, organ index=organ weights/body weight × 100.
Cervical tissue pathology: get vagina and be fixed in 10% formalin to subangle place, uterus tissue, will organize from center line longitudinal incision after fixing, routine paraffin wax embedding, section, microscopy after HE dyeing, mark by table 1 standard:
Table 1 cervix uteri pathological grading
6. data analysis: all data, all through the process of SPSS15.0 statistical software, adopting variance analysis, adopting t to check, with P<0.05 for there being statistical significance between group.
7. result:
7.1 Chinese medicine preparation of the present invention are on the impact of vagina cervicitis rat model vagina and cervix uteri organ index: compare with model control group, the large, medium and small dosage group of Traditional Chinese medicine preparation capsule of the present invention and FUKE QIANJIN PIAN group can make rat vagina cervix uteri organ index reduce, and difference has statistical significance (P<0.05 or P<0.01).Compare with FUKE QIANJIN PIAN group, the big or middle dosage group of Traditional Chinese medicine preparation capsule of the present invention can make rat vagina cervix uteri organ index reduce, and difference has statistical significance (P<0.05).In table 2.
Table 2 Chinese medicine preparation of the present invention is on the impact of vagina cervicitis rat model vagina and cervix uteri organ index
Note: compare with sham operated rats,
aap<0.01; Compare with model control group,
bbp<0.01; Compare with FUKE QIANJIN PIAN group,
cp<0.05.
7.2 Chinese medicine preparation of the present invention are on the pathological impact of vagina cervicitis rat model cervix uteri:
Compared with sham operated rats, model group rats cervical epithelial tissue ulcer, squama degree is obvious, chronic inflammatory infiltrates obviously, congestion and edema degree is also obvious, and difference all has statistical significance (P<0.05), and the success of vagina cervicitis model is described.Compared with model group, the big or middle dosage group of Traditional Chinese medicine preparation capsule of the present invention can reduce cervical epithelial tissue ulcer, squama degree, reduces cervix uteri inflammatory infiltration and reduce vagina cervix uteri congestion and edema, and difference all has statistical significance (P<0.05).Especially reduce cervical epithelial tissue ulcer squama degree and cervix uteri congestion and edema, this does not obviously observe, in table 3 in FUKE QIANJIN PIAN group.
Table 3 Chinese medicine preparation of the present invention is on the pathological impact of vagina cervicitis rat model cervix uteri
Note: compare with sham operated rats,
ap<0.05; Compare with model control group,
bp<0.05; Compare with FUKE QIANJIN PIAN group,
cp<0.05.
This experiment shows that Traditional Chinese medicine preparation capsule of the present invention has certain improvement result to vagina cervicitis rat model, vagina cervix uteri organ index is reduced, and cervical epithelial tissue ulcer squama degree, cervix uteri inflammatory infiltration and congestion and edema can be reduced, especially reduce cervical epithelial tissue ulcer squama degree and cervix uteri congestion and edema, this does not obviously observe in FUKE QIANJIN PIAN group.
Embodiment 9 clinical observation is tested
Physical data: choose the 210 routine cervical erosion of accepting for medical treatment between my center in March, 2013 in March, 2014 and merge cervical hypertrophy patients, be divided into observation group and matched group at random, wherein observation group patient 106 example, age is 24-43 year, mean age is (31.4 scholar 4.3) year, 53 examples that cervix uteri is slight loose (loose diameter 3-4cm), moderate hypertrophy (loose diameter 4-5cm) 37 example, severe hypertrophy (loose diameter >5cm) 16 example, all there is cervical erosion in various degree, wherein: slight rotten to the corn 16 examples, rotten to the corn 54 examples of moderate, rotten to the corn 36 examples of severe.Matched group patient 104 example, age is 22-46 year, mean age is (33.8 scholar 4.7) year, 53 examples that cervix uteri is slight loose (loose diameter 3-4cm), moderate hypertrophy (loose diameter 4-5cm) 36 example, severe hypertrophy (loose diameter >5cm) 15 example, all there is cervical erosion in various degree, wherein: slight rotten to the corn 15 examples, rotten to the corn 53 examples of moderate, rotten to the corn 36 examples of severe, two liang of group patient ages, rotten to the corn degree, the data no significant difference (P > 0.05) such as cervical hypertrophy situation, there is comparability.
2. diagnostic criteria: with reference to Le Jie edit " obstetrics and gynecology " sixth version formulate, according to the size of rotten to the corn area, cervical erosion is divided into gently, in, severe: slightly finger rotten to the corn area be less than 1/3 of whole cervix uteri area; Moderate refers to that rotten to the corn area accounts for the 1/3-2/3 of whole cervix uteri area; Severe refers to that rotten to the corn area accounts for more than 2/3 of whole cervix uteri area.The grade scale of cervical hypertrophy: cervix uteri is slight loose diameter 3-4cm, the loose diameter 4-5cm of moderate, severe loose diameter > 5cm.
3. include in and exclusion standard: meet above-mentioned diagnostic criteria, but do not comprise cervical ectropion, Nabothcyst, cervical polyp, endocervicitis, cervical squamous intraepithelialization life.Get rid of cervical cancer and precancerous lesion person; By infusorian, mycete, sexually transmitted disease (STD) (gonococcus), tubercule bacillus, virogenetic inflammation; Gestation or women breast-feeding their children, those who are allergic to this drug; Be associated with the severe primary diseases such as cardiovascular, liver, kidney and hemopoietic system, psychotic; Allly do not meet people's standard of receiving, not by regulation medication, the not congruent person of affecting the treatment of curative effect or data cannot be judged.
4. Therapeutic Method: observation group: Chinese medicinal capsule (0.35g/ grain) prepared by the oral embodiment of the present invention 1, the morning and evening twice, each 3-4 grain, menstrual period withdraw, and use 2 menstrual period continuously, avoid raw and cold maror.Matched group: use GONGJINGYANKANG SHUAN to be placed on vagina deep, every administration in a day, persistence places 10 days; Within 11st day, play BAOFUKANG SHUAN every day, continuous use is to carrying out warp.Prohibitive life and bath in a tub during two groups of patient treatments, forbid transvaginal medication menstrual period, and keep pudendum cleaning, uses 2 menstrual period continuously.
5. observation index: safety observations: general health check-up project, blood, urine, feces routine test, the heart, Liver and kidney function inspection.Health giving quality is observed: at the end for the treatment of, 3-6 month is followed up a case by regular visits to after treatment, observe cervical erosion face healing state and clinical symptoms change, vagina cleanness degree, recurrence also combines and carries out statistical estimation curative effect, observes that healing time, untoward reaction, neck tube are narrow, cervix uteri elastic reaction etc. simultaneously.
6. curative effect determinate standard
Clinical efficacy standard: cure: patient is conscious, and sense of discomfort disappears completely, the performance of gynecologial examination result display cervical hypertrophy is not obvious, smooth surface, does not have erosion, and the prompting of ultrasound diagnosis result does not have cervical hypertrophy symptom; Effective: the conscious sense of discomfort of patient substantially disappears or is clearly better, the performance of gynecologial examination result display cervical hypertrophy is not obvious, compare with before treatment, alleviate amplitude obvious, rotten to the corn face significantly reduces, the degree of depth obviously shoals, the transverse diameter of ultrasound diagnosis result prompting cervix uteri with treat before compare and reduce the scope more than 0.5cm; Effective: patient is conscious, and sense of discomfort alleviates to some extent, gynecologial examination result shows cervical hypertrophy and alleviates more to some extent with before treatment, and cervical erosion face slightly reduces, and ultrasound diagnosis result is pointed out the transverse diameter of cervix uteri and compared before treating and reduces the scope less than 0.5cm; Invalid: the subjective symptoms performance of patient and sign are without any change, and the prompting of ultrasound diagnosis result is without any improvement, or the state of an illness is to increasing the weight of future development.
Life quality scores: life quality scores content mainly comprises mobility, life feeling, Wb by five indices such as, Family Functions and daily life situations, Spitzer index is adopted to assess, total score system 10 points, marks higher, shows that quality of life is better.
7. statistical method: all data are all through the process of SPSS17.0 statistical software, and measurement data compares for paired t-test before and after taking medicine, and compare and adopt X between group
2inspection, with P<0.05 for there being statistical significance.
8. result
8.1 liang of group patient clinical comparitive study: observation group cures 47 examples, effective 33 examples, effective 19 examples, total effective rate 93.4%; And matched group cures 13 examples, effective 25 examples, effective 28 examples, total effective rate 63.5%, the therapeutic effect for the treatment of group is obviously better than matched group, and difference has statistical significance (P<0.05).In table 4.
Table 4 liang group Clinical efficacy comparison, example.
The life quality scores of 8.2 liang of group patients compare: the mobility of observation group patient, life feeling, Wb are by, Family Functions and the scoring of daily life situation all apparently higher than matched group, and difference has statistical significance (P<0.05).Specifically in table 5.
The life quality scores of table 5 liang group patient
Note: with matched group ratio, * P<0.05.
Routine blood test, routine urinalysis, stool routine, pelvic cavity color ultrasound, hepatic and renal function, electrocardiogram change without exception before and after treatment group patient treatment, in therapeutic process, vital sign steadily and without the untoward reaction such as nausea and vomiting, allergy, illustrate that clinical application of the present invention is safe and reliable.
This result of study shows, Chinese medicine preparation of the present invention is controlled cervical erosion and is merged cervical hypertrophy, its cure rate and overall efficiency are all apparently higher than matched group (traditional western medical treatment), simultaneously at the mobility of patient, life feeling, Wb by, Family Functions and the scoring of daily life situation, observation group is all apparently higher than matched group.
Claims (8)
1. treat the Chinese medicine preparation that cervical erosion merges cervical hypertrophy, it is characterized in that it is prepared from by certain weight by following traditional Chinese medicine raw: Herba Commelinae, Cortex Phellodendri, Herba Polygoni Avicularis, Radix Boehmeriae, Radix Rehmanniae Preparata, Herba Solani Lyrati, Stamen Nelumbinis, Semen Euryales, the Radix Angelicae Dahuricae, the Radix Astragali.
2. Chinese medicine preparation as claimed in claim 1, is characterized in that it is prepared from by the raw material of Chinese medicine of following preferred weight part proportioning: Herba Commelinae 35-45 part, Cortex Phellodendri 13-18 Fen, Herba Polygoni Avicularis 25-30 part, Radix Boehmeriae 13-18 part, Radix Rehmanniae Preparata 9-15 part, Herba Solani Lyrati 11-16 part, Stamen Nelumbinis 8-13 part, Semen Euryales 13-18 part, Radix Angelicae Dahuricae 6-10 part, Radix Astragali 11-16 part.
3. Chinese medicine preparation as claimed in claim 2, is characterized in that it is prepared from by the raw material of Chinese medicine of following weight: Herba Commelinae 35 parts, Cortex Phellodendri 15 Fen, Herba Polygoni Avicularis 30 parts, Radix Boehmeriae 15 parts, 10 parts, Radix Rehmanniae Preparata, Herba Solani Lyrati 12 parts, Stamen Nelumbinis 10 parts, Semen Euryales 13 parts, the Radix Angelicae Dahuricae 7 parts, the Radix Astragali 12 parts.
4. Chinese medicine preparation as claimed in claim 2, is characterized in that it is prepared from by the raw material of Chinese medicine of following weight: Herba Commelinae 40 parts, Cortex Phellodendri 16 Fen, Herba Polygoni Avicularis 25 parts, Radix Boehmeriae 15 parts, 15 parts, Radix Rehmanniae Preparata, Herba Solani Lyrati 15 parts, Stamen Nelumbinis 12 parts, Semen Euryales 15 parts, the Radix Angelicae Dahuricae 9 parts, the Radix Astragali 16 parts.
5. the Chinese medicine preparation as described in claim 1-4, is characterized in that it is peroral dosage form.
6. Chinese medicine preparation as claimed in claim 5, is characterized in that described peroral dosage form is preferably granule, tablet, capsule, oral liquid, soft capsule, drop pill, water pill etc.
7. Chinese medicine preparation as claimed in claim 6, is characterized in that described peroral dosage form is preferably capsule.
8. the Chinese medicine preparation as described in claim 1-7, it is characterized in that its preparation method comprises the following steps: by Herba Commelinae, Cortex Phellodendri, Herba Polygoni Avicularis, Radix Boehmeriae, Radix Rehmanniae Preparata, Herba Solani Lyrati, Stamen Nelumbinis, Semen Euryales, the Radix Angelicae Dahuricae, the Radix Astragali is soaked, decoct twice, first time decocts 2-3 hour, amount of water is 5-8 times of decocting herbs total weight parts, second time decocts 1-2 hour, amount of water is 4-6 times of decocting herbs total weight parts, collecting decoction, filter, filtrate reduced in volume, adding ethanol to concentration is 50%, in 0 DEG C of cold preservation 12 hours, filter, filtrate recycling ethanol, concentrate to obtain thick paste, dry, pulverize, add auxiliary materials and mixing, technique makes peroral dosage form suitable on pharmaceutics routinely, as granule, tablet, capsule, oral liquid, soft capsule, drop pill, water pill etc.
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| CN1107052A (en) * | 1994-07-16 | 1995-08-23 | 姚希德 | Medicine for curing tonsillitis and laryngopharyngitis |
| CN104491384A (en) * | 2014-11-29 | 2015-04-08 | 高春娟 | Medicine for treating chronic pharyngitis and preparation method of medicine |
| CN104491359A (en) * | 2014-12-03 | 2015-04-08 | 赵大勇 | Traditional Chinese medicine composition for treating oral ulcer and pharyngitis swelling and pain and preparation method thereof |
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|---|---|---|---|---|
| CN1107052A (en) * | 1994-07-16 | 1995-08-23 | 姚希德 | Medicine for curing tonsillitis and laryngopharyngitis |
| CN104491384A (en) * | 2014-11-29 | 2015-04-08 | 高春娟 | Medicine for treating chronic pharyngitis and preparation method of medicine |
| CN104491359A (en) * | 2014-12-03 | 2015-04-08 | 赵大勇 | Traditional Chinese medicine composition for treating oral ulcer and pharyngitis swelling and pain and preparation method thereof |
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| 夏桂成: "《夏桂成使用中医妇科学》", 31 October 2009, 中国中医药出版社 * |
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