CN104710413A - 二马来酸阿法替尼的制备方法 - Google Patents
二马来酸阿法替尼的制备方法 Download PDFInfo
- Publication number
- CN104710413A CN104710413A CN201310692113.8A CN201310692113A CN104710413A CN 104710413 A CN104710413 A CN 104710413A CN 201310692113 A CN201310692113 A CN 201310692113A CN 104710413 A CN104710413 A CN 104710413A
- Authority
- CN
- China
- Prior art keywords
- compound
- described step
- organic solvent
- preferred
- benzotriazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310692113.8A CN104710413B (zh) | 2013-12-16 | 2013-12-16 | 二马来酸阿法替尼的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310692113.8A CN104710413B (zh) | 2013-12-16 | 2013-12-16 | 二马来酸阿法替尼的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104710413A true CN104710413A (zh) | 2015-06-17 |
CN104710413B CN104710413B (zh) | 2019-05-03 |
Family
ID=53410196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310692113.8A Active CN104710413B (zh) | 2013-12-16 | 2013-12-16 | 二马来酸阿法替尼的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104710413B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106908523A (zh) * | 2015-12-22 | 2017-06-30 | 江苏万邦生化医药股份有限公司 | 一种二乙基磷乙酸的高效液相分析方法 |
CN107488171A (zh) * | 2016-06-10 | 2017-12-19 | 山东新时代药业有限公司 | 一种阿法替尼制备方法 |
CN107488172A (zh) * | 2016-06-10 | 2017-12-19 | 山东新时代药业有限公司 | 一种阿法替尼的制备方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101402631A (zh) * | 2003-10-17 | 2009-04-08 | 贝林格尔.英格海姆国际有限公司 | 氨基喹唑啉二马来酸盐、其制备方法及其用途 |
EP1981863B1 (en) * | 2006-01-26 | 2012-10-10 | Boehringer Ingelheim International GmbH | Process for preparing aminocrotonylamino-substituted quinazoline derivatives |
CN102731485A (zh) * | 2011-04-02 | 2012-10-17 | 齐鲁制药有限公司 | 4-(取代苯氨基)喹唑啉衍生物及其制备方法、药物组合物和用途 |
CN103073539A (zh) * | 2011-10-26 | 2013-05-01 | 齐鲁制药有限公司 | 4-(取代苯氨基)喹唑啉衍生物及其制备方法、药物组合物和用途 |
CN103242303A (zh) * | 2013-05-16 | 2013-08-14 | 苏州明锐医药科技有限公司 | 阿法替尼的制备方法 |
CN103288808A (zh) * | 2013-05-16 | 2013-09-11 | 苏州明锐医药科技有限公司 | 一种阿法替尼的制备方法 |
-
2013
- 2013-12-16 CN CN201310692113.8A patent/CN104710413B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101402631A (zh) * | 2003-10-17 | 2009-04-08 | 贝林格尔.英格海姆国际有限公司 | 氨基喹唑啉二马来酸盐、其制备方法及其用途 |
EP1981863B1 (en) * | 2006-01-26 | 2012-10-10 | Boehringer Ingelheim International GmbH | Process for preparing aminocrotonylamino-substituted quinazoline derivatives |
CN102731485A (zh) * | 2011-04-02 | 2012-10-17 | 齐鲁制药有限公司 | 4-(取代苯氨基)喹唑啉衍生物及其制备方法、药物组合物和用途 |
CN103073539A (zh) * | 2011-10-26 | 2013-05-01 | 齐鲁制药有限公司 | 4-(取代苯氨基)喹唑啉衍生物及其制备方法、药物组合物和用途 |
CN103242303A (zh) * | 2013-05-16 | 2013-08-14 | 苏州明锐医药科技有限公司 | 阿法替尼的制备方法 |
CN103288808A (zh) * | 2013-05-16 | 2013-09-11 | 苏州明锐医药科技有限公司 | 一种阿法替尼的制备方法 |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106908523A (zh) * | 2015-12-22 | 2017-06-30 | 江苏万邦生化医药股份有限公司 | 一种二乙基磷乙酸的高效液相分析方法 |
CN106908523B (zh) * | 2015-12-22 | 2019-11-22 | 江苏万邦生化医药股份有限公司 | 一种二乙基磷乙酸的高效液相分析方法 |
CN107488171A (zh) * | 2016-06-10 | 2017-12-19 | 山东新时代药业有限公司 | 一种阿法替尼制备方法 |
CN107488172A (zh) * | 2016-06-10 | 2017-12-19 | 山东新时代药业有限公司 | 一种阿法替尼的制备方法 |
CN107488172B (zh) * | 2016-06-10 | 2020-06-12 | 山东新时代药业有限公司 | 一种阿法替尼的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN104710413B (zh) | 2019-05-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104024262B (zh) | 埃克替尼和盐酸埃克替尼的制备方法及其中间体 | |
CN105330616A (zh) | 卡利拉嗪的制备方法 | |
CN105418483A (zh) | 一种结晶型乙磺酸尼达尼布的制备方法 | |
CN104926775A (zh) | 一种含氟吡喃衍生物的制备方法 | |
CN107337634B (zh) | 一种阿贝西利中间体化合物的制备方法 | |
CN104262257A (zh) | 一种吡唑衍生物的制备方法 | |
CN104710413A (zh) | 二马来酸阿法替尼的制备方法 | |
CN103242303B (zh) | 阿法替尼的制备方法 | |
CN104926798A (zh) | 阿法替尼中间体的高纯度制备方法 | |
CN103288808A (zh) | 一种阿法替尼的制备方法 | |
CN104829581A (zh) | 一种6-溴吡喃衍生物的制备方法 | |
CN103254183B (zh) | 阿法替尼的制备方法 | |
CN104829574A (zh) | 一种8-溴吡喃衍生物的制备方法 | |
CN103772278A (zh) | 一种重要四氢异喹啉衍生物中间体及其合成方法 | |
CN104860910A (zh) | 一种8-氟吡喃衍生物的制备方法 | |
CN104829575A (zh) | 一种6-氟吡喃衍生物的制备方法 | |
CN104829576A (zh) | 一种7-氟吡喃衍生物的制备方法 | |
CN103265482A (zh) | 博舒替尼的制备方法 | |
CN104844549A (zh) | 一种7-溴吡喃衍生物的制备方法 | |
CN103254182A (zh) | 一种阿法替尼的制备方法 | |
JPWO2015012271A1 (ja) | 複素環化合物の製造方法 | |
CN104447567B (zh) | 一种1位取代苯并咪唑衍生物的制备方法 | |
CN102731498B (zh) | 一种8-羟基久洛尼定及其衍生物的制备方法 | |
CN103467357B (zh) | 一种制备维拉唑酮中间体3-(4-氯丁基)-1h-吲哚-5-氰基的方法 | |
CN110981795B (zh) | 一种利用2-氰基异烟酸甲酯制备2-氨酰基异烟酸的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
CB02 | Change of applicant information |
Address after: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant after: JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. Applicant after: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address before: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant before: JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. Applicant before: JIANGSU HANSOH PHARMACEUTICAL GROUP LIANYUNGANG HONGCHUANG PHARMACEUTICAL Co.,Ltd. |
|
COR | Change of bibliographic data | ||
C41 | Transfer of patent application or patent right or utility model | ||
CB02 | Change of applicant information |
Address after: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant after: JIANGSU HANSOH PHARMACEUTICAL GROUP Co.,Ltd. Applicant after: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address before: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant before: Jiangsu best Pharmaceutical Co.,Ltd. Applicant before: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address after: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant after: Jiangsu best Pharmaceutical Co.,Ltd. Applicant after: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address before: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant before: JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. Applicant before: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. |
|
COR | Change of bibliographic data | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20160324 Address after: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Applicant after: JIANGSU HANSOH PHARMACEUTICAL GROUP Co.,Ltd. Address before: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant before: JIANGSU HANSOH PHARMACEUTICAL GROUP Co.,Ltd. Applicant before: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. |
|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |