CN107488171A - 一种阿法替尼制备方法 - Google Patents
一种阿法替尼制备方法 Download PDFInfo
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- CN107488171A CN107488171A CN201610406764.XA CN201610406764A CN107488171A CN 107488171 A CN107488171 A CN 107488171A CN 201610406764 A CN201610406764 A CN 201610406764A CN 107488171 A CN107488171 A CN 107488171A
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- reaction
- afatinib
- preparation
- organic solvent
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
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Priority Applications (1)
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CN201610406764.XA CN107488171B (zh) | 2016-06-10 | 2016-06-10 | 一种阿法替尼制备方法 |
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CN201610406764.XA CN107488171B (zh) | 2016-06-10 | 2016-06-10 | 一种阿法替尼制备方法 |
Publications (2)
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CN107488171A true CN107488171A (zh) | 2017-12-19 |
CN107488171B CN107488171B (zh) | 2020-08-28 |
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CN201610406764.XA Active CN107488171B (zh) | 2016-06-10 | 2016-06-10 | 一种阿法替尼制备方法 |
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CN (1) | CN107488171B (zh) |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0635498A1 (en) * | 1993-07-19 | 1995-01-25 | Zeneca Limited | Quinazoline derivatives and their use as anti-cancer agents |
WO2007085638A1 (en) * | 2006-01-26 | 2007-08-02 | Boehringer Ingelheim International Gmbh | Process for preparing aminocrotonylamino-substituted quinazoline derivatives |
CN1867564B (zh) * | 2003-10-17 | 2011-06-08 | 贝林格尔.英格海姆国际有限公司 | 氨基巴豆基化合物的制备方法 |
CN103242303A (zh) * | 2013-05-16 | 2013-08-14 | 苏州明锐医药科技有限公司 | 阿法替尼的制备方法 |
CN104151359A (zh) * | 2014-07-15 | 2014-11-19 | 杭州华东医药集团新药研究院有限公司 | 喹唑啉类化合物及其制备方法和在制备酪氨酸激酶抑制剂中的应用 |
CN104710413A (zh) * | 2013-12-16 | 2015-06-17 | 江苏豪森药业股份有限公司 | 二马来酸阿法替尼的制备方法 |
CN104926798A (zh) * | 2014-03-21 | 2015-09-23 | 江苏豪森药业股份有限公司 | 阿法替尼中间体的高纯度制备方法 |
-
2016
- 2016-06-10 CN CN201610406764.XA patent/CN107488171B/zh active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0635498A1 (en) * | 1993-07-19 | 1995-01-25 | Zeneca Limited | Quinazoline derivatives and their use as anti-cancer agents |
CN1867564B (zh) * | 2003-10-17 | 2011-06-08 | 贝林格尔.英格海姆国际有限公司 | 氨基巴豆基化合物的制备方法 |
WO2007085638A1 (en) * | 2006-01-26 | 2007-08-02 | Boehringer Ingelheim International Gmbh | Process for preparing aminocrotonylamino-substituted quinazoline derivatives |
CN103242303A (zh) * | 2013-05-16 | 2013-08-14 | 苏州明锐医药科技有限公司 | 阿法替尼的制备方法 |
CN104710413A (zh) * | 2013-12-16 | 2015-06-17 | 江苏豪森药业股份有限公司 | 二马来酸阿法替尼的制备方法 |
CN104926798A (zh) * | 2014-03-21 | 2015-09-23 | 江苏豪森药业股份有限公司 | 阿法替尼中间体的高纯度制备方法 |
CN104151359A (zh) * | 2014-07-15 | 2014-11-19 | 杭州华东医药集团新药研究院有限公司 | 喹唑啉类化合物及其制备方法和在制备酪氨酸激酶抑制剂中的应用 |
Non-Patent Citations (1)
Title |
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DISCLOSED ANONYMOUSLY: "Process for the preparation of afatinib", 《IP.COM JOURNAL》 * |
Also Published As
Publication number | Publication date |
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CN107488171B (zh) | 2020-08-28 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method of afatinib Effective date of registration: 20211224 Granted publication date: 20200828 Pledgee: Industrial and Commercial Bank of China Limited Feixian sub branch Pledgor: SHANDONG NEW TIME PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980016193 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20221028 Granted publication date: 20200828 Pledgee: Industrial and Commercial Bank of China Limited Feixian sub branch Pledgor: SHANDONG NEW TIME PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980016193 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method of alfatinib Effective date of registration: 20221103 Granted publication date: 20200828 Pledgee: Industrial and Commercial Bank of China Limited Feixian sub branch Pledgor: SHANDONG NEW TIME PHARMACEUTICAL Co.,Ltd. Registration number: Y2022980020531 |
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