CN104703965A - α羟基酰胺 - Google Patents

α羟基酰胺 Download PDF

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Publication number
CN104703965A
CN104703965A CN201380049287.0A CN201380049287A CN104703965A CN 104703965 A CN104703965 A CN 104703965A CN 201380049287 A CN201380049287 A CN 201380049287A CN 104703965 A CN104703965 A CN 104703965A
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Prior art keywords
dimethyl
diox
phenyl
group
hydroxyl
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CN201380049287.0A
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Chinese (zh)
Inventor
M·米泽勒尔
D·斯威内恩
J·斯尼撒米
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Merck Patent GmbH
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Merck Patent GmbH
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Publication of CN104703965A publication Critical patent/CN104703965A/zh
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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CN109476645A (zh) * 2016-07-14 2019-03-15 辉瑞大药厂 作为vanin-1酶抑制剂的新的嘧啶甲酰胺
CN113166104A (zh) * 2018-12-03 2021-07-23 勃林格殷格翰国际有限公司 作为vanin抑制剂的杂芳族化合物

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CA2894157A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
EP2935243B1 (en) 2012-12-21 2018-03-14 Epizyme, Inc. Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
EP3160477A4 (en) * 2014-06-25 2018-07-04 Epizyme, Inc. Prmt5 inhibitors and uses thereof
EP3177288A4 (en) 2014-08-04 2018-04-04 Epizyme, Inc. Prmt5 inhibitors and uses thereof
BR112017009577A2 (pt) 2014-11-06 2018-02-20 Radboud Universitair Medisch Centrum análogos de pantotenamida
JP2018516254A (ja) * 2015-05-29 2018-06-21 ファイザー・インク バニン１酵素の阻害薬としての新規なヘテロ環化合物
WO2017097838A1 (en) * 2015-12-08 2017-06-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of systemic sclerosis
AU2019326933B2 (en) * 2018-08-28 2024-12-05 Boehringer Ingelheim International Gmbh Heteroaromatic compounds as Vanin inhibitors
MX2021006489A (es) 2018-12-03 2021-07-06 Boehringer Ingelheim Int Compuestos heteroaromaticos como inhibidores de vanina.
EA202191477A1 (ru) 2018-12-03 2021-10-13 Бёрингер Ингельхайм Интернациональ Гмбх Гетероароматические соединения в качестве ингибиторов ванина
CN111592472B (zh) 2019-04-28 2022-10-21 纳莹(上海)生物科技有限公司 一种荧光染料及其制备方法和用途
EP4426277A1 (en) * 2021-11-02 2024-09-11 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods and pharmaceutical compositions for repairing intestinal mucosal
JP7506415B2 (ja) 2021-12-17 2024-06-26 学校法人大阪医科薬科大学 Ｖａｎｉｎ－１阻害剤

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JPS60248193A (ja) * 1984-05-23 1985-12-07 Dai Ichi Seiyaku Co Ltd パンテテインの製造法
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US7727738B2 (en) * 2005-07-11 2010-06-01 The Regents Of The University Of California Methods for generating analogs of coenzyme A
WO2011152721A1 (en) * 2010-05-31 2011-12-08 Umc St. Radboud Derivatives of pantothenic acid and their use for the treatment of malaria
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CN109476645A (zh) * 2016-07-14 2019-03-15 辉瑞大药厂 作为vanin-1酶抑制剂的新的嘧啶甲酰胺
CN113166104A (zh) * 2018-12-03 2021-07-23 勃林格殷格翰国际有限公司 作为vanin抑制剂的杂芳族化合物
CN114478485A (zh) * 2018-12-03 2022-05-13 勃林格殷格翰国际有限公司 作为vanin抑制剂的杂芳族化合物
CN114478485B (zh) * 2018-12-03 2024-04-05 勃林格殷格翰国际有限公司 作为vanin抑制剂的杂芳族化合物

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