AU2013324696B2 - Alpha hydroxy amides - Google Patents

Alpha hydroxy amides Download PDF

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Publication number
AU2013324696B2
AU2013324696B2 AU2013324696A AU2013324696A AU2013324696B2 AU 2013324696 B2 AU2013324696 B2 AU 2013324696B2 AU 2013324696 A AU2013324696 A AU 2013324696A AU 2013324696 A AU2013324696 A AU 2013324696A AU 2013324696 B2 AU2013324696 B2 AU 2013324696B2
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Australia
Prior art keywords
mmol
dimethyl
dioxane
amide
propyl
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AU2013324696A
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AU2013324696A1 (en
Inventor
Mathilde Muzerelle
Jeyaprakashnarayanan SEENISAMY
Dominique Swinnen
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Merck Patent GmbH
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Merck Patent GmbH
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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JP2016505002A (ja) 2012-12-21 2016-02-18 エピザイム，インコーポレイティド ジヒドロイソキノリンまたはテトラヒドロイソキノリンを含有するｐｒｍｔ５阻害剤およびその使用
US9365555B2 (en) 2012-12-21 2016-06-14 Epizyme, Inc. PRMT5 inhibitors and uses thereof
US10118918B2 (en) 2012-12-21 2018-11-06 Epizyme, Inc. PRMT5 inhibitors and uses thereof
WO2015200680A2 (en) * 2014-06-25 2015-12-30 Epizyme, Inc. Prmt5 inhibitors and uses thereof
AU2015301196A1 (en) 2014-08-04 2017-01-12 Epizyme, Inc. PRMT5 inhibitors and uses thereof
US20180282279A1 (en) * 2014-11-06 2018-10-04 Radboud Universitair Medisch Centrum Pantothenamide Analogues
WO2016193844A1 (en) 2015-05-29 2016-12-08 Pfizer Inc. Novel heterocyclic compounds as inhibitors of vanin-1 enzyme
WO2017097838A1 (en) * 2015-12-08 2017-06-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of systemic sclerosis
US10906888B2 (en) * 2016-07-14 2021-02-02 Pfizer Inc. Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
HUE061186T2 (hu) 2018-08-28 2023-06-28 Boehringer Ingelheim Int Heteroaromás vegyületek mint vanin-inhibitorok
ES2928919T3 (es) 2018-12-03 2022-11-23 Boehringer Ingelheim Int Compuestos heteroaromáticos como inhibidores de vanina
BR112021010823A2 (pt) 2018-12-03 2021-08-24 Boehringer Ingelheim International Gmbh Compostos heteroaromáticos como inibidores de vanina
JP7130873B2 (ja) * 2018-12-03 2022-09-05 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング バニン阻害剤としてのヘテロ芳香族化合物
CN111592472B (zh) 2019-04-28 2022-10-21 纳莹(上海)生物科技有限公司 一种荧光染料及其制备方法和用途
EP4426277A1 (en) * 2021-11-02 2024-09-11 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods and pharmaceutical compositions for repairing intestinal mucosal
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