CA2885778A1 - Alpha hydroxy amides - Google Patents

Alpha hydroxy amides Download PDF

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Publication number
CA2885778A1
CA2885778A1 CA2885778A CA2885778A CA2885778A1 CA 2885778 A1 CA2885778 A1 CA 2885778A1 CA 2885778 A CA2885778 A CA 2885778A CA 2885778 A CA2885778 A CA 2885778A CA 2885778 A1 CA2885778 A1 CA 2885778A1
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CA
Canada
Prior art keywords
dimethyl
mmol
hydroxy
carboxylic acid
amide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2885778A
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English (en)
French (fr)
Inventor
Mathilde Muzerelle
Dominique Swinnen
Jeyaprakashnarayanan SEENISAMY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of CA2885778A1 publication Critical patent/CA2885778A1/en
Abandoned legal-status Critical Current

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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JP2016505002A (ja) 2012-12-21 2016-02-18 エピザイム，インコーポレイティド ジヒドロイソキノリンまたはテトラヒドロイソキノリンを含有するｐｒｍｔ５阻害剤およびその使用
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US20170198006A1 (en) * 2014-06-25 2017-07-13 Epizyme, Inc. Prmt5 inhibitors and uses thereof
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EP3215496B1 (en) 2014-11-06 2019-01-02 Radboud Universitair Medisch Centrum Pantothenamide analogues
WO2016193844A1 (en) 2015-05-29 2016-12-08 Pfizer Inc. Novel heterocyclic compounds as inhibitors of vanin-1 enzyme
US20180364233A1 (en) * 2015-12-08 2018-12-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of systemic sclerosis
MX2019000536A (es) * 2016-07-14 2019-04-01 Pfizer Nuevas pirimidinas carboxamidas como inhibidores de enzima vanina-1.
PE20210478A1 (es) 2018-08-28 2021-03-11 Boehringer Ingelheim Int Compuestos heteroaromaticos como inhibidores de vanina
KR20210099093A (ko) 2018-12-03 2021-08-11 베링거 인겔하임 인터내셔날 게엠베하 바닌 억제제로서의 헤테로방향족 화합물
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PL3891142T3 (pl) 2018-12-03 2023-01-02 Boehringer Ingelheim International Gmbh Związki heteroaromatyczne jako inhibitory waniny
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US20040247524A1 (en) 2003-06-05 2004-12-09 Philippe Naquet Method of treatment of an inflammatory disorder with a Vanin-1 antagonist
US7727738B2 (en) * 2005-07-11 2010-06-01 The Regents Of The University Of California Methods for generating analogs of coenzyme A
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