CN104667048A - Traditional Chinese medicine for treating adolescent acne vulgaris - Google Patents

Abstract

The invention relates to a traditional Chinese medicine for treating adolescent acne vulgaris and belongs to the field of traditional Chinese medicine. The medicine comprises the following active ingredients: folium eriobotryae, radix rehmanniae, dittany bark, mulberry bark, cortex moutan radicis, herba hedyotis, salvia miltiorrhiza, radix scrophulariae, radix scutellariae, coptis roots, chrysanthemum, selfheal, semen coicis, rhizoma smilacis glabrae, cacumen biotae, tribulus terrestris, radix angelicae and liquorice. The medicine is effective and reliable, and has low possibility of recurrence and no obvious adverse effect for treating the adolescent acne vulgaris.

Description

A kind of Chinese medicine for the treatment of adolescence acne vulgaris

Technical field

The invention belongs to tcm field.

Background technology

Acne vulgaris is common a kind of hair follicle, the sebaceous gland chronic inflammatory disease of adolescence, mainly betides the place such as face, breast, forms the infringements such as acne, pimple, pustule, tuberosity, cyst.The sickness rate of adolescence acne vulgaris is higher, it is reported China 19 years old crowd in sickness rate be about 46.8%.As do not treated in time, Cutaneous cicatrix can be produced, pigmentation etc., having a strong impact on mental health and the appearance of patient.Existing western medicine, although part effectively, finds that there is the shortcoming of side effect and easily recurrence.

Summary of the invention

The object of the invention is to adopt theory of Chinese medical science, with clearing away heat-damp and promoting diuresis, the Chinese medicine of removing pathogenic heat from blood and toxic substance from the body treatment adolescence acne vulgaris.

Important part of raw material that the present invention makes effective ingredient consists of:

Folium Eriobotryae 10-30, Radix Rehmanniae 10-30, Cortex Dictamni 10-35, Cortex Mori 10-35, Cortex Moutan 10-35,

Herba Hedyotidis Diffusae 10-30, Radix Salviae Miltiorrhizae 10-30, Radix Scrophulariae 10-30, Radix Scutellariae 10-25, Rhizoma Coptidis 10-25, Flos Chrysanthemi 10-30,

Spica Prunellae 10-25, SEMEN COICIS 10-25, Rhizoma Smilacis Glabrae 10-30, Cacumen Platycladi 10-30, Fructus Atriplicis Sibiricae 10-25, Radix Angelicae Dahuricae 10-25, Radix Glycyrrhizae 5-10.

The present invention's application treatment by Chinese herbs adolescence acne vulgaris effectively, reliably, not easily recurs, without obvious adverse reaction.

Detailed description of the invention

Important part of raw material that the present invention makes effective ingredient consists of:

Folium Eriobotryae 10-30, Radix Rehmanniae 10-30, Cortex Dictamni 10-35, Cortex Mori 10-35, Cortex Moutan 10-35,

Herba Hedyotidis Diffusae 10-30, Radix Salviae Miltiorrhizae 10-30, Radix Scrophulariae 10-30, Radix Scutellariae 10-25, Rhizoma Coptidis 10-25, Flos Chrysanthemi 10-30,

Spica Prunellae 10-25, SEMEN COICIS 10-25, Rhizoma Smilacis Glabrae 10-30, Cacumen Platycladi 10-30, Fructus Atriplicis Sibiricae 10-25, Radix Angelicae Dahuricae 10-25, Radix Glycyrrhizae 5-10.

preparation method is:

By above Chinese medicine, add 8 times amount water soaking 30 minutes, decoct secondary, each 0.5 hour, filter, at merging filtrate, dense to 1000ml, add sodium benzoate 2g, dissolve to it, cold preservation 12 hours again, filters, and filtrate adds distilled water and is adjusted to 1000ml and stirs evenly, subpackage and get final product.

Embodiment 1:

Important part of raw material that the present invention makes effective ingredient consists of:

Folium Eriobotryae 10, the Radix Rehmanniae 10, Cortex Dictamni 10, Cortex Mori 10, Cortex Moutan 10,

Herba Hedyotidis Diffusae 10, Radix Salviae Miltiorrhizae 10, Radix Scrophulariae 10, Radix Scutellariae 10, Rhizoma Coptidis 10, Flos Chrysanthemi 10,

Spica Prunellae 10, SEMEN COICIS 105, Rhizoma Smilacis Glabrae 10, Cacumen Platycladi 10, Fructus Atriplicis Sibiricae 10, the Radix Angelicae Dahuricae 10, Radix Glycyrrhizae 5;

Preparation method is the same.

Embodiment 2:

Important part of raw material that the present invention makes effective ingredient consists of:

Folium Eriobotryae 15, the Radix Rehmanniae 15, Cortex Dictamni 22, Cortex Mori 22, Cortex Moutan 22,

Herba Hedyotidis Diffusae 20, Radix Salviae Miltiorrhizae 20, Radix Scrophulariae 20, Radix Scutellariae 17, Rhizoma Coptidis 17, Flos Chrysanthemi 20,

Spica Prunellae 17, SEMEN COICIS 17, Rhizoma Smilacis Glabrae 20, Cacumen Platycladi 20, Fructus Atriplicis Sibiricae 17, Radix Angelicae Dahuricae 10-25, Radix Glycyrrhizae 8;

Preparation method is the same.

Embodiment 3:

Important part of raw material that the present invention makes effective ingredient consists of:

Folium Eriobotryae 30, the Radix Rehmanniae 30, Cortex Dictamni 35, Cortex Mori 35, Cortex Moutan 35,

Herba Hedyotidis Diffusae 30, Radix Salviae Miltiorrhizae 30, Radix Scrophulariae 30, Radix Scutellariae 25, Rhizoma Coptidis 25, Flos Chrysanthemi 30,

Spica Prunellae 25, SEMEN COICIS 25, Rhizoma Smilacis Glabrae 30, Cacumen Platycladi 30, Fructus Atriplicis Sibiricae 25, the Radix Angelicae Dahuricae 25, Radix Glycyrrhizae 10;

Preparation method is the same.

Embodiment 4:

Important part of raw material that the present invention makes effective ingredient consists of: Folium Eriobotryae 20, the Radix Rehmanniae 20, Cortex Dictamni 20, Cortex Moutan 20, Cortex Mori 15, Herba Hedyotidis Diffusae 20, Radix Salviae Miltiorrhizae 20, Radix Scrophulariae 15, Radix Scutellariae 15, Rhizoma Coptidis 15, Flos Chrysanthemi 15, Spica Prunellae 15, SEMEN COICIS 15, Rhizoma Smilacis Glabrae 15, Cacumen Platycladi 15, Fructus Atriplicis Sibiricae 15, the Radix Angelicae Dahuricae 10, Radix Glycyrrhizae 5;

Preparation method is the same.

character:

This product is brown liquid, has a small amount of through the dispersible precipitation of jolting, feeble QI fragrance, bitter and puckery flavor.

differentiate:

Get this product 20ml and add formic acid 80ml, stir evenly, leave standstill 30 minutes, filtrate, evaporate to dryness, residue adds water the dissolving of 10ml, with chloroform extraction 3 times, each 20ml, discard chloroform solution, water layer again with water saturation, n-butanol extraction 3 times, each 20ml, merge n-butyl alcohol liquid, wash 2 times with n-butyl alcohol saturation water, each 25ml, after emulsifying, centrifugal in 4000 turns 1 point, divide and get n-butyl alcohol liquid, evaporate to dryness, residue adds methanol 1ml makes dissolving, as test sample solution, another extracting liquorice control medicinal material 1g, filters, filtrate evaporate to dryness.Every regulation that identification result is relevant under meeting mixture item.(Chinese Pharmacopoeia version in 2000 annex 1, j).

usage of the present invention and consumption:

Oral, a 100ml, 2 times on the one, temperatureization one after each meal.

untoward reaction:

Few patients occasionally has times of defecation to increase, but transference cure after drug withdrawal.

taboo and note item:

1. this Chinese medicine allergy sufferers avoids clothes.Careful clothes when 2. catching a cold.3. feminine menstrual phase careful clothes.4. Aqua Folium Camelliae sinensis and sweet mung bean soup is avoided.

The cause of disease of primary disease, pathogenesis is that ferritic sun heat is contained partially, and add that adolescence life is vigorous, nutrient blood is partial heat day by day, the outer harmony of heat in blood, and QI and blood stasis, accumulates resistance skin; Or the product of the pungent delicious food of surfeit, cause lung stomach accumulated heat, follow through upper smoked, blood with through row, in face.Therefore treatment is with clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body is main.Monarch drug Folium Eriobotryae of the present invention, Herba Hedyotidis Diffusae, with the heat of removing summer-heat lung stomach, ministerial drug is the Radix Rehmanniae, Radix Salviae Miltiorrhizae, Cacumen Platycladi, Cortex Moutan, Cortex Mori, Radix Scrophulariae, Fructus Atriplicis Sibiricae, the Radix Angelicae Dahuricae, Radix Scutellariae, has heat clearing and blood cooling, a merit that activating blood circulation to dissipate blood stasis, removing toxic substances disappear rash.Adjuvant drug is Spica Prunellae, Cortex Dictamni, Rhizoma Smilacis Glabrae, Semen Coicis, Flos Chrysanthemi, Rhizoma Coptidis have clearing away heat-damp and promoting diuresis, detumescence of dispeling the wind.Make medicine: Radix Glycyrrhizae, there is coordinating the actions of various ingredients in a prescription.In sum, we have clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, heat clearing away solution rash, clear rash eliminating stagnation.Just go out from two, unlikelyly to follow through upper criminal's women's head-ornaments, breast, butt skin and falling ill, thus effectively can treat the object of adolescence acne vulgaris.Should note through conventional Warm Wash face in clinical treatment, forbidding finger extruding erythra, the product of few food or the pungent plumpness of fasting, polyphagia fresh vegetables and fruit, keep free movement of the bowels, is conducive to the recovery of acne and prevents recurrence.

The present invention observation of curative effect:

object:observe a kind of Chinese Herbs for the treatment of adolescence acne vulgaris. method:adopt random packet, treatment group group 32 example, takes treatment by Chinese herbs.Matched group 31 example, takes minocycline.Then the skin lesion quantity of two groups of patient affected part acne, pimple, pustule, tuberosity, cyst is observed. result:treatment group total effective rate is (90.7%), and matched group total effective rate is (74.2%). conclusion:treatment by Chinese herbs adolescence acne vulgaris is effective, reliable, not easily recurs, without obvious untoward reaction.And matched group (Western medicine), although part is effectively, easily recur after finding edible maror, and have side effect.

one, clinical data:

1.1, this organized for 63 routine patient age 16-31 years, and average 20.7 years old, the course of disease was the shortest 1.5 months, the longest 9 years, average 3.4 years.Be divided into two groups at random, treatment group 32 example, man 17 example, female 15 example, age 15-28 year, the course of disease 2 months-7 years, matched group case male 16 example, female 15 example.Age 16-31 year, the course of disease 1.5 months-9 years.Two groups of patients compare in sex, age, course of disease length etc., have comparability.

1.2, diagnostic criteria, with reference to " clinical dermatology " standard that Zhao debates chief editor, is specially: conical pimple consistent with hair follicle appears in face, forehead, buccal and nose buccal and chest and back.Can divide again according to the state of an illness: 1. acne vulgaris, 2. acne papulosa, 3. pustular acne, 4. sclerancne, 5. acne cystica, 6. acne atrophica.The present invention is based on treatment by Chinese herbs acne vulgaris.

1.3, Therapeutic Method:

Treatment group adopts Chinese medicine for oral administration treatment, prescription: Folium Eriobotryae 20g, Radix Rehmanniae 15g, Cortex Dictamni 15g, Cortex Mori 15g, Cortex Moutan 15g, Herba Hedyotidis Diffusae 20g, Radix Salviae Miltiorrhizae 15g, Radix Scrophulariae 10g, Radix Scutellariae 10g, Rhizoma Coptidis 10g, Flos Chrysanthemi 15g, Spica Prunellae 15g, SEMEN COICIS 15g, Rhizoma Smilacis Glabrae 15, Cacumen Platycladi 15, Fructus Atriplicis Sibiricae 15, the Radix Angelicae Dahuricae 10, Radix Glycyrrhizae 5g.One day potion, decocting to 200ml, decoction being taken warmly after meal at twice.It within 15 days, is a course for the treatment of.Matched group is thrown and is taken Western medicine minocycline, and 50mg/2 time oral, within 15 days, is a course for the treatment of.

1.4, criterion of therapeutical effect: recovery from illness, face, breast, back pimple disappear completely; Effective: face, breast, back institute pimpling major part or partial disappearance, stay a small amount of pimple and pigmentation.Invalid: pimple number and form without significant change, or increase on the contrary.

Statistical method, data adopts X inspection, and measurement data adopts t inspection.

two, therapeutic outcome:

Two groups of patient treatment outcome compare in Table:

Group	n	Recovery from illness	Effectively	Invalid	Total effective rate %
						Treatment group	32	15	14	3	90.7△
Matched group	31	7	16	8	74.2△

Note: treatment group compares △ p<0.05 with matched group

three, discuss:

Acne vulgaris (acne vulgaris) is the chronic inflammation disease of the common hair follicle glandular integumentaria of a kind of adolescence, shows as acne, pimple, pustule, tuberosity, cyst and cicatrix, is apt to occur in the position of the rich adipose glands such as face, the back of the body, breast.From the angle analysis of the traditional Chinese medical science, the etiology and pathogenesis of adolescence acne vulgaris is that add that adolescence life is vigorous, nutrient blood is partial heat day by day because patient's ferritic sun heat is contained partially, the outer harmony of heat in blood, and QI and blood stasis, accumulates resistance skin; Or the product of the pungent delicious food of surfeit, cause lung stomach accumulated heat, follow through upper smoked, blood with through row, in face.The cause of disease of primary disease, pathogenesis is that ferritic sun heat is contained partially, and add that adolescence life is vigorous, nutrient blood is partial heat day by day, therefore treatment is with clearing away heat-damp and promoting diuresis, and removing pathogenic heat from blood and toxic substance from the body is main.Monarch drug Folium Eriobotryae of the present invention, Herba Hedyotidis Diffusae, with the heat of removing summer-heat lung stomach, ministerial drug is the Radix Rehmanniae, Radix Salviae Miltiorrhizae, Cacumen Platycladi, Cortex Moutan, Cortex Mori, Radix Scrophulariae, Fructus Atriplicis Sibiricae, the Radix Angelicae Dahuricae, Radix Scutellariae, has activating blood circulation to dissipate blood stasis, a merit that heat clearing and blood cooling, removing toxic substances disappear rash.Adjuvant drug is Spica Prunellae, Cortex Dictamni, Semen Coicis, Flos Chrysanthemi, Rhizoma Smilacis Glabrae, Rhizoma Coptidis have clearing away heat-damp and promoting diuresis, detumescence of dispeling the wind.Make medicine: Radix Glycyrrhizae, there is coordinating the actions of various ingredients in a prescription.In sum, we have clearing away heat-damp and promoting diuresis, heat-clearing and toxic substances removing, heat clearing away solution rash, clear rash eliminating stagnation.Just go out from two, unlikelyly to follow through upper criminal's women's head-ornaments, breast, butt skin and falling ill, thus effectively can treat the object of adolescence acne vulgaris.Should note through conventional Warm Wash face in clinical treatment, forbidding finger extruding erythra, the product of few food or the pungent plumpness of fasting, polyphagia fresh vegetables and fruit, keep free movement of the bowels, is conducive to the recovery of acne and prevents recurrence.

Claims (1)

1. treat a Chinese medicine for adolescence acne vulgaris, it is characterized in that: the important part of raw material of making effective ingredient consists of:

Folium Eriobotryae 10-30, Radix Rehmanniae 10-30, Cortex Dictamni 10-35, Cortex Mori 10-35, Cortex Moutan 10-35,

Herba Hedyotidis Diffusae 10-30, Radix Salviae Miltiorrhizae 10-30, Radix Scrophulariae 10-30, Radix Scutellariae 10-25, Rhizoma Coptidis 10-25, Flos Chrysanthemi 10-30,

Spica Prunellae 10-25, SEMEN COICIS 10-25, Rhizoma Smilacis Glabrae 10-30, Cacumen Platycladi 10-30, Fructus Atriplicis Sibiricae 10-25, Radix Angelicae Dahuricae 10-25,

Radix Glycyrrhizae 5-10.