CN101785811A

CN101785811A - Traditional Chinese medicine for senile pruritus treatment

Info

Publication number: CN101785811A
Application number: CN 201010127399
Authority: CN
Inventors: 张平; 李有田; 李洋
Original assignee: Individual
Current assignee: Individual
Priority date: 2010-03-19
Filing date: 2010-03-19
Publication date: 2010-07-28
Anticipated expiration: 2030-03-19
Also published as: CN101785811B

Abstract

The invention relates to a traditional Chinese medicine for senile pruritus treatment, belonging to the traditional Chinese medicine field. The invention aims at providing a traditional Chinese medicine for senile pruritus treatment, which has the main efficacies of nourishing blood, dispelling wind and arresting itching, and has the auxiliary efficacies of invigorating blood circulation, dispelling wind and arresting itching. The active ingredients of the traditional Chinese medicine are prepared from the raw materials of (by weight part): angelica, ligusticum wallichii, root of rehmannia, fleece-flower root, schizonepeta, parsnip, fructus kochiae, cortex dictamni, hops, white paeony root and liquorice. The invention has simple preparation method, low price, good curative effect, no toxic and side effect, short treatment time, good social and economical benefits. The traditional Chinese medicine is mainly used for the treatment of senile pruritus and the like.

Description

A kind of Chinese medicine for the treatment of senile pruritus

Technical field:

The invention belongs to the field of Chinese medicines.

Background technology:

Many because old people's the skin hypofunctions of senile skin pruritus, sebum secretion reduces, and causes old people's xerosis cutis and degeneration atrophy etc. former thereby cause.Very to itch, itch than the daytime night heavily clinically, scratch stranger and stranger to itch be feature, had a strong impact on old people's quality of life.Western medical treatment senile skin pruritus generally adopts Western medicine such as antihistamine, corticosteroids etc. at present, though can temporarily obtain certain effect, but because the toxic and side effects of Western medicine is bigger, and can cause gerontal patient's femur head necrosis untoward reaction such as (side effect of hormone medicine), seriously limited gerontal patient's application of treatment and curative effect thus, and common sympton drawback such as show effect repeatedly after the drug withdrawal.

Technology contents:

The objective of the invention is to adopt theory of Chinese medical science, control based on nourishing blood to expel wind antipruritic, assistant with invigorate blood circulation, the Chinese medicine of the treatment senile pruritus of dispelling wind for relieving itching.

The present invention makes the raw materials of effective components weight portion and consists of:

Radix Angelicae Sinensis 10～15 Rhizoma Chuanxiongs 8～15 Radix Rehmanniae 15～25 Radixs Polygoni Multiflori 8～15

Herba Schizonepetae 10～25 Radix Saposhnikoviaes 8～15 Fructus Kochiae 15～25 Cortex Dictamni 15～25

Hops 12～25 Radix Paeoniae Albas 15～25 Radix Glycyrrhizaes 5～10

The present invention makes raw materials of effective components optimum weight part and consists of:

Radix Angelicae Sinensis 15 Rhizoma Chuanxiongs 10 Radix Rehmanniae 20 Radixs Polygoni Multiflori 15

Herba Schizonepetae 20 Radix Saposhnikoviaes 15 Fructus Kochiae 20 Cortex Dictamni 20

Hops 20 Radix Paeoniae Albas 20 Radix Glycyrrhizaes 5

The present invention prepares simply, and is cheap, and good effect has no side effect, and treatment time is short, and is social and good in economic efficiency.The present invention is mainly used in treatment senile pruritus etc.

The specific embodiment:

Hops 12～25 Radix Paeoniae Albas 15～25 Radix Glycyrrhizaes 5～10

Hops 20 Radix Paeoniae Albas 20 Radix Glycyrrhizaes 5

Preparation method of the present invention is:

Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Rehmanniae, the Radix Polygoni Multiflori, Herba Schizonepetae, Radix Saposhnikoviae, the Fructus Kochiae, Cortex Dictamni, hops, the Radix Paeoniae Alba, Radix Glycyrrhizae are added the octuple water gaging to be soaked 30 minutes, big fire before this is fried boiling, change slow fire (little fire) then into and decoct after 45 minutes, filter, remerge filtrate, be concentrated into 1000ml, add sodium benzoate 2g (anticorrosion), make its dissolving, cold preservation is 12 hours again, filtration filtrate adding distil water transfers to 1000ml and stirs evenly, and packing promptly.

Embodiment 1:

Radix Angelicae Sinensis 10 Rhizoma Chuanxiongs 8 Radix Rehmanniae 15 Radixs Polygoni Multiflori 8

Herba Schizonepetae 10 Radix Saposhnikoviaes 8 Fructus Kochiae 15 Cortex Dictamni 15

Hops 12 Radix Paeoniae Albas 15 Radix Glycyrrhizaes 5

Embodiment 2:

Radix Angelicae Sinensis 14 Rhizoma Chuanxiongs 11 Radix Rehmanniae 20 Radixs Polygoni Multiflori 11

Herba Schizonepetae 17 Radix Saposhnikoviaes 11 Fructus Kochiae 20 Cortex Dictamni 20

Hops 18 Radix Paeoniae Albas 20 Radix Glycyrrhizaes 7

Preparation method is with embodiment 1.

Embodiment 3:

Radix Angelicae Sinensis 15 Rhizoma Chuanxiongs 15 Radix Rehmanniae 25 Radixs Polygoni Multiflori 15

Herba Schizonepetae 25 Radix Saposhnikoviaes 15 Fructus Kochiae 25 Cortex Dictamni 25

Hops 25 Radix Paeoniae Albas 25 Radix Glycyrrhizaes 10

Preparation method is with embodiment 1.

Most preferred embodiment:

Hops 20 Radix Paeoniae Albas 20 Radix Glycyrrhizaes 5

Preparation method is with embodiment 1.

Character:

This product is a brown liquid, has dispersible precipitation after jolting in a small amount, feeble QI perfume (or spice), bitter and puckery flavor.

Differentiate:

Get this product 20ml, add formic acid 80ml, stir evenly, leave standstill filtration in 30 minutes, filtrate evaporate to dryness, residue add water 10ml, make it dissolving, use chloroform extraction 3 times, each 20ml discards chloroform solution, and water layer is again with water saturation, n-butanol extraction 3 times, each 20ml merges n-butyl alcohol liquid, with n-butyl alcohol saturation water washing 2 times, and each 25ml, after the emulsifying, in 4000 rev/mins centrifugal, divide and to get n-butyl alcohol liquid, evaporate to dryness, residue add methanol 1ml makes dissolving, as test sample solution.Extracting liquorice control medicinal material 1g filters the filtrate evaporate to dryness in addition.Identification result meet the relevant every regulation of mixture project (appendix I of middle traditional Chinese medicines version in 2000, J)

Usage of the present invention and consumption:

An oral 100ml, 2 times on the one, warm taking medicine after meal.

Untoward reaction: the individual patient idol has drowsiness sense, disappears after the drug withdrawal.

Taboo and points for attention: 1. be not taken by pregnant women

2. this Chinese medicine allergy sufferers is avoided clothes

3. suffer from respiratory tract infection and woman month careful clothes in menstrual period

Senile pruritus, the traditional Chinese medical science think that the primary disease pathogeny is for getting old and weak weakness due to chronic disease, deficiency of qi and blood, ailment said due to cold or exposure is taken advantage of a weak point, and wind syndrome due to blood-deficiency, body skin lose foster and fall ill, or eating and drinking without temperance, surfeit is pungent processs bright, greasy, drinks, and impairing the spleen and stomach is given birth in damp and hot, change hot air wind producing, interior must not catharsis, must not reach thoroughly outward and strongly fragrantly fall ill, or because of depressed emotion in the skin space between skin and muscles, worried anxiety, zang-fu organs qi movement imbalance, five excessive emotions converting into internal fire, accumulate in the heat in blood, heat-transformation wind symptom and cause skin pruritus is so control with nourishing blood to expel wind antipruritic.Radix Angelicae Sinensis, the Radix Rehmanniae, the Radix Polygoni Multiflori skin moistening that nourishes blood in the side, Herba Schizonepetae, anti-wind energy dispelling wind for relieving itching, the Fructus Kochiae, favus skin, hops dispelling wind are antipruritic, ancients' cloud: " control wind and control blood earlier, the blood sector-style is from going out ".All medicines cooperate in the event side, play the antipruritic merit of nourishing blood to expel wind altogether.

Of the present invention clinical:

Senile pruritus patient 90 examples are made a definite diagnosis in selection, are divided into 2 groups at random, and going to a doctor according to the patient, (odd-numbered day was the treatment group in single, double day, be matched group even-numbered days), treatment group (of the present invention group) 48 examples, male 19 examples, woman's 29 examples, matched group (Chlorate group) 42 examples, male 15 examples, women 27 examples, 63～82 years old age, average 66.7 years old, the course of disease 5 months～17 years did not have significant difference (P＞0.05) at aspects such as sex, age, the courses of disease before two groups of case treatments and has comparability.

Diagnostic criteria: meet the diagnostic criteria of " clinical dermatology " pruritus, exclusion standard: the 1. pruritus that causes of viscera diseases such as complete, the internal tumor of diabetes, chronic hepatopathy, chronic nephropathy, kidney merit, autoimmune disease; 2. take immunosuppressant such as Radix Tripterygii Wilfordii in 4 weeks; 3. took the hydrocortisone hormone in 1 week; 4. medicine or food anaphylaxis history person are arranged.

Therapeutic Method:

Treatment group (of the present invention group) is made up of Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Rehmanniae, the Radix Polygoni Multiflori, Herba Schizonepetae, Radix Saposhnikoviae, the Fructus Kochiae, Cortex Dictamni, hops, the Radix Paeoniae Alba, Radix Glycyrrhizae, the 100ml/ bag, and 2 times on the one, each 100ml, oral, seven days is a course of treatment.

Matched group (Chlorate group) is produced by Tianjin Lisheng Pharmaceutical Co., Ltd., authentication code, and the accurate word H12020236 of traditional Chinese medicines, usage: every day 1 time, each 4mg, 7 days was 1 course of treatment, took before sleeping.During two groups of treatments, pungent stimulation foods such as fasting wine, seafood.

Criterion of therapeutical effect: recovery from illness: the skin pruritus symptom is all eliminated;

Produce effects: the degree of skin pruritus takes a turn for the better 75%～90%;

Effectively: the degree of skin pruritus takes a turn for the better 35%～75%;

Invalid: the degree of skin pruritus does not have obvious improvement.

Therapeutic outcome: specifically see table 1 for details

Table 1 liang group clinical efficacy relatively

Group	Example	Recovery from illness	Produce effects	Effectively	Invalid	Total effective rate (%)
Group	Example	Recovery from illness	Produce effects	Effectively	Invalid	Total effective rate (%)	The treatment group	??48	??21	??14	??10	??3	??93.3
Matched group	??42	??3	??8	??19	??12	??71.0	The treatment group	??48	??21	??14	??10	??3	??93.3

Annotate: compare (P＜0.01) with matched group

Last showing as seen: the total effective rate of treatment group (of the present invention group) treatment senile pruritus obviously is better than matched group, and significant difference is arranged.(P＜0.01)

Claims

1. Chinese medicine for the treatment of senile pruritus is characterized in that: make the raw materials of effective components weight portion and consist of:

Hops 12～25 Radix Paeoniae Albas 15～25 Radix Glycyrrhizaes 5～10

2. Chinese medicine for the treatment of senile pruritus is characterized in that: make raw materials of effective components optimum weight part and consist of:

Hops 20 Radix Paeoniae Albas 20 Radix Glycyrrhizaes 5