CN103041181B

CN103041181B - Umbilical compressed nursing cream for treating secondary bladder neck contracture

Info

Publication number: CN103041181B
Application number: CN201310027978.2A
Authority: CN
Inventors: 汪霞
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-01-25
Filing date: 2013-01-25
Publication date: 2014-04-02
Anticipated expiration: 2033-01-25
Also published as: CN103041181A

Abstract

The invention discloses an umbilical compressed nursing cream for treating secondary bladder neck contracture, which is used for solving the problem of treating secondary bladder neck contracture. The umbilical compressed nursing cream is characterized by being prepared from various Chinese medicinal herbs through processing, and the cream comprises the following raw materials in parts by weight: 10-20 parts of aspongopus, 8-15 parts of herbs of dense flower bulbophyllum, 8-15 parts of alyxia sinensis, 6-10 parts of Chinese usnea, 6-10 parts of golden buckwheat rhizomes, 8-15 parts of cuscuta chinensis, 6-10 parts of Chinese starjasmine stems, 8-15 parts of angelica and 3-6 parts of Japanese buttercup herbs. Clinical experiments prove that the umbilical compressed nursing cream for treating secondary bladder neck contracture disclosed by the invention has the characteristics of good curative effect and high safety, and is worthy of clinical application and promotion.

Description

A kind of deposited umbilicus nursing cream for the treatment of Secondary cases bladder neck contracture

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to treat the deposited umbilicus nursing cream of Secondary cases bladder neck contracture.

Background technology

Bladder neck contracture (bladder neck contracture, BNC) is that an important bladder neck blocks problem.So-called bladder neck means that internal urethral orifice, to the one section of tubular structure that extends approximately 1～2 centimeter of length in urethra, comprise internal sphincter, but internal sphincter is not the whole of bladder neck.BNC can have dividing of nature and nurture with regard to cause of disease, and congenital person is except local typical pathological change, normal without other clear and definite reasons, more with male; Posteriority person is often because local chronic inflammatory disease is as posterior urethritis, and due to prostatitis, trigonum inflammation etc., women's morbidity is low unlike male.

It is relevant with chronic inflammatory disease that the generation of BNC is thought more, and pathological manifestations cervical region tela submucosa smooth muscle is replaced by fibrous connective tissue, and neck of bladder loses color stiff and fixing, and eck stenosis is narrow.There is the performance of bladder neck obstruction, i.e. long dysuria.Pathology microscopy finds there are three kinds of situations, the one, and muscular tissue hypertrophy, the 2nd, connective tissue proliferation, the third situation is adenoid tissue hypertrophy.Clinical manifestation is frequent micturition, nocturia increases and the symptoms such as weak stream of urine, also some patient can cause because of chronic urinary retention urine bladder is full of and expands, urine is overflowed beyond control voluntarily because of hypertonia, medically this phenomenon is called to overflow incontinence.

Secondary cases bladder neck contracture and congenital contracture comparison, outside above-mentioned obvious inflammatory infiltration, the former connective tissue, adenoid tissue hypertrophy are more obvious, and local organization plumpness is solid, and rear urethra is narrow without reality.Except the mechanism effect of local organization plumpness, also may there is delayed ischemic neurological deficits, what is called is relaxed can not (Achalasia).

At present western medical treatment scheme mostly is symptomatic treatment, and expectant treatment is invalid takes urethral dilatation, or the loose tissue of per urethra mirror excision bladder neck, or operative treatment.Chinese medicine has reasonable effect, generally takes clearing heat and freeing strangury method to treat, and selects the medicines such as Rhizoma Smilacis Glabrae, Cortex Phellodendri, Herba Salviae Plebeiae, Herba Hedyotidis Diffusae, Herba Plantaginis, Pulvis Talci, Fructus Gardeniae, Herba Polygoni Avicularis, Herba Dianthi, Caulis Akebiae, Radix Et Rhizoma Rhei, Herba Lophatheri.But above-mentioned traditional Chinese medical therapeutic program is only to start with for this pathologic condition of chronic inflammatory disease, but can not make it restore for the hamartoplasia having occurred, the physics in resolver matter blocks, and causes treating unsuccessfully.

Summary of the invention

Technical assignment of the present invention is for above the deficiencies in the prior art, and the deposited umbilicus nursing cream of the sure treatment Secondary cases bladder neck contracture of a kind of curative effect is provided.

The technical scheme that the present invention solves its technical problem is: a kind of deposited umbilicus nursing cream for the treatment of Secondary cases bladder neck contracture, its composition of raw materials and weight proportion are: 10 ~ 20 parts of Aspongopuss, 8 ~ 15 parts of Herba Bulbophylli Odoratissims, 8 ~ 15 parts of Herba Alyxiae Sinensiss, 6 ~ 10 parts of Usneas, 6 ~ 10 parts of Rhizoma Fagopyri Dibotryis stem and leaf, 8 ~ 15 parts of Semen Cuscutae, 6 ~ 10 parts of Caulis Trachelospermis, 8 ~ 15 parts of Radix Angelicae Sinensis, 3 ~ 6 parts of Herba Ranunculi Japonicis.

Its optimum weight proportioning is: 15 parts of Aspongopuss, 10 parts of Herba Bulbophylli Odoratissims, 10 parts of Herba Alyxiae Sinensiss, 8 parts of Usneas, 8 parts of Rhizoma Fagopyri Dibotryis stem and leaf, 10 parts of Semen Cuscutae, 8 parts of Caulis Trachelospermis, 10 parts of Radix Angelicae Sinensis, 5 parts of Herba Ranunculi Japonicis.

Wherein said: Aspongopus is the dry body of Pentatomidae Insects Aspongopus Aspongopus chinensis Dallas.Nature and flavor are salty, temperature.Return liver,spleen,kidney warp.Merit can regulating QI to relieve pain, and warming middle-JIAO is supporing yang.

Herba Bulbophylli Odoratissim, for the orchid family Bulbophyllum platymiscium extremely fragrant Bulbophyllum Bulbophyllum odoratissimum (Swartz) Lindl., with all herbal medicine.Nature and flavor are sweet; Light; Cool.Return lung; Liver; Kidney channel.Merit can moistening the lung and resolving phlegm; Removing obstruction in the collateral to relieve pain.

Herba Alyxiae Sinensis is herb and the root of apocynaceae plant chain pearl rattan.Toil, flat.Enter lung, liver, spleen three warps.Merit can expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral.

Usnea is the thallus (thallus) of Usneaceae Usnea plant USNEA Usnea diffracta (female trailing plants, Herba Cucubali) Usnea diffracta Vain. or Usnea Longissima (Scolopendra Usnea, Herba Stellariae Alsines) U. longissima Ach..Nature and flavor are sweet, flat.Return lung; Liver; Kidney channel.Merit can heat-clearing and toxic substances removing, hemostasia and promoting granulation, and pain relieving, liver heat removing and eyesight improving, moves back nebula.

Rhizoma Fagopyri Dibotryis stem and leaf is the stem and leaf of polygonaceae plant Rhizoma Fagopyri Dibotryis Fagopyrum dibotrys (D.Don) Hara.Nature and flavor are bitter, pungent, cool in nature.Return lung, spleen, Liver Channel.Merit can heat-clearing and toxic substances removing, invigorating spleen to remove dampness, dispelling wind and removing obstruction in the collateral.

Semen Cuscutae is the dry mature seed of convolvulus cuscuta plant Cuscuta chinensis Lam..Nature and flavor are sweet, temperature.Return liver,kidney,spleen warp.Merit can nourishing the liver and kidney, and controlling nocturnal emission with astringent drugs reducing urination is antiabortive, improving eyesight, antidiarrheal.

Caulis Trachelospermi is the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem..Hardship, is slightly cold.GUIXIN, liver, kidney channel.Merit can dispelling wind and removing obstruction in the collateral, removing heat from blood detumescence.

Radix Angelicae Sinensis is the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor sweet, acrid, warm.Return liver, the heart, spleen channel.Merit can be enriched blood and be invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.

Herba Ranunculi Japonici, for Ranunculaceae ranunculus Herba Ranunculi Japonici Ranunculus japonicus Thunb., is used as medicine with whole herb with root.Pungent, micro-hardship, temperature.Poisonous.Merit can dampness removing, detumescence, pain relieving, nebula removing, preventing the attack (or recurrence) of malaria, parasite killing.

Composition principle: the generation of Secondary cases bladder neck contracture thinks relevant with chronic inflammatory disease more, but apart from outside above-mentioned obvious inflammatory infiltration, also more obvious with connective tissue, adenoid tissue hypertrophy, local organization plumpness is solid, and rear urethra is narrow without reality.Current Chinese medicine generally takes clearing heat and freeing strangury method to treat, and selects the medicines such as Rhizoma Smilacis Glabrae, Cortex Phellodendri, Herba Salviae Plebeiae, Herba Hedyotidis Diffusae, Herba Plantaginis, Pulvis Talci, Fructus Gardeniae, Herba Polygoni Avicularis, Herba Dianthi, Caulis Akebiae, Radix Et Rhizoma Rhei, Herba Lophatheri.But above-mentioned traditional Chinese medical therapeutic program is only to start with for this pathologic condition of chronic inflammatory disease, but can not make it restore for the hamartoplasia having occurred, the physics in resolver matter blocks, and causes treating unsuccessfully.

The present invention compared with the prior art, has following characteristics.

1, prescription is unique: in side, get Aspongopus, Herba Bulbophylli Odoratissim is monarch, described Aspongopus and one one cool cooperation of temperature of Herba Bulbophylli Odoratissim, for Secondary cases bladder neck contracture, can alleviate the pain of urinating by regulating qi and dredging collateral dissipating blood stasis, and then promotion is urinated; Be different from normally used " clearing heat and freeing strangury method ", because BNC is the narrow and then generation urination disorder causing due to contracture, the simple inflammatory that is not general urinary tract infection is main, Aspongopus warming middle-JIAO is supporing yang, help the walking of bladder activating QI, take and lead to as this, with positive power-assisted, and cell culture demonstration, 10mg/ml Aspongopus water extraction liquid can dwindle smooth muscle of bladder diameter of muscle fiber.

2, in side, get Herba Alyxiae Sinensis, Usnea is minister, Herba Alyxiae Sinensis expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral, can enter Liver Channel, Liver Channel network device, Herba Alyxiae Sinensis can specific alleviation irritation sign of bladder, helps and reduces the reflexive contracture of urinating and stimulating and causing; And inventor for many years Clinical and experimental study show, the spasm that Usnea can antagonism acetylcholine causes, has smooth muscle relaxation.

3, assistant helps deposited umbilicus nursing cream fewer but better, Rhizoma Fagopyri Dibotryis stem and leaf heat-clearing and toxic substances removing and dredging collateral; Semen Cuscutae nourishing the liver and kidney, solidifying gas under, anti-prolonged illness is impairment of the kidney; Caulis Trachelospermi enters Liver Channel, helps Herba Alyxiae Sinensis dredging collateral removing heat from blood; Chinese angelica blood supplementing promoting blood circulation and stopping pain.

4, get Herba Ranunculi Japonici, Herba Ranunculi Japonici nature and flavor are pungent, warm, pungent and wander away, and Wen Erqi is capable, draw in all medicines enter, and can strengthen the effect of Aspongopus.

5, the thing homogeneous medicine multiple-effect of getting it filled in side, contributes to reduce medicament categories and consumption, does not increase Liver and kidney burden after wound.

6, medicine material consumption of the present invention is groped in a large number to sum up through inventor and is drawn, each raw material consumption is for all to have good curative effect in following weight parts scope.

The specific embodiment

Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.

Embodiment 1, crude drug weight proportion: Aspongopus 10g, Herba Bulbophylli Odoratissim 8g, Herba Alyxiae Sinensis 8g, Usnea 6g, Rhizoma Fagopyri Dibotryis stem and leaf 6g, Semen Cuscutae 8g, Caulis Trachelospermi 6g, Radix Angelicae Sinensis 8g, Herba Ranunculi Japonici 3g.

Embodiment 2, crude drug weight proportion: Aspongopus 20g, Herba Bulbophylli Odoratissim 15g, Herba Alyxiae Sinensis 15g, Usnea 10g, Rhizoma Fagopyri Dibotryis stem and leaf 10g, Semen Cuscutae 15g, Caulis Trachelospermi 10g, Radix Angelicae Sinensis 15g, Herba Ranunculi Japonici 6g.

Embodiment 3, crude drug weight proportion: Aspongopus 15g, Herba Bulbophylli Odoratissim 10g, Herba Alyxiae Sinensis 10g, Usnea 8g, Rhizoma Fagopyri Dibotryis stem and leaf 8g, Semen Cuscutae 10g, Caulis Trachelospermi 8g, Radix Angelicae Sinensis 10g, Herba Ranunculi Japonici 5g.

During use, Chinese medicine Aspongopus of the present invention, Herba Bulbophylli Odoratissim, Herba Alyxiae Sinensis, Usnea, Rhizoma Fagopyri Dibotryis stem and leaf, Semen Cuscutae, Caulis Trachelospermi, Herba Ranunculi Japonici, Radix Angelicae Sinensis are decocted with water to twice, merging filtrate, heating is condensed into thick extractum

Effective combination of above-mentioned deposited umbilicus nursing cream, coordinates mutually, can effectively reach the object for the treatment of Secondary cases bladder neck contracture, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows, and wherein the use of the deposited umbilicus nursing of research cream is the crude drug weight proportion in embodiment 3.

1 object and method.

1.1 object.

1.1.1 inclusive criteria: be in January, 2008 ~ 2012 Secondary cases bladder neck contracture 40 examples in year August, patient all meets the diagnostic criteria of " Secondary cases bladder neck contracture ", and the equal nutriture of each case is good, and blood glucose, blood fat and hepatic and renal function are all in normal range.55～84 years old age, average 63.7 years old.Clinical manifestation is that frequent micturition, urine line attenuate, and even urine does not become the symptoms such as line, urine retention, urinary incontinence.Ultrasonic examination prompting wherein 37 routine patient's bladder residual urines increases; All patients all row freely urinate flow rate detection, Qmax (8.4 ± 4.2) ml/s, AFR (3.3 ± 1.7) ml/s, except 13 routine patients can not insert bladder piezometer tube, the analysis of the smooth row bladder pressure-flow rate of 27 routine patient is measured, prompting bladder outlet obstruction (BOO); Cystourethroscopy confirms that all patient's bladder necks organize scarring, hard, poor flexibility, and annular contracture is narrow, and posterior lip is obviously raised and is dykes and dams shape, and the rarely seen pin hole sample opening of severe patient bladder neck communicates with bladder.Patient IPSS scoring: (25.8 ± 3.5) minute.

1.2 method.

1.2.1 research method: the deposited umbilicus nursing cream that uses the crude drug weight proportion in embodiment 3 to make is treated, and treatment time is 4w.

1.2.2 safety evaluatio: all carry out the monitorings such as blood, urine, stool routine, liver, renal function, electrocardiogram before and after medication.

1.2.3 statistical analysis: carry out statistical analysis with SPSS 11.0, P< 0.05 indicates significant.

2 results.

2.1 curative effect situations: the symptoms such as 40Li patient main suit frequent micturition, dribbling, urine retention sense are obviously improved.Qmax (17.0 ± 4.1) ml/s, AFR (7.2 ± 1.3) ml/s, IPSS scoring: (6.4 ± 2.5) minute, through t check, more preoperative difference all has statistical significance (P < 0.05).

2.2 untoward reaction: patient's vital sign (blood pressure, heart rate, body temperature, breathing), physical examination, blood biochemical analysis, electrocardiogram and routine urinalysis Non Apparent Abnormality during treating.

3. conclusion.

The demonstration of this result of study, the present invention can effectively treat Secondary cases bladder neck contracture, can improve Secondary cases bladder neck contracture patient symptom.Clinical relevant lab testing (comprising electrocardiogram) and vital sign have no obvious change, and without obviously side reaction, clinic is selected.

Claims

1. a deposited umbilicus for the treatment of Secondary cases bladder neck contracture is nursed cream, it is characterized in that being processed by plurality of Chinese, its crude drug formula and weight proportion are: 10 ~ 20 parts of Aspongopuss, 8 ~ 15 parts of Herba Bulbophylli Odoratissims, 8 ~ 15 parts of Herba Alyxiae Sinensiss, 6 ~ 10 parts of Usneas, 6 ~ 10 parts of Rhizoma Fagopyri Dibotryis stem and leaf, 8 ~ 15 parts of Semen Cuscutae, 6 ~ 10 parts of Caulis Trachelospermis, 8 ~ 15 parts of Radix Angelicae Sinensis, 3 ~ 6 parts of Herba Ranunculi Japonicis.

2. a kind of deposited umbilicus nursing cream for the treatment of Secondary cases bladder neck contracture according to claim 1, is characterized in that its weight proportion is: 15 parts of Aspongopuss, 10 parts of Herba Bulbophylli Odoratissims, 10 parts of Herba Alyxiae Sinensiss, 8 parts of Usneas, 8 parts of Rhizoma Fagopyri Dibotryis stem and leaf, 10 parts of Semen Cuscutae, 8 parts of Caulis Trachelospermis, 10 parts of Radix Angelicae Sinensis, 5 parts of Herba Ranunculi Japonicis.