CN104667048B - A kind of Chinese medicine for treating puberty acne vulgaris - Google Patents

Abstract

A kind of Chinese medicine for treating puberty acne vulgaris, belongs to tcm field.The present invention be made active ingredient raw material composition be：Loguat leaf, the dried rhizome of rehmannia, dittany bark, the root bark of white mulberry, moutan bark, oldenlandia diffusa, Radix Salviae Miltiorrhizae, radix scrophulariae, radix scutellariae, the coptis, chrysanthemum, selfheal, SEMEN COICIS, smilax, cacumen biotae, tribulus terrestris, the root of Dahurain angelica, radix glycyrrhizae.The present invention is effective, reliable, uneasy to recur using Chinese medicine treatment puberty acne vulgaris, no obvious adverse reaction.

Description

A kind of Chinese medicine for treating puberty acne vulgaris

Technical field

The invention belongs to tcm field.

Background technology

Acne vulgaris is a kind of puberty common hair follicle, sebaceous glands chronic inflammation, takes place mostly in face, chest etc. Place, forms the infringement such as acne, papule, warts, tubercle, tumour.The incidence of puberty acne vulgaris is higher, it was reported that China Incidence is about 46.8% in 19 years old crowds.Such as not treatment in time, skin scars, pigmentation etc. can be produced, seriously affects trouble The mental health and appearance of person.Existing western medicine, although part is effectively, discovery has the shortcomings that side effect and easily recurrence.

The content of the invention

The purpose of the present invention is using theory of traditional Chinese medical science, with clearing heat and promoting diuresis, puberty acne vulgaris is treated in removing pattogenic heat from the blood and toxic material from the body Chinese medicine.

Raw material important part composition that active ingredient is made in the present invention is：

Loguat leaf 10-30, dried rhizome of rehmannia 10-30, dittany bark 10-35, root bark of white mulberry 10-35, moutan bark 10-35,

Oldenlandia diffusa 10-30, Radix Salviae Miltiorrhizae 10-30, radix scrophulariae 10-30, radix scutellariae 10-25, coptis 10-25, chrysanthemum 10-30,

Selfheal 10-25, SEMEN COICIS 10-25, smilax 10-30, cacumen biotae 10-30, tribulus terrestris 10-25, root of Dahurain angelica 10- 25th, radix glycyrrhizae 5-10.

The present invention is effective, reliable, uneasy to recur using Chinese medicine treatment puberty acne vulgaris, no obvious adverse reaction.

Embodiment

Raw material important part composition that active ingredient is made in the present invention is：

Loguat leaf 10-30, dried rhizome of rehmannia 10-30, dittany bark 10-35, root bark of white mulberry 10-35, moutan bark 10-35,

Oldenlandia diffusa 10-30, Radix Salviae Miltiorrhizae 10-30, radix scrophulariae 10-30, radix scutellariae 10-25, coptis 10-25, chrysanthemum 10-30,

Selfheal 10-25, SEMEN COICIS 10-25, smilax 10-30, cacumen biotae 10-30, tribulus terrestris 10-25, root of Dahurain angelica 10- 25th, radix glycyrrhizae 5-10.

Preparation method is：

By above Chinese medicine, add 8 times of amount water and soak 30 minutes, decoct it is secondary, every time 0.5 it is small when, filtration, is filtered merging Liquid, it is dense to 1000ml, add sodium benzoate 2g, to its dissolving, then refrigerate 12 it is small when, filtration, filtrate adds distilled water to be adjusted to 1000ml is stirred evenly, and is dispensed to obtain the final product.

Embodiment 1：

Raw material important part composition that active ingredient is made in the present invention is：

Loguat leaf 10, the dried rhizome of rehmannia 10, dittany bark 10, the root bark of white mulberry 10, moutan bark 10,

Oldenlandia diffusa 10, Radix Salviae Miltiorrhizae 10, radix scrophulariae 10, radix scutellariae 10, the coptis 10, chrysanthemum 10,

Selfheal 10, SEMEN COICIS 105, smilax 10, cacumen biotae 10, tribulus terrestris 10, the root of Dahurain angelica 10, radix glycyrrhizae 5；

Preparation method is same as above.

Embodiment 2：

Raw material important part composition that active ingredient is made in the present invention is：

Loguat leaf 15, the dried rhizome of rehmannia 15, dittany bark 22, the root bark of white mulberry 22, moutan bark 22,

Oldenlandia diffusa 20, Radix Salviae Miltiorrhizae 20, radix scrophulariae 20, radix scutellariae 17, the coptis 17, chrysanthemum 20,

Selfheal 17, SEMEN COICIS 17, smilax 20, cacumen biotae 20, tribulus terrestris 17, root of Dahurain angelica 10-25, radix glycyrrhizae 8；

Preparation method is same as above.

Embodiment 3：

Raw material important part composition that active ingredient is made in the present invention is：

Loguat leaf 30, the dried rhizome of rehmannia 30, dittany bark 35, the root bark of white mulberry 35, moutan bark 35,

Oldenlandia diffusa 30, Radix Salviae Miltiorrhizae 30, radix scrophulariae 30, radix scutellariae 25, the coptis 25, chrysanthemum 30,

Selfheal 25, SEMEN COICIS 25, smilax 30, cacumen biotae 30, tribulus terrestris 25, the root of Dahurain angelica 25, radix glycyrrhizae 10；

Preparation method is same as above.

Embodiment 4：

Raw material important part composition that active ingredient is made in the present invention is：Loguat leaf 20, the dried rhizome of rehmannia 20, dittany bark 20, moutan bark 20th, the root bark of white mulberry 15, oldenlandia diffusa 20, Radix Salviae Miltiorrhizae 20, radix scrophulariae 15, radix scutellariae 15, the coptis 15, chrysanthemum 15, selfheal 15, SEMEN COICIS 15th, smilax 15, cacumen biotae 15, tribulus terrestris 15, the root of Dahurain angelica 10, radix glycyrrhizae 5；

Preparation method is same as above.

Character：

This product is brown liquid, is had on a small quantity through shaking dispersible precipitation, the micro- fragrance of gas, bitter and puckery flavor.

Differentiate：

Take this product 20ml to add formic acid 80ml, stir evenly, stand 30 minutes, filtrate, is evaporated, and residue adds the dissolving of water 10ml, uses Chloroform recovery 3 times, each 20ml, discards chloroform solution, and water layer is extracted 3 times, each 20ml with water saturation, n-butanol, merged just again Butanol liquid, with n-butanol saturation water washing 2 times, each 25ml, after emulsification, the heart is separated in 4000 turn 1, point takes n-butanol liquid, is steamed Dry, residue adds methanol 1ml to make dissolving, and as test sample solution, another extracting liquorice control medicinal material 1g is filtered, and filtrate is evaporated.Identification result Meet every regulation related under mixture item.（Chinese Pharmacopoeia one annex 1, j of version in 2000）.

The suggested use and dosage of the present invention：

It is oral, a 100ml, 2 times a day, temperatureization one after each meal.

Adverse reaction：

Few patients occasionally have times of defecation to increase, but symptom disappears after drug withdrawal.

Taboo and note item：

1. this Chinese medicine allergy sufferers avoid clothes.2. careful clothes when catching a cold.3. feminine menstrual phase careful clothes.4. avoid Aqua Folium Camelliae sinensis and mung bean Soup.

This sick cause of disease, the interpretation of the cause, onset and process of an illness are that ferritic sun heat is contained partially, ying blood increasingly partial heat vigorous plus puberty life, outside blood-head Harmony, qi and blood stasis, accumulates resistance skin；Or the product of the pungent delicious food of overfeeding, cause lung stomach accumulated heat, follow through upper smoked, blood with through row, in face Portion.Therefore treatment is with clearing heat and promoting diuresis, based on removing pattogenic heat from the blood and toxic material from the body.Monarch drug in a prescription loguat leaf of the present invention, oldenlandia diffusa, with the heat of removing summer-heat lung stomach, Ministerial drug is the dried rhizome of rehmannia, Radix Salviae Miltiorrhizae, cacumen biotae, moutan bark, the root bark of white mulberry, radix scrophulariae, tribulus terrestris, the root of Dahurain angelica, radix scutellariae, has heat clearing and blood cooling, promoting blood circulation The work(for rash that change is become silted up, removing toxic substances disappears.Adjutant is selfheal, the root bark of shaggy-fruited dittany, smilax, Semen Coicis, chrysanthemum, the coptis have clearing heat and promoting diuresis, wind-dispelling Detumescence.Make medicine：Radix glycyrrhizae, has coordinating the drug actions of a prescription.In conclusion we have clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body, heat-clearing solution rash, clear rash Dissipating bind.Just go out from two, will not follow through it is upper criminal head, chest, butt skin and fall ill, so as to effectively treat puberty acne vulgaris Purpose.It should be noted that washing one's face portion through common warm water in clinical treatment, disabling finger extruding fash, few food or the pungent plumpness of fasting Product, it is eat fresh vegetables and fruit more, free movement of the bowels is kept, is conducive to the recovery of acne and prevents from recurring.

Observation of curative effect of the present invention：

Purpose：Observe a kind of Chinese Herbs for treating puberty acne vulgaris.Method：Using random packet, treatment group Group 32, takes Chinese medicine treatment.Control group 31, takes minocycline.Then two groups of patient affected part acne, papule, purulence are observed Blister, tubercle, the skin lesion quantity of tumour.As a result：Treatment group's total effective rate is（90.7%）, control group total effective rate is（74.2%）. Conclusion：Chinese medicine treatment puberty acne vulgaris is effectively, reliably, uneasy to recur, without obvious adverse reaction.And control group（West Medicine）Although part is easily recurred after effectively, finding edible maror, and has side effect.

First, clinical data：

1.1st, 63 patient ages 16-31 Sui of this group, 20.7 years old average, the course of disease is most 1.5 months short, most 9 years long, average 3.4 year.It is randomly divided into two groups, treatment group 32, male 17, female 15, age 15-28 Sui, the course of disease -7 years 2 months, control group Case male 16, female 15.Age 16-31 Sui, the course of disease -9 years 1.5 months.Two groups of patients are in gender, age, course of disease length Etc. compare, be comparable.

1.2nd, diagnostic criteria, debates chief editor's with reference to Zhao《Clinical dermatology》Standard, is specially：Face, forehead, cheek and There is conical papule consistent with hair follicle in nose cheek and chest and back.It can be divided again according to the state of an illness：1. acne vulgaris, 2. papular Cuo Sore, 3. acne pustulosa, 4. sclerancne, 5. cystic acne, 6. acne atrophica.The present invention is treated common with Chinese medicine Based on acne.

1.3rd, treatment method：

Treatment group is treated using traditional Chinese medicine for oral administration, prescription：It is loguat leaf 20g, dried rhizome of rehmannia 15g, dittany bark 15g, root bark of white mulberry 15g, male Root bark of tree peony 15g, oldenlandia diffusa 20g, Radix Salviae Miltiorrhizae 15g, radix scrophulariae 10g, radix scutellariae 10g, coptis 10g, chrysanthemum 15g, selfheal 15g, Semen Coicis Benevolence 15g, smilax 15, cacumen biotae 15, tribulus terrestris 15, the root of Dahurain angelica 10, radix glycyrrhizae 5g.One day one, decocting to 200ml, at twice meal After warmly take.15 days as a treatment course.Control group, which is thrown, takes Western medicine minocycline, and 50mg/2 times oral, 15 days as a treatment course.

1.4th, criterion of therapeutical effect：Recovery from illness, face, chest, back papule are wholly absent；Effectively：Face, chest, the big portion of pimpling of back institute Point or partial disappearance, stay a small amount of papule and pigmentation.It is invalid：Papule number and form increase without significant change, or on the contrary.

Statistical method, data are examined using X, and measurement data is examined using t.

2nd, treatment results：

Two groups of patient treatment outcomes are relatively shown in Table：

Group	n	Recovery from illness	Effectively	It is invalid	Total effective rate %
						Treatment group	32	15	14	3	90.7△
Control group	31	7	16	8	74.2△

Note：Treatment group △ p compared with the control group<0.05

3rd, discuss：

Acne vulgaris (acne vulgaris) is a kind of chronic inflammation disease of common hair follicle glandula integumentaria of puberty Disease, shows as acne, papule, warts, tubercle, tumour and scar, is apt to occur in the position of the rich adipose gland such as face, the back of the body, chest.From the traditional Chinese medical science Angle analysis, the etiology and pathogenesis of puberty acne vulgaris is due to that patient's ferritic sun heat is contained partially, vigorous plus puberty life, Ying blood increasingly partial heat, the outer harmony of blood-head, qi and blood stasis, accumulates resistance skin；Or the product of the pungent delicious food of overfeeding, cause lung stomach accumulated heat, follow through It is upper smoked, blood with through row, in face.This sick cause of disease, the interpretation of the cause, onset and process of an illness are that ferritic sun heat is contained partially, ying blood vigorous plus puberty life Increasingly partial heat, therefore treat with clearing heat and promoting diuresis, based on removing pattogenic heat from the blood and toxic material from the body.Monarch drug in a prescription loguat leaf of the present invention, oldenlandia diffusa, with removing summer-heat lung stomach Heat, ministerial drug for the dried rhizome of rehmannia, Radix Salviae Miltiorrhizae, cacumen biotae, moutan bark, the root bark of white mulberry, radix scrophulariae, tribulus terrestris, the root of Dahurain angelica, radix scutellariae, have activate blood circulation and disperse blood clots, Heat clearing and blood cooling, removing toxic substances disappear the work(of rash.Adjutant is selfheal, the root bark of shaggy-fruited dittany, Semen Coicis, chrysanthemum, smilax, the coptis have clearing heat and promoting diuresis, Wind-dispelling is subsided a swelling.Make medicine：Radix glycyrrhizae, has coordinating the drug actions of a prescription.In conclusion we have clearing heat and promoting diuresis, clearing heat and detoxicating, heat-clearing solution rash, Clear rash dissipating bind.Just go out from two, will not follow through it is upper criminal head, chest, butt skin and fall ill, it is ordinary so as to effectively treat puberty The purpose of property acne.It should be noted that washing one's face portion through common warm water, disabling finger extruding fash, few food or fasting are pungent in clinical treatment The product of plumpness, it is eat fresh vegetables and fruit more, free movement of the bowels is kept, is conducive to the recovery of acne and prevents from recurring.

Claims (1)

1. A kind of 1. Chinese medicine for treating puberty acne vulgaris, it is characterised in that：The parts by weight of raw materials composition of active ingredient is made For：

   Loguat leaf 10-30, dried rhizome of rehmannia 10-30, dittany bark 10-35, root bark of white mulberry 10-35, moutan bark 10-35,

   Oldenlandia diffusa 10-30, Radix Salviae Miltiorrhizae 10-30, radix scrophulariae 10-30, radix scutellariae 10-25, coptis 10-25, chrysanthemum 10-30,

   Selfheal 10-25, SEMEN COICIS 10-25, smilax 10-30, cacumen biotae 10-30, tribulus terrestris 10-25, root of Dahurain angelica 10-25,

   Radix glycyrrhizae 5-10.