CN105943512B - A kind of Exocarpium Citri Rubrum lozenge and preparation method thereof - Google Patents
A kind of Exocarpium Citri Rubrum lozenge and preparation method thereof Download PDFInfo
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- CN105943512B CN105943512B CN201610440128.9A CN201610440128A CN105943512B CN 105943512 B CN105943512 B CN 105943512B CN 201610440128 A CN201610440128 A CN 201610440128A CN 105943512 B CN105943512 B CN 105943512B
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention belongs to field of medicaments, and in particular to a kind of Exocarpium Citri Rubrum lozenge and preparation method thereof.Exocarpium Citri Rubrum lozenge is made of the raw material of following parts by weight: 15-20 parts of Exocarpium Citri Rubrum, 8-15 parts of Poria cocos, and 3-8 parts of rhizoma polygonati, 10-20 parts of fingered citron, 2-8 parts of semen ziziphi spinosae, 2-8 parts of Chinese olive, 1-5 parts of Radix Glycyrrhizae, 200-400 parts of excipient, 0.05-0.1 parts of sweetener.Preparation method includes the following steps: (1) taking Exocarpium Citri Rubrum, Poria cocos, rhizoma polygonati, fingered citron, semen ziziphi spinosae, Chinese olive, Radix Glycyrrhizae to add water to cook, filter, concentration obtains thick paste；(2) excipient is added to the water, is heated to being completely dissolved, add thick paste and sweetener made from step (1), mixed；Tanning is to moisture 7% hereinafter, cooling, tabletting is to get product.The formula of the invention is reasonable, significant in efficacy, without any side effects, simple production process, and production cost is low.
Description
[technical field]
The present invention relates to field of medicaments, and in particular to a kind of Exocarpium Citri Rubrum lozenge and preparation method thereof.
[background technique]
Exocarpium Citri Rubrum, alias are that rue skin, rue be red, river Exocarpium Citri Rubrum, be rutaceae orange Citrus reticulata Blanco and
The drying outside rind of its variety, warm-natured, acrid flavour, hardship, return lung, the spleen channel, cold dispelling eliminating dampness, regulating qi-flowing for eliminating phlegm, wide middle invigorating the spleen.It is main
Control cough due to wind-cold evil's abundant expectoration circulation of vital energy in the wrong direction, nausea and vomiting, chest institute swollen ruffian yin.
" medicine origin " " reason in the heart, lung qi " Compendium of Material Medica " lower gas dissolving phlegm " " book on Chinese herbal medicine converges " " can deliver " " Tan Ye except trembling with fear
Father-in-law test side " control " pained on the way " " plucking member side " " controlling wind phlegm numbness " " married woman's good recipe " " temper is unfavorable after managing property, urinary obstruction "
" book on Chinese herbal medicine meets original " " specially main lung cold cough is more for Exocarpium Citri Rubrum for Holy Benevolent Prescriptions " control acute mastitis, do not tie and dissipate, tied and burst, extremely unbearably painful person "
Phlegm, deficient side are mostly used it, and gas of so coughing long is let out, but it is non-preferably " " medical center bun is wanted " " and Exocarpium Citri Rubrum specially enters lung, and to deliver, go it is intradermal it
White, lighter empty floating also removes lung heresy ear ".
Exocarpium Citri Rubrum contains a variety of flavonoids such as aurantiamarin, neohesperidin, flavone compound (Flavonoids)
It is a kind of polyphenol compound distributed widely in nature, because of the diversity of structure, such compound has a variety of lifes
Object activity, such as anti-oxidant, lowering blood pressure and blood fat, anticancer etc., modern pharmacological studies have shown that aurantiamarin, which has, maintains osmotic pressure
The effects of, it can be used for the adjuvant treatment of disease of cardiovascular system.
Currently, having operative treatment, Microendoscopic radiofrequency ablation therapy and drug therapy for the treatment method of pharyngitis.Wherein
Operative treatment, Microendoscopic radiofrequency ablation therapy has good curative effect to early stage patient, but its treatment cost is expensive, is not easy by patient
Receive.Although the drug type in addition treating pharyngitis is many, mostly expensive and ineffective.Some therapeutic agents.With
Dose is big, but also can bring many side effects.Generate ill effect.
[summary of the invention]
Goal of the invention of the invention is: in view of the above problems, provide it is a kind of formula rationally, significant in efficacy, nothing
Any toxic side effect, simple production process, the low Exocarpium Citri Rubrum lozenge of production cost.
To achieve the goals above, The technical solution adopted by the invention is as follows:
A kind of Exocarpium Citri Rubrum lozenge, is made of the raw material of following parts by weight: 15-20 parts of Exocarpium Citri Rubrum, 8-15 parts of Poria cocos, rhizoma polygonati 3-8
Part, 10-20 parts of fingered citron, 2-8 parts of semen ziziphi spinosae, 2-8 parts of Chinese olive, 1-5 parts of Radix Glycyrrhizae, 200-400 parts of excipient, sweetener 0.05-0.1
Part.
Further, the excipient is selected from the mixture of one or both of white granulated sugar or glucose.
Further, the sweetener is selected from Sucralose or Aspartame.
Preferably, the Exocarpium Citri Rubrum lozenge, is made of the raw material of following parts by weight: 15 parts of Exocarpium Citri Rubrum, 8 parts of Poria cocos, rhizoma polygonati 3
Part, 10 parts of fingered citron, 2 parts of semen ziziphi spinosae, 2 parts of Chinese olive, 1 part of Radix Glycyrrhizae, 200 parts of excipient, 0.05 part of sweetener.
Preferably, the Exocarpium Citri Rubrum lozenge, is made of the raw material of following parts by weight: 20 parts of Exocarpium Citri Rubrum, 15 parts of Poria cocos, rhizoma polygonati 8
Part, 20 parts of fingered citron, 8 parts of semen ziziphi spinosae, 8 parts of Chinese olive, 5 parts of Radix Glycyrrhizae, 400 parts of excipient, 0.1 part of sweetener.
Preferably, the Exocarpium Citri Rubrum lozenge, is made of the raw material of following parts by weight: 18 parts of Exocarpium Citri Rubrum, 11 parts of Poria cocos, rhizoma polygonati 5
Part, 15 parts of fingered citron, 5 parts of semen ziziphi spinosae, 6 parts of Chinese olive, 3 parts of Radix Glycyrrhizae, 300 parts of excipient, 0.08 part of sweetener.
Exocarpium Citri Rubrum lozenge of the present invention, is made by following steps:
(1) it takes Exocarpium Citri Rubrum, Poria cocos, rhizoma polygonati, fingered citron, semen ziziphi spinosae, Chinese olive, Radix Glycyrrhizae to add water to cook, filters, concentration obtains thick paste；
(2) excipient is added to the water, is heated to being completely dissolved, add thick paste and sweetener made from step (1), mixed
It is even；Tanning is to moisture 7% hereinafter, cooling, tabletting is to get product.
Raw material effect used in the present invention is as follows:
Exocarpium Citri Rubrum, alias are that rue skin, rue be red, river Exocarpium Citri Rubrum, be rutaceae orange Citrus reticulata Blanco and
The drying outside rind of its variety, warm-natured, acrid flavour, hardship, return lung, the spleen channel, cold dispelling eliminating dampness, regulating qi-flowing for eliminating phlegm, wide middle invigorating the spleen.
Poria cocos is the dry sclerotia of polyporaceae fungus Poria cocos (Schw.) Wolf.It is sweet, light, it puts down.Return
The heart, lung, spleen, kidney channel.Clearing damp and promoting diuresis, invigorating the spleen, calming heart.
Rhizoma polygonati, this product are liliaceous plant polygonatum kingianurn Polygonatum kingianum Coll.et Hemsl., rhizoma polygonati
The dry rhizome of Polygonatum sibiricum Red. or polygonatum cyrtonema Polygonatum cyrtonema Hua.It is sweet,
It is flat.Returns spleen, lung, kidney channel.Boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing.
Fingered citron is the drying of rutaceae fingered citron Citrus medica L.var.sarcodactylis Swingle
Fruit.It is pungent, bitter, sour, temperature.Return liver, spleen, stomach, lung channel.Dispersing stagnated hepatoqi, protecting the stomach and relieve the pain is eliminating dampness and eliminating phlegm.
Semen ziziphi spinosae is rhamnaceae plant wild jujube Ziziphus jujuba Mill.var.spinosa (Bunge) Hu ex
The dry mature seed of H.F.Chou.It is sweet, sour, it puts down.Return liver, gallbladder, the heart channel of Hang-Shaoyin.Nourishing heart tonifying liver, antitoxic heart-soothing and sedative, arrest sweating act as expectorant.
Chinese olive, this product are the dry mature fruit of olive subject plant olive Canarium album Raeusch..It is sweet, sour,
It is flat.It attaches to the lung and stomach meridians.Clearing heat and detoxicating, relieving sore-throat is promoted the production of body fluid.
Radix Glycyrrhizae, this product are glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix
The dry root and rhizome of Glycyrrhiza inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L..Sweet and neutral.
Return heart, lung, spleen, stomach meridian.It invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.
In conclusion by adopting the above-described technical solution, the beneficial effects of the present invention are:
(1) inventive formulation is scientific and reasonable, Exocarpium Citri Rubrum cold dispelling eliminating dampness in prescription, invigorating the spleen in width；Poria cocos excreting dampness diuresis, stomach function regulating are strong
Spleen；Rhizoma polygonati not only tonifying spleen, can also boosting qi and nourishing yin, help Exocarpium Citri Rubrum and Poria cocos with strengthening the spleen and replenishing qi；Three medicines share, and replenish qi to invigorate the spleen, and dehumidify, altogether
For monarch drug in a prescription.Fingered citron is the medicine of spleen, lung two through gas point, is shared with Qi-tonifying drug rhizoma polygonati, is allowed to mend without stagnant, receives preferably treatment effect
Fruit；Semen ziziphi spinosae resolving sputum, Chinese olive promote the production of body fluid, and the two matches, and it is altogether adjutant that relieving sore-throat, which is promoted the production of body fluid,；Radix Glycyrrhizae QI invigorating is in, moistening lung to arrest cough, reconciles
All medicines are to make medicine.All medicine compatibilities, mending it, empty then temper is good for fortune, clean air must rise, and essence of water and grain is brought about the desired sensation with the defeated cloth of transporting；Its is wet then for benefit
Turbid yin must drop, and water-wet must be changed；The function of strengthening the spleen and reducing phlegm, secretion replenishing and throat moistening is played altogether.It is applicable in through clinic, treats pharyngitis significant effect.
(2) for inventive formulation without any incompatibility, used raw material all comes from health ministry dual-purpose of drug and food list
In raw material.It is at low cost, it is without any side effects.
(3) simple production process of the present invention is suitble to industrialized production.
[specific embodiment]
Embodiment 1:
Prescription: Exocarpium Citri Rubrum 15g, Poria cocos 8g, rhizoma polygonati 3g, fingered citron 10g, semen ziziphi spinosae 2g, Chinese olive 2g, Radix Glycyrrhizae 1g, glucose 200g,
Sucralose 0.05g.
Preparation method:
(1) Exocarpium Citri Rubrum, Poria cocos, rhizoma polygonati, fingered citron, semen ziziphi spinosae, Chinese olive, Radix Glycyrrhizae are taken, adds water 100ml every time, is decocted three times, every time
Decocting time is 2 hours, and filtration, merging filtrate, relative density 1.2, obtains thick paste when being concentrated into 70 DEG C；
(2) glucose is added in 50ml water, is heated to being completely dissolved, thick paste and trichlorine sugarcane made from step (1) is added
Sugar mixes；When tanning to moisture 7%, it is cooled to room temperature, tabletting, every slice weight 2.0g.
Above-mentioned Exocarpium Citri Rubrum lozenge measure of merit:
1. diagnostic criteria
Pharyngeal pain, it is dry uncomfortable, there are foreign body sensation, burning heat sensation, pharyngeal mucosa diffusivity is congested.
2. clinical data
200 are patient medical history.Male 102, female 98, the age 23-58 years old, average age was 36 years old, was met above-mentioned
Diagnostic criteria；200 through the barivm meal fluoroscopy (screem) of upper digestive tract x-ray or fibergastroscopy no abnormality seen.
3. treatment method
The product of the present embodiment is taken, mouth containing takes, one at a time, six times a day.
4. therapeutic effect determines
Recovery from illness: pharyngalgia, dry, scorching hot, foreign body sensation disappear, and pharyngeal mucosa is congested without obvious diffusivity；
Improve: pharyngalgia, dry, scorching hot, foreign body sensation is substantially reduced, diffusivity that pharyngeal mucosa is slight is congested；
Invalid: pharyngalgia, for dry, scorching hot, foreign body sensation without substantially reduced, pharyngeal mucosa is still in diffusivity hyperemia.
5. treatment results
Sum 200 improves 10 wherein curing 185, and invalid 5, total effective rate 97.5%.
It can be seen that the application of the present invention clinically has significant curative effect.
Embodiment 2:
Prescription: Exocarpium Citri Rubrum 20g, Poria cocos 15g, rhizoma polygonati 8g, fingered citron 20g, semen ziziphi spinosae 8g, Chinese olive 8g, Radix Glycyrrhizae 5g, white granulated sugar
400g, Aspartame 0.1g.
Preparation method:
(1) Exocarpium Citri Rubrum, Poria cocos, rhizoma polygonati, fingered citron, semen ziziphi spinosae, Chinese olive, Radix Glycyrrhizae are taken, adds water 100ml every time, is decocted three times, every time
Decocting time is 2 hours, and filtration, merging filtrate, relative density 1.3, obtains thick paste when being concentrated into 70 DEG C；
(2) white granulated sugar is added in 100ml water, is heated to being completely dissolved, thick paste and A Siba made from step (1) is added
Sweet tea mixes；When tanning to moisture 6%, it is cooled to room temperature, tabletting, every slice weight 2.0g.
Above-mentioned Exocarpium Citri Rubrum lozenge measure of merit:
1. diagnostic criteria
Pharyngeal pain, it is dry uncomfortable, there are foreign body sensation, burning heat sensation, pharyngeal mucosa diffusivity is congested.
2. clinical data
200 are patient medical history.Male 105, female 95, the age 22-56 years old, average age was 35 years old, was met above-mentioned
Diagnostic criteria；200 through the barivm meal fluoroscopy (screem) of upper digestive tract x-ray or fibergastroscopy no abnormality seen.
3. treatment method
The product of the present embodiment is taken, mouth containing takes, one at a time, six times a day.
4. therapeutic effect determines
Recovery from illness: pharyngalgia, dry, scorching hot, foreign body sensation disappear, and pharyngeal mucosa is congested without obvious diffusivity；
Improve: pharyngalgia, dry, scorching hot, foreign body sensation is substantially reduced, diffusivity that pharyngeal mucosa is slight is congested；
Invalid: pharyngalgia, for dry, scorching hot, foreign body sensation without substantially reduced, pharyngeal mucosa is still in diffusivity hyperemia.
5. treatment results
Sum 200 improves 11 wherein curing 183, and invalid 6, total effective rate 97.0%.
It can be seen that the application of the present invention clinically has significant curative effect.
Embodiment 3:
Prescription: Exocarpium Citri Rubrum 18g, Poria cocos 11g, rhizoma polygonati 5g, fingered citron 15g, semen ziziphi spinosae 5g, Chinese olive 6g, Radix Glycyrrhizae 3g, white granulated sugar
200g, glucose 100g, Aspartame 0.08g.
Preparation method:
(1) Exocarpium Citri Rubrum, Poria cocos, rhizoma polygonati, fingered citron, semen ziziphi spinosae, Chinese olive, Radix Glycyrrhizae are taken, adds water 100ml every time, is decocted three times, every time
Decocting time is 2 hours, and filtration, merging filtrate, relative density 1.4, obtains thick paste when being concentrated into 70 DEG C；
(2) white granulated sugar and glucose are added in 80ml water, are heated to being completely dissolved, thick paste made from step (1) is added
And Aspartame, it mixes；When tanning to moisture 6.5%, it is cooled to room temperature, tabletting, every slice weight 2.0g.
Above-mentioned Exocarpium Citri Rubrum lozenge measure of merit:
1. diagnostic criteria
Pharyngeal pain, it is dry uncomfortable, there are foreign body sensation, burning heat sensation, pharyngeal mucosa diffusivity is congested.
2. clinical data
200 are patient medical history.Male 100, female 100, the age 24-57 years old, average age was 37 years old, was met above-mentioned
Diagnostic criteria；200 through the barivm meal fluoroscopy (screem) of upper digestive tract x-ray or fibergastroscopy no abnormality seen.
3. treatment method
The product of the present embodiment is taken, mouth containing takes, one at a time, six times a day.
4. therapeutic effect determines
Recovery from illness: pharyngalgia, dry, scorching hot, foreign body sensation disappear, and pharyngeal mucosa is congested without obvious diffusivity；
Improve: pharyngalgia, dry, scorching hot, foreign body sensation is substantially reduced, diffusivity that pharyngeal mucosa is slight is congested；
Invalid: pharyngalgia, for dry, scorching hot, foreign body sensation without substantially reduced, pharyngeal mucosa is still in diffusivity hyperemia.
5. treatment results
Sum 200 improves 8 wherein curing 186, and invalid 6, total effective rate 97.0%.
It can be seen that the application of the present invention clinically has significant curative effect.
Above description is the detailed description for the present invention preferably possible embodiments, but embodiment is not limited to this hair
Bright patent claim, it is all the present invention suggested by technical spirit under completed same changes or modifications change, should all belong to
In the covered the scope of the patents of the present invention.
Claims (6)
1. a kind of Exocarpium Citri Rubrum lozenge, it is characterised in that be made of the raw material of following parts by weight: 15-20 parts of Exocarpium Citri Rubrum, 8-15 parts of Poria cocos,
3-8 parts of rhizoma polygonati, 10-20 parts of fingered citron, 2-8 parts of semen ziziphi spinosae, 2-8 parts of Chinese olive, 1-5 parts of Radix Glycyrrhizae, 200-400 parts of excipient, sweetener
0.05-0.1 parts；
The preparation method of the Exocarpium Citri Rubrum lozenge includes the following steps:
(1) it takes Exocarpium Citri Rubrum, Poria cocos, rhizoma polygonati, fingered citron, semen ziziphi spinosae, Chinese olive, Radix Glycyrrhizae to add water to cook, filters, concentration obtains thick paste；
(2) excipient is added to the water, is heated to being completely dissolved, add thick paste and sweetener made from step (1), mixed；
Tanning is to moisture 7% hereinafter, cooling, tabletting is to get product.
2. Exocarpium Citri Rubrum lozenge as described in claim 1, it is characterised in that the excipient is in white granulated sugar or glucose
One or two kinds of mixtures.
3. Exocarpium Citri Rubrum lozenge as described in claim 1, it is characterised in that the sweetener is selected from Sucralose or Aspartame.
4. the Exocarpium Citri Rubrum lozenge as described in any one of claim 1-3, it is characterised in that by the raw material system of following parts by weight
At: 15 parts of Exocarpium Citri Rubrum, 8 parts of Poria cocos, 3 parts of rhizoma polygonati, 10 parts of fingered citron, 2 parts of semen ziziphi spinosae, 2 parts of Chinese olive, 1 part of Radix Glycyrrhizae, 200 parts of excipient, sweet tea
0.05 part of taste agent.
5. the Exocarpium Citri Rubrum lozenge as described in any one of claim 1-3, it is characterised in that by the raw material system of following parts by weight
At: 20 parts of Exocarpium Citri Rubrum, 15 parts of Poria cocos, 8 parts of rhizoma polygonati, 20 parts of fingered citron, 8 parts of semen ziziphi spinosae, 8 parts of Chinese olive, 5 parts of Radix Glycyrrhizae, 400 parts of excipient,
0.1 part of sweetener.
6. the Exocarpium Citri Rubrum lozenge as described in any one of claim 1-3, it is characterised in that by the raw material system of following parts by weight
At: 18 parts of Exocarpium Citri Rubrum, 11 parts of Poria cocos, 5 parts of rhizoma polygonati, 15 parts of fingered citron, 5 parts of semen ziziphi spinosae, 6 parts of Chinese olive, 3 parts of Radix Glycyrrhizae, 300 parts of excipient,
0.08 part of sweetener.
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| CN114903109A (en) * | 2022-04-22 | 2022-08-16 | 深圳市新派古中医科技有限公司 | Pressure reducing composition, pressure reducing preparation containing same, and preparation method and application of pressure reducing composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899551A (en) * | 2006-07-13 | 2007-01-24 | 广东化州中药厂制药有限公司 | Sugar-free type red tangerine peel granular agent for treating productive cough |
| CN105343681A (en) * | 2015-12-13 | 2016-02-24 | 黑龙江江恒医药科技有限公司 | Cough-relieving exocarpium citri grandis capsules and preparation method thereof |
-
2016
- 2016-06-20 CN CN201610440128.9A patent/CN105943512B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899551A (en) * | 2006-07-13 | 2007-01-24 | 广东化州中药厂制药有限公司 | Sugar-free type red tangerine peel granular agent for treating productive cough |
| CN105343681A (en) * | 2015-12-13 | 2016-02-24 | 黑龙江江恒医药科技有限公司 | Cough-relieving exocarpium citri grandis capsules and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 橘红利咽汤治疗慢性咽炎186例;赵晨光等;《四川中医》;20021231;第20卷(第5期);第69页 |
| 橘红片制备工艺研究;程岚等;《时珍国医国药》;19991231;第10卷(第6期);第423-424页 |
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Application publication date: 20160921 Assignee: Yulin Baixian Native Chinese Herbal Medicine Co.,Ltd. Assignor: LUCHUAN COUNTY YINHU EXOCARPIUM CITRI PLANTING PROFESSIONAL COOPERATIVES Contract record no.: X2019450000017 Denomination of invention: Exocarpium citri rubrum lozenge and preparing method thereof Granted publication date: 20190315 License type: Common License Record date: 20190903 |
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Effective date of registration: 20231216 Address after: 525100 Building B on the south side (plot 14) of the first phase of the Yangmei Industrial Transfer Park in Huazhou City, Maoming City, Guangdong Province Patentee after: Dunkang Biotechnology Co.,Ltd. Address before: No. 54, Qinghutang Team, Qinghu Village, Qinghu Town, Luchuan County, Yulin City, Guangxi Zhuang Autonomous Region, 537700 Patentee before: LUCHUAN COUNTY YINHU EXOCARPIUM CITRI PLANTING PROFESSIONAL COOPERATIVES |
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