CN107362314A - A kind of Chinese olive lozenge and preparation method thereof - Google Patents
A kind of Chinese olive lozenge and preparation method thereof Download PDFInfo
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- CN107362314A CN107362314A CN201710643106.7A CN201710643106A CN107362314A CN 107362314 A CN107362314 A CN 107362314A CN 201710643106 A CN201710643106 A CN 201710643106A CN 107362314 A CN107362314 A CN 107362314A
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- lozenge
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- chinese olive
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention belongs to health care buccal tablets technical field, and in particular to a kind of Chinese olive lozenge and preparation method thereof.The Chinese olive lozenge, it is made up of following components ratio by weight：30~50 parts of Fructus Canarii extract, 30~50 parts of intelligence development extract, 200~400 parts of excipient, 5~10 parts of sweetener.Chinese olive lozenge prepared by the present invention has the carsick effect of concertedness treatment, and effect is good, convenient to take, has no side effect safely, is adapted to children to be taken with the elderly.
Description
【Technical field】
The present invention relates to health care buccal tablets technical field, and in particular to a kind of Chinese olive lozenge and preparation method thereof.
【Background technology】
Carsickness, English name motionsickness, also cry motion sickness, train sickness, pelagism, air-sickness, universe cinetosis
Disease, it is caused when being automobile, steamer or airplane motion any type of accelerated motion such as to jolt, wave or rotate, stimulate people
The vestibular nerve of body and the disease occurred.Patient feels epigastric discomfort at the beginning, after having nausea, pale complexion, cold sweat, soon has
Dizziness, mental depression, salivary secretion increase and vomitted, and severe patient can have drop in blood pressure, breathing deep and the disease such as slow, nystagmus
Shape.Symptom dozens of minutes or disappearance or mitigation in a few houres typically after out of service or deceleration, after repeatedly morbidity, symptom is anti-
And can mitigate, do not occur even.
Preventing that carsick the most frequently used method is exactly to take carsick medicine, carsick medicine in the market is mainly Western medicine tablet,
Its main component is the compound of Ben Hai Lamines and aminophylline, and such medicine has inhibitory action to cerebral cortex, can calm, town
Tell, but there is the side effect such as drowsiness, dizzy simultaneously.During children taking, the stimulation of medicine is possible to can be to developmental brain god
Through causing certain damage；And old friend, due to being getting in years, the metabolism of body is slow, various to be eaten up with illness, and takes
The stimulation of medicine afterwards is possible to cause some diseases aggravation, and present carsick medicine is mainly tablet form, children
Compare repulsion, difficult when taking, therefore, need a kind of safety of exploitation badly and have no side effect and carsick medicine convenient to take.
【The content of the invention】
In order to solve the above-mentioned technical problem, the present invention provides a kind of lozenge of carsickness-proof, and the lozenge uses herbal raw material,
Safety has no side effect, and convenient to take.
To achieve these goals, the technical solution adopted by the present invention is as follows：
A kind of Chinese olive lozenge, it is made up of following components ratio by weight：30~50 parts of Fructus Canarii extract, intelligence development extract
30~50 parts, 200~400 parts of excipient, 5~10 parts of sweetener.
Further, the Fructus Canarii extract is made in accordance with the following methods：Chinese olive is crushed, it is 70% to add volume fraction
Ethanol solution, 90 DEG C of refluxing extractions, filtering, take filtrate, reclaim ethanol, dry, produce Fructus Canarii extract.
Further, the intelligence development extract is made in accordance with the following methods：Intelligence development is crushed, it is 80% to add volume fraction
Ethanol solution mix, extract 20min at 20-30 DEG C of ultrasonic power 150W and temperature, filter, filtrate recycling ethanol, do
It is dry, produce intelligence development extract.
Further, described excipient is selected from the mixture of one or both of white granulated sugar or glucose.
Further, described sweetener is selected from Sucralose or Aspartame.
A kind of method for preparing Chinese olive lozenge of the present invention, comprises the following steps：
Excipient is added to the water, is heated to being completely dissolved, then adds Fructus Canarii extract, intelligence development extract by weight proportion
And sweetener, mix；Boil to moisture below 7%, cool down, tabletting, produce Chinese olive lozenge.
In summary, by adopting the above-described technical solution, the beneficial effects of the invention are as follows：
Contain Fructus Canarii extract and intelligence development extract in lozenge of the present invention, the total acid that Fructus Canarii extract contains extracts with intelligence development
The general flavone composition of thing acts synergistically, and greatly strengthen the effect of carsickness-proof, convenient to take, has no side effect safely, is adapted to
Children take with the elderly.
【Embodiment】
Embodiment 1
A kind of Chinese olive lozenge, it is made up of following components ratio by weight：50 parts of Fructus Canarii extract, intelligence development extract 30
Part, 400 parts of white granulated sugar, 5 parts of Aspartame.
Wherein Fructus Canarii extract is made in accordance with the following methods：Chinese olive is crushed, it is molten to add the ethanol that volume fraction is 70%
Liquid, 90 DEG C of refluxing extractions, filtering, filtrate is taken, reclaim ethanol, dried, produce Fructus Canarii extract；Intelligence development extract is according to lower section
Method is made：Intelligence development is crushed, the ethanol solution that volume fraction is 80% is added and mixes, in ultrasonic power 150W and temperature 20-
20min is extracted at 30 DEG C, is filtered, filtrate recycling ethanol, dries, produces intelligence development extract；
A kind of method for preparing Chinese olive lozenge described in the present embodiment, comprises the following steps：
White granulated sugar is added to the water, is heated to being completely dissolved, then adds Fructus Canarii extract, intelligence development extract by weight proportion
And Aspartame, mix；Boil to moisture below 7%, cool down, tabletting, every weight 0.5g.
Embodiment 2
A kind of Chinese olive lozenge, it is made up of following components ratio by weight：30 parts of Fructus Canarii extract, intelligence development extract 50
Part, 200 parts of glucose, 10 parts of Sucralose.
Wherein Fructus Canarii extract is made in accordance with the following methods：Chinese olive is crushed, it is molten to add the ethanol that volume fraction is 70%
Liquid, 90 DEG C of refluxing extractions, filtering, filtrate is taken, reclaim ethanol, dried, produce Fructus Canarii extract；Intelligence development extract is according to lower section
Method is made：Intelligence development is crushed, the ethanol solution that volume fraction is 80% is added and mixes, in ultrasonic power 150W and temperature 20-
20min is extracted at 30 DEG C, is filtered, filtrate recycling ethanol, dries, produces intelligence development extract；
A kind of method for preparing Chinese olive lozenge described in the present embodiment, comprises the following steps：
Glucose is added to the water, is heated to being completely dissolved, then adds Fructus Canarii extract, intelligence development extract by weight proportion
And Sucralose, mix；Boil to moisture below 7%, cool down, tabletting, every weight 0.5g.
Embodiment 3
A kind of Chinese olive lozenge, it is made up of following components ratio by weight：40 parts of Fructus Canarii extract, intelligence development extract 35
Part, 300 parts of white granulated sugar, 7 parts of Sucralose.
Wherein Fructus Canarii extract is made in accordance with the following methods：Chinese olive is crushed, it is molten to add the ethanol that volume fraction is 70%
Liquid, 90 DEG C of refluxing extractions, filtering, filtrate is taken, reclaim ethanol, dried, produce Fructus Canarii extract；Intelligence development extract is according to lower section
Method is made：Intelligence development is crushed, the ethanol solution that volume fraction is 80% is added and mixes, in ultrasonic power 150W and temperature 20-
20min is extracted at 30 DEG C, is filtered, filtrate recycling ethanol, dries, produces intelligence development extract；
A kind of method for preparing Chinese olive lozenge described in the present embodiment, comprises the following steps：
White granulated sugar is added to the water, is heated to being completely dissolved, then adds Fructus Canarii extract, intelligence development extract by weight proportion
And Sucralose, mix；Boil to moisture below 7%, cool down, tabletting, every weight 0.5g.
Comparative example 1
The Chinese olive lozenge of comparative example 1, is made up of by weight percentage following component：50 parts of Fructus Canarii extract, white granulated sugar
400 parts, 5 parts of Aspartame.Preparation method is the same as embodiment 1.
Comparative example 2
The Chinese olive lozenge of comparative example 1, is made up of by weight percentage following component：30 parts of intelligence development extract, white granulated sugar
400 parts, 5 parts of Aspartame.Preparation method is the same as embodiment 1.
The effect of test example Chinese olive lozenge of the present invention is to carsickness
1st, general information：
Selection by bus, by ship or feel dizzy during aircraft, have a stomach upset, Nausea and vomiting, body are felt bad or other are uncomfortable
Person, age 24-57 year, average age are 37 years old.
2nd, medicine：Embodiment 1~3, comparative example 1 and 2.
3rd, treatment method：
Trip by bus, before ship or aircraft 30-60 minutes take, each one, and set control group and carry out Contrast on effect, control
Group takes phenobarbital Scopolamine Hydrobromide Tablets.
4th, criterion of therapeutical effect：
It is effective：Using ridden in an automobile after the present invention, the sensation of aircraft, ship without any discomfort, all are as before；
Effectively：Carsick phenomenon mitigates or obvious mitigation；
It is invalid：Carsick phenomenon is without any improvement, using preceding with using rear indifference.
5th, result of the test
The effect of embodiment 1~3 of table 1, comparative example 1 and 2 pairs of carsickness
| Group | Effective (example) | Effectively (example) | Invalid (example) | Total effective rate |
| Embodiment 1 | 79 | 14 | 7 | 93.0% |
| Embodiment 2 | 87 | 8 | 5 | 95.0% |
| Embodiment 3 | 86 | 14 | 0 | 100.0% |
| Comparative example 1 | 24 | 8 | 68 | 32.0% |
| Comparative example 2 | 25 | 11 | 64 | 36.0% |
| Control group | 60 | 8 | 32 | 68.0% |
As it can be seen from table 1 the significant effect that 1~3 pair for the treatment of of embodiment is carsick, effective percentage reach more than 96.0%, said
The bright Fructus Canarii extract under certain proportion and intelligence development extract produce synergistic therapeutic action, during medication, find no any poison
Side effect, drug safety.
Described above is the detailed description for the present invention preferably possible embodiments, but embodiment is not limited to this hair
Bright patent claim, the equal change completed or modification change under the technical spirit suggested by all present invention, all should belong to
Cover the scope of the claims in the present invention.
Claims (6)
1. a kind of Chinese olive lozenge, it is characterised in that be made up of following components ratio by weight：30~50 parts of Fructus Canarii extract,
30~50 parts of intelligence development extract, 200~400 parts of excipient, 5~10 parts of sweetener.
2. Chinese olive lozenge as claimed in claim 1, it is characterised in that the Fructus Canarii extract is made in accordance with the following methods：Will
Chinese olive crushes, and adds the ethanol solution that volume fraction is 70%, 90 DEG C of refluxing extractions, filtering, takes filtrate, reclaim ethanol, dries,
Produce Fructus Canarii extract.
3. Chinese olive lozenge as claimed in claim 1, it is characterised in that the intelligence development extract is made in accordance with the following methods：Will
Intelligence development crushes, and adds the ethanol solution that volume fraction is 80% and mixes, is extracted at 20-30 DEG C of ultrasonic power 150W and temperature
20min, filtering, filtrate recycling ethanol, dry, produce intelligence development extract.
4. Chinese olive lozenge as claimed in claim 1, it is characterised in that described excipient is in white granulated sugar or glucose
One or two kinds of mixtures.
5. Chinese olive lozenge as claimed in claim 1, it is characterised in that described sweetener is selected from Sucralose or Aspartame.
A kind of 6. method for preparing any one of Claims 1 to 5 Chinese olive lozenge, it is characterised in that comprise the following steps：
Excipient is added to the water, is heated to being completely dissolved, then adds Fructus Canarii extract, intelligence development extract and sweet tea by weight proportion
Taste agent, mix；Boil to moisture below 7%, cool down, tabletting, produce Chinese olive lozenge.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710643106.7A CN107362314A (en) | 2017-07-31 | 2017-07-31 | A kind of Chinese olive lozenge and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710643106.7A CN107362314A (en) | 2017-07-31 | 2017-07-31 | A kind of Chinese olive lozenge and preparation method thereof |
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| CN107362314A true CN107362314A (en) | 2017-11-21 |
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| CN201710643106.7A Pending CN107362314A (en) | 2017-07-31 | 2017-07-31 | A kind of Chinese olive lozenge and preparation method thereof |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1306838A (en) * | 2000-02-01 | 2001-08-08 | 刘庭驹 | Car sickness preventing beverage |
| CN103798436A (en) * | 2014-02-27 | 2014-05-21 | 青岛崂好人海洋生物技术有限公司 | Carsickness relieving tea |
| CN103911270A (en) * | 2014-03-31 | 2014-07-09 | 李嘉 | Fruit vinegar capable of preventing carsickness and preparation method of fruit vinegar |
| CN104306945A (en) * | 2014-11-07 | 2015-01-28 | 福建省德化县祥意金蓝农业有限责任公司 | Herbal tea substitute and preparation method therefor |
| CN105582443A (en) * | 2016-03-10 | 2016-05-18 | 王沫学 | Traditional Chinese medicine for preventing and treating motion sickness |
| CN105943512A (en) * | 2016-06-20 | 2016-09-21 | 陆川县银湖橘红种植专业合作社 | Exocarpium citri rubrum lozenge and preparing method thereof |
-
2017
- 2017-07-31 CN CN201710643106.7A patent/CN107362314A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1306838A (en) * | 2000-02-01 | 2001-08-08 | 刘庭驹 | Car sickness preventing beverage |
| CN103798436A (en) * | 2014-02-27 | 2014-05-21 | 青岛崂好人海洋生物技术有限公司 | Carsickness relieving tea |
| CN103911270A (en) * | 2014-03-31 | 2014-07-09 | 李嘉 | Fruit vinegar capable of preventing carsickness and preparation method of fruit vinegar |
| CN104306945A (en) * | 2014-11-07 | 2015-01-28 | 福建省德化县祥意金蓝农业有限责任公司 | Herbal tea substitute and preparation method therefor |
| CN105582443A (en) * | 2016-03-10 | 2016-05-18 | 王沫学 | Traditional Chinese medicine for preventing and treating motion sickness |
| CN105943512A (en) * | 2016-06-20 | 2016-09-21 | 陆川县银湖橘红种植专业合作社 | Exocarpium citri rubrum lozenge and preparing method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 喜气DE羊羊: "吃摈榔可以预防晕车吗", 《TAG.120ASK.COM/JINGYAN/8LWV3LWVO0WVAO80YV.HTML》 * |
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Application publication date: 20171121 |