CN101455802A

CN101455802A - Oral medicine for treating acne

Info

Publication number: CN101455802A
Application number: CNA2008101592754A
Authority: CN
Inventors: 朱新华
Original assignee: Individual
Current assignee: Individual
Priority date: 2008-11-27
Filing date: 2008-11-27
Publication date: 2009-06-17
Anticipated expiration: 2028-11-27
Also published as: CN101455802B

Abstract

The invention provides an oral drug for treating acne. The oral drug is prepared from the following Chinese medicine materials: folia eriobotryae, root of rehmannia, moutan bark, radices sophorae flavescentis, rhizoma imperatae, radices scutellariae, rhizoma smilacis glabrae, hawkthorn, semen coicis, caladium, cortex mori radicis, rhizoma coptidis, radix paeoniae rubra, radix angelicae formosanae, selfheal, radices lithospermi, isatidis root, fructus forsythiae, matricaria indica, herba schizeneptae, oldenlandia diffusa, bunge corydalis herb and herba taching. The drug uses Chinese traditional herbal medicines as raw materials and is prepared through a scientific formulation and repeated validation of clinical test and meets the theory of traditional Chinese medicine; the drug has the advantages that the drug has no toxicity and side effect, can rapidly improve diseased symptoms of patients, has high cure rate and is uneasy to recur; therefore, the drug has good social benefits when being widely popularized.

Description

A kind of oral drugs for the treatment of acne

1, technical field

The present invention relates to a kind of Chinese medicine preparation, specifically a kind of oral drugs for the treatment of acne.

2, background technology

Acne is " comedo ", acne, whelk, skin sore again, is a kind of common hair follicle, the chronic inflammatory disease dermatoses of sebaceous gland, is more common in youth of both sexes.It mainly causes that by endocrine alteration the sebaceous gland function is vigorous, sebum secretion strengthens, the while abnormal cornification of pilosebaceous duct, the epithelial cell that follicular wall comes off mixes the obstruction follicular orifice with sebum, form acne, and infection such as secondary propionibacterium acnes, cause the formation of skin lesion such as struvite pimple, pus kitchen.The method that is used for the acne clinical treatment at present is more, mainly is to adopt medicine to smear antiinflammatory, germ-resistant method, and its therapeutic effect is all not really desirable, also causes patient's skin infection easily, so do not used widely by patient.

3, summary of the invention

The purpose of this invention is to provide the oral drugs that a kind of therapeutic effect is good, be free from side effects, have the treatment acne of bactericidal antiphlogistic, anti-acne granulation promoting beauty.

Technical problem to be solved by this invention provide a kind of simpler than prior art processing technology, curative effect is quick, cure rate is high, be difficult for the oral drugs of the treatment acne of recurrence.It is raw material that medicine of the present invention is to use the traditional Chinese herbal medicine of China, passes through the prescription of science, and formulated by verifying repeatedly of clinical trial, meets the theory of Chinese medicine.

The present invention is by wanting following materials of weight proportions to make:

Folium Eriobotryae 15-28 part, Radix Rehmanniae 12-25 part, Cortex Moutan 12-20 part, Radix Sophorae Flavescentis 8-15 part,

Rhizoma Imperatae 12-20 part, Radix Scutellariae 10-18 part, Rhizoma Smilacis Glabrae 18-30 part, Fructus Crataegi 20-32 part,

Semen Coicis 15-25 part, Bulbus Fritillariae Uninbracteatae 12-20 part, Cortex Mori 25-38 part, Rhizoma Coptidis 22-35 part,

Radix Paeoniae Rubra 20-32 part, Radix Angelicae Dahuricae 18-25 part, Spica Prunellae 18-25 part, Radix Arnebiae (Radix Lithospermi) 10-18 part,

Radix Isatidis 15-22 part, Fructus Forsythiae 15-28 part, Flos Chrysanthemi Indici 10-18 part, Herba Schizonepetae 12-18 part,

Herba Hedyotidis Diffusae 10-20 part, Herba Corydalis Bungeanae 15-22 part, Folium Isatidis 8-18 part;

Preparation process is as follows:

Take by weighing each herbal medicine pulverize separately by formula proportion and become fine powder, be processed into said tablet, powder, pill, granule or capsule in the pharmaceutics by traditional pharmaceutical technology.

The outstanding good effect of this medicine is to have no side effect, radical cure efficient height.Be mainly used in the acne of removing patient face, can effectively remove the intravital inflammation of people simultaneously, existing therapeutical effect has the effect of protection skin again, makes the patient be easy to accept.

The specific embodiment

Embodiment 1 prescription is as follows:

Folium Eriobotryae 15g, Radix Rehmanniae 12g, Cortex Moutan 12g, Radix Sophorae Flavescentis 8g, Rhizoma Imperatae 12g,

Radix Scutellariae 10g, Rhizoma Smilacis Glabrae 18g, Fructus Crataegi 20g, Semen Coicis 15g, Bulbus Fritillariae Uninbracteatae 12g,

Cortex Mori 25g, Rhizoma Coptidis 22g, Radix Paeoniae Rubra 20g, Radix Angelicae Dahuricae 18g, Spica Prunellae 18g,

Radix Arnebiae (Radix Lithospermi) 10g, Radix Isatidis 15g, Fructus Forsythiae 15g, Flos Chrysanthemi Indici 10g, Herba Schizonepetae 12g,

Herba Hedyotidis Diffusae 10g, Herba Corydalis Bungeanae 15g, Folium Isatidis 8g.

Embodiment 2 prescriptions are as follows:

Folium Eriobotryae 28g, Radix Rehmanniae 25g, Cortex Moutan 20g, Radix Sophorae Flavescentis 15g, Rhizoma Imperatae 20g,

Radix Scutellariae 18g, Rhizoma Smilacis Glabrae 30g, Fructus Crataegi 32g, Semen Coicis 25g, Bulbus Fritillariae Uninbracteatae 20g,

Cortex Mori 38g, Rhizoma Coptidis 35g, Radix Paeoniae Rubra 32g, Radix Angelicae Dahuricae 25g, Spica Prunellae 25g,

Radix Arnebiae (Radix Lithospermi) 18g, Radix Isatidis 22g, Fructus Forsythiae 28g, Flos Chrysanthemi Indici 18g, Herba Schizonepetae 18g,

Herba Hedyotidis Diffusae 20g, Herba Corydalis Bungeanae 22g, Folium Isatidis 18g;

Embodiment 3 prescriptions are as follows:

Folium Eriobotryae 18g, Radix Rehmanniae 15g, Cortex Moutan 15g, Radix Sophorae Flavescentis 10g, Rhizoma Imperatae 14g,

Radix Scutellariae 12g, Rhizoma Smilacis Glabrae 20g, Fructus Crataegi 25g, Semen Coicis 18g, Bulbus Fritillariae Uninbracteatae 14g,

Cortex Mori 30g, Rhizoma Coptidis 25g, Radix Paeoniae Rubra 25g, Radix Angelicae Dahuricae 20g, Spica Prunellae 20g,

Radix Arnebiae (Radix Lithospermi) 12g, Radix Isatidis 16g, Fructus Forsythiae 20g, Flos Chrysanthemi Indici 12g, Herba Schizonepetae 14g,

Herba Hedyotidis Diffusae 12g, Herba Corydalis Bungeanae 16g, Folium Isatidis 10g.

Embodiment 4 prescriptions are as follows:

Folium Eriobotryae 25g, Radix Rehmanniae 20g, Cortex Moutan 18g, Radix Sophorae Flavescentis 14g, Rhizoma Imperatae 18g,

Radix Scutellariae 15g, Rhizoma Smilacis Glabrae 25g, Fructus Crataegi 30g, Semen Coicis 22g, Bulbus Fritillariae Uninbracteatae 18g,

Cortex Mori 35g, Rhizoma Coptidis 32g, Radix Paeoniae Rubra 30g, Radix Angelicae Dahuricae 22g, Spica Prunellae 22g,

Radix Arnebiae (Radix Lithospermi) 16g, Radix Isatidis 20g, Fructus Forsythiae 25g, Flos Chrysanthemi Indici 15g, Herba Schizonepetae 16g,

Herba Hedyotidis Diffusae 18g, Herba Corydalis Bungeanae 20g, Folium Isatidis 15g.

Embodiment 5 prescriptions are as follows:

Folium Eriobotryae 22g, Radix Rehmanniae 18g, Cortex Moutan 16g, Radix Sophorae Flavescentis 12g, Rhizoma Imperatae 16g,

Radix Scutellariae 14g, Rhizoma Smilacis Glabrae 22g, Fructus Crataegi 28g, Semen Coicis 20g, Bulbus Fritillariae Uninbracteatae 16g,

Cortex Mori 32g, Rhizoma Coptidis 28g, Radix Paeoniae Rubra 28g, Radix Angelicae Dahuricae 21g, Spica Prunellae 21g,

Radix Arnebiae (Radix Lithospermi) 14g, Radix Isatidis 18g, Fructus Forsythiae 22g, Flos Chrysanthemi Indici 13g, Herba Schizonepetae 15g,

Herba Hedyotidis Diffusae 15g, Herba Corydalis Bungeanae 18g, Folium Isatidis 12g.

Embodiment 6 prescriptions are as follows:

Folium Eriobotryae 20g, Radix Rehmanniae 18g, Cortex Moutan 15g, Radix Sophorae Flavescentis 12g, Rhizoma Imperatae 15g,

Radix Scutellariae 15g, Rhizoma Smilacis Glabrae 25g, Fructus Crataegi 26g, Semen Coicis 20g, Bulbus Fritillariae Uninbracteatae 15g,

Cortex Mori 30g, Rhizoma Coptidis 30g, Radix Paeoniae Rubra 26g, Radix Angelicae Dahuricae 22g, Spica Prunellae 22g,

Radix Arnebiae (Radix Lithospermi) 15g, Radix Isatidis 18g, Fructus Forsythiae 22g, Flos Chrysanthemi Indici 15g, Herba Schizonepetae 14g,

Herba Hedyotidis Diffusae 15g, Herba Corydalis Bungeanae 18g, Folium Isatidis 14g.

Preparation process is as follows:

Take by weighing each herbal medicine pulverize separately by above-mentioned formula proportion and become fine powder, be processed into said tablet, powder, pill, granule or capsule in the pharmaceutics by traditional pharmaceutical technology, or make the said oral liquid of pharmaceutics by pharmaceutical technologies such as traditional coarse crushing, immersion, heating extraction.

MethodsThe cases enrolled: among the 100 routine patients through curing with this prescription, wherein male 57 examples, women 43 examples are the oldest 26 years old, minimum 14 years old, 18 years old mean age, the shortest two weeks of the course of disease, the longest 2 years.

Efficacy determination: adopt 4 grade standards

Recovery from illness clinical improvements rate 〉=95%

Produce effects clinical improvements rate＜95%,

Effective clinical improvements rate＜60%,

Invalid clinical improvements rate＜20%

The therapeutic effect statistics sees Table

This a kind of its treatment cure rate of oral drugs for the treatment of acne is 85%, and effectively cure rate is 94%.

The typical clinical case

Case 1: the king so-and-so, the man, 20 years old, mainly show as facial acne, the red pimple of rising, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, forehead, cheeks are work.Diagnosis acne vulgaris (II level).Take this medicine once a day, use this medicine one week back first meeting effect continuously, take three all backs pimples continuously and all disappear, acne subtract obviously few, fully recover around taking continuously.

Case 2, Lee, the woman, 15 years old, mainly show as facial red pimple, the pustule of rising, the course of disease four months, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, pustule, forehead, cheeks were once used external medication, DeGrain for work.Take this medicine once a day, take two all left and right sides symptoms and disappear substantially, the back state of an illness recovery from illness of three weeks.

Case 3, field, man 24 years old, ill 1 year, show as facial acne, red pimple, the pustule of rising, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, pustule, forehead, cheeks are work.Take this medicine and be careful in one's diet simultaneously, two weeks back first meeting effect, state of an illness recovery from illness in back grows a little acne around having taken after half a year, adds a week again, does not have recurrence again after the drug withdrawal.

Case 4, Yang, woman, 19 years old.Mainly show as and facial played acne, red pimple, pustule 6 months, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, pustule, forehead, cheeks are work.Take this medicine once a day, the back pustule disappearance of 1 week, pimple reduces; 3 all pimples all disappear, and are dispersed in a little acne.

Claims

1, a kind of oral drugs for the treatment of acne is characterized in that it being to be made by following materials of weight proportions:

Preparation process is as follows:

2, a kind of oral drugs for the treatment of acne according to claim 1 is characterized in that it being to be made by following weight proportion raw material:

Folium Eriobotryae 18-25 part, Radix Rehmanniae 15-20 part, Cortex Moutan 15-18 part, Radix Sophorae Flavescentis 10-14 part,

Rhizoma Imperatae 14-18 part, Radix Scutellariae 12-15 part, Rhizoma Smilacis Glabrae 20-25 part, Fructus Crataegi 25-30 part,

Semen Coicis 18-22 part, Bulbus Fritillariae Uninbracteatae 14-18 part, Cortex Mori 30-35 part, Rhizoma Coptidis 25-32 part,

Radix Paeoniae Rubra 25-30 part, Radix Angelicae Dahuricae 20-22 part, Spica Prunellae 20-22 part, Radix Arnebiae (Radix Lithospermi) 12-16 part,

Radix Isatidis 16-20 part, Fructus Forsythiae 20-25 part, Flos Chrysanthemi Indici 12-15 part, Herba Schizonepetae 14-16 part,

Herba Hedyotidis Diffusae 12-18 part, Herba Corydalis Bungeanae 16-20 part, Folium Isatidis 10-15 part.

3, a kind of oral drugs for the treatment of acne according to claim 1 is characterized in that it being to be made by following weight proportion raw material:

22 parts of Folium Eriobotryaes, 18 parts in the Radix Rehmanniae, 16 parts of Cortex Moutans, 12 parts of Radix Sophorae Flavescentiss,

16 parts of Rhizoma Imperataes, 14 parts of Radix Scutellariaes, 22 parts of Rhizoma Smilacis Glabraes, 28 parts of Fructus Crataegis,

20 parts of Semen Coiciss, 16 parts of Bulbus Fritillariae Uninbracteataes, 32 parts of Cortex Mori, 28 parts of Rhizoma Coptidis,

28 parts of Radix Paeoniae Rubras, 21 parts of the Radixs Angelicae Dahuricae, 21 parts of Spica Prunellaes, 14 parts of Radix Arnebiae (Radix Lithospermi)s,

18 parts of Radix Isatidis, 22 parts of Fructus Forsythiaes, 13 parts of Flos Chrysanthemi Indicis, 15 parts of Herba Schizonepetae,

15 parts of Herba Hedyotidis Diffusaes, 18 parts of Herba Corydalis Bungeanaes, 12 parts of Folium Isatidiss.