CN104661649A - 包含替格瑞洛的固态口服医药制剂 - Google Patents

包含替格瑞洛的固态口服医药制剂 Download PDF

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Publication number
CN104661649A
CN104661649A CN201380050404.5A CN201380050404A CN104661649A CN 104661649 A CN104661649 A CN 104661649A CN 201380050404 A CN201380050404 A CN 201380050404A CN 104661649 A CN104661649 A CN 104661649A
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CN
China
Prior art keywords
preparation according
hygroscopic
preparation
cellulose
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380050404.5A
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English (en)
Chinese (zh)
Inventor
格雷戈尔·塞德马克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zentiva KS
Original Assignee
Zentiva KS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva KS filed Critical Zentiva KS
Publication of CN104661649A publication Critical patent/CN104661649A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
CN201380050404.5A 2012-10-16 2013-10-15 包含替格瑞洛的固态口服医药制剂 Pending CN104661649A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZPV2012-705 2012-10-16
CZ2012-705A CZ2012705A3 (cs) 2012-10-16 2012-10-16 Pevná orální farmaceutická formulace obsahující ticagrelor
PCT/CZ2013/000130 WO2014059955A1 (en) 2012-10-16 2013-10-15 A solid oral pharmaceutical formulation containing ticagrelor

Publications (1)

Publication Number Publication Date
CN104661649A true CN104661649A (zh) 2015-05-27

Family

ID=49619770

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380050404.5A Pending CN104661649A (zh) 2012-10-16 2013-10-15 包含替格瑞洛的固态口服医药制剂

Country Status (13)

Country Link
EP (1) EP2908802A1 (cs)
JP (1) JP6301934B2 (cs)
KR (1) KR20150067153A (cs)
CN (1) CN104661649A (cs)
BR (1) BR112015008076A2 (cs)
CZ (1) CZ2012705A3 (cs)
EA (1) EA201590745A1 (cs)
HK (1) HK1205456A1 (cs)
IL (1) IL238036B (cs)
MX (1) MX2015003866A (cs)
UA (1) UA116784C2 (cs)
WO (1) WO2014059955A1 (cs)
ZA (1) ZA201501954B (cs)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105193759A (zh) * 2015-09-18 2015-12-30 乐普药业股份有限公司 一种替格瑞洛片及其制备方法
CN106667926A (zh) * 2015-11-09 2017-05-17 石药集团中奇制药技术（石家庄）有限公司 一种法匹拉韦片剂及其制备方法
CN107530288A (zh) * 2016-04-21 2018-01-02 阿斯利康(瑞典)有限公司 口腔崩解片

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160012706A (ko) * 2014-07-25 2016-02-03 동아에스티 주식회사 서방성 제제
CN106074357B (zh) * 2015-04-29 2021-07-02 江苏恒瑞医药股份有限公司 一种替格瑞洛或其可药用盐的制剂
TR201601835A2 (tr) * 2016-02-12 2017-08-21 Ali Raif Ilac Sanayi Ve Ticaret Anonim Sirketi Ti̇kagrelor i̇çeren formülasyonlar i̇çi̇n üreti̇m yöntemi̇
TR201617983A2 (tr) * 2016-12-07 2018-06-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Ti̇cagrelorun kati oral farmasöti̇k bi̇leşi̇mleri̇
KR102610876B1 (ko) * 2018-03-05 2023-12-06 주식회사 파마코스텍 티카그렐러 푸마르산 i형 결정 및 그 제조방법
EP3761965A1 (en) 2018-03-08 2021-01-13 Pharmaceutical Oriented Services Ltd Ticagrelor-containing tablet formulation
WO2020021110A1 (en) 2018-07-27 2020-01-30 Krka, D.D., Novo Mesto Pharmaceutical composition of ticagrelor
CN111450067A (zh) * 2019-01-18 2020-07-28 北京万全德众医药生物技术有限公司 一种替格瑞洛分散片及其制备方法
CN116370423A (zh) * 2023-02-28 2023-07-04 天津力生制药股份有限公司 一种替格瑞洛口腔崩解片及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1432018A (zh) * 2000-06-02 2003-07-23 阿斯特拉曾尼卡有限公司 三唑并[4,5－d]嘧啶化合物的新晶形和非晶形
WO2008024044A1 (en) * 2006-08-21 2008-02-28 Astrazeneca Ab Compositions, suitable for oral administration, comprising a triazolo [4, 5] pyrimidin derivate
CN101505754A (zh) * 2006-08-21 2009-08-12 阿斯利康(瑞典)有限公司 包括三唑并[4,5-d]嘧啶衍生物的适于口服给药的组合物
WO2011076749A2 (en) * 2009-12-23 2011-06-30 Ratiopharm Gmbh Solid pharmaceutical dosage form

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW530058B (en) 1997-07-22 2003-05-01 Astra Pharma Prod Triazolo [4,5-d]pyrimidine compounos and their use and process for preparation
JPH11199517A (ja) * 1997-10-31 1999-07-27 Meiji Seika Kaisha Ltd 口腔内速崩壊性錠剤
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
WO2007018057A1 (ja) * 2005-08-05 2007-02-15 Freund Corporation 口腔内速崩壊錠およびその製造法
EP2507242A1 (en) 2009-12-03 2012-10-10 AstraZeneca AB Co - crystals of a triazolo [4,5 - d]pyrimidine platelet aggregation inhibitor

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1432018A (zh) * 2000-06-02 2003-07-23 阿斯特拉曾尼卡有限公司 三唑并[4,5－d]嘧啶化合物的新晶形和非晶形
WO2008024044A1 (en) * 2006-08-21 2008-02-28 Astrazeneca Ab Compositions, suitable for oral administration, comprising a triazolo [4, 5] pyrimidin derivate
CN101505754A (zh) * 2006-08-21 2009-08-12 阿斯利康(瑞典)有限公司 包括三唑并[4,5-d]嘧啶衍生物的适于口服给药的组合物
WO2011076749A2 (en) * 2009-12-23 2011-06-30 Ratiopharm Gmbh Solid pharmaceutical dosage form
WO2011076749A3 (en) * 2009-12-23 2011-08-18 Ratiopharm Gmbh Solid pharmaceutical dosage form of ticagrelor

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105193759A (zh) * 2015-09-18 2015-12-30 乐普药业股份有限公司 一种替格瑞洛片及其制备方法
CN105193759B (zh) * 2015-09-18 2018-07-03 乐普药业股份有限公司 一种替格瑞洛片及其制备方法
CN106667926A (zh) * 2015-11-09 2017-05-17 石药集团中奇制药技术（石家庄）有限公司 一种法匹拉韦片剂及其制备方法
CN106667926B (zh) * 2015-11-09 2020-01-17 石药集团中奇制药技术（石家庄）有限公司 一种法匹拉韦片剂及其制备方法
CN107530288A (zh) * 2016-04-21 2018-01-02 阿斯利康(瑞典)有限公司 口腔崩解片
CN107530288B (zh) * 2016-04-21 2022-01-25 阿斯利康(瑞典)有限公司 口腔崩解片

Also Published As

Publication number Publication date
ZA201501954B (en) 2017-04-26
HK1205456A1 (en) 2015-12-18
WO2014059955A1 (en) 2014-04-24
JP2015533129A (ja) 2015-11-19
JP6301934B2 (ja) 2018-03-28
EP2908802A1 (en) 2015-08-26
IL238036B (en) 2019-05-30
BR112015008076A2 (pt) 2017-07-04
UA116784C2 (uk) 2018-05-10
KR20150067153A (ko) 2015-06-17
MX2015003866A (es) 2015-07-17
EA201590745A1 (ru) 2015-08-31
IL238036A0 (en) 2015-05-31
CZ2012705A3 (cs) 2014-04-23

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