CN104603147A - 六酯肽类似物作为抗癌化合物 - Google Patents

六酯肽类似物作为抗癌化合物 Download PDF

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Publication number
CN104603147A
CN104603147A CN201380036225.6A CN201380036225A CN104603147A CN 104603147 A CN104603147 A CN 104603147A CN 201380036225 A CN201380036225 A CN 201380036225A CN 104603147 A CN104603147 A CN 104603147A
Authority
CN
China
Prior art keywords
compound
cancer
formula
alkyl
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380036225.6A
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English (en)
Chinese (zh)
Inventor
普拉布·杜特·米什拉
斯瑞库马尔·桑卡兰纳拉亚南·依雅曼迪琪伊奥
萨吉·大卫·乔治
沙伦答腊·索纳韦恩
纳拉亚南·苏巴什·查克罗
阿伯吉特·罗伊乔杜里
拉吉夫·夏尔马
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Piramal Life Sciences Ltd
Original Assignee
Piramal Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Piramal Life Sciences Ltd filed Critical Piramal Life Sciences Ltd
Publication of CN104603147A publication Critical patent/CN104603147A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201380036225.6A 2012-05-07 2013-05-06 六酯肽类似物作为抗癌化合物 Pending CN104603147A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261643814P 2012-05-07 2012-05-07
US61/643,814 2012-05-07
PCT/IB2013/053613 WO2013168075A1 (en) 2012-05-07 2013-05-06 Hexadepsipeptide analogues as anticancer compounds

Publications (1)

Publication Number Publication Date
CN104603147A true CN104603147A (zh) 2015-05-06

Family

ID=49550252

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380036225.6A Pending CN104603147A (zh) 2012-05-07 2013-05-06 六酯肽类似物作为抗癌化合物

Country Status (15)

Country Link
US (2) US9475842B2 (enExample)
EP (1) EP2847212A4 (enExample)
JP (1) JP2015517485A (enExample)
KR (1) KR20150008173A (enExample)
CN (1) CN104603147A (enExample)
AR (1) AR090959A1 (enExample)
AU (1) AU2013257609A1 (enExample)
BR (1) BR112014027843A2 (enExample)
CA (1) CA2872813A1 (enExample)
IL (1) IL235600A0 (enExample)
IN (1) IN2014MN02433A (enExample)
MX (1) MX2014013498A (enExample)
NZ (1) NZ702684A (enExample)
RU (1) RU2014149097A (enExample)
WO (1) WO2013168075A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102389725B1 (ko) * 2020-02-14 2022-04-25 서울대학교산학협력단 피페라진산을 함유하는 사이클릭 펩티드 화합물, 이의 생산 방법, 및 이의 용도
WO2022178403A1 (en) * 2021-02-22 2022-08-25 Lodo Therapeutics Corporation Hexadepsipeptide compounds and methods of using the same
WO2023081764A1 (en) * 2021-11-05 2023-05-11 Zymergen Inc. Hexadepsipeptide compounds and methods of using the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0792886A1 (en) * 1994-10-25 1997-09-03 Sekisui Chemical Co., Ltd. Novel peptide and therapeutic agent
US8076287B2 (en) * 2006-03-29 2011-12-13 Thallion Pharmaceuticals Inc. Cyclic hexadepsipeptides, processes for their production and their use as pharmaceuticals

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3148851B2 (ja) * 1994-10-25 2001-03-26 積水化学工業株式会社 新規抗腫瘍剤
JPH11269090A (ja) * 1998-03-24 1999-10-05 Sekisui Chem Co Ltd 医療材料

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0792886A1 (en) * 1994-10-25 1997-09-03 Sekisui Chemical Co., Ltd. Novel peptide and therapeutic agent
US8076287B2 (en) * 2006-03-29 2011-12-13 Thallion Pharmaceuticals Inc. Cyclic hexadepsipeptides, processes for their production and their use as pharmaceuticals

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
IHOR E. KOPKA ET AL: "SELECTIVE SEMISYNTHETIC MODIFICATION OF L156-602, A NOVEL CYCLIC HEXADEPSIPEPTIDE ANTIBIOTIC", 《TETMHEDRON LETTERS》 *
P.GRIGORIEV ET AL: "Formation of membrane pores by aurantimycins A and B,new lipopeptide antibiotics from Streptomyces aurantiacus", 《BIOELECTROCHEMISTRY AND BIOENERGETICS》 *
UENO,M. ET AL: "IC101,Extracellular Matrix Antagonist produced by Streptomyces sp. MJ202-72F3 Production,isolation,structure determination,and biological activity.", 《THE JOURNAL OF ANTIBIOTICS》 *

Also Published As

Publication number Publication date
JP2015517485A (ja) 2015-06-22
NZ702684A (en) 2016-08-26
MX2014013498A (es) 2015-11-13
CA2872813A1 (en) 2013-11-14
WO2013168075A1 (en) 2013-11-14
IN2014MN02433A (enExample) 2015-08-21
BR112014027843A2 (pt) 2017-06-27
US20150080312A1 (en) 2015-03-19
IL235600A0 (en) 2015-01-29
AR090959A1 (es) 2014-12-17
AU2013257609A1 (en) 2014-12-18
RU2014149097A (ru) 2016-06-27
EP2847212A1 (en) 2015-03-18
US20160354430A1 (en) 2016-12-08
EP2847212A4 (en) 2015-12-30
KR20150008173A (ko) 2015-01-21
US9475842B2 (en) 2016-10-25

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Application publication date: 20150506

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