CN104603124B - 用作布鲁顿酪氨酸激酶(btk)抑制剂的杂芳族化合物 - Google Patents

用作布鲁顿酪氨酸激酶(btk)抑制剂的杂芳族化合物 Download PDF

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CN104603124B
CN104603124B CN201380041869.4A CN201380041869A CN104603124B CN 104603124 B CN104603124 B CN 104603124B CN 201380041869 A CN201380041869 A CN 201380041869A CN 104603124 B CN104603124 B CN 104603124B
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mmol
compound
mixture
pharmaceutically acceptable
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CN104603124A (zh
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J·M·本茨恩
A·K·贝里
T·博萨纳克
M·J·伯克
D·T·蒂萨尔沃
J·C·霍兰
梁爽
毛灿
毛望
沈悦
F·索利曼扎德
R·M·津德尔
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Boehringer Ingelheim International GmbH
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  • Dermatology (AREA)
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  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
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CN201380041869.4A 2012-08-10 2013-08-08 用作布鲁顿酪氨酸激酶(btk)抑制剂的杂芳族化合物 Expired - Fee Related CN104603124B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261681684P 2012-08-10 2012-08-10
US61/681,684 2012-08-10
PCT/US2013/054096 WO2014025976A1 (en) 2012-08-10 2013-08-08 Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors

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CN104603124A CN104603124A (zh) 2015-05-06
CN104603124B true CN104603124B (zh) 2018-04-17

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WO2014068527A1 (en) * 2012-11-02 2014-05-08 Pfizer Inc. Bruton's tyrosine kinase inhibitors
CN103848810A (zh) * 2012-11-30 2014-06-11 北京赛林泰医药技术有限公司 鲁顿酪氨酸激酶抑制剂
EP2970163B1 (en) * 2013-03-14 2018-02-28 Boehringer Ingelheim International GmbH 5-thiazolecarboxamide dervatives and their use as btk inhibitors
EP2970300B1 (en) 2013-03-15 2018-05-16 Boehringer Ingelheim International GmbH Heteroaromatic compounds as btk inhibitors
KR102311329B1 (ko) * 2013-03-15 2021-10-14 얀센 파마슈티카 엔.브이. 약제를 제조하기 위한 방법 및 중간체
WO2015048662A2 (en) * 2013-09-30 2015-04-02 X-Rx Discovery, Inc. Substituted nicotinimide inhibitors of btk and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
US9512084B2 (en) 2013-11-29 2016-12-06 Novartis Ag Amino pyrimidine derivatives
EP3099674B1 (en) * 2014-01-29 2018-10-24 Boehringer Ingelheim International Gmbh Pyrazole compounds as btk inhibitors
WO2015185998A2 (en) * 2014-04-11 2015-12-10 Acerta Pharma B.V. Methods of blocking the cxcr-4/sdf-1 signaling pathway with inhibitors of bone marrow x kinase
CN105085474B (zh) * 2014-05-07 2018-05-18 北京赛林泰医药技术有限公司 鲁顿酪氨酸激酶抑制剂
CN105884747B (zh) * 2014-08-28 2021-01-05 首药控股(北京)有限公司 一种制备布鲁顿酪氨酸激酶(btk)激酶抑制剂的制备方法
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