CN104529883A - 可用作抗菌剂的氟吡啶酮衍生物 - Google Patents

可用作抗菌剂的氟吡啶酮衍生物 Download PDF

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Publication number
CN104529883A
CN104529883A CN201410611970.5A CN201410611970A CN104529883A CN 104529883 A CN104529883 A CN 104529883A CN 201410611970 A CN201410611970 A CN 201410611970A CN 104529883 A CN104529883 A CN 104529883A
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CN
China
Prior art keywords
fluoro
methyl
methylsulfonyl
butanamide
phenyl
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Pending
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CN201410611970.5A
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English (en)
Chinese (zh)
Inventor
M·F·布朗
车晔
M·J·梅尔尼克
J·I·蒙哥马利
M·S·普卢默
L·M·普赖斯
U·赖利
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SmithKline Beecham Ltd
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SmithKline Beecham Ltd
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Publication of CN104529883A publication Critical patent/CN104529883A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201410611970.5A 2011-03-07 2012-02-22 可用作抗菌剂的氟吡啶酮衍生物 Pending CN104529883A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161449825P 2011-03-07 2011-03-07
US61/449,825 2011-03-07

Related Parent Applications (1)

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CN201280012230.9A Division CN103443079B (zh) 2011-03-07 2012-02-22 可用作抗菌剂的氟吡啶酮衍生物

Publications (1)

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CN104529883A true CN104529883A (zh) 2015-04-22

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CN201280012230.9A Active CN103443079B (zh) 2011-03-07 2012-02-22 可用作抗菌剂的氟吡啶酮衍生物

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US (2) US8624034B2 (https=)
EP (1) EP2683689B1 (https=)
JP (1) JP5620020B2 (https=)
KR (1) KR101593288B1 (https=)
CN (2) CN104529883A (https=)
AP (1) AP3336A (https=)
AR (1) AR085615A1 (https=)
AU (1) AU2012226473B8 (https=)
BR (1) BR112013022536B1 (https=)
CA (1) CA2828337C (https=)
CL (1) CL2013002417A1 (https=)
CO (1) CO6761338A2 (https=)
CR (1) CR20130403A (https=)
CU (1) CU20130117A7 (https=)
DO (1) DOP2013000200A (https=)
EA (1) EA024782B1 (https=)
EC (1) ECSP13012928A (https=)
ES (1) ES2626457T3 (https=)
GE (1) GEP20156370B (https=)
GT (1) GT201300213A (https=)
HK (1) HK1209734A1 (https=)
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MA (1) MA34963B1 (https=)
MX (1) MX341977B (https=)
NI (1) NI201300077A (https=)
PE (1) PE20140397A1 (https=)
PH (1) PH12013501780A1 (https=)
SG (1) SG192766A1 (https=)
TN (1) TN2013000353A1 (https=)
TW (1) TWI453197B (https=)
UA (1) UA107423C2 (https=)
UY (1) UY33936A (https=)
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ZA (1) ZA201306515B (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110699312A (zh) * 2019-11-28 2020-01-17 西北农林科技大学 一种猪种布鲁氏菌bi-1基因缺失菌株及其构建方法和应用
CN110699312B (zh) * 2019-11-28 2022-08-12 西北农林科技大学 一种猪种布鲁氏菌bi-1基因缺失菌株及其构建方法和应用

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UY33936A (es) 2012-10-31
JP5620020B2 (ja) 2014-11-05
NI201300077A (es) 2014-01-07
CO6761338A2 (es) 2013-09-30
IL228100A0 (en) 2013-09-30
UA107423C2 (en) 2014-12-25
US20140057919A1 (en) 2014-02-27
US8779148B2 (en) 2014-07-15
ES2626457T3 (es) 2017-07-25
AU2012226473B2 (en) 2015-06-11
WO2012120397A1 (en) 2012-09-13
MX341977B (es) 2016-09-07
AU2012226473A1 (en) 2013-09-05
NZ614205A (en) 2014-06-27
BR112013022536B1 (pt) 2020-05-26
AU2012226473B8 (en) 2015-10-15
HK1209734A1 (en) 2016-04-08
MA34963B1 (fr) 2014-03-01
CU20130117A7 (es) 2013-10-29
GEP20156370B (en) 2015-09-25
CR20130403A (es) 2013-09-18
EP2683689A1 (en) 2014-01-15
CL2013002417A1 (es) 2013-12-13
AP2013007074A0 (en) 2013-08-31
US20120232083A1 (en) 2012-09-13
CN103443079B (zh) 2015-06-03
KR20130131459A (ko) 2013-12-03
TWI453197B (zh) 2014-09-21
US8624034B2 (en) 2014-01-07
CA2828337A1 (en) 2012-09-13
BR112013022536A2 (pt) 2016-11-29
JP2014507464A (ja) 2014-03-27
EA024782B1 (ru) 2016-10-31
PH12013501780A1 (en) 2019-07-03
ECSP13012928A (es) 2013-11-29
DOP2013000200A (es) 2014-06-15
TW201249798A (en) 2012-12-16
AP3336A (en) 2015-07-31
HK1191951A1 (en) 2014-08-08
PE20140397A1 (es) 2014-03-28
EA201391072A1 (ru) 2014-02-28
MX2013010276A (es) 2013-10-01
ZA201306515B (en) 2014-05-28
EP2683689B1 (en) 2017-04-12
CN103443079A (zh) 2013-12-11
GT201300213A (es) 2014-06-06
CA2828337C (en) 2016-05-03
KR101593288B1 (ko) 2016-02-11
SG192766A1 (en) 2013-09-30
TN2013000353A1 (fr) 2015-01-20
AR085615A1 (es) 2013-10-16

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