CN104524093B - Treat the Chinese herbal medicine perfusate of cow endometritis - Google Patents
Treat the Chinese herbal medicine perfusate of cow endometritis Download PDFInfo
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Abstract
A kind of Chinese herbal medicine perfusate for treating cow endometritis, it is made up of the bulk drug of following weight parts：7 parts of motherwort 5 part, 6 parts of cordate houttuynia 4 part, 4 parts of field pennycress 2 part, 4 parts of frutus cnidii 2 part, 4 parts of kuh-seng 2 part, 4 parts of Sargent gloryvine 2 part, play both sides of the street 2 parts 4 parts, 3 parts of the root of bidentate achyranthes 1 part, 3 parts of hypericum japonicum 1 part, 2 parts of rhizoma cyperi 1 part, 2 parts of cattail pollen 1 part, 2 parts of radix glycyrrhizae 1 part.The Chinese herbal medicine perfusate of this treatment cow endometritis, for treating cow endometritis, short treating period, cost are low, cure rate is high, safe and free of toxic and side effects, easy to use.
Description
Technical field
The present invention relates to the Chinese herbal medicine of milk cattle cultivating, and in particular to a kind of Chinese herbal medicine for treating cow endometritis fills
Fluid injection.
Background technology
Cow endometritis is the common disease in cow reproductive system, and the incidence of disease is up to 20%-40%, seriously shadow
The reproductive capacity and production performance of milk cow are rung, causes the economic benefit of milk cow production to reduce, hinders the sound development of dairy.Milk
Bovine endometritis causes milk cow infertile, increases tire spacing, reduces the yield of milk, and huge economic damage is caused to milk cow production
Lose.The pathogen of cow endometritis kind up to more than 80, mainly there is bacterium, Mycoplasma, fungi and virus, bacterium mainly with
Based on staphylococcus and streptococcus.At present, treat cow endometritis using it is more be Antibiotics Western medicine, although having
The effect of certain, but shortcoming is that the resistance to the action of a drug and side effect are more serious, and chemicals residue is had in meat and milk, to the mankind
Health care belt carrys out potential threat.Chinese herbal medicine have it is natural, have no toxic side effect, without chemicals residue, be not likely to produce the spies such as the resistance to the action of a drug
Point.Prior art discloses the Chinese herbal medicine for the treatment of cow endometritis, but its weak curative effect, and cure rate is low, course for the treatment of length and cost
It is high.
The content of the invention
It is an object of the invention in view of the above-mentioned problems, provide it is a kind of it is easy to use, cost is low, can effectively treat milk cow
The Chinese herbal medicine perfusate of endometritis.
The technical scheme is that：A kind of Chinese herbal medicine perfusate for treating cow endometritis, it is by following heavy
The bulk drug of amount part is made：5 parts -7 parts of motherwort, 4 parts -6 parts of cordate houttuynia, 2 parts -4 parts of field pennycress, 2 parts -4 parts of frutus cnidii, kuh-seng
2 parts -4 parts, 2 parts -4 parts of Sargent gloryvine, play both sides of the street 2 parts -4 parts, 1 part -3 parts of the root of bidentate achyranthes, 1 part -3 parts of hypericum japonicum, 1 part -2 parts of rhizoma cyperi, cattail pollen 1
- 2 parts of part, 1 part -2 parts of radix glycyrrhizae.
The preferred feedstock medicine parts by weight of the Chinese herbal medicine perfusate of cost treatment cow endometritis processed are：7 parts of motherwort,
6 parts of cordate houttuynia, 4 parts of field pennycress, 3 parts of frutus cnidii, 3 parts of kuh-seng, 3 parts of Sargent gloryvine, play both sides of the street 3 parts, 3 parts of the root of bidentate achyranthes, 3 parts of hypericum japonicum, perfume
Attached 2 parts, 2 parts of cattail pollen, 1 part of radix glycyrrhizae.
The preparation method of the Chinese herbal medicine perfusate of this treatment cow endometritis is carried out according to the following steps：
(1) weigh respectively by weight motherwort, cordate houttuynia, field pennycress, frutus cnidii, kuh-seng, Sargent gloryvine, play both sides of the street, the root of bidentate achyranthes,
Hypericum japonicum, rhizoma cyperi, cattail pollen, the taste herbal decoction piece of radix glycyrrhizae 12, and it is respectively crushed into Chinese herbal medicine coarse powder；
(2) take cordate houttuynia, field pennycress, kuh-seng, Sargent gloryvine, play both sides of the street, the root of bidentate achyranthes, hypericum japonicum, rhizoma cyperi, radix glycyrrhizae Chinese herbal medicine coarse powder,
The 7 of the Chinese herbal medicine coarse powder gross weight obtained by step (1) extraordinarily injection water immersion 20min-30min, heating decoct 25min-
35min, add motherwort, frutus cnidii, cattail pollen Chinese herbal medicine coarse powder and decoct 25min-35min, pour out first time boil liquid, then by step
Suddenly the extraordinarily injection water of the 5 of the Chinese herbal medicine coarse powder gross weight that (1) obtains decocts twice, decocts 25min-35min every time, obtains second
Secondary boil liquid and third time boil liquid；
(3) boil liquid three times that combining step (2) obtains, filtering, is concentrated into every milliliter of injection water 1g containing crude drug, is concentrated
Boil liquid；
(4) ethanol that the concentration that the concentration boil liquid for obtaining step (3) adds 3 times of weight is 95%, is stirred while adding,
24h is stood, removes and precipitates and reclaim ethanol, be concentrated into every milliliter of injection water 2g containing crude drug, obtain concentrated medicament；
(5) pH that the concentrated medicament that dilute sodium hydroxide obtains step (4) is added dropwise reaches 7.0, by the concentrated medicament weight
The 0.15% of amount adds activated carbon, boils 25-30min, places 12h, then respectively add benzene first by the 1% of the concentrated medicament weight
Alcohol and Tween-80, are stirred evenly, and G-3 sintered glass funnels filtering, filtrate complements to every milliliter of injection water with injection water and contains crude drug
2g, filling, sterilizing, i.e., the Chinese herbal medicine perfusate of obtained this treatment cow endometritis.
Each component pharmacological effect is in the Chinese herbal medicine perfusate prescription of this treatment cow endometritis：
Motherwort effect：The female wormwood artemisia of motherwort alias benefit, the female Chinese mugwort of benefit, safflower Chinese mugwort, female grass, wild rhizoma Gastrodiae, teosinte, Chinese lantern,
Iron fiber crops are dry etc..It is bitter in taste, pungent, it is slightly cold, Return liver, pericardium channel.Containing leonurine, stachydrine, leonuridine, leonurinine, flax
Acid, β-leukotrienes, laurate, oleic acid, benzoic acid, rutin, fumaric acid, sterol, vitamin A etc., in addition also containing arginine,
4- guanidine radicals-n-butyl alcohol, 4- guanidine radicals-butyric acid, stachyose.Tool promoting blood circulation, dissolving stasis, disappear water the effect of.Had difficult labour for threatened abortion, afterbirth is not
Under, abdominal pain due to blood stasis, rush down blood, carbuncle swells sore.
Cordate houttuynia effect：Cordate houttuynia alias Cen grass, purple back of the body cordate houttuynia.Cold nature, bitter, return lung, liver, bladder, large intestine channel.
Containing volatile oil, antibiotic effective ingredient decanoyl acetaldehyde, lauryl aldehyde, a- firpenes and linalool are included, methyl n-nonyl ketone, lauro lene,
Laurene, limonene, Bronyl acetate, cloves alkene, afzerin, hyperin, rutin.Have it is clearing heat and detoxicating, inducing diuresis to remove edema it
Effect.For pneumonia, lung abscess, hot dysentery, malaria, oedema, carbuncle swells, prolapse of the anus, eczema, the favus of the scalp, mange.
Field pennycress effect：Field pennycress alias Chinese ixeris herb, bitter dish, small bitter wheat dish, Patrinia scaniosaefolia, bitter numb dish, bitter leaves dish, mountain Chinese cabbage,
Sweet vernal grass etc..Nature and flavor are worked hard, are slightly cold, Return liver, stomach, large intestine channel.Containing volatile oil, potassium myronate, oleanolic acid, helexin
Member, cupreol-β-D-Glucose glucoside, alkaloid, tannin, starch.There is the effect of clearing heat and detoxicating, apocenosis broken stasis of blood.For acute appendicitis,
Diarrhea, red eye, swell pain, carbuncle swells mange etc..
Frutus cnidii effect：Frutus cnidii alias open country fennel, cnidium monnieri reality, cnidium monnieri benevolence, snake pearl, corn radish bowl, Tu Zihua, snake rice
Deng.Nature and flavor are pungent, bitter, temperature, return kidney channel.Containing volatile oil, main component is firpene, amphene, different into sour borneol acetate, isoborneol；Contain again
Osthole, cnidimine, different kiss-me case, bergapten, columbianetin and its angelate, acetic acid esters, mouth
Isovalerate, cnidiadin, isobutyl acyloxy o-acetylcolumbianetin；Also containing the cloudy element of cnidium monnieri, isopimpinellin, other Petroselinum element
Second, xanthotoxol, ammidin etc..The effect of tool heat-clearing and damp-drying drug, desinsection is antipruritic, removing toxic substances analgesic, and anti-corrosion is subsided a swelling.For palace
Cold, morbid leucorrhoea duye, arthritis with fixed pain caused by dampness pain in the back etc..
Kuh-seng effect：Kuh-seng alias Chinese scholartree, Hao Hanzhi, Albizzia kalkora be sub, wild Chinese scholartree.It is bitter in taste, tremble with fear, the thoughts of returning home, liver, stomach, large intestine, wing
Guang passes through.Containing alkaloid such as matrine, oxymatrine, N- oxidation sophocarpines.Also the new alcohol of such as kuh-seng containing a variety of flavone compounds,
Kuh-seng chalcone, kuh-seng chalcone alcohol, kuh-seng alcohol, kurarinone, kushenin etc..In addition, also contain triterpenoid saponin such as kuh-seng saponin,
Soyasaponins etc..Have heat-clearing and damp-drying drug, desinsection, the effect of diuresis.For hot dysentery, have blood in stool, jaundice renal shutdown, leukorrhea with reddish discharge, eczema is wet
Sore, pruitus, mange leprosy etc..
Sargent gloryvine effect：Sargent gloryvine alias blood rattan, sargentodoxa cuneata, big promoting blood circulation, big blood are logical etc..It is bitter in taste, put down, Return liver, large intestine channel.Contain
Rheum emodin, Physcion, cupreol, Daucosterol, stearic acid, salidroside, dextrorotation syringaresinol diglucoside are right
Revolve dihydroguaiaretic acid, Chrysophanol, vanillic acid, protocatechuic acid and p-Coumaric Acid-p-hydroxyphenylethanol ester and Sargent gloryvine polysaccharide.
Has the effect of promoting blood circulation and removing obstruction in channels, beaten stasis, wind dispelling insecticide.For abdominalgia with intestinal abscess, traumatic injury, pain in rheumatoid joints etc..
Play both sides of the street effect：The Confucius maple of alias nine that plays both sides of the street is real, ball on maple, sweetgum fruit, maple fruit, chicken maple, Japanese maple, big
It is Ye Feng, six logical etc..It is bitter in taste, put down, Return liver kidney channel.First oleanonic acid is removed containing 28-, styracin, left-handed cinnamic acid borneol acetate,
Epoxy styracin, different epoxy styracin, trans-Caryophyllene oxide, play both sides of the street ketone acid, 24- ethyl cholesteric -5- enols.Have wind-dispelling to live
Network, Li Shui stimulates the menstrual flow, the effect of the promoting flow of qi and blood circulation.For joint pain, numbness contracture, oedema turgor, breast is few etc..
Root of bidentate achyranthes effect：Hundred times of root of bidentate achyranthes alias, ox stem, pin this pedal, cherish sunset, bosom knee, Radix Achyranthis Bidentatae, RADIX ACHYRANTHIS LONGIFOLIAE, sub- root of stickweed etc..
Nature and flavor are sweet, bitter, sour, flat, return liver and kidney channel.Containing triterpenoid saponin, contain a variety of polysaccharide again, also containing ecdysterone, Inokosterone, red amaranth
Sterone and arginine, glycine, serine, aspartic acid, glutamic acid, threonine, proline, tyrosine, tryptophan, figured silk fabrics ammonia
Acid, phenylalanine, leucine and alkaloids and Coumarins compound.Has the effect of scattered blood stasis, subduing inflammation.For waist and knee acid
Bitterly, flaccidity and weakness of the lower limbs, postpartum abdominal pain due to blood stasis, placenta retension, heat gonorrhea, blood strangury, traumatic injury, Carbuncle swells dislikes sore, abscess of throat etc..
Hypericum japonicum effect：Hypericum japonicum alias hypericum japonicum, vanilla, tongue of sparrow grass, Artemisia anomala.Nature and flavor bitter, flat, Return liver, gallbladder channel.
Containing quercitrin, Isoquercitrin, Quercetin -7- rhamnosides-pentahydroxyflavone -7- rhamnosides, the plain hypericum japonicum rib of hypericum japonicum spirit
Plain A, B, filicic acid.Have removing dampness through diuresis and removing jaundice, it is clearing heat and detoxicating, the effect of activating blood circulation and reducing swelling.For jaundice heat gonorrhea, malignant sore, pyogenic infections etc..
Rhizoma cyperi effect：Rhizoma cyperi alias perfume (or spice) head is careless, later blue or green, sparrow head is fragrant.http://baike.baidu.com/picture/ 147375/147375/2658492/63d9f2d3572c11df902565da632762d0f603c257.htmlFr= Lemma＆ct=coverThe pungent slight bitter of nature and flavor is sweet, puts down, Return liver, tri-jiao channel.Containing glucose, fructose, starch, volatile oil.In volatile oil
Predominantly rhizome of nutgrass flatsedge alkene, cyperol, isocyperol, and containing nopinene, amphene, 1, 8-Cineole, limonene, selinatriene, β-
Selinene, α-cyperolone, β-cyperolone, cyperolone, rotundone, epoxyguaine Azulene ketone, kobusone and isokobusone.Also contain
Triterpenes, flavonoids and alkaloid etc..Have regulating the flow of vital energy Xie Yu, menstruction regulating and pain relieving, it is antiabortive the effect of.For the distending pain in hypochondrium, breast swelling,
Hernia pain, epigastric abdominal fullness pain, belch acid regurgitation, evil of vomitting, fetal irritability indigestion, chest gastral cavity ruffian etc..
Cattail pollen effect：Cattail pollen alias Pu li pollen, Pu Hua, cattail's spike pollen, the stem or leaf of cattail are yellow, hair wax, and nature and flavor are sweet, micro-pungent, channel tropism
Liver, the heart, the spleen channel.It is that cattail is new containing flavones ingredient such as naringenin, Isorhamnetin, Quercetin, Isorhamnetin -3-O- rutinosides
Glucoside, Quercetin -3-O- α-L- rhamnopyranosyls (1-2)-[α-L- rhamnopyranosyls (1-6)]-β-D- glucopyanosides.
Tool hemostasis, stagnation resolvation, it is treating stranguria the effect of.For spitting blood, bleeding from five sense organs or subcutaneous tissue, spitting of blood, traumatism and bleeding, gastral cavity abdomen shouting pain, tumbling and swelling, blood strangury is puckery
Bitterly.
Radix glycyrrhizae effect：Radix glycyrrhizae is mainly containing glycyrrhizic acid, glycyrrhizin, 24- hydroxyls enoxolone, licoflavone, glycyrrhizin, different
The compositions such as glycyrrhizin, licorice polysaccharide.Glycyrrhizic acid is natural antidote, available for body anti-aging, strengthen immunity, maintains water salt
Metabolic balance etc..Invigorate the spleen and benefit qi, be clearing heat and detoxicating, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia,
Gastral cavity abdomen, alleviate drug toxicity, strong.
The Chinese herbal medicine perfusate prescription foundation of this treatment cow endometritis：Chinese veterinarian's cow endometritis is referred to as band
Disease, more because of dam postpartum bacterium, the infection of virus, or because pregnancy period feeding management is not good at, pregnancy burden is excessive, excessive usage,
The factors such as childbirth cause qi and blood retardance or deficient, and then the positive deficiency of vital energy of body declines, and perverse trend is taken advantage of a weak point.Principle of reatment is typically to invigorate blood circulation
Dissolving stasis, promoting the circulation of qi of enriching blood.Therefore, prescription should with anti-inflammation, promoting blood circulation and removing blood stasis, clearing heat and detoxicating, astringing to arrest bleeding, go to lose myogenic and enhancing
Immunity of organisms is principle.Cordate houttuynia, field pennycress, frutus cnidii, kuh-seng anti-inflammation, heat-clearing and damp-drying drug, desinsection in side.Motherwort has
Promoting blood circulation for regulating menstruation, get rid of illness raw new effect, can strengthen uterine contraction and contraction frequency, improve the tensile force of uterus muscle, accelerator
Palace restoration of old ways process.Sargent gloryvine, play both sides of the street, the root of bidentate achyranthes, hypericum japonicum, rhizoma cyperi, cattail pollen can invigorate blood circulation, dissolving stasis, there is stronger promotion blood
Liquid circulation, adjustment uterus function, dissipate the effects such as the turbid, swelling and pain relieving of stasis of blood row.Frutus cnidii, kuh-seng also have stronger osmosis,
Medicine can be promoted in intrauterine acceleration diffusion, be evenly distributed, absorbed to transmucosal, strengthened anti-inflammatory anti-itch effect, be advantageous to fill
The effect of intrauterine medicine is waved in distribution.With the sweet temperature QI invigorating of radix glycyrrhizae, invigorating spleen, pass through twelve channels and collaterals, coordinating the drug actions of a prescription.All medicines in side
Xiang He, plays promoting blood circulation and removing blood stasis, clearing heat and detoxicating, anti-inflammation, involution of uterus altogether, the effect of improving immunity of organisms and resistance against diseases.
Suitable for cow endometritis caused by a variety of causes.For convenience of use, perfusion liquid is made.
The Chinese herbal medicine perfusate of this treatment cow endometritis, be on the basis of a large amount of practical applications have been carried out, according to
According to traditional medicine ancient prescription, formed with reference to modern popular disease, aetology and immunologic theoretical screening, for treating cow uteri
Intimitis, short treating period, cost are low, cure rate is high, safe and free of toxic and side effects, easy to use.
Embodiment
With reference to embodiment, the invention will be further described.
Embodiment：
1st, bulk drug (herbal decoction piece) motherwort 175g, cordate houttuynia 150g, field pennycress 100g, frutus cnidii are weighed respectively
75g, kuh-seng 75g, Sargent gloryvine 75g, play both sides of the street 75g, root of bidentate achyranthes 75g, hypericum japonicum 75, rhizoma cyperi 50g, cattail pollen 50g, radix glycyrrhizae 25g.
2nd, above-mentioned raw materials medicine is respectively crushed into Chinese herbal medicine coarse powder；
3rd, by cordate houttuynia, field pennycress, kuh-seng, Sargent gloryvine, play both sides of the street, the root of bidentate achyranthes, hypericum japonicum, rhizoma cyperi, traditional Chinese medicine of licorice root coarse powder mix,
After adding water 7000mL immersions 1h, 30min is cooked by slow fire, motherwort, frutus cnidii, cattail pollen Chinese herbal medicine coarse powder is placed into, is cooked by slow fire
30min, first time boil liquid is obtained, then add water 5000mL to decoct every time again secondary, decoct 30min every time, boiled for the second time
Liquid and third time boil liquid；
4th, merge above-mentioned boil liquid three times, filtering, be concentrated into every milliliter of injection water 1g containing crude drug, obtain concentrating boil liquid, then
The ethanol 1500mL that concentration is 95% is added, is stirred while adding, 24h is stood, goes precipitation to take supernatant, boil off ethanol, is concentrated
To every milliliter of injection water 2g containing crude drug, concentrated medicament is obtained；
5th, dilute sodium hydroxide is added dropwise makes the pH of above-mentioned concentrated medicament reach 7.0, adds the work of the concentrated medicament weight 0.15%
Property charcoal boil 30min, place 12h, filtering, then respectively add by the concentrated medicament weight 1% phenmethylol and Tween-80 stirs evenly,
No. G-3 vertical banyan glass funnel filtering, filtrate are supplied 500mL, filling every bottle of 10mL with injection water, 100 DEG C, 30min sterilizings, that is, made
Obtain the Chinese herbal medicine perfusate of this treatment cow endometritis.
Some experiments carried out using the Chinese herbal medicine perfusate of this treatment cow endometritis are as follows：
1st, this Chinese herbal medicine perfusate is to cow endometritis the main pathogenic fungi drug sensitive test
Choose clinic and suffer from endometritis milk cow case, through separating, identifying, select pathogenic 2 kinds of stronger pathogens such as
Staphylococcus aureus and Streptococcusagalactiae.A certain amount of Chinese herbal medicine perfusate is weighed, 4 DEG C save backup.It will be clinically separated
Staphylococcus aureus, Streptococcusagalactiae be first inoculated in flat board, in 37 DEG C cultivate 18h after, select colonies typical and be inoculated in 5mL
In meat soup, after 37 DEG C are cultivated 18h, bacterium solution is diluted to 10 by 0.5 maxwell unit standard opacity tube than turbid with meat soup6CFU/mL,
It is standby.
Medicament sensitivity test uses plate punch method, and 1g/mL this Chinese herbal medicine perfusate is added in hole, with fill it up with without
Overfolw hole is advisable outside.Separately take penicillin 10IU/ pieces, μ g/mL of ampicillin 5, the medicine of the tri- kinds of antibiotic of μ g/mL of Ciprofloxacin 1
Quick experiment compares, and is placed in 37 DEG C of constant incubators and cultivates 24h, measures antibacterial circle diameter, the drug sensitive test weight of every kind of medicine
Again three times.Criterion：According to《Pharmacology of Chinese materia medica》With《U.S. clinical Laboratory Standard research institute version in 2005 is about susceptibility
Testing standard》Standard, i.e. bacteriostatic diameter >=20mm is extremely quick, 20mm>Bacteriostatic diameter >=15mm is Gao Min；15mm>It is antibacterial
Diameter >=10mm is quick in being, below 10mm is muting sensitive.
This Chinese herbal medicine perfusate medicament sensitivity test the results are shown in Table 1.
Drug sensitive test result mm of 1 Chinese herbal medicine perfusate of table to two kinds of bacterium
| Medicine | Staphylococcus aureus | Streptococcusagalactiae |
| Penicillin | 20.0±1.5 | 19.5±0.5 |
| Ampicillin | 19.5±0.5 | 19.5±1.0 |
| Ciprofloxacin | 19.5±1.0 | 20.0±1.5 |
| This Chinese herbal medicine perfusate | 22.5±1.5 | 21.5±1.5 |
Table 1 is shown, to staphylococcus aureus, this Chinese herbal medicine perfusate is extremely quick, and bacteriostatic diameter reaches 22.5mm, mould
Element, ampicillin and Ciprofloxacin are Gao Min；To Streptococcusagalactiae, this Chinese herbal medicine perfusate is extremely quick, and bacteriostatic diameter reaches
21.5mm, other medicines such as penicillin, ampicillin and Ciprofloxacin are Gao Min.Drug sensitivity test shows, golden yellow Portugal
Grape coccus and Streptococcusagalactiae are most sensitive to this Chinese herbal medicine perfusate；Ampicillin takes second place；This Chinese herbal medicine perfusate is to golden yellow
The inhibitory action of color staphylococcus and Streptococcusagalactiae is stronger, and ampicillin takes second place.This Chinese herbal medicine perfusate is to cow uteri
The inhibition of 2 kinds of pathogens of intimitis is good compared with antibiotic such as penicillin, should be used as in treatment cow endometritis practice
It is preferred.
2. the safety testing of a Chinese herbal medicine perfusate
2.1 acute toxicity test
2.1.1 method is gavaged：20 mouse, are randomly divided into 5 groups, every group 4, male and female half and half.Each test group is distinguished mouse
With 0.2mL/20g, 0.4mL/20g, 0.6mL/20g, 0.8mL/20g (1mL is equivalent to crude drug in whole 1g) gavage；Control group mice with
0.8mL/20g gavages distilled water.By experiment, to mouse stomach, (1mL is equivalent to original by 0.8mL/20g for this Chinese herbal medicine perfusate
Crude drug 1g) do not cause dead mouse.Illustrate mouse to the minimum dosis tolerata of this Chinese herbal medicine perfusate in more than 0.8g/20g.Experiment
Group mouse compared with control group has no abnormal changes in spirit, hair, behavior, appetite etc..
2.1.2 intraperitoneal injection：6 mouse of pilot study are divided into 3 groups, male and female half and half.Said preparation is injected intraperitoneally, according to small
Mouse survival number obtains the maximum dose 0.2mL/20g for making mouse survival, and being obtained according to dead mouse number makes the whole death of mouse
Minimum dose 1.0mL/20g (1mL is equivalent to crude drug in whole 1g).30 mouse of formal test are randomly divided into 6 groups, every group 5.According to
Pilot study result, if 5 dosage groups：10.0g/kg, 15.0g/kg, 22.5g/kg, 33.8g/kg, 50.6g/kg (dosage group
Between agent away from than no more than 1.5), 1 control group：Intraperitoneal injection of saline 1.0mL/20g.Mouse performance breathing is anxious after medication
Promoting, palpitating speed, exophthalmos, hair is erect, and hogback, whole body is micro- to be trembled, and tail is crispaturaed, and sufficient pawl shrinks, low position walking, and then
Postural reflex disappears, and upper and lower catacleisis simultaneously has discharge of eye, and respiratory rate slows down, then dead.Cut open inspection is shown in heart extravasated blood, its
Its organ no abnormality seen.By formula：Log LD50=Xm-d (∑ p-0.5), this Chinese herbal medicine perfusate can be tried to achieve to mouse
LD50 is 0.6942g/20g (LD50 34710mg/kg).According to medicinesafety evaluation criterion, work as LD50>During 5000mg/kg
Belong to actual nontoxic, this Chinese herbal medicine perfusate is 34710mg/kg to the LD50 of mouse>5000mg/kg, illustrate nontoxic.
2.2 rabbit eyes irritation tests：Using androgynous own control.Healthy rabbits 4 are taken, check the two of every rabbit
Eye, normal person can be used for testing.Palpebra inferior is gently pulled open, after eyeball, by this Chinese herbal medicine perfusate and physiological saline
Each 0.1mL is respectively dropped into the right and left eyes conjunctival sac of rabbit, and two infusion volumes are equal, and then gently sleep eyelid about 1s-2s, in order to avoid medicine
Liquid and physiological saline outflow, influence result of the test.Eye conjunctiva whether there is congested, water when 1h, 6h, 12h, 24h and 36h after observation administration
Swollen, photophobia and the stimulate the reaction such as shed tears.
By to 4 rabbit right and left eyes medications and the control of physiological saline, as a result show after medication 1h have it is slight shed tears and
Congested phenomenon, stopping of shedding tears after 12h, congested phenomenon is more obvious, and congested phenomenon gradually weakens after 24h, and 36h hyperemia phenomenons disappear
Lose.Result of the test shows that this Chinese herbal medicine perfusate is nonirritant to mucous membrane.
The detection of hematological indices before and after 2.3 Chinese herbal medicine perfusate treatment cow endometritis medications：Clinical definite
For the case 10 (Chinese herbal medicine perfusate treatment) that cow uteri film is scorching, same period healthy control group milk cow 8 (non-medication treatment),
Ill control group milk cow 10 (non-medication treatment).This Chinese herbal medicine perfusate treatment group milk cow is after illness is made a definite diagnosis with this Chinese herbal medicine
Perfusion liquid is treated, and dosage 400mL-500mL, waits warm uterine perfusion, 1 time a day, 3d is 1 course for the treatment of.This Chinese herbal medicine perfusate is controlled
Each jugular vein blood collection once, carries out red blood cell count(RBC), white blood cell count(WBC) to treatment group milk cow before medication after making a definite diagnosis and after healing respectively,
Content of hemoglobin, Arneth's count etc..Healthy cow control group and the blood sampling of the ill milk cow control group same period, it is same to carry out
Red blood cell count(RBC), white blood cell count(WBC), content of hemoglobin, Arneth's count.Red blood cell number in blood, hemoglobin content and
The measurement result of packed cell volume is shown in Table 2, and blood middle leukocytes sum and Arneth's count the results are shown in Table 3.
The measurement result unit of red blood cell number, hemoglobin content and packed cell volume in the blood of table 2：Ten thousand/mm3, gram/
Ml, %
The blood middle leukocytes of table 3 sum and Arneth's count result unit：Ten thousand/mm3, %
As can be seen from Table 2, the cow blood red blood cell number of postpartum health, content of hemoglobin, packed cell volume are basic
Normal level is maintained, it is less to suffer from the red blood cell number of endometritis milk cow, content of hemoglobin, packed cell volume, this medium-height grass
Medicine perfusion liquid treatment group the milk cow red blood cell number of milk cow, content of hemoglobin, packed cell volume after medication healing remain normal
Level, illustrate that this Chinese herbal medicine perfusate can increase the red blood cell, content of hemoglobin, packed cell volume quantity of milk cow.It is red thin
Born of the same parents and hemoglobin play an important role in body hematopoiesis and oxygen transportation, particularly significant to animal survival, growth and production, and
And red blood cell also has partial immunity function.After the endometritis of this Chinese herbal medicine perfusate treatment milk cow, this three indexs
Significantly increase, reach normal value, illustrate that this Chinese herbal medicine perfusate has red blood cell number and content of hemoglobin in increase blood
Effect.
As can be seen from Table 3, total white blood cells, neutrophil leucocyte number, the monokaryon suffered from endometritis cow blood are thin
Born of the same parents are significantly higher than same period healthy cow, and after being treated with this Chinese herbal medicine perfusate, total white blood cells, neutrophil leucocyte number, monokaryon are thin
Born of the same parents are remarkably decreased, and total white blood cells, neutrophil leucocyte number, the monokaryon of the ill milk cow without the treatment of this Chinese herbal medicine perfusate are thin
Born of the same parents maintain higher level all the time, higher than healthy control group, illustrate that this Chinese herbal medicine perfusate can reduce and suffer from endometritis milk
Total white blood cells, neutrophil leucocyte number, monocyte in bovine blood, are allowed to recover normal level；Suffer from endometritis milk cow
Percentage of lymphocyte it is more relatively low than same period healthy cow, with this Chinese herbal medicine perfusate treat after, the ratio rapid increase, after healing
Milk cow compared with healthy cow the indicator difference it is not notable, show that this Chinese herbal medicine perfusate can improve and suffer from endometritis milk
Percentage of lymphocyte in bovine blood leucocyte.Leucocyte is the important immunocyte of body, is only prevented when body is in infection
During imperial phase, this cell just can largely breed, and neutrophil leucocyte is the most common in the suppurative infection phase, and now, the cell is from hematopoiesis device
Official is discharged into peripheral blood, and is disengaged from microcirculatory vascular, is infiltrated in areas of inflammation.This cell has active motion energy
Power and phagocytic function, but the life-span is shorter, is changed into pyocyte after dead, and this is also that endometritis is often converted into chronic purulence
One of the reason for Endometrium inflammation, neutrophil leucocyte increase the evolution for also having prompted local inflammation in milk cow body.In experiment,
The neutrophil leucocyte of this Chinese herbal medicine perfusate treatment group milk cow is remarkably decreased, also just reflecting this Chinese herbal medicine perfusate played compared with
Good effect, eliminates internal proinflammatory factors, the ratio of neutrophil leucocyte is returned to normal level.Lymphocyte is also
Important immunocompetent cell, does not possess phagocytic function, the main antibody materials produced in body, when generation viral infection
When, internal quantity significantly rises, and when Abwehrkraft des Koepers decline or immunologic hypofunction, the ratio regular meeting of the cell declines, this examination
Test the middle percentage of lymphocyte for suffering from endometritis milk cow to be remarkably decreased, also reflect that these milk cows are low due to the immunity of itself
Under, cause some conditioned pathogen amount reproductions of intrauterine and trigger cow endometritis, this Chinese herbal medicine perfusate is exactly to adjust
The total defense function of animal body has been saved, has improved the autoimmunity of ill milk cow, the ratio of lymphocyte just rises to
Normal level.Under normal circumstances, monocyte is present among blood, but negligible amounts.When body is locally inflamed, due to
Inflammatory stimulus, the cell are largely bred, and by blood circulation, are reached areas of inflammation, are played phagocytic function, it often comes across inflammation
Later stage, chronic inflammation processes etc..The result of the test shows that this Chinese herbal medicine perfusate can increase monocyte ratio, make son
The scorching symptom mitigation of Endometrium, illustrates that body is repaired to the endometrium of inflammatory destruction.
Test result indicates that, the Chinese herbal medicine perfusate of this treatment cow endometritis has anti-inflammation, adjustment above
Uterus function, improve local blood circulation, adjustment intrauterine environment, increase medicine intrauterine diffusion, infiltration and absorption,
It is nonirritant, improve immunity the features such as.
Claims (2)
1. a kind of Chinese herbal medicine perfusate for treating cow endometritis, it is characterised in that it is the bulk drug by following weight parts
It is made：5 parts -7 parts of motherwort, 4 parts -6 parts of cordate houttuynia, 2 parts -4 parts of field pennycress, 2 parts -4 parts of frutus cnidii, 2 parts -4 parts of kuh-seng, Sargent gloryvine
2 parts -4 parts, play both sides of the street 2 parts -4 parts, 1 part -3 parts of the root of bidentate achyranthes, 1 part -3 parts of hypericum japonicum, 1 part -2 parts of rhizoma cyperi, 1 part -2 parts of cattail pollen, radix glycyrrhizae 1
- 2 parts of part；
The preparation method of the Chinese herbal medicine perfusate is carried out according to the following steps：
(1) motherwort, cordate houttuynia are weighed respectively by weight, field pennycress, frutus cnidii, kuh-seng, Sargent gloryvine, is played both sides of the street, the root of bidentate achyranthes, nostoc commune
Grass, rhizoma cyperi, cattail pollen, the taste herbal decoction piece of radix glycyrrhizae 12, and it is respectively crushed into Chinese herbal medicine coarse powder；
(2) take cordate houttuynia, field pennycress, kuh-seng, Sargent gloryvine, play both sides of the street, the root of bidentate achyranthes, hypericum japonicum, rhizoma cyperi, radix glycyrrhizae Chinese herbal medicine coarse powder, by step
Suddenly the 7 of the Chinese herbal medicine coarse powder gross weight that (1) obtains extraordinarily injection water immersion 20min-30min, heating decoct 25min-35min,
Add motherwort, frutus cnidii, cattail pollen Chinese herbal medicine coarse powder and decoct 25min-35min, pour out first time boil liquid, then by step (1)
The extraordinarily injection water of the 5 of obtained Chinese herbal medicine coarse powder gross weight decocts twice, decocts 25min-35min every time, is boiled for the second time
Liquid and third time boil liquid；
(3) boil liquid three times that combining step (2) obtains, filtering, is concentrated into every milliliter of injection water 1g containing crude drug, obtains concentration and boil
Liquid；
(4) ethanol that the concentration that the concentration boil liquid for obtaining step (3) adds 3 times of weight is 95%, is stirred while adding, and is stood
24h, remove and precipitate and reclaim ethanol, be concentrated into every milliliter of injection water 2g containing crude drug, obtain concentrated medicament；
(5) pH that the concentrated medicament that dilute sodium hydroxide obtains step (4) is added dropwise reaches 7.0, by the concentrated medicament weight
0.15% adds activated carbon, boils 25-30min, places 12h, then by the 1% of the concentrated medicament weight respectively add phenmethylol and
Tween-80, stir evenly, G-3 sintered glass funnels filtering, filtrate complements to every milliliter of injection water 2g containing crude drug with injection water, fills
Dress, sterilizing, i.e., the Chinese herbal medicine perfusate of obtained this treatment cow endometritis.
2. the Chinese herbal medicine perfusate for the treatment of cow endometritis according to claim 1, it is characterised in that it is under
The bulk drug for stating parts by weight is made：7 parts of motherwort, 6 parts of cordate houttuynia, 4 parts of field pennycress, 3 parts of frutus cnidii, 3 parts of kuh-seng, 3 parts of Sargent gloryvine,
Play both sides of the street 3 parts, 3 parts of the root of bidentate achyranthes, 3 parts of hypericum japonicum, 2 parts of rhizoma cyperi, 2 parts of cattail pollen, 1 part of radix glycyrrhizae.
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| RU2697403C1 (en) * | 2018-09-19 | 2019-08-14 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Российский государственный аграрный университет - МСХА имени К.А. Тимирязева" (ФГБОУ ВО РГАУ-МСХА имени К.А. Тимирязева) | "venus" preparation for prevention and treatment of postnatal endometritis in cows |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104958704A (en) * | 2015-07-17 | 2015-10-07 | 胡洪杰 | Pharmaceutical composition for treating bovine endometritis and preparation method of pharmaceutical composition |
| RU2617538C1 (en) * | 2016-02-19 | 2017-04-25 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Донской государственный аграрный университет" | Means for farm animals postpartum endometritis treatment and prevention |
| CN105726681A (en) * | 2016-04-28 | 2016-07-06 | 青岛海之星生物科技有限公司 | Injection for treating dairy cattle endometritis and preparing method of injection |
| CN106177447A (en) * | 2016-09-09 | 2016-12-07 | 马玉珍 | A kind of treat the cow uteri the most complete Chinese medicine composition of retraction |
| CN107714850A (en) * | 2017-10-18 | 2018-02-23 | 河南永辉生物科技股份有限公司 | For sow midwifery, the palace of the Qing Dynasty, progestogenic Chinese prescription perfusion liquid |
| RU2751034C1 (en) * | 2020-03-11 | 2021-07-07 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Кубанский государственный аграрный университет имени И.Т. Трубилина" | Method of production of a preparation for treatment of bovine endometritis |
| CN113144006B (en) * | 2021-04-27 | 2022-04-08 | 湖南美可达生物资源股份有限公司 | Traditional Chinese medicine composition for treating endometritis of female animals and preparation method and application thereof |
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| CN101647967B (en) * | 2009-09-21 | 2011-07-06 | 路平 | Preparation method of traditional Chinese medicine for treating endometritis |
| CN102100753B (en) * | 2011-03-05 | 2012-07-04 | 中国农业科学院兰州畜牧与兽药研究所 | Medicine for treating endometritis of milk cow |
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