CN104520297B - 作为肾酪氨酸激酶抑制剂的双环杂芳基环烷基二胺衍生物 - Google Patents

作为肾酪氨酸激酶抑制剂的双环杂芳基环烷基二胺衍生物 Download PDF

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Publication number
CN104520297B
CN104520297B CN201380041562.4A CN201380041562A CN104520297B CN 104520297 B CN104520297 B CN 104520297B CN 201380041562 A CN201380041562 A CN 201380041562A CN 104520297 B CN104520297 B CN 104520297B
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Prior art keywords
amino
pyrido
cyclohexylamino
ketone
pyridazine
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CN201380041562.4A
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Chinese (zh)
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CN104520297A (zh
Inventor
G·托马
P·比尔迈耶
艾斯 M·范
M·范艾斯
A·B·史密斯
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Swiss Iran Animal Health Care Co Ltd
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Novartis Tiergesundheit AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201380041562.4A 2012-08-13 2013-08-12 作为肾酪氨酸激酶抑制剂的双环杂芳基环烷基二胺衍生物 Active CN104520297B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261682392P 2012-08-13 2012-08-13
US61/682,392 2012-08-13
PCT/IB2013/056589 WO2014027300A1 (en) 2012-08-13 2013-08-12 Bicyclic heteroaryl cycloalkyldiamine derivatives as inhibitors of spleen tyrosine kinases (syk)

Publications (2)

Publication Number Publication Date
CN104520297A CN104520297A (zh) 2015-04-15
CN104520297B true CN104520297B (zh) 2016-08-24

Family

ID=49385306

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380041562.4A Active CN104520297B (zh) 2012-08-13 2013-08-12 作为肾酪氨酸激酶抑制剂的双环杂芳基环烷基二胺衍生物

Country Status (14)

Country Link
US (2) US9315500B2 (https=)
EP (1) EP2882747B1 (https=)
JP (1) JP6236083B2 (https=)
KR (1) KR20150042256A (https=)
CN (1) CN104520297B (https=)
AU (1) AU2013303824B2 (https=)
BR (1) BR112015003058A2 (https=)
CA (1) CA2880790C (https=)
EA (1) EA201590372A1 (https=)
ES (1) ES2576692T3 (https=)
HK (1) HK1209421A1 (https=)
IN (1) IN2015DN00950A (https=)
MX (1) MX2015002006A (https=)
WO (1) WO2014027300A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104520297B (zh) * 2012-08-13 2016-08-24 瑞士诺华动物保健有限公司 作为肾酪氨酸激酶抑制剂的双环杂芳基环烷基二胺衍生物
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN119173446A (zh) 2022-03-08 2024-12-20 赤盾医疗有限公司 机器人药物制备系统中的流体转移站

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102548992A (zh) * 2009-07-30 2012-07-04 Irm责任有限公司 作为syk激酶抑制剂的2,7-萘啶-1-酮衍生物
CN102574847A (zh) * 2009-07-30 2012-07-11 Irm责任有限公司 作为syk激酶抑制剂的化合物和组合物
WO2012097479A1 (en) * 2011-01-21 2012-07-26 Abbott Laboratories Bicyclic inhibitors of anaphastic lymphoma kinase

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1524747A (en) 1976-05-11 1978-09-13 Ici Ltd Polypeptide
ATE28864T1 (de) 1982-07-23 1987-08-15 Ici Plc Amide-derivate.
GB9721069D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Polymeric derivatives of camptothecin
JP2007524596A (ja) 2003-02-28 2007-08-30 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 共結晶医薬組成物
KR100781704B1 (ko) 2005-04-20 2007-12-03 에스케이케미칼주식회사 피리딘 유도체와 이의 제조방법, 및 이를 포함하는약제조성물
CN101405001A (zh) 2006-03-20 2009-04-08 霍夫曼-拉罗奇有限公司 抑制btk和syk蛋白质激酶的方法
TW200938542A (en) * 2008-02-01 2009-09-16 Irm Llc Compounds and compositions as kinase inhibitors
MX2012004846A (es) 2009-10-29 2012-10-05 Genosco Inhibidores de cinasa.
CN104520297B (zh) * 2012-08-13 2016-08-24 瑞士诺华动物保健有限公司 作为肾酪氨酸激酶抑制剂的双环杂芳基环烷基二胺衍生物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102548992A (zh) * 2009-07-30 2012-07-04 Irm责任有限公司 作为syk激酶抑制剂的2,7-萘啶-1-酮衍生物
CN102574847A (zh) * 2009-07-30 2012-07-11 Irm责任有限公司 作为syk激酶抑制剂的化合物和组合物
WO2012097479A1 (en) * 2011-01-21 2012-07-26 Abbott Laboratories Bicyclic inhibitors of anaphastic lymphoma kinase

Also Published As

Publication number Publication date
IN2015DN00950A (https=) 2015-06-12
CA2880790A1 (en) 2014-02-20
BR112015003058A2 (pt) 2017-07-04
CA2880790C (en) 2020-09-08
KR20150042256A (ko) 2015-04-20
WO2014027300A1 (en) 2014-02-20
JP2015524838A (ja) 2015-08-27
EP2882747B1 (en) 2016-04-27
AU2013303824B2 (en) 2016-03-31
JP6236083B2 (ja) 2017-11-22
EA201590372A1 (ru) 2015-05-29
AU2013303824A1 (en) 2015-02-26
EP2882747A1 (en) 2015-06-17
US9315500B2 (en) 2016-04-19
MX2015002006A (es) 2015-06-02
US20150218157A1 (en) 2015-08-06
HK1209421A1 (en) 2016-04-01
ES2576692T3 (es) 2016-07-08
US20160213670A1 (en) 2016-07-28
CN104520297A (zh) 2015-04-15

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