CN104487568B - 人胚胎干细胞衍生的间充质样干细胞、方法及其应用 - Google Patents
人胚胎干细胞衍生的间充质样干细胞、方法及其应用 Download PDFInfo
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261670192P | 2012-07-11 | 2012-07-11 | |
| US61/670,192 | 2012-07-11 | ||
| US201261684509P | 2012-08-17 | 2012-08-17 | |
| US61/684,509 | 2012-08-17 | ||
| PCT/US2013/050077 WO2014011881A2 (en) | 2012-07-11 | 2013-07-11 | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104487568A CN104487568A (zh) | 2015-04-01 |
| CN104487568B true CN104487568B (zh) | 2017-08-15 |
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ID=49916687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380036985.7A Active CN104487568B (zh) | 2012-07-11 | 2013-07-11 | 人胚胎干细胞衍生的间充质样干细胞、方法及其应用 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9725698B2 (https=) |
| EP (1) | EP2872619B1 (https=) |
| JP (1) | JP6277187B2 (https=) |
| CN (1) | CN104487568B (https=) |
| AU (1) | AU2013290146B2 (https=) |
| CA (2) | CA2876512C (https=) |
| WO (1) | WO2014011881A2 (https=) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106434527A (zh) | 2006-04-14 | 2017-02-22 | 安斯泰来再生医药协会 | 血管瘤集落形成细胞 |
| US20170114323A1 (en) | 2014-06-19 | 2017-04-27 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
| US20160095885A1 (en) * | 2014-10-01 | 2016-04-07 | WibiWorks Therapeutics, Inc. | Induction Medium & Methods for Stem Cell Culture & Therapy |
| US20180355319A1 (en) * | 2015-08-07 | 2018-12-13 | Kyoto Prefectural Public University Corporation | Method for preparing brown adipocyte |
| KR101779932B1 (ko) * | 2015-09-15 | 2017-09-21 | 주식회사 스템랩 | 나노그(Nanog)를 도입한 양수 내 태아 유래 중간엽 줄기세포를 이용한 육모 촉진용 조성물의 제조방법 |
| CN105326864A (zh) * | 2015-11-30 | 2016-02-17 | 奥思达干细胞有限公司 | 一种治疗系统性红斑狼疮的干细胞制剂及其制备方法 |
| WO2017100498A1 (en) | 2015-12-11 | 2017-06-15 | The Johns Hopkins University | Isolation of fusion-competent myoblasts and therapeutic applications thereof related to muscular dystrophy |
| CN105754936B (zh) * | 2016-02-25 | 2018-06-08 | 付清玲 | 人诱导性多能干细胞诱导为间充质干细胞的方法 |
| US11174461B2 (en) * | 2016-03-16 | 2021-11-16 | Cynata Therapeutics Limited | Colony forming medium and use thereof |
| CN105769911A (zh) * | 2016-03-23 | 2016-07-20 | 中国人民解放军第二军医大学 | 间充质干细胞诱导斑秃处毛发再生的方法及应用 |
| US20200140851A1 (en) * | 2016-08-23 | 2020-05-07 | The Scripps Research Institute | Methods and Compositions Related to In Vivo Selection of Functional Molecules |
| KR101971322B1 (ko) * | 2016-10-17 | 2019-04-23 | 사회복지법인 삼성생명공익재단 | Socs의 발현 또는 활성 억제를 이용한 고효능 줄기세포 선별방법 |
| KR101971323B1 (ko) * | 2016-10-17 | 2019-04-23 | 사회복지법인 삼성생명공익재단 | 면역질환 치료를 위한 고효능 줄기세포 선별방법 |
| CN108121161A (zh) * | 2016-11-26 | 2018-06-05 | 中国科学院大连化学物理研究所 | 一种高通量形成拟胚体的微阵列芯片的制备方法与应用 |
| WO2018119213A1 (en) * | 2016-12-23 | 2018-06-28 | StemBios Technologies, Inc. | Use of somatic stem cells for decreasing il-6 level |
| CN106754715A (zh) * | 2017-02-13 | 2017-05-31 | 四川新生命干细胞科技股份有限公司 | 一种用于造血干细胞培养的滋养层的制备方法 |
| WO2018170390A1 (en) * | 2017-03-17 | 2018-09-20 | Senti Biosciences, Inc. | Immunomodulating cell circuits |
| KR20180112547A (ko) * | 2017-04-04 | 2018-10-12 | 경북대학교 산학협력단 | 역분화 줄기세포의 지속적인 계대배양을 통한 중간엽 줄기세포로의 분화방법 |
| WO2018191619A1 (en) | 2017-04-13 | 2018-10-18 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| WO2018218105A1 (en) * | 2017-05-26 | 2018-11-29 | Kite Pharma, Inc. | Methods of making and using embryonic mesenchymal progenitor cells |
| US11547730B2 (en) | 2017-05-26 | 2023-01-10 | Steminent Biotherapeutics Inc. | Therapy for polyglutamine (polyQ) diseases |
| US11773376B2 (en) | 2017-07-13 | 2023-10-03 | National University Corporation Tokyo Medical And Dental University | Artificial tendon or ligament tissue produced using three-dimensional mechanosignaling cell culture system |
| CN107460169B (zh) * | 2017-07-14 | 2020-12-11 | 中国科学院广州生物医药与健康研究院 | 维生素c在制备培养基中的用途 |
| CN111849899B (zh) * | 2017-07-28 | 2022-06-14 | 杨涛 | 定向诱导hiPSC分化为神经细胞体系的诱导培养基 |
| CN109666630A (zh) * | 2017-10-17 | 2019-04-23 | 澳门大学 | 多能干细胞分化为间充质干细胞的方法及其培养基和应用 |
| CA3080691C (en) * | 2017-11-10 | 2022-11-15 | Regenesis Science Co., Ltd. | Method for producing cultured cell, and method for producing therapeutic agent for spinal cord injury disease |
| WO2019104466A1 (en) * | 2017-11-28 | 2019-06-06 | Harvatek Corporation | Methods of producing populations of mesenchymal stem cells from peripheral blood and uses thereof |
| CN108324993B (zh) * | 2018-01-15 | 2020-11-03 | 朱剑虹 | 一种诱导毛发再生的干细胞复合体、其制备方法及应用 |
| CN108570448B (zh) * | 2018-01-26 | 2019-04-02 | 皓昇莱生物制药有限公司 | 一种高效的hPSCs向MSCs分化的方法 |
| CN108570447A (zh) * | 2018-01-26 | 2018-09-25 | 皓昇莱生物制药有限公司 | 一种筛选分化hPSCs向MSCs的方法 |
| TW201938788A (zh) * | 2018-03-06 | 2019-10-01 | 美商歐瑞3恩公司 | 用於軟骨修復之源自iPSC之細胞組合物及相關系統與方法 |
| CN110295145B (zh) * | 2018-03-22 | 2020-10-16 | 苏州麦迪耐斯医药科技有限公司 | 一种体外培养脑肿瘤细胞的培养液及培养方法 |
| CN108504627A (zh) * | 2018-04-02 | 2018-09-07 | 中国人民解放军陆军军医大学第二附属医院 | 人类黄韧带干细胞的提取方法 |
| CN108498452A (zh) * | 2018-04-10 | 2018-09-07 | 上海交通大学医学院附属仁济医院 | 一种用于治疗勃起功能障碍的含干细胞可注射水凝胶及其制备方法 |
| KR20240033089A (ko) * | 2018-06-06 | 2024-03-12 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 신경 줄기 세포 조성물 및 신경변성 장애를 치료하는 방법 |
| CN109055307B (zh) * | 2018-08-26 | 2021-06-11 | 杭州爱唯生命科技有限公司 | 一种bmp-2激活剂及在干细胞诱导分化方面的应用 |
| AU2019359890B2 (en) | 2018-10-17 | 2024-10-24 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| CN110352951A (zh) * | 2018-11-15 | 2019-10-22 | 崔磊 | 一种无血清无dmso组织工程骨冻存液及其制备和冻存方法 |
| CN109536444B (zh) * | 2018-12-11 | 2022-06-28 | 吉林省拓华生物科技有限公司 | 一种适用于恶性实体瘤肿瘤浸润t淋巴细胞的分离诱导方法 |
| CN113518635A (zh) * | 2018-12-17 | 2021-10-19 | 哈佛学院院长等 | 用于调节免疫系统的生物工程化支架及其用途 |
| JP7628499B2 (ja) * | 2019-02-27 | 2025-02-10 | 武田薬品工業株式会社 | 同種異系療法のための改良された幹細胞集団 |
| US20200318113A1 (en) * | 2019-03-05 | 2020-10-08 | MiRagen Therapeutics, Inc. | Polynucleotide conjugates and uses thereof |
| AU2020284114B2 (en) * | 2019-05-31 | 2025-06-26 | Fibrobiologics, Inc. | Concurrent activation of regenerative and tolerogenic processes by fibroblast-based compositions for the treatment of multiple sclerosis |
| AU2020293287A1 (en) * | 2019-06-14 | 2022-01-06 | FUJIFILM Cellular Dynamics, Inc. | Methods for the production of multiple lineages from induced pluripotent stem cells using charged surfaces |
| CN112094804B (zh) * | 2019-06-18 | 2024-05-14 | 中国医学科学院基础医学研究所 | 一种异质性干细胞群、其制备方法及用途 |
| EP4004191A4 (en) * | 2019-07-26 | 2022-10-12 | Brexogen Inc. | Precursor cells of induced pluripotent stem cell-derived mesenchymal stem cells and method for preparing the same |
| CN110499282B (zh) * | 2019-09-03 | 2021-05-11 | 广州赛莱拉干细胞科技股份有限公司 | 一种培养基及其应用和诱导肌腱干细胞向脂肪细胞分化的方法 |
| CN110713973B (zh) * | 2019-09-30 | 2021-05-14 | 浙江大学 | 一种诱导多能干细胞分化为间充质干细胞的培养基组合及方法 |
| CN110862983B (zh) * | 2019-11-05 | 2021-04-06 | 桂林医学院 | 一种特异靶向小鼠Gdf5基因的sgRNA导向序列及其应用 |
| CN115087730A (zh) * | 2019-11-28 | 2022-09-20 | 香港大学 | 间充质基质细胞作为ipsc诱导的重编程来源 |
| CN113018316A (zh) * | 2019-12-24 | 2021-06-25 | 厦门大学 | 多能干细胞来源的间充质干细胞在修复皮肤损伤中的应用 |
| CN111454892A (zh) * | 2020-03-12 | 2020-07-28 | 成都世联康健生物科技有限公司 | 牙间充质干细胞培养基及在牙髓干细胞内的活性验证方法 |
| CN111471648A (zh) * | 2020-04-10 | 2020-07-31 | 南京大学 | 一种预处理活化的间充质干细胞的制备方法及其在髓系白血病治疗中的应用 |
| TW202208613A (zh) * | 2020-05-05 | 2022-03-01 | 美商加速生物科學有限公司 | 非永生的多潛能幹細胞 |
| TWI806051B (zh) * | 2020-05-13 | 2023-06-21 | 長聖國際生技股份有限公司 | 生產類紅血球及/或紅血球之方法 |
| WO2021232062A1 (en) * | 2020-05-13 | 2021-11-18 | Figene, Llc | Fibroblast based therapy for treatment of parkinson's disease |
| CN111557952A (zh) * | 2020-05-28 | 2020-08-21 | 澳门大学 | 间充质干细胞在制备用于促进脂肪移植的制剂中的应用 |
| WO2022016165A2 (en) * | 2020-06-02 | 2022-01-20 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Differentiation of trophectoderm lineage cells from pluripotent stem cells |
| US20230250394A1 (en) * | 2020-06-24 | 2023-08-10 | Syracuse University | Generation of perinatal-like mesenchymal stem cells from human induced pluripotent stem cells |
| WO2022004938A1 (ko) * | 2020-06-30 | 2022-01-06 | 주식회사 미래셀바이오 | 유사 중간엽 줄기세포의 제조방법 |
| CN112359012B (zh) * | 2020-10-22 | 2022-11-25 | 中国科学院水生生物研究所 | 诱导多能干细胞分化制备心脏瓣膜内皮细胞的方法及其应用 |
| CN114504596A (zh) * | 2020-10-23 | 2022-05-17 | 厦门大学 | 多能干细胞来源的间充质干细胞在治疗银屑病中的应用 |
| CN113462642A (zh) * | 2021-08-12 | 2021-10-01 | 呈诺再生医学科技(珠海横琴新区)有限公司 | 间充质干细胞的快速诱导分化方法、试剂盒及其应用 |
| WO2023090589A1 (ko) * | 2021-11-22 | 2023-05-25 | 주식회사 미래셀바이오 | 전분화능 줄기세포 기반 과민성 면역반응에 의한 피부질환의 예방 또는 치료용 조성물 |
| CN113975298A (zh) * | 2021-11-29 | 2022-01-28 | 海南康盾生物制药有限公司 | 一种用于小儿自闭症的细胞治疗药物及其制备方法 |
| CN114438037B (zh) * | 2022-01-25 | 2024-06-04 | 深圳市乐土生物医药有限公司 | 一种制备诱导性间充质干细胞的方法 |
| CN114574436A (zh) * | 2022-05-06 | 2022-06-03 | 深圳汉盛汇融再生医学科技有限公司 | 一种治疗膝关节退行性病变的干细胞制剂及其制备方法 |
| CN115785221B (zh) * | 2022-07-11 | 2023-07-04 | 北京大学 | 一种转录因子hoxb9磷酸化位点的特异性抗体及其制备方法和应用 |
| EP4689077A2 (en) * | 2023-03-31 | 2026-02-11 | Pluristyx, Inc. | Conditionally immortalized stem cells and uses thereof |
| CN116376828B (zh) * | 2023-06-02 | 2023-08-11 | 成都云测医学生物技术有限公司 | 一种诱导CD4+T细胞生成Treg细胞的方法及应用 |
| WO2025221594A1 (en) * | 2024-04-16 | 2025-10-23 | The Regents Of The University Of California | Methods for generating dopaminergic neurons and organoids thereof |
| CN120009537B (zh) * | 2025-02-14 | 2025-12-26 | 上海安库生医生物科技有限公司 | Tacstd2蛋白在制备检测和鉴定人羊膜上皮细胞的产品中的应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102317442A (zh) * | 2008-12-17 | 2012-01-11 | 斯克里普斯研究所 | 干细胞的产生和保持 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3654090A (en) | 1968-09-24 | 1972-04-04 | Organon | Method for the determination of antigens and antibodies |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US4016043A (en) | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5981180A (en) | 1995-10-11 | 1999-11-09 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
| CA2306501C (en) | 1997-10-14 | 2011-03-29 | Luminex Corporation | Precision fluorescently dyed particles and methods of making and using same |
| ATE239801T1 (de) | 1998-01-22 | 2003-05-15 | Luminex Corp | Mikropartikel mit multiplen fluoreszenz-signalen |
| EP1108011A2 (en) | 1998-06-08 | 2001-06-20 | Osiris Therapeutics, Inc. | In vitro maintenance of hematopoietic stem cells |
| US6384105B1 (en) | 1999-04-16 | 2002-05-07 | William Marsh Rice University | Poly(Propylene Fumarate) cross linked with Poly(Ethylene Glycol) |
| US6355699B1 (en) | 1999-06-30 | 2002-03-12 | Ethicon, Inc. | Process for manufacturing biomedical foams |
| NZ535243A (en) * | 2002-03-15 | 2008-05-30 | Wicell Res Inst Inc | Method for generating primate trophoblasts |
| WO2006091766A2 (en) * | 2005-02-24 | 2006-08-31 | Jau-Nan Lee | Human trophoblast stem cells and use thereof |
| EP1937801A1 (en) * | 2005-09-02 | 2008-07-02 | Agency for Science, Technology and Research | Method of deriving mesenchymal stem cells |
| US20090304647A1 (en) * | 2008-05-30 | 2009-12-10 | The Board Of Trustees Of The University Of Illinois | Production of Neural Stem Cells from Bone Marrow Tissue and Use Thereof |
| JP2010094062A (ja) | 2008-10-15 | 2010-04-30 | Saitama Medical Univ | 間葉系幹細胞の多分化能維持用培地、培養方法、及び分化方法 |
| WO2010124290A2 (en) * | 2009-04-24 | 2010-10-28 | Whitehead Institute For Biomedical Research | Compositions and methods for deriving or culturing pluripotent cells |
| WO2011019092A1 (en) * | 2009-08-12 | 2011-02-17 | Kyoto University | Method for inducing differentiation of pluripotent stem cells into neural precursor cells |
| KR101193541B1 (ko) | 2009-08-24 | 2012-10-22 | 한국과학기술원 | 인간 배아줄기세포에서 중간엽 줄기세포로 분화시키는 방법 |
| WO2012068170A2 (en) * | 2010-11-15 | 2012-05-24 | Jau-Nan Lee | Generation of neural stem cells from human trophoblast stem cells |
| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
| SI2785359T1 (sl) | 2011-11-30 | 2018-11-30 | Astellas Institute For Regenerative Medicine | Mezenhimske stromalne celice in uporabe povezane z njimi |
-
2013
- 2013-07-11 JP JP2015521809A patent/JP6277187B2/ja active Active
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-
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- 2020-10-09 US US17/066,642 patent/US20210085725A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102317442A (zh) * | 2008-12-17 | 2012-01-11 | 斯克里普斯研究所 | 干细胞的产生和保持 |
Non-Patent Citations (1)
| Title |
|---|
| 辐射对骨髓间充质干细胞增殖分化及相关基因表达的影响;徐小雅,金慰芳,高建军,周轶,盛辉;《辐射研究与辐射工艺学报》;20090430;第27卷(第2期);第111-114页 * |
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| EP2872619B1 (en) | 2018-02-14 |
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| WO2014011881A2 (en) | 2014-01-16 |
| US9725698B2 (en) | 2017-08-08 |
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