CN104427979B - 具有特定的取代基分布的酯化的纤维素醚 - Google Patents

具有特定的取代基分布的酯化的纤维素醚 Download PDF

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Publication number
CN104427979B
CN104427979B CN201280072177.1A CN201280072177A CN104427979B CN 104427979 B CN104427979 B CN 104427979B CN 201280072177 A CN201280072177 A CN 201280072177A CN 104427979 B CN104427979 B CN 104427979B
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methyl
groups
hydroxypropyl
glucoside unit
substituted
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Expired - Fee Related
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Chinese (zh)
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CN104427979A (zh
Inventor
R·L·施米特
R·L·萨姆勒
M·布拉克哈根
O·彼得曼
R·阿登
N·S·格拉斯曼
S·J·吉劳多
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Dow Global Technologies LLC
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Dow Global Technologies LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/193—Mixed ethers, i.e. ethers with two or more different etherifying groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B13/00—Preparation of cellulose ether-esters

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
CN201280072177.1A 2012-04-11 2012-10-24 具有特定的取代基分布的酯化的纤维素醚 Expired - Fee Related CN104427979B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261622754P 2012-04-11 2012-04-11
US61/622,754 2012-04-11
PCT/US2012/061586 WO2013154607A1 (en) 2012-04-11 2012-10-24 Esterified cellulose ethers having a specific substituent distribution

Publications (2)

Publication Number Publication Date
CN104427979A CN104427979A (zh) 2015-03-18
CN104427979B true CN104427979B (zh) 2018-02-16

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Country Status (6)

Country Link
US (1) US9320799B2 (cg-RX-API-DMAC10.html)
EP (1) EP2836205B1 (cg-RX-API-DMAC10.html)
JP (1) JP6133969B2 (cg-RX-API-DMAC10.html)
KR (1) KR20140146181A (cg-RX-API-DMAC10.html)
CN (1) CN104427979B (cg-RX-API-DMAC10.html)
WO (1) WO2013154607A1 (cg-RX-API-DMAC10.html)

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JP6456849B2 (ja) 2013-03-01 2019-01-23 ハーキュリーズ・インコーポレーテッドＨｅｒｃｕｌｅｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 高められた性能及び改善された加工性を有する医薬組成物
CN105025887B (zh) * 2013-03-07 2017-07-28 陶氏环球技术有限责任公司 新颖极低粘度酯化纤维素醚
JP6334574B2 (ja) * 2013-03-07 2018-05-30 ダウ グローバル テクノロジーズ エルエルシー 新規の超高分子量のエステル化セルロースエーテル
EP2997046B1 (en) * 2013-05-14 2019-09-25 Dow Global Technologies LLC Cellulose ethers esterified with dicarboxylic acids
KR102286952B1 (ko) * 2013-12-31 2021-08-09 롯데정밀화학 주식회사 입도분포가 조절된 히드록시프로필 메틸셀룰로오스 아세테이트 숙시네이트(hpmcas) 입자의 제조방법 및 hpmcas 분말
WO2015126576A1 (en) * 2014-02-20 2015-08-27 Dow Global Technologies Llc Novel esterified cellulose ethers of high molecular weight and homogeneity
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JP6203702B2 (ja) * 2014-11-18 2017-09-27 信越化学工業株式会社 ヒプロメロース酢酸エステルコハク酸エステルを用いたスプレードライ用溶液及び固体分散体の製造方法
JP6356923B2 (ja) * 2015-03-16 2018-07-11 ダウ グローバル テクノロジーズ エルエルシー 水溶性エステル化セルロースエーテル
MX2017011095A (es) 2015-03-16 2017-11-10 Dow Global Technologies Llc Eteres de celulosa esterificados solubles en agua que tienen grado bajo de neutralizacion.
MX2017011128A (es) * 2015-03-16 2017-11-28 Dow Global Technologies Llc Eteres de celulosa esterificada de gelificacion.
BR112017018146A2 (pt) * 2015-03-16 2018-04-10 Dow Global Technologies Llc processo para a preparação de um éter de celulose esterificado na presença de um ácido carboxílico alifático
WO2016148970A1 (en) * 2015-03-16 2016-09-22 Dow Global Technologies Llc Aqueous solution of an esterified cellulose ether
CN107567462B (zh) * 2015-05-15 2020-10-16 陶氏环球技术有限责任公司 用于制造具有极高分子量和低粘度的酯化纤维素醚的方法
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US20180273646A1 (en) * 2015-09-24 2018-09-27 Dow Global Technologies Llc. Process for preparing an ester of a cellulose ether in the presence of acetic acid and a reaction catalyst
BR112018005463A2 (pt) * 2015-10-02 2018-10-09 Dow Global Technologies Llc composição aquosa compreendendo éter de celulose esterificado disperso
US9884922B2 (en) * 2016-03-11 2018-02-06 Shin-Etsu Chemical Co., Ltd. Hypromellose acetate succinate, method for producing the same and composition containing the same
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WO2018170060A1 (en) * 2017-03-17 2018-09-20 Dow Global Technologies Llc Process for recovering an esterified cellulose ether from a reaction product mixture
MX2019013469A (es) * 2017-08-16 2020-02-07 Dow Global Technologies Llc Metodo para la preparacion controlada de eter de celulosa de bajo peso molecular.
JP7526727B2 (ja) * 2018-12-18 2024-08-01 ニュートリション アンド バイオサイエンシズ ユーエスエー １，リミティド ライアビリティ カンパニー ヒドロキシアルキルメチルセルロースを含む徐放性組成物
US11819503B2 (en) 2019-04-23 2023-11-21 F2G Ltd Method of treating coccidioides infection
JP7128782B2 (ja) 2019-08-09 2022-08-31 信越化学工業株式会社 エアゾール食品用組成物、ヒドロキシプロピルメチルセルロース及びヒドロキシプロピルメチルセルロースの製造方法
CN112704671B (zh) * 2020-12-28 2022-04-19 普洛药业股份有限公司 一种阿莫西林克拉维酸钾胶囊及其制备方法
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Publication number Publication date
KR20140146181A (ko) 2014-12-24
CN104427979A (zh) 2015-03-18
JP2015521209A (ja) 2015-07-27
EP2836205B1 (en) 2016-10-19
JP6133969B2 (ja) 2017-05-24
US20150065547A1 (en) 2015-03-05
US9320799B2 (en) 2016-04-26
WO2013154607A1 (en) 2013-10-17
EP2836205A1 (en) 2015-02-18

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