CN104383116B - 一种黑果枸杞片剂 - Google Patents
一种黑果枸杞片剂 Download PDFInfo
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Abstract
本发明涉及一种枸杞片剂，尤其是涉及一种黑果枸杞片剂，其特征在于：该片剂是将黑果枸杞冻干粉与越桔提取物、糊精、微晶纤维素、羧甲基淀粉钠和硬脂酸镁以重量份数比为4～7：1～3：0.3～0.6：0.1～0.3：0.1～0.4：0.1～0.4混合后制粒，最后干燥后压片即可；原料制作方法独特、提高了黑果枸杞功效成分花色苷的含量，利于黑果枸杞花色苷的长期保存、并能有效保持黑果枸杞功效成分的活性，具有抗疲劳、降血压、降血脂、美容养颜等作用，适用于高血脂患者及妇女血瘀腹痛、面色枯槁、营养不良者。
Description
技术领域
本发明涉及一种枸杞片剂，尤其是涉及一种黑果枸杞片剂。
背景技术
花色苷是含多个酚羟基的黄酮类化合物，是羟基供体，能将氢供给脂类化合物自由基，自身转变成酚基自由基。酚基自由基能够降低自动氧化链反应的传递速度，从而引起了抑制脂类进一步被氧化的作用。流行病学调查发现，长期摄入富含花色苷的食物，显示出抗炎、保护心血管、抗肿瘤等多种生物活性。尤其是明显降低动脉粥样硬化（AS）等心血管疾病的发病率，揭示花色苷可能具有潜在的抗AS作用。许多富含花色苷的物质如蓝莓、葡萄皮、紫薯、紫甘蓝等在国外已经得到了研究或开发利用。
枸杞养生历史由来已久，如今更受到专家学者的高度重视。黑果枸杞称“旁玛”，为茄科枸杞属植物。果实成熟后呈紫黑色，《四部医典》、《晶珠本草》等藏医药经典著作称黑果枸杞味甘、性平，清心热，用于治疗心热病、心脏病、月经不调、停经等病症。
现代医学及营养学表明，黑果枸杞，果实黑色，富含天然活性成分—花色苷，含量高达4.1%，且花色苷结构独特，具有抗癌、降血脂、降血压等多种功效。花色苷类化合物特别是其抗氧化、抗衰老、预防心脑血管疾病的显著作用，使其成为当前天然产物研究的一个热点和焦点之一。
但目前市场上黑果枸杞花色苷的保健产品极少。
发明内容
本发明的目的主要是克服现有技术的不足，提供一种原料制作方法独特、提高了黑果枸杞功效成分花色苷的含量，利于黑果枸杞花色苷的长期保存、并能有效保持黑果枸杞功效成分的活性，具有抗疲劳、降血压、降血脂、美容养颜等作用，适用于高血脂患者及妇女血瘀腹痛、面色枯槁、营养不良者的一种黑果枸杞片剂。
本发明通过如下方式实现：
一种黑果枸杞片剂，其特征在于：该片剂是将黑果枸杞冻干粉与越桔提取物、糊精、微晶纤维素、羧甲基淀粉钠和硬脂酸镁以重量份数比为4～7：1～3：0.3～0.6：0.1～0.3：0.1～0.4：0.1～0.4混合后制粒，最后干燥后压片即可；
所述黑果枸杞冻干粉将除杂的黑果枸杞用中药粉碎机粉碎，将粉碎的黑果枸杞采用80%的食用酒精或醋酸调至pH3-pH4溶液于进行超声波提取，料液比为1:20、超声波功率250W、频率40kHz，提取10min，重复三次，合并滤液过滤，滤液低于40℃减压浓缩至膏状，将经过预处理的XAD-7大孔吸附树脂装填于层析柱中，将质量浓度为1.0mg/mL的黑果枸杞花色苷提取液以1.0mL/min流速上样，当树脂吸附饱和时，停止上样，先用一定体积的蒸馏水冲洗层析柱，除去糖、酸等杂质，然后用含1.0%醋酸的食用酒精洗脱，自动部分收集器收集，合并颜色较深收集液，减压浓缩，得到纯化的黑果枸杞花色苷浓缩物，低于40℃减压浓缩后冷冻干燥即可；
所述越桔提取物中花色苷的质量百分含量为10%；
所述中药粉碎机粉碎的粒度为100目；
所述所得干燥粉中花色苷的质量百分含量≥50%。
本发明具有如下效果：
1）原料制作方法独特：本发明以黑果枸杞为君，辅以淀粉、微晶纤维素等，制得黑果枸杞片剂，具体方法如下：将除杂的黑果枸杞用中药粉碎机粉碎，将粉碎的黑果枸杞采用80%的食用酒精或醋酸调至pH3-pH4溶液于进行超声波提取，料液比为1:20、超声波功率250W、频率40kHz，提取10min，重复三次，合并滤液过滤，滤液低于40℃减压浓缩至膏状。将经过预处理的XAD-7大孔吸附树脂装填于层析柱中，将质量浓度为1.0mg/mL的黑果枸杞花色苷提取液以1.0mL/min流速上样，当树脂吸附饱和时，停止上样，先用一定体积的蒸馏水冲洗层析柱，除去糖、酸等杂质，然后用含1.0%醋酸的食用酒精洗脱，自动部分收集器收集。合并颜色较深收集液，减压浓缩，得到纯化的黑果枸杞花色苷浓缩物，低于40℃减压浓缩后冷冻干燥。干燥粉中花色苷含量≥50%，将所得黑果枸杞冻干粉与越桔提取物，花色苷含量10%、糊精、微晶纤维素、羧甲基淀粉钠、硬脂酸镁等混合制粒：混合比例为4～7：1～3：0.3～0.6：0.1～0.3：0.1～0.4：0.1～0.4。干燥后压片。
2）本发明提供的黑果枸杞片剂具有方便服用、保留功能成分活性、产品不易氧化变质、复水性好等特点。
3）本发明提供的黑果枸杞片剂提高了黑果枸杞功效成分花色苷的含量，利于黑果枸杞花色苷的长期保存、并能有效保持黑果枸杞功效成分的活性。经功能试验证明，具有抗疲劳、降血压、降血脂、美容养颜等作用。
4）本发明提供的黑果枸杞片剂适用于高血脂患者及妇女血瘀腹痛、面色枯槁、营养不良者。
具体实施方式
实施例一：一种黑果枸杞片剂，该片剂是将黑果枸杞冻干粉与越桔提取物、糊精、微晶纤维素、羧甲基淀粉钠和硬脂酸镁以重量份数比为4：3：0.3：0.1：0.1：0.4混合后制粒，最后干燥后压片即可。
实施例二：一种黑果枸杞片剂，该片剂是将黑果枸杞冻干粉与越桔提取物、糊精、微晶纤维素、羧甲基淀粉钠和硬脂酸镁以重量份数比为7：1：0.6：0.3：0.4：0.1混合后制粒，最后干燥后压片即可。
实施例三：一种黑果枸杞片剂，该片剂是将黑果枸杞冻干粉与越桔提取物、糊精、微晶纤维素、羧甲基淀粉钠和硬脂酸镁以重量份数比为６：２：0.４：0.２：0.３：0.３混合后制粒，最后干燥后压片即可。
实施例四：一种黑果枸杞片剂，该片剂是将黑果枸杞冻干粉与越桔提取物、糊精、微晶纤维素、羧甲基淀粉钠和硬脂酸镁以重量份数比为５：２.５：0.５：0.２５：0.２：0.２混合后制粒，最后干燥后压片即可。
上述黑果枸杞冻干粉将除杂的黑果枸杞用中药粉碎机粉碎，将粉碎的黑果枸杞采用80%的食用酒精或醋酸调至pH3-pH4溶液于进行超声波提取，料液比为1:20、超声波功率250W、频率40kHz，提取10min，重复三次，合并滤液过滤，滤液低于40℃减压浓缩至膏状，将经过预处理的XAD-7大孔吸附树脂装填于层析柱中，将质量浓度为1.0mg/mL的黑果枸杞花色苷提取液以1.0mL/min流速上样，当树脂吸附饱和时，停止上样，先用一定体积的蒸馏水冲洗层析柱，除去糖、酸等杂质，然后用含1.0%醋酸的食用酒精洗脱，自动部分收集器收集，合并颜色较深收集液，减压浓缩，得到纯化的黑果枸杞花色苷浓缩物，低于40℃减压浓缩后冷冻干燥即可。冷冻干燥粉中花色苷含量≥50%。上述食用酒精或醋酸的浓度为质量浓度。
上述越桔提取物中花色苷的质量百分含量为10%。
上述中药粉碎机粉碎的粒度为100目。
上述所得干燥粉中花色苷的质量百分含量≥50%。
Claims (4)
1.一种黑果枸杞片剂，其特征在于：该片剂是将黑果枸杞冻干粉与越桔提取物、糊精、微晶纤维素、羧甲基淀粉钠和硬脂酸镁以重量份数比为4～7：1～3：0.3～0.6：0.1～0.3：0.1～0.4：0.1～0.4混合后制粒，最后干燥后压片即可，所述黑果枸杞冻干粉将除杂的黑果枸杞用中药粉碎机粉碎，将粉碎的黑果枸杞采用80%的食用酒精或醋酸调至pH3-pH4溶液于进行超声波提取，料液比为1:20、超声波功率250W、频率40kHz，提取10min，重复三次，合并滤液过滤，滤液低于40℃减压浓缩至膏状，将经过预处理的XAD-7大孔吸附树脂装填于层析柱中，将质量浓度为1.0mg/mL的黑果枸杞花色苷提取液以1.0mL/min流速上样，当树脂吸附饱和时，停止上样，先用一定体积的蒸馏水冲洗层析柱，除去糖、酸等杂质，然后用含1.0%醋酸的食用酒精洗脱，自动部分收集器收集，合并颜色较深收集液，减压浓缩，得到纯化的黑果枸杞花色苷浓缩物，低于40℃减压浓缩后冷冻干燥即可。
2.如权利要求1所述的一种黑果枸杞片剂，其特征在于：所述越桔提取物中花色苷的质量百分含量为10%。
3.如权利要求1所述的一种黑果枸杞片剂，其特征在于：所述中药粉碎机粉碎的粒度为100目。
4.如权利要求1所述的一种黑果枸杞片剂，其特征在于：所述所得干燥粉中花色苷的质量百分含量≥50%。
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| CN104957630A (zh) * | 2015-06-17 | 2015-10-07 | 蚌埠市天星树脂有限责任公司 | 一种美容养颜保健药品原药提取所用树脂及其制备方法 |
| CN105105123B (zh) * | 2015-09-06 | 2017-11-21 | 青海之也科技咨询服务有限公司 | 一种黑果枸杞保健片及其制备方法 |
| FR3042413B1 (fr) * | 2015-10-20 | 2019-07-12 | Valbiotis | Composition comprenant un melange de molecules extraites de chrysanthellum indicum et de cynara scolymus et utilisation pour agir sur le metabolisme glucidique et/ou lipidique |
| CN105231447B (zh) * | 2015-10-28 | 2018-05-18 | 青海之也科技咨询服务有限公司 | 一种缓解眼疲劳的黑果枸杞保健片 |
| CN105961792A (zh) * | 2016-04-11 | 2016-09-28 | 甘肃大禹黑枸杞农业科技有限公司 | 一种黑果枸杞压片糖果 |
| CN109259009A (zh) * | 2017-07-17 | 2019-01-25 | 宁夏中宁县尚江南枸杞制品有限公司 | 一种枸杞汁的制备方法 |
| CN108185438A (zh) * | 2017-12-22 | 2018-06-22 | 中国科学院西北高原生物研究所 | 黑果枸杞粉压片及其制备工艺 |
| CN108497378A (zh) * | 2018-03-02 | 2018-09-07 | 中国科学院过程工程研究所 | 一种黑果枸杞速溶粉及其制备方法和用途 |
| CN110227149A (zh) * | 2019-07-15 | 2019-09-13 | 广东省阳春市信德生物科技发展有限公司 | 一种美白养颜片剂 |
| CN110464012A (zh) * | 2019-09-20 | 2019-11-19 | 宁夏农林科学院枸杞工程技术研究所 | 一种枸杞花色苷糖肽片的制备方法 |
| CN111617163A (zh) * | 2020-07-06 | 2020-09-04 | 新疆医科大学 | 黑果枸杞分散片及其配方和制备方法 |
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| CN103230473A (zh) * | 2013-02-28 | 2013-08-07 | 上海基赛生物医药科技有限公司 | 黑枸杞有效提取物、提取方法以及提取物应用 |
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