CN104379564B - 通过2,2-二氟乙胺的烷基化制备2,2-二氟乙胺衍生物的方法 - Google Patents
通过2,2-二氟乙胺的烷基化制备2,2-二氟乙胺衍生物的方法 Download PDFInfo
- Publication number
- CN104379564B CN104379564B CN201380033732.4A CN201380033732A CN104379564B CN 104379564 B CN104379564 B CN 104379564B CN 201380033732 A CN201380033732 A CN 201380033732A CN 104379564 B CN104379564 B CN 104379564B
- Authority
- CN
- China
- Prior art keywords
- difluoroethylamine
- formula
- pyridin
- chlorine
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- TUGMELZNXQMNLE-QURAEUELSA-N C[C@](CN)(C1CC(N)N)C1S Chemical compound C[C@](CN)(C1CC(N)N)C1S TUGMELZNXQMNLE-QURAEUELSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12174277.9 | 2012-06-29 | ||
| EP12174277 | 2012-06-29 | ||
| PCT/EP2013/063116 WO2014001245A1 (de) | 2012-06-29 | 2013-06-24 | Verfahren zur herstellung von 2,2-difluorethylamin-derivaten durch alkylierung von 2,2-difluorethylamin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104379564A CN104379564A (zh) | 2015-02-25 |
| CN104379564B true CN104379564B (zh) | 2016-08-24 |
Family
ID=48670571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380033732.4A Active CN104379564B (zh) | 2012-06-29 | 2013-06-24 | 通过2,2-二氟乙胺的烷基化制备2,2-二氟乙胺衍生物的方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9376389B2 (https=) |
| EP (1) | EP2867208B1 (https=) |
| JP (1) | JP6175136B2 (https=) |
| KR (1) | KR20150032537A (https=) |
| CN (1) | CN104379564B (https=) |
| BR (1) | BR112014032479B1 (https=) |
| DK (1) | DK2867208T3 (https=) |
| ES (1) | ES2603287T3 (https=) |
| IL (1) | IL236257A (https=) |
| IN (1) | IN2014DN10440A (https=) |
| MX (1) | MX361289B (https=) |
| TW (1) | TWI593677B (https=) |
| WO (1) | WO2014001245A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6533233B2 (ja) * | 2014-03-21 | 2019-06-19 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | ２，２−ジフルオロエチルアミンをアルキル化することによりｎ−［（６−クロロピリジノ−３−イル）メチル］−２，２−ジフルオロエタン−１−アミンを調製する方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001046170A1 (en) * | 1999-12-20 | 2001-06-28 | Astrazeneca Ab | Amidine derivatives which are inhibitors of nitric oxide synthase |
| CN101466705A (zh) * | 2006-03-31 | 2009-06-24 | 拜尔农作物科学股份公司 | 被取代的烯氨羰基化合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4821849B2 (ja) | 2006-04-10 | 2011-11-24 | 株式会社村田製作所 | 複合基板及び複合基板の製造方法 |
| DE102006033572A1 (de) * | 2006-07-20 | 2008-01-24 | Bayer Cropscience Ag | N'-Cyano-N-halogenalkyl-imidamid Derivate |
| EP2039684A1 (de) * | 2007-09-18 | 2009-03-25 | Bayer CropScience AG | Verfahren zur Herstellung von 2,2-Difluorethylamin-Derivaten durch Imin-Hydrierung |
| KR101565391B1 (ko) | 2007-09-18 | 2015-11-03 | 바이엘 크롭사이언스 악티엔게젤샤프트 | 아미드 수소화에 의한 2,2-디플루오로에틸아민 유도체의 제조방법 |
| EP2230231A1 (de) * | 2009-03-16 | 2010-09-22 | Bayer CropScience AG | Verfahren zur Herstellung von 2,2-Difluorethylamin-Derivaten durch Imin-Hydrierung |
| EP2582673B1 (de) * | 2010-06-15 | 2014-08-06 | Bayer Intellectual Property GmbH | Verfahren zur herstellung von 2,2-difluorethylamin-derivaten durch alkylierung mit 2,2- difluor-1-halogenethanen |
| WO2012062740A1 (de) * | 2010-11-12 | 2012-05-18 | Bayer Cropscience Ag | Verfahren zur herstellung von 2,2-difluorethylamin-derivaten ausgehend von n-(2,2-difluorethyl)prop-2-en-1-amin |
-
2013
- 2013-06-24 CN CN201380033732.4A patent/CN104379564B/zh active Active
- 2013-06-24 WO PCT/EP2013/063116 patent/WO2014001245A1/de not_active Ceased
- 2013-06-24 JP JP2015519021A patent/JP6175136B2/ja active Active
- 2013-06-24 EP EP13730578.5A patent/EP2867208B1/de active Active
- 2013-06-24 IN IN10440DEN2014 patent/IN2014DN10440A/en unknown
- 2013-06-24 DK DK13730578.5T patent/DK2867208T3/en active
- 2013-06-24 US US14/411,173 patent/US9376389B2/en active Active
- 2013-06-24 KR KR20147036103A patent/KR20150032537A/ko not_active Ceased
- 2013-06-24 ES ES13730578.5T patent/ES2603287T3/es active Active
- 2013-06-24 BR BR112014032479-4A patent/BR112014032479B1/pt active IP Right Grant
- 2013-06-24 MX MX2014015622A patent/MX361289B/es active IP Right Grant
- 2013-06-28 TW TW102123118A patent/TWI593677B/zh not_active IP Right Cessation
-
2014
- 2014-12-15 IL IL236257A patent/IL236257A/en active IP Right Grant
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001046170A1 (en) * | 1999-12-20 | 2001-06-28 | Astrazeneca Ab | Amidine derivatives which are inhibitors of nitric oxide synthase |
| CN101466705A (zh) * | 2006-03-31 | 2009-06-24 | 拜尔农作物科学股份公司 | 被取代的烯氨羰基化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104379564A (zh) | 2015-02-25 |
| IN2014DN10440A (https=) | 2015-08-21 |
| JP2015522574A (ja) | 2015-08-06 |
| JP6175136B2 (ja) | 2017-08-02 |
| ES2603287T3 (es) | 2017-02-24 |
| BR112014032479A2 (pt) | 2017-06-27 |
| EP2867208A1 (de) | 2015-05-06 |
| BR112014032479B1 (pt) | 2020-03-10 |
| IL236257A (en) | 2016-11-30 |
| DK2867208T3 (en) | 2016-12-05 |
| MX2014015622A (es) | 2015-03-20 |
| EP2867208B1 (de) | 2016-08-24 |
| KR20150032537A (ko) | 2015-03-26 |
| WO2014001245A1 (de) | 2014-01-03 |
| IL236257A0 (en) | 2015-02-26 |
| MX361289B (es) | 2018-12-03 |
| TWI593677B (zh) | 2017-08-01 |
| TW201408639A (zh) | 2014-03-01 |
| US20150322011A1 (en) | 2015-11-12 |
| US9376389B2 (en) | 2016-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |