ES2603287T3 - Procedimiento para preparar derivados de 2,2-difluoroetilamina por alquilación de 2,2-difluoroetilamina - Google Patents

Procedimiento para preparar derivados de 2,2-difluoroetilamina por alquilación de 2,2-difluoroetilamina Download PDF

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Publication number
ES2603287T3
ES2603287T3 ES13730578.5T ES13730578T ES2603287T3 ES 2603287 T3 ES2603287 T3 ES 2603287T3 ES 13730578 T ES13730578 T ES 13730578T ES 2603287 T3 ES2603287 T3 ES 2603287T3
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ES
Spain
Prior art keywords
chlorine
formula
fluorine
difluoroethylamine
bromine
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES13730578.5T
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English (en)
Inventor
Christian Funke
Norbert Lui
Rafael Warsitz
Albert Schnatterer
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Bayer CropScience AG
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Bayer CropScience AG
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Publication of ES2603287T3 publication Critical patent/ES2603287T3/es
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Procedimiento para preparar una 2,2-difluoroetilamina de fórmula (III)**Fórmula** en el que la 2,2-difluoroetilamina de fórmula (I)**Fórmula** se hace reaccionar con un haluro de fórmula (II)**Fórmula** donde Hal representa cloro, bromo o yodo, en presencia de diisopropiletilamina, donde en las fórmulas (II) y (III) A representa un radical pirid-2-ilo, pirid-10 4-ilo o pirid-3-ilo de los que cada uno puede estar sustituido en la posición 6 con flúor, cloro, bromo, metilo, trifluorometilo o trifluorometoxi, o representa piridazin-3-ilo, que puede estar sustituido en la posición 6 con cloro o metilo, o representa un radical pirazin-3-ilo, 2- cloropirazin-5-ilo o 1,3-tiazol-5-ilo que pueden estar sustituidos en cada caso en la posición 2 con cloro o metilo, o representa un radical pirimidinilo, pirazolilo, tiofenilo, oxazolilo, isoxazolilo, 1,2,4-oxadiazolilo, isotiazolilo, 1,2,4-triazolilo o 1,2,5-tiadiazolilo que pueden estar sustituidos con flúor, cloro, bromo, ciano, nitro, alquilo C1-C4 dado el caso sustituido con flúor y/o cloro, alquiltio C1-C3 dado el caso sustituido con flúor y/o cloro, o alquilsulfonilo C1-C3 dado el caso sustituido con flúor y/o cloro, o representa un pirid-3-ilo de la siguiente fórmula**Fórmula** donde X representa flúor, cloro, bromo, yodo, alquilo C1-C6 o haloalquilo C1-C6 y Y representa flúor, cloro, bromo, yodo, alquilo C1-C6, haloalquilo C1-C6, haloalcoxi C1-C6, azido o ciano.

Description

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Claims (1)

  1. imagen1
ES13730578.5T 2012-06-29 2013-06-24 Procedimiento para preparar derivados de 2,2-difluoroetilamina por alquilación de 2,2-difluoroetilamina Active ES2603287T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12174277 2012-06-29
EP12174277 2012-06-29
PCT/EP2013/063116 WO2014001245A1 (de) 2012-06-29 2013-06-24 Verfahren zur herstellung von 2,2-difluorethylamin-derivaten durch alkylierung von 2,2-difluorethylamin

Publications (1)

Publication Number Publication Date
ES2603287T3 true ES2603287T3 (es) 2017-02-24

Family

ID=48670571

Family Applications (1)

Application Number Title Priority Date Filing Date
ES13730578.5T Active ES2603287T3 (es) 2012-06-29 2013-06-24 Procedimiento para preparar derivados de 2,2-difluoroetilamina por alquilación de 2,2-difluoroetilamina

Country Status (13)

Country Link
US (1) US9376389B2 (es)
EP (1) EP2867208B1 (es)
JP (1) JP6175136B2 (es)
KR (1) KR20150032537A (es)
CN (1) CN104379564B (es)
BR (1) BR112014032479B1 (es)
DK (1) DK2867208T3 (es)
ES (1) ES2603287T3 (es)
IL (1) IL236257A (es)
IN (1) IN2014DN10440A (es)
MX (1) MX361289B (es)
TW (1) TWI593677B (es)
WO (1) WO2014001245A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102360975B1 (ko) * 2014-03-21 2022-02-08 바이엘 크롭사이언스 악티엔게젤샤프트 2,2-디플루오로에틸아민의 알킬화에 의한 n-[(6-클로로피리딘-3-일)메틸]-2,2-디플루오로에탄-1-아민의 제조 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9904676D0 (sv) * 1999-12-20 1999-12-20 Astra Ab Novel compounds
DE102006015467A1 (de) * 2006-03-31 2007-10-04 Bayer Cropscience Ag Substituierte Enaminocarbonylverbindungen
WO2007116544A1 (ja) 2006-04-10 2007-10-18 Murata Manufacturing Co., Ltd. 複合基板及び複合基板の製造方法
DE102006033572A1 (de) * 2006-07-20 2008-01-24 Bayer Cropscience Ag N'-Cyano-N-halogenalkyl-imidamid Derivate
JP5329547B2 (ja) * 2007-09-18 2013-10-30 バイエル・クロップサイエンス・アーゲー アミドの水素化により２，２−ジフルオロエチルアミン誘導体を調製する方法
EP2039684A1 (de) 2007-09-18 2009-03-25 Bayer CropScience AG Verfahren zur Herstellung von 2,2-Difluorethylamin-Derivaten durch Imin-Hydrierung
EP2230231A1 (de) * 2009-03-16 2010-09-22 Bayer CropScience AG Verfahren zur Herstellung von 2,2-Difluorethylamin-Derivaten durch Imin-Hydrierung
KR101790159B1 (ko) * 2010-06-15 2017-10-25 바이엘 인텔렉쳐 프로퍼티 게엠베하 2,2-디플루오로-1-할로에탄의 알킬화에 의한 2,2-디플루오로에틸아민 유도체의 제조 방법
CN103313969A (zh) * 2010-11-12 2013-09-18 拜耳知识产权有限责任公司 用于由n-(2，2-二氟乙基)丙-2-烯-1-胺起始制备2，2-二氟乙基胺衍生物的方法

Also Published As

Publication number Publication date
MX361289B (es) 2018-12-03
MX2014015622A (es) 2015-03-20
IL236257A (en) 2016-11-30
IL236257A0 (en) 2015-02-26
BR112014032479A2 (pt) 2017-06-27
CN104379564B (zh) 2016-08-24
DK2867208T3 (en) 2016-12-05
JP2015522574A (ja) 2015-08-06
BR112014032479B1 (pt) 2020-03-10
EP2867208A1 (de) 2015-05-06
TWI593677B (zh) 2017-08-01
CN104379564A (zh) 2015-02-25
IN2014DN10440A (es) 2015-08-21
TW201408639A (zh) 2014-03-01
JP6175136B2 (ja) 2017-08-02
KR20150032537A (ko) 2015-03-26
WO2014001245A1 (de) 2014-01-03
US9376389B2 (en) 2016-06-28
US20150322011A1 (en) 2015-11-12
EP2867208B1 (de) 2016-08-24

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