CN104352984A - 一种适用于热毒炽盛型的肺抑瘤膏及其制备方法 - Google Patents
一种适用于热毒炽盛型的肺抑瘤膏及其制备方法 Download PDFInfo
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- CN104352984A CN104352984A CN201410668907.5A CN201410668907A CN104352984A CN 104352984 A CN104352984 A CN 104352984A CN 201410668907 A CN201410668907 A CN 201410668907A CN 104352984 A CN104352984 A CN 104352984A
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Abstract
本发明涉及一种适用于热毒炽盛型的肺抑瘤膏及其制备方法,肺抑瘤膏的原料药成分如下:党参,黄芪,炒白术,云苓,蛇舌草,半枝莲,薏苡仁,浙贝,夏枯草,山慈菇,莪术,蜂房,黄精,甘草;金银花,黄芩,生石膏,羚羊粉。本发明所述的适用于热毒炽盛型的肺抑瘤膏,配伍合理,组方严谨,药精力专,符合中医药理论,诸药合用,共奏益气养阴,清热解毒,化痰散瘀,去积除痞,具有抑癌抗瘤之效。
Description
技术领域
本发明涉及一种适用于热毒炽盛型的肺抑瘤膏及其制备方法,属于中医药技术领域。
背景技术
肺癌为当前世界各地最常见的恶性肿瘤之一,严重威胁着人类的健康和生命。肺癌患者在确诊时绝大多数已属中晚期,应用单一治疗方法均难以获得满意疗效。目前,包括中医药在内的综合治疗已经显示出较好的疗效,中医药治疗肿瘤是我国的特色和优势,通过辨证论治配合化疗等可以起到减毒增效,带瘤延年的良好效果。
现代医学模式已经开始由生物医学模式向生物-心理-社会医学模式转变,由此,肿瘤的治疗思路也已不再是单纯的追求杀灭肿瘤细胞,消灭或缩小肿瘤实体,而是同时改善患者的生理及心理症状,提高患者生存质量,生存质量这一新的健康指标日益受到人们的重视。随着中医对肺癌治疗的不断探索,临床及实验研究进展迅速,中医在改善肺癌患者临床症状、减毒增效、提高患者生存质量、延长生存期等方面的疗效得以肯定,而中医药的疗效也从分子水平和基因水平方面得到一定的证实。中医药对肺癌的治疗与西医相比,它的缩瘤作用弱于放化疗,但副反应少,同时具有瘤体稳定率高、恶化率低等特点,具有较好的提高生存质量,延长生存期,改善临床症状等作用。
经多年临床经验发现,该病基本病机以气阴两虚,血瘀、痰凝、毒聚贯穿于疾病的始终。中医认为化疗药物是一种火热毒邪,进入人体后能对抗抑制癌瘤毒邪(肿瘤细胞),同时又导致脾胃功能失调(消化道反应),气血损伤(骨髓造血系统损伤)以及肝肾亏损(肝肾功能损伤)等病理变化,故肺癌患者在化疗期间本虚更为突出,标实之征象亦趋明显。肺抑瘤合剂以益气养阴,清热解毒,化痰散瘀中药组成,切合肺癌病机实际,将攻补融为一体,使补而不助邪,攻而不伤正。全方扶正祛邪,攻补兼施,起到了增强肺癌患者自身抗癌能力,提高机体免疫力,抑瘤抗癌的作用,同时在化疗进程中能够减毒增效,辅助化疗顺利的完成。如中国文献《郑心教授肺康方加减治疗肺癌》(《实用中医内科杂志》,2012年02期)一文,公开了病机为本虚标实,以气阴两虚为本,痰瘀毒热为标。当辨证与辨病,扶正与祛邪,整体与局部相结合,以益气养阴为治本之要,分阴虚内热、气滞血瘀、毒热炽盛、脾虚痰湿、气阴两虚五型,自拟肺康方加减或加化疗、放疗等,疗效可靠,能缩小肿块,不仅可以减轻症状,提高有效率,还可能提高生存质量,延长生存期。该文中提及肺康方如下:党参24g,黄芪18g,炒白术12g,云苓15g,麦冬20g,蛇舌草24g,半枝莲24g,薏苡仁30g,浙贝母15g,贯众15g,夏枯草18g,女贞子21g,山慈菇21g,莪术18g,蜂房15g,甘草6g;并提及热毒炽盛型增加连翘12g,鱼腥草18g,炙百部12g。
但上述方剂中,连翘、鱼腥草、炙百部重在止咳祛痰排脓,清热解毒力弱,对于热毒炽盛型病症效果不佳。
发明内容
本发明针对现有技术的不足,提供一种适用于热毒炽盛型的肺抑瘤膏及其制备方法。
一种适用于热毒炽盛型的肺抑瘤中药组合物,原料药成分如下,均为重量份:
处方:党参21~27份,黄芪15~21份,炒白术9~15份,云苓12~18份,蛇舌草21~27份,半枝莲21~27份,薏苡仁27~33份,浙贝12~18份,夏枯草15~21份,山慈菇18~24份,莪术15~21份,蜂房12~18份,黄精18~24份,甘草3~9份;
随症加入:金银花15~21份,黄芩12~18份,生石膏18~24份,羚羊粉3份。
根据本发明优选的,所述肺抑瘤中药组合物,原料药成分如下,均为重量份:
处方:党参24份,黄芪18份,炒白术12份,云苓15份,蛇舌草24份,半枝莲24份,薏苡仁30份,浙贝15份,夏枯草18份,山慈菇21份,莪术18份,蜂房15份,黄精21份,甘草6份;
随症加入:金银花18份,黄芩15份,生石膏21份,羚羊粉3份。
一种适用于热毒炽盛型的肺抑瘤膏,原料药成分如下,均为重量份:
处方:党参21~27份,黄芪15~21份,炒白术9~15份,云苓12~18份,蛇舌草21~27份,半枝莲21~27份,薏苡仁27~33份,浙贝12~18份,夏枯草15~21份,山慈菇18~24份,莪术15~21份,蜂房12~18份,黄精18~24份,甘草3~9份;
随症加入:金银花15~21份,黄芩12~18份,生石膏18~24份,羚羊粉3份。
根据本发明优选的,所述肺抑瘤膏,原料药成分如下,均为重量份:
处方:党参24份,黄芪18份,炒白术12份,云苓15份,蛇舌草24份,半枝莲24份,薏苡仁30份,浙贝15份,夏枯草18份,山慈菇21份,莪术18份,蜂房15份,黄精21份,甘草6份;
随症加入:金银花18份,黄芩15份,生石膏21份,羚羊粉3份。
上述适用于热毒炽盛型的肺抑瘤膏的制备方法,步骤如下:
(1)将上述原料药浸入水中,浸泡1.5~3小时,然后煮沸1.5~2.5小时,取出药汁,再加水煎煮0.5~1.5小时,滤除药渣,合并药汁并静置5~7小时,制得药液;
(2)羚羊粉温水冲化,制得羚羊粉水溶液;
(3)取步骤(1)制得的药液,经药筛滤过后,加入步骤(2)制得的羚羊粉水溶液,煮沸后,去除浮沫,制得浓缩药液;
(4)按现有技术将步骤(3)制得的浓缩药液制膏,即得。
根据本发明优选的,所述步骤(3)中,药筛的筛孔为80目。
将上述原料药制备成肺抑瘤膏也可按现有常规制膏方法制备。
配伍分析
君:党参;臣:白花蛇舌草、半枝莲、薏苡仁;佐:黄芪18g、炒白术12g云苓15g、浙贝、黄精、夏枯草、山慈菇、莪术、蜂房;使:甘草。
党参为君药。党参甘、平,归脾、肺二经,能补脾肺气,补血、生津。《本草正义》:“补脾养胃,润肺生津,健运中气,本与人参不甚相远”;《本草从新》:“补中益气,和脾胃,除烦渴。中气微虚,用以调补,甚为平安”。
白花蛇舌草、半枝莲、薏苡仁为臣药。白花蛇舌草微苦、甘,寒,归胃、大肠、小肠经。善解毒清热,利湿通淋。半枝莲味辛、微苦,平,入心、小肠、肺经,具清热解毒、利水消肿、活血化瘀之效。薏苡仁甘、淡,凉,归脾、胃、肺经,有健脾利水、消肿、除痹、清热排脓之效。《本草纲目》:“薏苡仁,阳明药也,能健脾益胃。虚则补其母,故肺痿、肺痈用之”。
黄芪甘,微温,归脾、肺经,具健脾补气、升阳举陷、益卫固表、生津、利水消肿、托疮生肌之功效。其重在补气,为补脾、肺气之要药。《名医别录》:“补丈夫虚损,五劳赢瘦,止渴、腹痛泄利,益气,利阴气”;张仲景《金匮要略》:用黄芪治疗“虚劳里急,诸不足。”方中重用黄芪补脾肺之气,脾健运化,中气建立,则肺气健旺,肺脾虚损之证自除。白术甘、苦、温,归脾、胃二经,有补气健脾、燥湿利尿、止汗、安胎之效,为补脾之要药。《本草疏经》云:“术,其气芳烈,其味甘浓,其性纯阳,为安脾胃之神品。”茯苓甘、淡,平,可利水渗湿,健脾宁心。《世补斋医书》:“茯苓一味,为治痰主药,痰之本,水也,茯苓可以行水;痰之动,湿也,茯苓可以行湿。”茯苓和白术,可增强黄芪、党参补脾之力,使脾气健旺、运化如常、痰湿自除。麦冬甘、微苦、寒,入肺、胃二经,可养阴润肺,益胃生津,清心除烦。《本草汇言》中云:“清心润肺之药。主……肺热肺燥,咳声连连,肺痿叶焦,短气虚喘,火伏肺中,咯血咳血”。其味甘、性寒,甘寒益阴,可养肺阴,润肺燥,为治疗肺阴虚咳嗽之要药。
浙贝苦、寒,归肺、心经,有清热解毒、散结消痈之功效。《本草纲目拾遗》:“解毒利痰,开宣肺气,凡肺家夹风火有痰者宜此。”黄精甘、平,归脾、肺、肾经,有补气养阴、健脾、润肺、益肾之效。四药共为佐药,增强了补气养阴,健脾祛湿,清热化痰之效。
夏枯草辛、苦,寒,归肝、胆二经,清热泻火,散结消肿。《重庆堂笔记》:“夏枯草,味辛而甘,故散结之中,兼有合阳养阴之功。”山慈菇甘、微辛,凉,归肝、脾二经,清热解毒,散结消痈。莪术辛、苦,温,归肝、脾二经,有破血消积,行气止痛之效,既入血分,又入气分。《药品化义》:“莪术味辛性烈,专攻气中之血,主破积消坚,去积聚痞块。”
黄精性平、味甘,归脾、肺、肾经,具有补脾润肺、益气养阴之功效,用于脾胃虚弱,体倦乏力,口干食少,肺虚燥咳,精血不足,内热消渴。《别录》:“主补中益气,除风湿,安五脏。”《滇南本草》:“补虚添精.”《本草从新》:“平补气血而润。”甘草甘、平,功效补中益气,祛痰止咳,缓急止痛,清热解毒。生用甘草主取其清热解毒之效,又调和诸药,为使药。甘草甘、平,功效补中益气,祛痰止咳,缓急止痛,清热解毒。生用甘草主取其清热解毒之效,又调和诸药,为使药。
金银花性寒、味甘;归肺、胃经;清热解毒,疏散风热。自古被誉为清热解毒的良药。它性甘寒气芳香,甘寒清热而不伤胃,芳香透达又可祛邪。金银花既能宣散风热,还善清解血毒,用于各种热性病,如身热、发疹、发斑、热毒疮痈、咽喉肿痛等证,均效果显著;
黄芩泻实火,除湿热,止血,安胎。治壮热烦渴,肺热咳嗽,湿热泻痢,黄疸,热淋,吐、衄、崩、漏,目赤肿痛,胎动不安,痈肿疔疮。《本经》记载:"主诸热黄疸,肠澼,泄利,逐水,下血闭,(治)恶疮,疽蚀,火疡。"
石膏首载于《神农本草经》,为清解气分实热的首选药。因其气味辛甘大寒,临床又被列为峻药和猛药。陈士铎在《本草秘录》中指出:“石膏救死之药也,用石膏能变死为生。”
羚羊粉指的是羚羊角制成的粉,是比较贵的凉药之一。作用及功效:有清热镇惊息风,平肝凉血,清热解毒的作用,去除血液里的热毒清除。
纵观全方,配伍合理,组方严谨,药精力专,符合中医药理论,诸药合用,共奏益气养阴,清热解毒,化痰散瘀,去积除痞,抑癌抗瘤之效。
有益效果
本发明所述的适用于热毒炽盛型的肺抑瘤膏,配伍合理,组方严谨,药精力专,符合中医药理论,诸药合用,共奏益气养阴,清热解毒,化痰散瘀,去积除痞,具有抑癌抗瘤之效。
具体实施方式
下面结合实施例对本发明的技术方案做进一步说明,但本发明所保护范围不限于此。
实施例1
一种适用于热毒炽盛型的肺抑瘤膏,原料药成分如下,均为重量份:
处方:党参24g,黄芪18g,炒白术12g,云苓15g,蛇舌草24g,半枝莲24g,薏苡仁30g,浙贝15g,夏枯草18g,山慈菇21g,莪术18g,蜂房15g,黄精21g,甘草6g;
随症加入:金银花18g,黄芩15g,生石膏21g,羚羊粉3g。
上述适用于热毒炽盛型的肺抑瘤膏的制备方法,步骤如下:
(1)将上述原料药浸入水中,浸泡2小时,然后煮沸2小时,取出药汁,再加水煎煮1小时,滤除药渣,合并药汁并静置6小时,制得药液;
(2)羚羊粉温水冲化,制得羚羊粉水溶液;
(3)取步骤(1)制得的药液,经80目药筛滤过后,加入步骤(2)制得的羚羊粉水溶液,煮沸后,去除浮沫,制得浓缩药液;
(4)按现有技术将步骤(2)制得的浓缩药液制膏,即得。
病例应用
病例1
患者5月前无明显诱因出现憋喘咳血,量少色鲜红,晨起咳嗽伴大量脓黏痰,难咳出。于2014.2.11在当地医院行胸部CT示:右肺上叶一不规则软组织密度灶,密度均匀,边缘毛糙,有毛刺。于2014.2.25于山东省立医院行病理活检示:腺癌。
现症见:偶有咳嗽,咳少量黏黄痰,纳眠可,大便干。舌淡红苔黄脉沉弱。
治疗:用实施例1所述膏剂12剂,日服一剂。
现症见咳血症状消失,咳嗽症状明显缓解,咳痰不易咳出。咳黄黏痰,偶有间断性右上胸部隐痛,牵扯至右上臂,活动后加剧,唇周有散在疮,纳眠可,大便干结,小便调。舌红苔黄厚脉细滑。
病例2
胸膜间皮瘤化疗5月后复诊,患者自第5次化疗后出现发热,体温波动在38.5左右,偶咳,无痰,纳眠可,小便黄,大便可。舌淡红苔黄厚,脉细滑。
诊断:胸膜间皮瘤
治疗:用实施例1所述膏剂120剂,日3剂。
服药平妥,查出霍奇金氏淋巴瘤2年,现症见体力不佳,1月前感冒,低烧10余日,双手微肿发胀,纳眠可二便调。舌淡红苔黄厚,脉细滑。
对比例1
肺康方,原料药成分如下:
处方:党参24g,黄芪18g,炒白术12g,云苓15g,麦冬20g,蛇舌草24g,半枝莲24g,薏苡仁30g,浙贝母15g,贯众15g,夏枯草18g,女贞子21g,山慈菇21g,莪术18g,蜂房15g,甘草6g;
随症加入:连翘12g,鱼腥草18g,炙百部12g。
按实施例1的制膏方法制备成膏剂。
实施例2
一种适用于热毒炽盛型的肺抑瘤膏,原料药成分如下,均为重量份:
处方:党参21份,黄芪21份,炒白术9份,云苓18份,蛇舌草21份,半枝莲27份,薏苡仁27份,浙贝18份,夏枯草15份,山慈菇24份,莪术15份,蜂房18份,黄精18份,甘草9份;
随症加入:金银花15份,黄芩18份,生石膏18份,羚羊粉3份。
实施例3
处方:党参27份,黄芪15份,炒白术15份,云苓12份,蛇舌草27份,半枝莲21份,薏苡仁33份,浙贝12份,夏枯草21份,山慈菇18份,莪术21份,蜂房12份,黄精24份,甘草3份;
随症加入:金银花21份,黄芩12份,生石膏24份,羚羊粉3份。
实验例
针对20例症状相似的热毒炽盛患者,10例应用对比例1的膏剂,10例应用实施例1的膏剂,观察应用后临床症状,如表1所示:
表1
由表1的数据可以看出,对比例1中虽有鱼腥草祛瘀排脓,但清热力差,发明人根据多年临床经验分析,清热对热毒炽盛患者的病患改善更加有效,因此将对比例1中的处方改为实施例1中的处方,加入金银花,黄芩,生石膏,羚羊粉,清热力强,临床上尤其对于发热的病号,效果佳。从临床总结的数据表格来看,应用实施例1的患者症状好转率明显优于对比例1。
Claims (6)
1.一种适用于热毒炽盛型的肺抑瘤中药组合物,其特征在于,原料药成分如下,均为重量份:
处方:党参21~27份,黄芪15~21份,炒白术9~15份,云苓12~18份,蛇舌草21~27份,半枝莲21~27份,薏苡仁27~33份,浙贝12~18份,夏枯草15~21份,山慈菇18~24份,莪术15~21份,蜂房12~18份,黄精18~24份,甘草3~9份;
随症加入:金银花15~21份,黄芩12~18份,生石膏18~24份,羚羊粉3份。
2.如权利要求1所述的肺抑瘤中药组合物,其特征在于,原料药成分如下,均为重量份:
处方:党参24份,黄芪18份,炒白术12份,云苓15份,蛇舌草24份,半枝莲24份,薏苡仁30份,浙贝15份,夏枯草18份,山慈菇21份,莪术18份,蜂房15份,黄精21份,甘草6份;
随症加入:金银花18份,黄芩15份,生石膏21份,羚羊粉3份。
3.一种适用于热毒炽盛型的肺抑瘤膏,其特征在于,原料药成分如下,均为重量份:
处方:党参21~27份,黄芪15~21份,炒白术9~15份,云苓12~18份,蛇舌草21~27份,半枝莲21~27份,薏苡仁27~33份,浙贝12~18份,夏枯草15~21份,山慈菇18~24份,莪术15~21份,蜂房12~18份,黄精18~24份,甘草3~9份;
随症加入:金银花15~21份,黄芩12~18份,生石膏18~24份,羚羊粉3份。
4.如权利要求3所述的肺抑瘤膏,其特征在于,原料药成分如下,均为重量份:
处方:党参24份,黄芪18份,炒白术12份,云苓15份,蛇舌草24份,半枝莲24份,薏苡仁30份,浙贝15份,夏枯草18份,山慈菇21份,莪术18份,蜂房15份,黄精21份,甘草6份;
随症加入:金银花18份,黄芩15份,生石膏21份,羚羊粉3份。
5.权利要求3所述适用于热毒炽盛型的肺抑瘤膏的制备方法,其特征在于,步骤如下:
(1)将上述原料药浸入水中,浸泡1.5~3小时,然后煮沸1.5~2.5小时,取出药汁,再加水煎煮0.5~1.5小时,滤除药渣,合并药汁并静置5~7小时,制得药液;
(2)羚羊粉温水冲化,制得羚羊粉水溶液;
(3)取步骤(1)制得的药液,经药筛滤过后,加入步骤(2)制得的羚羊粉水溶液,煮沸后,去除浮沫,制得浓缩药液;
(4)按现有技术将步骤(3)制得的浓缩药液制膏,即得。
6.如权利要求5所述的制备方法,其特征在于,所述步骤(3)中,药筛的筛孔为80目。
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106266765A (zh) * | 2016-08-31 | 2017-01-04 | 郑心 | 一种适用于痰湿质的抗肺癌药物及其制备方法 |
CN110279803A (zh) * | 2019-07-11 | 2019-09-27 | 楚雄彝族自治州中医医院 | 一种扶正祛邪、清热化毒的药物 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101485823A (zh) * | 2009-02-24 | 2009-07-22 | 曹培琳 | 一种用于治疗肺癌的药物及其制备方法 |
WO2012134169A2 (ko) * | 2011-03-28 | 2012-10-04 | 주식회사 한국전통의학연구소 | 조각인 추출물을 포함하는 폐암 치료용 조성물 및 건강 기능성 식품 |
-
2014
- 2014-11-20 CN CN201410668907.5A patent/CN104352984B/zh not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101485823A (zh) * | 2009-02-24 | 2009-07-22 | 曹培琳 | 一种用于治疗肺癌的药物及其制备方法 |
WO2012134169A2 (ko) * | 2011-03-28 | 2012-10-04 | 주식회사 한국전통의학연구소 | 조각인 추출물을 포함하는 폐암 치료용 조성물 및 건강 기능성 식품 |
Non-Patent Citations (4)
Title |
---|
李雪妮: "肺抑瘤膏联合DC-CIK细胞治疗晚期肺腺癌的临床观察及对VEGF分泌影响的实验研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
王璐: "肺抑瘤膏联合DC-CIK细胞治疗晚期肺腺癌的临床和实验研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
郑心等: "肺抑瘤膏联合树突状细胞_细胞因子诱导的杀伤细胞治疗晚期肺腺癌23例", 《安徽中医学院学报》 * |
马秀荣: "肺抑瘤膏联合DC-CIL细胞治疗ⅢB,Ⅳ期肺腺癌临床与实验研究", 《中国优秀硕士学位论文 医药卫生科技辑》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106266765A (zh) * | 2016-08-31 | 2017-01-04 | 郑心 | 一种适用于痰湿质的抗肺癌药物及其制备方法 |
CN106266765B (zh) * | 2016-08-31 | 2019-05-10 | 郑心 | 一种适用于痰湿质的抗肺癌药物及其制备方法 |
CN110279803A (zh) * | 2019-07-11 | 2019-09-27 | 楚雄彝族自治州中医医院 | 一种扶正祛邪、清热化毒的药物 |
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