CN104321321B - 二环噻唑类化合物 - Google Patents
二环噻唑类化合物 Download PDFInfo
- Publication number
- CN104321321B CN104321321B CN201380026183.8A CN201380026183A CN104321321B CN 104321321 B CN104321321 B CN 104321321B CN 201380026183 A CN201380026183 A CN 201380026183A CN 104321321 B CN104321321 B CN 104321321B
- Authority
- CN
- China
- Prior art keywords
- thiazole
- mixture
- ylamino
- carboxamide
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CCOC(c1c(N)[s]c(*)n1)=O Chemical compound CCOC(c1c(N)[s]c(*)n1)=O 0.000 description 8
- IXZSWLSUBCWFMH-UHFFFAOYSA-N CCOC(c1c(N)[s]c(Nc2ccc(cccc3)c3c2)n1)=O Chemical compound CCOC(c1c(N)[s]c(Nc2ccc(cccc3)c3c2)n1)=O IXZSWLSUBCWFMH-UHFFFAOYSA-N 0.000 description 1
- AZDIMLOSMFZQLP-UHFFFAOYSA-N CCOC(c1c(N)[s]cn1)=O Chemical compound CCOC(c1c(N)[s]cn1)=O AZDIMLOSMFZQLP-UHFFFAOYSA-N 0.000 description 1
- RIKQGKZCGFFZEO-UHFFFAOYSA-N NC(c1c(N)[s]c(Nc2cc3ccccc3cn2)n1)=O Chemical compound NC(c1c(N)[s]c(Nc2cc3ccccc3cn2)n1)=O RIKQGKZCGFFZEO-UHFFFAOYSA-N 0.000 description 1
- DDYYJYKSPCYKAF-UHFFFAOYSA-N S=C=Nc1ccnc2ccccc12 Chemical compound S=C=Nc1ccnc2ccccc12 DDYYJYKSPCYKAF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/479,396 US20130317218A1 (en) | 2012-05-24 | 2012-05-24 | Novel bicyclic thiazole compounds |
| US13/479,396 | 2012-05-24 | ||
| PCT/JP2013/064960 WO2013176293A1 (en) | 2012-05-24 | 2013-05-22 | Novel bicyclic thiazole compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104321321A CN104321321A (zh) | 2015-01-28 |
| CN104321321B true CN104321321B (zh) | 2017-07-07 |
Family
ID=48628877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380026183.8A Expired - Fee Related CN104321321B (zh) | 2012-05-24 | 2013-05-22 | 二环噻唑类化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20130317218A1 (https=) |
| EP (1) | EP2855470B1 (https=) |
| JP (1) | JP6095195B2 (https=) |
| KR (1) | KR102042296B1 (https=) |
| CN (1) | CN104321321B (https=) |
| WO (1) | WO2013176293A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130317218A1 (en) | 2012-05-24 | 2013-11-28 | Masaaki Sawa | Novel bicyclic thiazole compounds |
| WO2016202935A1 (en) * | 2015-06-19 | 2016-12-22 | Bayer Pharma Aktiengesellschaft | Glucose transport inhibitors |
| JP6881309B2 (ja) * | 2015-10-14 | 2021-06-02 | 日産化学株式会社 | 液晶配向剤、液晶配向膜、及び液晶表示素子 |
| WO2024111626A1 (ja) * | 2022-11-25 | 2024-05-30 | カルナバイオサイエンス株式会社 | 新規チアゾール誘導体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4038661B2 (ja) * | 2002-05-21 | 2008-01-30 | 株式会社大塚製薬工場 | ホスホン酸ジエステル誘導体 |
| US8323943B2 (en) * | 2008-02-21 | 2012-12-04 | National Cancer Center | Screening method for anticancer drug |
| US20100137386A1 (en) * | 2008-12-01 | 2010-06-03 | Tesshi Yamada | Tnik inhibitor and the use |
| US20130317218A1 (en) | 2012-05-24 | 2013-11-28 | Masaaki Sawa | Novel bicyclic thiazole compounds |
-
2012
- 2012-05-24 US US13/479,396 patent/US20130317218A1/en not_active Abandoned
-
2013
- 2013-05-22 US US14/403,071 patent/US9102637B2/en not_active Expired - Fee Related
- 2013-05-22 KR KR1020147032428A patent/KR102042296B1/ko not_active Expired - Fee Related
- 2013-05-22 EP EP13729492.2A patent/EP2855470B1/en not_active Not-in-force
- 2013-05-22 CN CN201380026183.8A patent/CN104321321B/zh not_active Expired - Fee Related
- 2013-05-22 WO PCT/JP2013/064960 patent/WO2013176293A1/en not_active Ceased
- 2013-05-22 JP JP2014556280A patent/JP6095195B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN104321321A (zh) | 2015-01-28 |
| WO2013176293A1 (en) | 2013-11-28 |
| US20150133656A1 (en) | 2015-05-14 |
| KR102042296B1 (ko) | 2019-11-07 |
| EP2855470B1 (en) | 2018-10-17 |
| US9102637B2 (en) | 2015-08-11 |
| JP6095195B2 (ja) | 2017-03-15 |
| JP2015517453A (ja) | 2015-06-22 |
| EP2855470A1 (en) | 2015-04-08 |
| US20130317218A1 (en) | 2013-11-28 |
| KR20150014931A (ko) | 2015-02-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170707 Termination date: 20200522 |