CN104297505A - High-capacity and high-speed quasi automatic chemiluminiscence immunoassay instrument - Google Patents
High-capacity and high-speed quasi automatic chemiluminiscence immunoassay instrument Download PDFInfo
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- CN104297505A CN104297505A CN201410610034.2A CN201410610034A CN104297505A CN 104297505 A CN104297505 A CN 104297505A CN 201410610034 A CN201410610034 A CN 201410610034A CN 104297505 A CN104297505 A CN 104297505A
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Abstract
The invention discloses a high-capacity and high-speed quasi automatic chemiluminiscence immunoassay instrument which comprises a box body unit, a plate moving unit, a plate taking and conveying unit, a plate releasing unit, a vibration unit, a cleaning unit, an incubation unit, a substrate injection unit, a detection unit and a system operation control part. The instrument can automatically finish vibration uniform mixing, incubation, plate washing, substrate injection and luminous value measurement and reading operation; a large quantity of samples can be treated by one step; a plurality of incubation positions are provided; the high-capacity and high-speed quasi automatic chemiluminiscence immunoassay instrument and an assorted sample injection machine are combined to form a complete full-automatic plate type chemiluminiscence immunoassay instrument, and an extremely high working efficiency is achieved.
Description
Technical field
The present invention relates to a kind of immunoassay instrument of medicine equipment analyser technical field, relate to a kind of accurate robotics luminescence immunoassay instrument particularly.
Background technology
Chemiluminescence immune assay comprises two parts, i.e. chemiluminescence analysis system and immune response system, is mark substance to be marked at the immunoassay by chemiluminescent substance quality detection on antigen or antibody.Chemiluminescence Immunoassay compares with traditional radioimmunoassay technique, has environmental protection, safety, detection sensitivity is high, sensing range is wide, detects the generally accreditation that the advantage such as accurate obtains people, become the Main Means of current clinical immunization diagnosis.
Application number is the semi-automatic tubular chemiluminescence immune assay instrument of 200920160359.X, mainly comprises rotating table system, sample adding system, chemiluminescence detection system, control system, software systems composition.Its structure is simple, dirigibility strong, but needs to manually add reaction tube, have impact on detection speed.Current existing Full-automatic chemiluminescence analyser mostly is magnetic particle system, reaction cup application of sample, hatches, washes plate, Magneto separate, reagent adding, reading.
Each reaction cup need wait for that previous processing just can carry out next step, cannot batch processing, and cause unit interval processing speed slow, and instrument cost is high, maintenance cost increases.
Summary of the invention
Fundamental purpose of the present invention is in conjunction with the semi-automatic technological merit with Full automatic product.It is large that design has sample size, and detection efficiency is high, and structure is relatively simple, failure rate is low, easy care, the product technology of the advantages such as cost is lower, highly sensitive, easy and simple to handle.The supporting composition high-speed full-automatic chemical illumination immunity analysis instrument with automatic sample machine can be realized simultaneously.
For achieving the above object, chemical illumination immunity analysis instrument of this invention comprises box unit, moves Slab element, fetches and delivers Slab element, puts Slab element, vibration unit, cleaning unit, hatches unit, substrate filling unit, detecting unit and system operations control section.Described casing is primarily of framework and housing composition, be divided into main cavity and control chamber and be provided with the air channel of inner air circulation and heating blower parts to keep the equalized temperature stable and uniform in casing, while being isolated from the outside, enclosure interior is provided with the effect that thermofin plays insulation; The described Slab element that moves between each working cell, carries out transfer work for realizing microwell plate follow procedure, be made up of the tracks of moving sheet tray supporting guide and optical axis, drive toothed belt transmission to complete in length and breadth to two dimensional motion and by detection optocoupler correction location by stepper motor; Described Slab element of fetching and delivering is be fixed on to move push-pull mechanism in sheet tray and electromagnetic chuck device composition.Getting plate and putting plate work of in casing each working position has been driven by push-pull mechanism after being sucked with the microwell plate of sheet metal end by magnechuck; It is described that to put Slab element be at instrument external reception sample and the parts being transferred to instrument internal working position.Manual operation can place sample, simultaneously also can with the function adding model machine auxiliary work and realize full automatic plate type chemical illumination immunity analysis instrument; Described vibration unit can realize mixing the vibration of sample, rotating with eccentric motor the compound vibration that pallet that the eccentric moment that produces makes spring steel wire support produces upper frequency by being fixed on pallet, in pallet side, electromagnet being installed simultaneously and making it move with pallet to clamp sample.Its skew is provided constraints by guard shield to control tray position side-play amount; Described cleaning unit be by washing syringe needle, liquid feeding washs pin, pin is washed in discharge opeing, guide rail, stepper motor, optocoupler are finished the work jointly, stepper motor drives realization to move up and down through driving wheel, engaged wheel, Timing Belt, micro pump controls the closed of vacuum pump and charging valve, use accurate location during optocoupler component calibrates its work of position assurance simultaneously, wash plate work; Described unit of hatching is that a kind of Large Copacity individual cavity hatches structure.Formed external overall by riser, base plate, top board, cover plate and had thermofin to be incubated, centre is provided with the camera incubata that several layers of dividing plate form one group of separate space, and this is designed to 30 chambers and can hatches operation to 30 microwell plates simultaneously and can adjust capacity on demand.Cavity wall is provided with sensor detected temperatures and by control system control temperature.By the conduction of wire chamber wall, homogeneous temperature in each chamber is stablized after electric heating sheets heating, detected by sensor and obtain incubation temperature accurately.Simultaneously placed in the middle at chamber for preventing the edge effect of hatching from adopting reference column and block to limit microwell plate position.Described substrate filling unit is made up of guide rail, stepper motor, substrate sample needle, ceramic plunger micro sample-adding pump, and chemical luminous substrate is filled in microwell plate by pipeline by substrate sample needle, and controls substrate application of sample amount by plunger micro sample-adding pump; Described optical detection and system control unit amplify disposable plates, tally, optic probe, communication module etc. by photomultiplier, signal and form.Fibre-optical probe is measured the light that sample sends, optical fiber transports light on the test surface of photomultiplier, after multiplier tube amplifies, convert electric signal transmission to amplify disposable plates to signal and send communication module to, be connected with computing machine by data-interface, operator is realized the setting of whole instrument and control by computing machine.
Compared with prior art, the present invention has following technological merit:
The present invention is simple for structure reliable, perfect in shape and function, and work efficiency is high, and process capacity is large.Not only there is the technical characterstic that semi-automated instrument structure is simple, reliability is high, possess the advantage that full-automatic instrument treatment capacity is large, efficiency is high simultaneously.Automatically can set that vibration mix, hatches, washes plate, the operation of luminous value is read in substrate filling, survey by follow procedure, combined the Full-automatic chemiluminescence immunoassay analysis meter device that can become complete set with supporting application of sample machine and possess high work efficiency.
Accompanying drawing explanation
Fig. 1 is the agent structure schematic diagram of high-capacity and high-speed of the present invention accurate robotics luminescence immunoassay instrument;
Fig. 2 be high-capacity and high-speed of the present invention accurate robotics luminescence immunoassay instrument box unit, put Slab element structural representation;
Fig. 3 be high-capacity and high-speed of the present invention accurate robotics luminescence immunoassay instrument move Slab element structural representation;
Fig. 4 be high-capacity and high-speed of the present invention accurate robotics luminescence immunoassay instrument fetch and deliver Slab element structural representation;
Fig. 5 is the structural representation of the vibration unit of high-capacity and high-speed of the present invention accurate robotics luminescence immunoassay instrument;
Fig. 6 is the structural representation of hatching unit of high-capacity and high-speed of the present invention accurate robotics luminescence immunoassay instrument;
Fig. 7 is the structural representation of the cleaning unit of high-capacity and high-speed of the present invention accurate robotics luminescence immunoassay instrument;
Fig. 8 is the structural representation of the substrate filling unit of high-capacity and high-speed of the present invention accurate robotics side light immunity analysis instrument;
Fig. 9 is the structural representation of the detecting unit of high-capacity and high-speed of the present invention accurate robotics luminescence immunoassay instrument.
Wherein 101 is box unit, 102 for moving Slab element, 103 for fetching and delivering Slab element, 104 for putting Slab element, 105 is vibration unit, 106 is cleaning unit, 107 for hatching unit, 108 is substrate filling unit, 109 is detecting unit, 201 is housing, 202 is sliding door, 203 for putting sheet tray, 204 is screw mandrel stepper motor, 205 is linear bearing case, 206 is optical axis, 207 for detecting optocoupler, 208 is fan assembly, 209 electric heaters and temperature detection, 210 is cycle control parts, 211 is Timing Belt, 212 is stepper motor, 301 is stepper motor, 302 is supporting guide, 303 for moving sheet tray, 304 is optical axis, 305 is Timing Belt, 306 is the wheels that float, 307 is balancing weight, 308 is transverse axis, 309 is linear bearing case, 310 is horizontal stepper motor, 311 is Timing Belt, 312 is bearing housing, 313 for moving grillage, 314 for fetching and delivering Slab element, 401 for detecting optocoupler, 402 is stepper motor, 403 is Timing Belt, 404 is guide rail, 405 is guide rail slide block, 406 is belt wheel, 407 is Acetabula device, 408 is magnechuck, 409 is microwell plate, 410 for detecting optocoupler, 411 for moving sheet tray, 412 is tray supporter, 501 is vibrating bottom plate, 502 guard shields, 503 is vibrating spring, 504 is pallet, 505 is vibrating motor, 506 is eccentric wheel, 507 is electromagnet, 601 is reference column, 602 is riser, 603 is electric heating sheets, 604 is top board, 605 is block, 606 is dividing plate, 607 is temperature sensor, 608 is thermofin, 609 is cover plate, 610 is base plate, 701 is optical axis, 702 for washing syringe needle, 703 is hair washing link plate, 704 for detecting optocoupler, 705 is line slideway, 706 is belt wheel, 707 is Timing Belt, 708 is stepper motor, 709 is liquid feeding washing pin, 710 is discharge opeing washing pin, 711 is Timing Belt, 712 is belt wheel, 713 is stepper motor, 801 for bag is by plate, 802 is substrate head, 803 is substrate filler pipe, 804 is line slideway, 805 is belt wheel, 806 Timing Belts, 807 slide blocks, 808 belt wheels, 809 stepper motors, 810 for detecting optocoupler, 811 substrate supports, 901 is Timing Belt, 902 is line slideway, 903 is optocoupler sheet, 904 is head-measuring rack, 905 is photomultiplier, 906 is optical fiber, 907 is electromagnet, 908 is belt wheel, 909 is measuring chamber, 910 for detecting optocoupler, 911 is screw mandrel stepper motor, 912 for driving door-plate, 913 is optical measuring head, 914 is pressing plate, 915 for measuring pallet, 916 is optical axis, 917 is bearing housing, 918 is plectrum, 919 is belt pulley, 920 is fixing belt block, 921 is optocoupler sheet, 922 is Timing Belt, 923 is stepper motor, 924 is stepper motor.
Embodiment
Below in conjunction with accompanying drawing, a kind of high-capacity and high-speed of the present invention accurate robotics luminescence immunoassay instrument is described in detail.
As shown in Figure 1, high-capacity and high-speed of the present invention accurate robotics luminescence immunoassay instrument mainly comprises box unit 101, moves Slab element 102, fetches and delivers Slab element 103, puts Slab element 104, vibration unit 105, cleaning unit 106, hatches unit 107, substrate filling unit 108, detecting unit 109 and control system composition.Box unit 101 base plate first half is provided with and moves Slab element 102, box unit 101 latter half lower left quarter is provided with puts Slab element 104, put above Slab element and vibration unit 105 is installed, that 3 camera incubatas formations hatch unit 107 in the middle of box unit 101 rear portion, hatching that unit 107 turns right again is detecting unit 109, hatch unit 107 and detecting unit 109 top is a platform, platform is provided with cleaning unit 106, substrate filling unit 108.
As shown in Figure 2, in box unit, be provided with heating and thermostatic control module, ensure proper temperature in work space.Box unit comprises: fan assembly, put plate door and housing 201; Fan assembly is primarily of blower fan 208, and electric heater and temperature detection 209, cycle control parts 210 form; Put plate door to be made up of sliding door 202, screw mandrel stepper drive motors 204, positioning detection mechanism; Housing 201 is made up of each panel, framework etc., and is provided with air channel and is beneficial to air circulation flow in cavity, makes each spot temperature even.The internal temperature set need be kept during the work of instrument original state, be thermal source by electric heater and temperature detection 209, make inner air circulate the working temperature keeping compartment equalization suitable along inner air channel through blower fan 208, the inner-outer circulation flowed by circulating control device 210 control instrument air switches.Put Slab element 104 and comprise driving, movement, detection control three part; Drive part comprises stepper motor 212, engaged wheel and the Timing Belt 211 that driving pulley is housed be fixed on base plate.Movable part comprises the pallet and axle clamp 203 that are connected and fixed with two parallel optical axis 206, optical axis be fixed on base plate and in parallel with Timing Belt two groups of linear bearing casees 205 slide.Detection control realizes the accurate location of holding tray by detecting optocoupler 207.Pallet for placing microwell plate, software control its put plate door with casing and coordinate and realize automatically shifting out and regaining action.When needing when there being sample to detect, programmed instruction screw mandrel stepper motor 204 starts and is risen by sliding door 202 through screw nut driving, simultaneously instruction step motor 212 works and makes the fixing optical axis 206 of axle clamp on bearing housing 205, do linear slide through Timing Belt 211 transmission will to put sheet tray 203 and outwards move to desired location, manual or after microwell plate after application of sample being put into pallet 203 by application of sample instrument before online, pallet 203 is brought microwell plate in instrument desired location and closed sliding door.Each initialized location is by detection optocoupler calibration location.
As shown in Figure 3, the transfer of microwell plate between each station in inside by moving Slab element 102, fetch and deliver Slab element 103 and complete.That moves that Slab element drives Timing Belt 305,311 to make to be connected and fixed with belt block respectively by longitudinal stepper motor 301, horizontal stepper motor 310 moves sheet tray 303 and moves grillage 313 and realize doing vertical transverse movement along optical axis and supporting guide respectively in two-dimensional space, corrects location obtain accurate locus to make moving sheet tray by detection optocoupler.The parallel optical axis 304 that vertical structure is individually fixed in upper bottom plate by two two ends forms, upper bottom plate is equipped with stepper motor 301 and engaged wheel respectively, connected by Timing Belt 305 and drive and move sheet tray 303 and move up and down, linear bearing case 309 coordinates restriction to move sheet tray to rotate and tilting freedom with optical axis.Timing Belt opposite side is fixing to balance upper and lower driving moment with the balancing weight 307 be installed on line slideway, and mechanism is operated steadily.Transversary is coordinated with the supporting guide 302 being fixed on box bottom by the bearing housing 312 being installed on bottom plate, and the floating wheels 306 of upper mounted plate coordinate with the transverse axis 308 being fixed on cabinet wall and form.Move sheet tray to be provided with and to fetch and deliver Slab element 314.Stepper motor 310 drives to drive through Timing Belt 311 transmission and moves grillage 313 and bearing housing 312 and to move along supporting guide 302 and make to move sheet tray to horizontal assigned address.Vertically move to be driven through Timing Belt 305 transmission by stepper motor 301 simultaneously and move grillage 313 and to coordinate with the linear slide of optical axis 304 along bearing housing 309 and do longitudinal adjustment.What be fixedly connected with Timing Belt 305 has balancing weight 307, can balance the driving moment of stepper motor 301.Horizontal and longitudinal initialized location corrects location by detection optocoupler.Move the spacing of Slab element 102 top to have been coordinated with floating roller assembly 306 by optical axis 308.When moving sheet tray 303 and moving on to designating step position, by fetch and deliver Slab element 103 by microwell plate take out or put into operating position.
As shown in Figure 4, fetching and delivering Slab element is be fixed on to move push-pull mechanism on sheet tray support 412 and electromagnetic chuck device composition.Push-pull mechanism drives the Acetabula device 407 be fixed on guide rail slide block 405 to seesaw along guide rail 404 by stepper motor 402, principal and subordinate's belt wheel 406 and Timing Belt 403.Electromagnetic chuck device sucks or decontrols by possessing the magnechuck 408 regulated that floats the microwell plate 409 posting bar steel plate.Each mechanism kinematic position and microwell plate location confirmation all have detection optocoupler 401,410 feedback information.Fetching and delivering plate action drives Timing Belt 403 to drive Acetabula device 407 to realize moving back and forth along slide block 405 with coordinating of line slideway 404 by stepper motor 402.When Acetabula device 407 is stained with microwell plate 409 adhesive of steel plate close to energising magnechuck 408 and end face during microwell plate, complete picking and placeing of microwell plate by moving back and forth, correct location by detection optocoupler 401,410.After sample enters instrument by above-mentionedly moving Slab element 102, fetch and deliver Slab element 103 sample be transferred in the vibratory tray 504 of vibration unit 105.
As shown in Figure 5, vibration unit is equipped with eccentric wheel 506 by one group of vibrating spring 503 connection of being fixed on vibrating bottom plate 501, the pallet 504 of vibrating motor 505 forms, be provided with simultaneously there is limit function guard shield 502 to control pallet side-play amount, pallet is provided with electromagnet 507 and vibrating motor and is fixedly clamped microwell plate make it vibrate together with pallet simultaneously.System accuses that the eccentric force produced by eccentric block 506 after vibrating motor 505 processed starts makes vibratory tray 504 on vibrating spring 503, do iterative motion with it, electromagnet 507 and vibrating motor 505 work simultaneously microwell plate is clamped in vibratory tray 504 interior be synchronized with the movement to realize mixing with it operate.Guard shield 502 pairs of pallets 504 play position-limiting action simultaneously.
As shown in Figure 6, hatching unit is a kind of Large Copacity individual cavity micropore plate incubation structure.Be fixed on base plate 610 and top board 604 by vertical plates on both sides 602, there is cover plate 609 at rear portion, and centre is provided with the camera incubata that several layers of dividing plate 606 form one group of separate space.Vertical plates on both sides is double-decker, and centre is lined with electric heating sheets 603, and cavity wall is provided with several temperature sensor 607, and is arranged with thermofin 608 outside.By metallic cavity conduction, homogeneous temperature in each chamber is stablized after electric heating sheets heating, detected by sensor and obtain incubation temperature accurately.In order to prevent the edge effect of hatching to be provided with reference column 601 and block 605, to control microwell plate position placed in the middle simultaneously.
As shown in Figure 7, washing operation is carried out by cleaning unit 106 pairs of microwell plates.Stepper motor 713,708 makes hair washing link plate 703 move arrival assigned address along optical axis 701 and line slideway 705 through belt wheel 706,712 and Timing Belt 707,711 transmission respectively.Wash pin 709 by liquid feeding respectively, discharge opeing washing pin 710 carries out fluid injection, discharge opeing washing operation to microwell plate successively.For improving the efficiency of washing operation, instrument is provided with 2 groups of cleaning units.Cleaning unit comprises: liquid feeding washing pin 709, discharge opeing washing pin 710, washing pin mobile device and washing pin rinse bath; Described washing pin mobile device comprises longitudinal moving device and moves up and down device; Longitudinal moving device is driven through linear bearing by stepper motor 713, driving pulley 712, driven pulley and Timing Belt 711 and coordinates the support doing lengthwise movement to realize with two parallel optical axis 701; Move up and down that device is the stepper motor 708 be fixed on support, principal and subordinate's belt wheel 706 and Timing Belt 707 be driven through the hair washing link plate 703 that slide block moves up and down at line slideway 705 and form; Wash syringe needle 702 to be installed on hair washing link plate, wash liquid feeding that on syringe needle, plug-in mounting is identical with microwell plate line number and wash pin and discharge opeing is washed pin and is connected with pipeline, the action of cooperation fluid path system control valve makes to wash syringe needle and completes cleaning operation to microwell plate.
Described substrate filling unit 108 as shown in Figure 8.Substrate head 802 is substrate filling parts, and its lengthwise movement is consistent with cleaning unit.Transverse movement drives the substrate head 802 be fixed on slide block 807 to move along slide block 807 with the direction that coordinates of line slideway 804 by stepper motor 809 by belt wheel 808,805 and the transmission of Timing Belt 806.It corrects location and is completed by detection optocoupler 810.Substrate filling unit uses the longitudinal moving device identical with cleaning unit, and driving the substrate head 802 be fixed on slide block 807 to move on horizontal line slideway 804 by the stepper motor 809 on substrate support 811, principal and subordinate's belt wheel 808,805 and Timing Belt 806, support one end is provided with detects optocoupler 810 to realize the running fix of substrate head; Substrate filler pipe 803 one end is inserted on substrate head, the other end is connected with fixed displacement pump, completes substrate filled function by the cross shifting of substrate head.
Described detecting unit 109 as shown in Figure 9.Detecting unit comprises measuring chamber, tray moving apparatus, gauge head mobile device, optical detection apparatus; Measuring chamber 909 is that the lucifuge casing of band automatic opening and closing door prevents light leak.Screw mandrel stepper motor 911 drives door-plate 912 to slide in pressing plate 914 draw-in groove, and coordinate and fetch and deliver Slab element by microwell plate immigration measurement pallet 915, its action corrects location by detecting optocoupler 910.In tray moving apparatus, the bearing housing 917 of tray bottom coordinates with the parallel optical axis 916 that two ends are fixed on measuring chamber inwall and does transverse movement, driven by fixing belt block 920 by stepper motor 923, principal and subordinate's belt wheel 919 and Timing Belt 922, and be provided with and detect optocoupler sheet 921 and correct lateral attitude.Gauge head mobile device by the stepper motor 924 on bogie, principal and subordinate's belt wheel 908, Timing Belt 901 by belt block drive be fixed on head-measuring rack 904 on slide block linearly guide rail 902 do lengthwise movement, and be provided with and detect optocoupler sheet 903 calibration accuracy position.Optical measuring head 913 is fixed on head-measuring rack, rear end connecting fiber 906, and the optical fiber other end connects photomultiplier 905; Electromagnet (907) on head-measuring rack drives gauge head to complete by plectrum 918 and reads action to the survey of microwell plate, and luminous intensity is through fiber optic conduction and by application program process acquisition testing result after amplifying conversion.Screw mandrel stepper motor 911 drives feed screw nut to open to drive microwell plate after door-plate 912 by fetching and delivering on measurement pallet 915 that Slab element 103 sends in measuring unit 109, and driving gate 912 counteragent is closed.Measure pallet 915 to be driven by stepper motor 923 slide with coordinating of bearing housing 917 along optical axis 916 through Timing Belt 922, belt pulley 919, fixing belt block 920.Head-measuring rack 904 drives linearly guide rail 902 to slide by stepper motor 924 through Timing Belt 901, belt wheel 908 simultaneously.Each position corrects location by detection optocoupler.On head-measuring rack 904, the switching electricity of electromagnet 907 drives moving up and down of gauge head plectrum 918, and gauge head plectrum is also provided with optical measuring head 913.Optical measuring head 913 rear end is provided with optical fiber 906, and optical fiber 906 other end connects multiplier tube 905, connects pick-up unit, through software calculation process experimental data after multiplier tube.
Claims (10)
1. a high-capacity and high-speed accurate robotics luminescence immunoassay instrument, comprises box unit (101), moves Slab element (102), fetches and delivers Slab element (103), puts Slab element (104), vibration unit (105), cleaning unit (106), hatches unit (107), substrate annotates unit (108), detecting unit (109), it is characterized in that: box unit base plate first half is provided with and moves Slab element (102), box unit (101) latter half lower left quarter is provided with puts Slab element (104), put above Slab element and vibration unit (105) is installed, that 3 camera incubatas formations hatch unit (107) in the middle of box unit (101) rear portion, hatching that unit (107) turns right again is detecting unit (109), hatch unit (107) and detecting unit (109) top is a platform, platform is provided with cleaning unit (106), substrate filling unit (108).
2. accurate robotics luminescence immunoassay instrument according to claim 1, is characterized in that: be provided with heating and thermostatic control module in described box unit, ensures proper temperature in work space; Box unit comprises: fan assembly, put plate door and housing (201); Fan assembly primarily of blower fan (208), electric heater and temperature detection (209), cycle control parts (210) composition; Put plate door to be made up of sliding door (202), screw mandrel stepper drive motors (204), positioning detection mechanism; Housing (201) is made up of each panel, framework etc., and is provided with air channel and is beneficial to air circulation flow in cavity, makes each spot temperature even; Described in claim 1, all the other each unit are arranged in casing.
3. accurate robotics luminescence immunoassay instrument according to claim 1, is characterized in that: described in put Slab element (104) and comprise driving, movement, detection control three part; Drive part comprises the stepper motor (212) that driving pulley is housed, engaged wheel and the Timing Belt (211) that are fixed on base plate; Movable part comprises the pallet and axle clamp (203) that are connected and fixed with two parallel optical axis (206), optical axis be fixed on base plate and in parallel with Timing Belt two groups of linear bearing casees (205) slide; Detection control realizes the accurate location of holding tray mainly through detecting optocoupler (207); Pallet for placing microwell plate, software control its put plate door with casing and coordinate and realize automatically shifting out and regaining action.
4. accurate robotics luminescence immunoassay instrument according to claim 1, it is characterized in that: described in move that Slab element drives Timing Belt (305,311) to make to be connected and fixed with belt block respectively by longitudinal stepper motor (301), horizontal stepper motor (310) move sheet tray (303) and move grillage (313) and realize doing vertical transverse movement along optical axis and supporting guide respectively in two-dimensional space, corrected to locate by detection optocoupler and obtain accurate locus to make moving sheet tray; The parallel optical axis (304) that vertical structure is individually fixed in upper bottom plate by two two ends forms, upper bottom plate is equipped with stepper motor (301) and engaged wheel respectively, connected by Timing Belt (305) and drive and move sheet tray (303) and move up and down, linear bearing case (309) coordinates restriction to move sheet tray to rotate and tilting freedom with optical axis; Timing Belt opposite side is fixing to balance upper and lower driving moment with the balancing weight (307) be installed on line slideway, and mechanism is operated steadily; Transversary is coordinated with the supporting guide (302) being fixed on box bottom by the bearing housing (312) being installed on bottom plate, and the floating wheels (306) of upper mounted plate coordinate with the transverse axis (308) being fixed on cabinet wall and form; Move sheet tray to be provided with and to fetch and deliver Slab element (314).
5. accurate robotics luminescence immunoassay instrument according to claim 1, is characterized in that: described in fetch and deliver Slab element and move push-pull mechanism on sheet tray support (412) and electromagnetic chuck device composition for being fixed on; Push-pull mechanism drives the Acetabula device (407) be fixed on guide rail slide block (405) to seesaw along guide rail (404) by stepper motor (402), principal and subordinate's belt wheel (406) and Timing Belt (403); Electromagnetic chuck device sucks or decontrols by possessing the magnechuck (408) regulated that floats the microwell plate (409) posting bar steel plate; Each mechanism kinematic position and microwell plate location confirmation all have detection optocoupler (401,410) feedback information.
6. accurate robotics luminescence immunoassay instrument according to claim 1, it is characterized in that: described vibration unit is equipped with eccentric wheel (506) by one group of vibrating spring (503) connection of being fixed on vibrating bottom plate (501), pallet (504) composition of vibrating motor (505), be provided with simultaneously there is limit function guard shield (502) to control pallet side-play amount, pallet is provided with electromagnet (507) and vibrating motor and is fixedly clamped microwell plate make it vibrate together with pallet simultaneously.
7. accurate robotics luminescence immunoassay instrument according to claim 1, is characterized in that: described in hatch unit be a kind of Large Copacity individual cavity micropore plate incubation structure; Be fixed on base plate (610) and top board (604) by vertical plates on both sides (602), there is cover plate (609) at rear portion, and centre is provided with the camera incubata that several layers of dividing plate (606) form one group of separate space; Vertical plates on both sides is double-decker, and centre is lined with electric heating sheets (603), and cavity wall is provided with several temperature sensor (607), and is arranged with thermofin (608) outside; By metallic cavity conduction, homogeneous temperature in each chamber is stablized after electric heating sheets heating, detected by sensor and obtain incubation temperature accurately; In order to prevent the edge effect of hatching to be provided with reference column (601) and block (605), to control microwell plate position placed in the middle simultaneously.
8. accurate robotics luminescence immunoassay instrument according to claim 1, is characterized in that: described cleaning unit comprises: liquid feeding washing pin (709), discharge opeing washing pin (710), washing pin mobile device and washing pin rinse bath; Described washing pin mobile device comprises longitudinal moving device and moves up and down device; Longitudinal moving device is driven through linear bearing by stepper motor (713), driving pulley (712), driven pulley and Timing Belt (711) and coordinates the support doing lengthwise movement to realize with two parallel optical axis (701); Move up and down that device is the stepper motor (708) be fixed on support, principal and subordinate's belt wheel (706) and Timing Belt (707) be driven through hair washing link plate (703) composition that slide block moves up and down at line slideway (705); Wash syringe needle (702) to be installed on hair washing link plate, wash liquid feeding that on syringe needle, plug-in mounting is identical with microwell plate line number and wash pin and discharge opeing is washed pin and is connected with pipeline, the action of cooperation fluid path system control valve makes to wash syringe needle and completes cleaning operation to microwell plate.
9. accurate robotics luminescence immunoassay instrument according to claim 1, it is characterized in that: described substrate filling unit uses the longitudinal moving device identical with cleaning unit, and driving the substrate head (802) be fixed on slide block (807) above to move at horizontal line slideway (804) by stepper motor (809), principal and subordinate's belt wheel (808,805) and the Timing Belt (806) on substrate support (811), support one end is provided with detects optocoupler (810) to realize the running fix of substrate head; Substrate filler pipe (803) one end is inserted on substrate head, the other end is connected with fixed displacement pump, completes substrate filled function by the cross shifting of substrate head.
10. accurate robotics luminescence immunoassay instrument according to claim 1, is characterized in that: described detecting unit comprises measuring chamber, tray moving apparatus, gauge head mobile device, optical detection apparatus; Measuring chamber (909) is that the lucifuge casing of band automatic opening and closing door prevents light leak; Screw mandrel stepper motor (911) drives door-plate (912) to slide in pressing plate (914) draw-in groove, coordinate and fetch and deliver Slab element by microwell plate immigration measurement pallet (915), its action corrects location by detecting optocoupler (910); In tray moving apparatus, the bearing housing (917) of tray bottom coordinates with the parallel optical axis (916) that two ends are fixed on measuring chamber inwall and does transverse movement, driven by fixing belt block (920) by stepper motor (923), principal and subordinate's belt wheel (919) and Timing Belt (922), and be provided with detection optocoupler sheet (921) correction lateral attitude; Gauge head mobile device by the stepper motor (924) on bogie, principal and subordinate's belt wheel (908), Timing Belt (901) by belt block drive be fixed on head-measuring rack (904) on slide block linearly guide rail (902) do lengthwise movement, and be provided with and detect optocoupler sheet (903) calibration accuracy position; Optical measuring head (913) is fixed on head-measuring rack, rear end connecting fiber (906), and the optical fiber other end connects photomultiplier (905); Electromagnet (907) on head-measuring rack drives gauge head to complete by plectrum (918) and reads action to the survey of microwell plate, and luminous intensity is through fiber optic conduction and by application program process acquisition testing result after amplifying conversion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410610034.2A CN104297505A (en) | 2014-11-04 | 2014-11-04 | High-capacity and high-speed quasi automatic chemiluminiscence immunoassay instrument |
Applications Claiming Priority (1)
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| CN105242055A (en) * | 2014-05-21 | 2016-01-13 | 凯和生物科技(上海)有限公司 | Improved strip-type immune fully-automatic analyzer |
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| CN108957022B (en) * | 2018-08-15 | 2023-12-26 | 烟台艾德康生物科技有限公司 | Sample detection device and method based on protein chip |
| CN108956977A (en) * | 2018-08-15 | 2018-12-07 | 烟台艾德康生物科技有限公司 | A kind of enzyme linked immunological transfer device and enzyme-linked immunologic workstation |
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| CN109142709B (en) * | 2018-09-02 | 2023-10-03 | 广州源起健康科技有限公司 | Puncture pipetting device of time-resolved fluoroimmunoassay analyzer |
| CN109030808A (en) * | 2018-10-24 | 2018-12-18 | 嘉兴凯实生物科技有限公司 | A kind of improved automatic chemical illumination immunity analysis instrument |
| CN109030808B (en) * | 2018-10-24 | 2024-06-07 | 嘉兴凯实生物科技股份有限公司 | Improved full-automatic chemiluminescence immunoassay instrument |
| CN109991407A (en) * | 2019-03-18 | 2019-07-09 | 嘉兴科瑞迪医疗器械有限公司 | A kind of dibit incubator for immunological response |
| CN109946471A (en) * | 2019-03-22 | 2019-06-28 | 博奥赛斯（天津）生物科技有限公司 | A kind of automatic door opening-and-closing mechanism for automatical analysis instrument |
| CN109946471B (en) * | 2019-03-22 | 2024-03-26 | 天津博奥赛斯生物科技股份有限公司 | Automatic door opening and closing mechanism for full-automatic analysis instrument |
| CN110646622A (en) * | 2019-10-09 | 2020-01-03 | 亳州市新健康科技有限公司 | Immunodetection device based on HPV16 type E7 protein and use method |
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| CN113499813A (en) * | 2021-07-28 | 2021-10-15 | 英诺维尔智能科技（苏州）有限公司 | Novel integrated liquid operation system |
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