CN203490229U - Quasi-automatic plate type immune analyzer - Google Patents
Quasi-automatic plate type immune analyzer Download PDFInfo
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- CN203490229U CN203490229U CN201320060534.4U CN201320060534U CN203490229U CN 203490229 U CN203490229 U CN 203490229U CN 201320060534 U CN201320060534 U CN 201320060534U CN 203490229 U CN203490229 U CN 203490229U
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Abstract
The utility model discloses a quasi-automatic plate type immune analyzer which mainly consists of a box body, a placing unit, a incubation unit, a cleaning unit, a primer filling unit, an optical detection unit and a system operation control unit. The quasi-automatic plate type immune analyzer disclosed by the utility model realizes the whole process of incubation of a reaction liquid, plate washing with the reaction liquid and self-injection of the reaction liquid as well as primer measurement, and two microporous plates can be placed at the same time during operation. The utility model provides the quasi-automatic plate type immune analyzer which is simple in structure, high in work efficiency, low in cost and high in test sensitivity.
Description
Technical field
The utility model relates to a kind of immunoassay instrument of medicine equipment analyser technical field, relates to particularly the automatic board-like immunity analysis instrument of a kind of standard.
Background technology
During the nearly last ten years, immuno analytical method has been widely used in contemporary biomedical fundamental research and clinical disease diagnosis association area.Conventional method has at present, radioimmunoassay (RIA), enzymoimmunoassay (EIA), chemiluminescent immunoassay (CLIA) etc.Chemiluminescence immunoassay method has environmental protection, the feature such as quick, accurate has been approved by people, becomes the main method of current clinical immunodiagnosis.
Common chemiluminescence immunoassay product is mainly semi-automatic chemical luminescence immunoassay instrument and the large class of Full-automatic chemiluminescence immunoassay analysis meter two in the market.Semi-automatic chemical luminescence immunoassay instrument is simple in structure, and operating personnel's technical merit is had relatively high expectations, and human factor impact is larger, and labour intensity is large.Its function of Full-automatic chemiluminescence immunoassay analysis meter is more comprehensive, by operator, reagent and blood sample etc. in kit is positioned over to corresponding memory block, and completes all operating process by software set program.Its advantage is to effectively reduce operator's labour intensity, and artifical influence factor is little, but also because of its complex structure, causes failure rate high, safeguards trouble, and instrument is expensive, is difficult for universal.
Application number a kind of accurate robotics luminescence immunoassay instrument that has been 201010285548.7 Introduction To Cn Patent, mainly comprises analyser control center, analyser shell, substrate container, substrate shower nozzle, valveless ram pump, chemiluminescence measuring chamber.Other reacts necessary correlation step with electrochemiluminescent immunoassay as must be by operating personnel manual or assist by other equipment in mixed, hatch, wash plate etc.Therefore, operating personnel's technical merit is had relatively high expectations, artifical influence factor is larger, and labour intensity is large.
Summary of the invention
Fundamental purpose of the present invention is to solve the deficiencies in the prior art, and semi-automatic instrument is higher to operating personnel's technical requirement, and human factor impact is large; The problems such as full-automatic instrument structure is more complicated, failure rate height, provide a kind of standard simple in structure, with low cost, that measurement sensitivity is high automatic board-like immunity analysis instrument.
For achieving the above object, the automatic board-like immunity analysis instrument of standard provided by the invention comprises: casing, placement unit, hatch unit, cleaning unit, substrate filling unit, optical detection unit and system Operations Analysis.Described casing, is that other parts of whole analyser are played to effect fixing and that support, according to schematic diagram, test suite and correlation unit is assembled on casing; Described placement unit is by identical A, B
Two groups of unit form, and are about to two pallets and are installed on guide rail, and reciprocatingly moved through belt gear by stepper motor.Two side ends is equipped with optocoupler assembly and realizes location and calibration.Can place two 48 or the coated plate of 96 micropores simultaneously, when programmed control pallet is done short distance rapid movement on guide rail, sample be mixed to operation; Described hatch the heating and thermal insulation circulation system that unit is formed in a closed metal casing by ptc heater, temperature controller, blower fan, circulating fan etc.Be provided with temperature detection feedback assembly simultaneously, sample carried out to stable accurately temperature and hatch process; The described plate unit of washing is jointly to finish the work by washing syringe needle, liquid feeding washing pin, discharge opeing washing pin, guide rail, stepper motor, optocoupler, stepper motor drives to realize through driving wheel, engaged wheel, Timing Belt and moves up and down, micro pump is controlled the closure of vacuum pump and charging valve, uses optocoupler assembly calibration location to guarantee its work simultaneously
Accurate location while doing, completes the plate work of washing; Described substrate filling unit is comprised of guide rail, stepper motor, substrate container, substrate sample needle, ceramic plunger micro sample-adding pump, described substrate container is splendid attire chemical luminous substrate, described substrate sample needle is filled into chemical luminous substrate in reaction cup in substrate container, and described ceramic plunger micro sample-adding pump is by analysis and Control center, to be controlled the adding amount of ram pump; Described optical detection unit and system Operations Analysis amplify disposable plates, tally, optical measuring head, optical fiber, master control borad, communication module etc. by photomultiplier, signal and form.Faint light that measuring sonde is recorded is converted to electric signal after amplifying and sends the parts of communication module to, by data-interface, be connected with computing machine, operator by computer realization to the setting of whole instrument and control.
Compared with prior art, the present invention has following useful technique effect:
Function of the present invention is more comprehensive, simple to operate, and work efficiency is high, simple for structure, and flexibility ratio is high, reliable stable.Reliability and full-automatic the functional of analyser that detect of compatible semi-automatic detection analyser are integrated.The coated plate of micropore is positioned on pallet and can follow procedure control once completes whole work or complete some work.
Accompanying drawing explanation
Fig. 1 is the agent structure schematic diagram of the automatic board-like immunity analysis instrument of standard of the present invention;
Fig. 2 be the automatic board-like immunity analysis instrument of standard of the present invention wash plate cellular construction schematic diagram;
Fig. 3 be the automatic board-like immunity analysis instrument of standard of the present invention placement unit, hatch cellular construction schematic diagram;
Fig. 4 is the substrate filling cellular construction schematic diagram of the automatic board-like immunity analysis instrument of standard of the present invention;
The structural representation of the optical detection unit of the automatic board-like immunity analysis instrument of Fig. 5 standard of the present invention.
Wherein 001 be casing, 101 for placement unit, 201 for cleaning unit, 301 for substrate annotate unit,
401 is detecting unit, 501 for hatching unit, 601 is control module, 110 is holding tray, 111 is slide block, 112 is slot optical coupling, 113 is engaged wheel, 114 is fixing belt piece, 115 is pallet A Timing Belt, 116 is 96 orifice plates, 117 for washing needle tray, 118 is driving wheel, 119 is stepper motor, 120 is tray rail, 210 is stepper motor, 211 is driving pulley, 212 for washing plate Timing Belt, 213 is slot optical coupling, 214 for washing board mount, 215 for washing board mount guide rail-1, 216 is slide block, 217 is driven pulley, 218 is stepper motor, 219 stand to frame-1 for washing plate, 220 is driving pulley, 221 for washing plate arm Timing Belt, 222 for washing panel guide, 223 is slot optical coupling, 224 is fixing belt piece, 225 for washing needle-carrier, 226 is fixing belt piece, 227 for washing syringe needle, 228 is liquid feeding washing pin, 229 is discharge opeing washing pin, 230 is driven pulley, 231 is slide block, 310 is substrate support-1, 311 is stepper motor, 312 is driving pulley, 313 is driven pulley, 314 is substrate frame Timing Belt, 315 is substrate measurement bay guide rail, 316 is fixing belt piece, 317 is slot optical coupling, 318 is slide block, 319 is substrate brace-1, 320 is substrate frame-1, 321 is substrate filler pipe, 410 is stepper motor, 411 is driving wheel band, 412 is slot optical coupling, 413 is engaged wheel band, 414 is measurement bay Timing Belt, 415 is measurement bay guide rail, 416 is fixing belt piece, 417 is slide block, 418 is optical fibre frame, 419 is optical fiber, 420 is optical measuring head, 421 is gauge head plectrum, 422 is electromagnet, 510 is blower fan, 511 is well heater, 512 is temperature detection, 513 is control assembly.
embodiment
Below in conjunction with accompanying drawing, the automatic board-like immunity analysis instrument of a kind of standard of the present invention is described in detail.
As shown in Figure 1, the automatic board-like immunity analysis instrument of standard of the present invention, comprises casing 001, placement unit 101, cleaning unit 201, substrate filling unit 301, detecting unit 401, hatches unit 501 and control module 601 compositions.
As shown in Figure 3, placement unit 101 of the present invention is comprised of holding tray mobile device and two groups of holding trays 110, 96 orifice plates 116 after manual application of sample are put into after holding tray 110, control module 601 is given stepper motor 119 signals of wall box, between driving wheel 118 and engaged wheel 113, be provided with pallet synchronous belt 115, the tray rail 120 parallel with Timing Belt is provided with slide block 111, slide block 111 is connected with holding tray 110, holding tray is provided with fixedly belt piece 114, fixedly belt piece 114 is connected with pallet Timing Belt 115, running with pallet Timing Belt 115 drives holding tray 110 to move along guide rail 120, slot optical coupling 112 is realized holding tray 110 and is moved to the assigned address of hatching district.
As shown in Figure 3, the unit 501 of hatching of the present invention is comprised of well heater 511, blower fan 510, Temperature Detector 512 and control assembly 513, holding tray 110 runs to hatches behind district, Temperature Detector 512 is controlled the temperature of incubator, blower fan 512 transmits temperature is heated evenly sample, in the casing of whole sealing, by incubation time, sample is completed to the whole process of hatching.
As shown in Figure 2, the plate unit 201 of washing of the present invention comprises: liquid feeding washing pin 228, discharge opeing washing pin 229, washing pin mobile device and washing pin rinse bath 117 form.Sample has been hatched, and control module 601 is given stepper motor 119 signals, and slot optical coupling 112 is realized holding tray 110 and along guide rail 120, run to the assigned address of cleaning unit 201.Stepper motor 210 is provided with driving pulley 211, wash board mount 214 and be provided with driven pulley 217, between driving pulley 211 and driven belt opinion 217, be provided with and wash plate Timing Belt 212, the guide rail 215 parallel with washing plate Timing Belt 212 is provided with slide block 216, slide block with wash plate and stand to support 219 and be fixedly connected with, fixedly belt piece 226 is connected with Timing Belt 212, with the running of washing plate Timing Belt 212, drive and to wash plate and stand to support-1 along guide rail 215 and move, at the slot optical coupling 213 of washing on board mount 214, determine the assigned address of washing board mount transverse shifting.Washing plate stands to support 219 and is provided with stepper motor 218, between driving pulley 220 and driven pulley 230, be provided with and wash plate arm Timing Belt 221, the wash panel guide 222 parallel with washing plate arm Timing Belt 221 is provided with slide block 231, slide block 231 with wash needle-carrier 225 and be connected, wash fixedly belt piece 224 in needle-carrier 225 and wash plate arm Timing Belt 221 and be connected, with washing 221 tape travels of plate arm Timing Belt, wash needle-carrier 225 and move up and down along guide rail 222; Slot optical coupling 223 is realized the fixed position moving up and down; The Timing Belt 115 of stepper motor 119 drives holding tray 110 along guide rail 120 simultaneously
moved the plate process of washing.
As shown in Figure 4, substrate of the present invention filling unit 301, wash plate after control module 601 to stepper motor 119 signals, slot optical coupling 112 determines that holding tray 110 runs to the annotate assigned address of unit 301 of substrate along guide rail 120.Stepper motor 311 is provided with driving pulley 312, substrate support 310 is provided with driven pulley 313, driving pulley 312 and driven pulley 313 are provided with substrate frame Timing Belt 314, the substrate measurement bay guide rail 315 parallel with substrate frame Timing Belt 314 is provided with slide block 316, and slide block is connected with substrate brace 319.Fixedly belt piece 316 is connected with substrate frame Timing Belt 314, with the running substrate brace 319 of substrate frame Timing Belt 314, along guide rail 315, moves, and slot optical coupling 317 is realized the accurate location that substrate frame moves.The Timing Belt 115 of stepper motor 119 drives holding tray 110 to move substrate filling process along guide rail 120 simultaneously.
As shown in Figure 5, optical detection unit 401 of the present invention, substrate has been annotated, holding tray 110 runs to measuring unit 401 along guide rail 120, substrate support 310 is provided with stepper motor 410, driving pulley 411 and from
Between movable belt pulley 413, be provided with measurement bay Timing Belt 414, the measurement bay guide rail 415 parallel with measuring Timing Belt 414 is provided with slide block 417, and slide block 417 is connected with optical fibre frame 418.Fixedly belt piece 416 is connected with measurement Timing Belt 414, along with measuring the running of Timing Belt 414, drives optical fibre frame 418 measurement bays along guide rail 415 operations, and slot optical coupling 412 is determined the shift position of optical fibre frame 418.On substrate frame, the switching of electromagnet 422 electricity drives moving up and down of gauge head plectrum 421, and gauge head plectrum is also provided with optical measuring head 420.Optical measuring head 420 rear ends are provided with optical fiber 419, and optical fiber 419 other ends connect multiplier tube, connect pick-up unit, through software calculation process experimental data after multiplier tube.
Claims (6)
1. the automatic board-like immunity analysis instrument of standard, comprises placement unit, hatches unit, cleaning unit, substrate filling unit, detecting unit; It is characterized in that: casing (001) is inner for hatching unit; Casing (001) bottom is provided with placement unit (101) that can lengthwise movement, in the cabinet space of the top of placement unit plane, cleaning unit (201), substrate filling unit (301), detecting unit (401) have been installed from front to back successively; Placement unit can move to the below of any one unit in above-mentioned cleaning unit, substrate filling unit, detecting unit.
2. the automatic board-like immunity analysis instrument of standard according to claim 1, is characterized in that: described in hatch the casing (001) that unit comprises thermal source and constant temperature sealing; Thermal source is by blower fan (510), well heater (511) and temperature detection (512), and control assembly (513) forms; In the casing (001) of constant temperature sealing, there are placement unit (101), cleaning unit (201), substrate filling unit (301), optical detection unit (401).
3. the automatic board-like immunity analysis instrument of standard according to claim 2, is characterized in that: described placement unit (101) comprises holding tray mobile device and two groups of holding trays (110); Holding tray mobile device comprises the stepper motor (119) being arranged on wall box, and stepper motor is provided with driving pulley (118), and wall box is also provided with driven pulley (113), is provided with Timing Belt (115) between driving pulley and driven pulley; Wall box is provided with the rolling guide parallel with Timing Belt (120), on guide rail, be provided with slide block (111), slide block is fixedly connected with holding tray (110), holding tray is provided with fixedly belt piece (114), fixedly belt piece is connected with Timing Belt, running with Timing Belt drives holding tray to move along guide rail, and guide rail one end is provided with slot optical coupling (112) on wall box, to realize the location of holding tray mobile device; Described two groups of holding trays can be placed the coated plate (116) in two 48 holes or 96 holes simultaneously, and when programmed control holding tray mobile device is done scale and moved on guide rail, sample to be checked is sent to different station; When programmed control holding tray mobile device is done the quick back and forth movement of short distance on guide rail, realize mixing sample.
4. the automatic board-like immunity analysis instrument of standard according to claim 2, is characterized in that: described cleaning unit (201) comprising: liquid feeding washing pin (228), discharge opeing washing pin (229), washing pin mobile device and washing pin rinse bath (117), described washing pin mobile device comprises along horizontal mobile device between holding tray and move up and down device above holding tray, horizontal mobile device comprises and is arranged on the stepper motor (210) of washing on board mount (214), stepper motor (210) is provided with driving pulley (211), wash board mount (214) and be also provided with driven pulley (217), between driving pulley (211) and driven pulley (217), be provided with Timing Belt (212), be provided with the rolling guide (215) parallel with Timing Belt (212) washing board mount (214), on guide rail, be provided with slide block (216), slide block with wash plate and stand to support-1(219) be fixedly connected with, washing plate stands and to support-1, is provided with fixedly belt piece (226), fixedly belt piece is connected with Timing Belt (212), with the running drive of Timing Belt, washing plate stands mobile along guide rail (215) to frame-1, guide rail one end is provided with slot optical coupling (213) washing on board mount (214), to realize the location of horizontal mobile device, move up and down device comprise being arranged on wash plate and stand to frame-1(219) on stepper motor (218), stepper motor is provided with driving pulley (220), washing plate stands and to frame-1, is provided with driven pulley (230), between driving pulley and driven pulley, be provided with Timing Belt (221), stand on frame-1 and be provided with the rolling guide parallel with Timing Belt (222) washing plate, guide rail is provided with slide block (231), slide block with wash needle-carrier (225) and be fixedly connected with, wash needle-carrier and be provided with fixedly belt piece (224), fixedly belt piece is connected with Timing Belt (221), with synchronous tape travel drive, washing needle-carrier moves up and down along guide rail, in guide rail one end, wash in needle-carrier and be provided with slot optical coupling (223), to realize the location that moves up and down device, wash needle-carrier and be provided with and wash syringe needle (227), wash plug-in mounting liquid feeding washing pin (228) and discharge opeing washing pin (229) on syringe needle.
5. the automatic board-like immunity analysis instrument of standard according to claim 2, is characterized in that: described substrate filling unit (301) comprises substrate frame mobile device and substrate filler pipe (321), substrate frame mobile device comprise be arranged on substrate support-1(310) on stepper motor (311), stepper motor is provided with driving pulley (312), substrate support-1 is provided with driven pulley (313), between driving pulley and driven pulley, be provided with Timing Belt (314), on substrate support-1, be also provided with the rolling guide parallel with Timing Belt (315), on guide rail, be provided with slide block (318), slide block and substrate brace-1(319) be fixedly connected with, substrate brace-1 is provided with fixedly belt piece (316) and substrate frame-1(320), fixedly belt piece is connected with Timing Belt (314), running with Timing Belt drives substrate brace-1 to move along guide rail, guide rail one end is at substrate support-1(310) on be provided with slot optical coupling (317), to realize the location of substrate frame mobile device, substrate filler pipe (321) one end is inserted on substrate frame-1, the other end is connected with fixed displacement pump.
6. the automatic board-like immunity analysis instrument of standard according to claim 2, is characterized in that: described optical detection unit (401) comprises optical measuring head (420) and gauge head mobile device, optical measuring head rear end is provided with optical fiber (419), and the optical fiber other end connects multiplier tube, connects pick-up unit after multiplier tube, gauge head mobile device comprise be arranged on substrate support-1(310) on stepper motor (410), stepper motor is provided with driving pulley (411), substrate support-1 is also provided with driven pulley (413), between driving pulley and driven pulley, be provided with Timing Belt (414), substrate support-1 is provided with the rolling guide parallel with Timing Belt (415), on guide rail, be provided with slide block (417), slide block is fixedly connected with optical fibre frame (418), optical fibre frame is provided with fixedly belt piece (416) and electromagnet (422), fixedly belt piece is connected with Timing Belt (414), running with Timing Belt drives optical fibre frame mobile along guide rail (415), guide rail one end is at substrate support-1(310) on be provided with slot optical coupling (412), the location of moving to realize optical fibre frame, the switching electricity of electromagnet (422) drives the upper and lower scale motion of gauge head plectrum (421), and gauge head plectrum is also provided with optical measuring head (420), the motion of optical fibre frame (418) and gauge head plectrum, has formed gauge head mobile device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320060534.4U CN203490229U (en) | 2013-02-04 | 2013-02-04 | Quasi-automatic plate type immune analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320060534.4U CN203490229U (en) | 2013-02-04 | 2013-02-04 | Quasi-automatic plate type immune analyzer |
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| CN203490229U true CN203490229U (en) | 2014-03-19 |
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| CN201320060534.4U Expired - Fee Related CN203490229U (en) | 2013-02-04 | 2013-02-04 | Quasi-automatic plate type immune analyzer |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104215783A (en) * | 2014-05-21 | 2014-12-17 | 凯和生物科技(上海)有限公司 | Strip type immune fully-automatic analyzer |
| CN104237496A (en) * | 2014-09-30 | 2014-12-24 | 博奥赛斯（天津）生物科技有限公司 | Chemiluminescent immune assay substrate adding device |
| CN109142708A (en) * | 2018-09-02 | 2019-01-04 | 广州源起健康科技有限公司 | A kind of Full-automatic magnetic beads time-resolved fluorescence immunoassay instrument |
-
2013
- 2013-02-04 CN CN201320060534.4U patent/CN203490229U/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104215783A (en) * | 2014-05-21 | 2014-12-17 | 凯和生物科技(上海)有限公司 | Strip type immune fully-automatic analyzer |
| CN104215783B (en) * | 2014-05-21 | 2015-10-07 | 凯和生物科技(上海)有限公司 | A kind of bar formula immunity fully-automatic analyzer |
| CN105319379A (en) * | 2014-05-21 | 2016-02-10 | 凯和生物科技(上海)有限公司 | Full-automatic analyzer for immunity |
| CN105353158A (en) * | 2014-05-21 | 2016-02-24 | 凯和生物科技(上海)有限公司 | Improved strip type automatic immunoassay analyzer |
| CN105319379B (en) * | 2014-05-21 | 2017-02-22 | 凯和生物科技(上海)有限公司 | Full-automatic analyzer for immunity |
| CN105353158B (en) * | 2014-05-21 | 2017-02-22 | 凯和生物科技(上海)有限公司 | Improved strip type automatic immunoassay analyzer |
| CN104237496A (en) * | 2014-09-30 | 2014-12-24 | 博奥赛斯（天津）生物科技有限公司 | Chemiluminescent immune assay substrate adding device |
| CN109142708A (en) * | 2018-09-02 | 2019-01-04 | 广州源起健康科技有限公司 | A kind of Full-automatic magnetic beads time-resolved fluorescence immunoassay instrument |
| WO2020042596A1 (en) * | 2018-09-02 | 2020-03-05 | 广州源起健康科技有限公司 | Fully-automatic magnetic bead time-resolved fluoroimmunoassay instrument |
| CN109142708B (en) * | 2018-09-02 | 2023-01-24 | 广州源起健康科技有限公司 | Full-automatic magnetic bead time-resolved fluorescence immunoassay appearance |
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Granted publication date: 20140319 Termination date: 20210204 |