CN104284970A - 乳化剂组合物及其用途 - Google Patents
乳化剂组合物及其用途 Download PDFInfo
- Publication number
- CN104284970A CN104284970A CN201280073199.XA CN201280073199A CN104284970A CN 104284970 A CN104284970 A CN 104284970A CN 201280073199 A CN201280073199 A CN 201280073199A CN 104284970 A CN104284970 A CN 104284970A
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- Prior art keywords
- acid
- oil
- ester
- alcohol
- water
- Prior art date
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- 239000003995 emulsifying agent Substances 0.000 title claims abstract description 54
- 239000000203 mixture Substances 0.000 title claims abstract description 54
- -1 amido amine Chemical class 0.000 claims abstract description 106
- 239000007762 w/o emulsion Substances 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 10
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 7
- 239000000194 fatty acid Substances 0.000 claims abstract description 7
- 229930195729 fatty acid Natural products 0.000 claims abstract description 7
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- 239000002243 precursor Substances 0.000 claims abstract description 4
- 239000003921 oil Substances 0.000 claims description 35
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 28
- 235000019198 oils Nutrition 0.000 claims description 27
- 239000002253 acid Substances 0.000 claims description 25
- 150000002632 lipids Chemical class 0.000 claims description 17
- 239000012071 phase Substances 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 15
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 14
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 14
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 14
- 239000005642 Oleic acid Substances 0.000 claims description 14
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 14
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 14
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 14
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 14
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 14
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 14
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 14
- 229920000570 polyether Polymers 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 13
- 229910052799 carbon Inorganic materials 0.000 claims description 12
- 150000002148 esters Chemical class 0.000 claims description 12
- 239000000839 emulsion Substances 0.000 claims description 11
- 125000003368 amide group Chemical group 0.000 claims description 10
- 239000008346 aqueous phase Substances 0.000 claims description 10
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 10
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 9
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 9
- 239000005639 Lauric acid Substances 0.000 claims description 8
- 239000004743 Polypropylene Substances 0.000 claims description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 8
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 8
- OOCSVLHOTKHEFZ-UHFFFAOYSA-N icosanamide Chemical compound CCCCCCCCCCCCCCCCCCCC(N)=O OOCSVLHOTKHEFZ-UHFFFAOYSA-N 0.000 claims description 8
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 8
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 8
- 229920001155 polypropylene Polymers 0.000 claims description 8
- 229920001296 polysiloxane Polymers 0.000 claims description 8
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 claims description 6
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 6
- MNWFXJYAOYHMED-UHFFFAOYSA-N hexane carboxylic acid Natural products CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 claims description 6
- DAZXVJBJRMWXJP-UHFFFAOYSA-N n,n-dimethylethylamine Chemical compound CCN(C)C DAZXVJBJRMWXJP-UHFFFAOYSA-N 0.000 claims description 6
- 150000003254 radicals Chemical class 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol Substances OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 claims description 4
- HBXWUCXDUUJDRB-UHFFFAOYSA-N 1-octadecoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC HBXWUCXDUUJDRB-UHFFFAOYSA-N 0.000 claims description 4
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 claims description 4
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 4
- HPEUJPJOZXNMSJ-UHFFFAOYSA-N Methyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC HPEUJPJOZXNMSJ-UHFFFAOYSA-N 0.000 claims description 4
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 4
- 235000021355 Stearic acid Nutrition 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- 229920001400 block copolymer Polymers 0.000 claims description 4
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 4
- 229940086555 cyclomethicone Drugs 0.000 claims description 4
- UZBQIPPOMKBLAS-UHFFFAOYSA-N diethylazanide Chemical compound CC[N-]CC UZBQIPPOMKBLAS-UHFFFAOYSA-N 0.000 claims description 4
- 150000002170 ethers Chemical class 0.000 claims description 4
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- ZUHZZVMEUAUWHY-UHFFFAOYSA-N n,n-dimethylpropan-1-amine Chemical compound CCCN(C)C ZUHZZVMEUAUWHY-UHFFFAOYSA-N 0.000 claims description 4
- KFYKZKISJBGVMR-UHFFFAOYSA-N n-ethylbutan-2-amine Chemical compound CCNC(C)CC KFYKZKISJBGVMR-UHFFFAOYSA-N 0.000 claims description 4
- BKIMMITUMNQMOS-UHFFFAOYSA-N nonane Chemical compound CCCCCCCCC BKIMMITUMNQMOS-UHFFFAOYSA-N 0.000 claims description 4
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 4
- 239000000344 soap Substances 0.000 claims description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000008117 stearic acid Substances 0.000 claims description 4
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 3
- 150000005215 alkyl ethers Chemical class 0.000 claims description 3
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 2
- NKJOXAZJBOMXID-UHFFFAOYSA-N 1,1'-Oxybisoctane Chemical compound CCCCCCCCOCCCCCCCC NKJOXAZJBOMXID-UHFFFAOYSA-N 0.000 claims description 2
- ZQCIPRGNRQXXSK-UHFFFAOYSA-N 1-octadecoxypropan-2-ol Chemical compound CCCCCCCCCCCCCCCCCCOCC(C)O ZQCIPRGNRQXXSK-UHFFFAOYSA-N 0.000 claims description 2
- HANWHVWXFQSQGJ-UHFFFAOYSA-N 1-tetradecoxytetradecane Chemical compound CCCCCCCCCCCCCCOCCCCCCCCCCCCCC HANWHVWXFQSQGJ-UHFFFAOYSA-N 0.000 claims description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims description 2
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 claims description 2
- OBETXYAYXDNJHR-UHFFFAOYSA-N 2-Ethylhexanoic acid Chemical compound CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims description 2
- SFAAOBGYWOUHLU-UHFFFAOYSA-N 2-ethylhexyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(CC)CCCC SFAAOBGYWOUHLU-UHFFFAOYSA-N 0.000 claims description 2
- OPJWPPVYCOPDCM-UHFFFAOYSA-N 2-ethylhexyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CC)CCCC OPJWPPVYCOPDCM-UHFFFAOYSA-N 0.000 claims description 2
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 2
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 claims description 2
- XXBAQTDVRLRXEV-UHFFFAOYSA-N 3-tetradecoxypropan-1-ol Chemical compound CCCCCCCCCCCCCCOCCCO XXBAQTDVRLRXEV-UHFFFAOYSA-N 0.000 claims description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 2
- 235000011437 Amygdalus communis Nutrition 0.000 claims description 2
- 244000144725 Amygdalus communis Species 0.000 claims description 2
- 244000056139 Brassica cretica Species 0.000 claims description 2
- 235000003351 Brassica cretica Nutrition 0.000 claims description 2
- 235000003343 Brassica rupestris Nutrition 0.000 claims description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
- XTJFFFGAUHQWII-UHFFFAOYSA-N Dibutyl adipate Chemical compound CCCCOC(=O)CCCCC(=O)OCCCC XTJFFFGAUHQWII-UHFFFAOYSA-N 0.000 claims description 2
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 claims description 2
- 244000068988 Glycine max Species 0.000 claims description 2
- 235000010469 Glycine max Nutrition 0.000 claims description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 2
- 239000005662 Paraffin oil Substances 0.000 claims description 2
- 235000019483 Peanut oil Nutrition 0.000 claims description 2
- 241000283222 Physeter catodon Species 0.000 claims description 2
- 229920002367 Polyisobutene Polymers 0.000 claims description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 2
- 235000019484 Rapeseed oil Nutrition 0.000 claims description 2
- 229930182558 Sterol Natural products 0.000 claims description 2
- SZAMSYKZCSDVBH-CLFAGFIQSA-N [(z)-octadec-9-enyl] (z)-docos-13-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(=O)OCCCCCCCC\C=C/CCCCCCCC SZAMSYKZCSDVBH-CLFAGFIQSA-N 0.000 claims description 2
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 2
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000005907 alkyl ester group Chemical group 0.000 claims description 2
- 125000002947 alkylene group Chemical group 0.000 claims description 2
- 125000001118 alkylidene group Chemical group 0.000 claims description 2
- 229910052782 aluminium Inorganic materials 0.000 claims description 2
- 229910052788 barium Inorganic materials 0.000 claims description 2
- PXTQQOLKZBLYDY-UHFFFAOYSA-N bis(2-ethylhexyl) carbonate Chemical compound CCCCC(CC)COC(=O)OCC(CC)CCCC PXTQQOLKZBLYDY-UHFFFAOYSA-N 0.000 claims description 2
- 235000014121 butter Nutrition 0.000 claims description 2
- ULBTUVJTXULMLP-UHFFFAOYSA-N butyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCC ULBTUVJTXULMLP-UHFFFAOYSA-N 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- 239000011575 calcium Substances 0.000 claims description 2
- 239000001110 calcium chloride Substances 0.000 claims description 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 2
- ALSTYHKOOCGGFT-UHFFFAOYSA-N cis-oleyl alcohol Natural products CCCCCCCCC=CCCCCCCCCO ALSTYHKOOCGGFT-UHFFFAOYSA-N 0.000 claims description 2
- 235000019864 coconut oil Nutrition 0.000 claims description 2
- 239000003240 coconut oil Substances 0.000 claims description 2
- 235000009508 confectionery Nutrition 0.000 claims description 2
- SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 claims description 2
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- VJZWIFWPGRIJSN-XRHABHTOSA-N dilinoleic acid Chemical class CCCCC\C=C/C\C=C/CCCCCCCC(O)=O.CCCCC\C=C/C\C=C/CCCCCCCC(O)=O VJZWIFWPGRIJSN-XRHABHTOSA-N 0.000 claims description 2
- 239000003792 electrolyte Substances 0.000 claims description 2
- CAMHHLOGFDZBBG-UHFFFAOYSA-N epoxidized methyl oleate Natural products CCCCCCCCC1OC1CCCCCCCC(=O)OC CAMHHLOGFDZBBG-UHFFFAOYSA-N 0.000 claims description 2
- ZYNDJIBBPLNPOW-UHFFFAOYSA-N eurucic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCCCCCC(=O)OC ZYNDJIBBPLNPOW-UHFFFAOYSA-N 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 2
- YQNXSNGULXTRIW-UHFFFAOYSA-N hexan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)CCCC YQNXSNGULXTRIW-UHFFFAOYSA-N 0.000 claims description 2
- 229940100554 isononyl isononanoate Drugs 0.000 claims description 2
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims description 2
- 229940089456 isopropyl stearate Drugs 0.000 claims description 2
- 229940119170 jojoba wax Drugs 0.000 claims description 2
- 229940070765 laurate Drugs 0.000 claims description 2
- 229960004232 linoleic acid Drugs 0.000 claims description 2
- 229940057995 liquid paraffin Drugs 0.000 claims description 2
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- 239000011777 magnesium Substances 0.000 claims description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- ZYNDJIBBPLNPOW-KHPPLWFESA-N methyl erucate Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(=O)OC ZYNDJIBBPLNPOW-KHPPLWFESA-N 0.000 claims description 2
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 claims description 2
- 239000002480 mineral oil Substances 0.000 claims description 2
- 235000010446 mineral oil Nutrition 0.000 claims description 2
- 230000004048 modification Effects 0.000 claims description 2
- 238000012986 modification Methods 0.000 claims description 2
- 235000010460 mustard Nutrition 0.000 claims description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 2
- SZHOJFHSIKHZHA-UHFFFAOYSA-N n-Tridecanoic acid Natural products CCCCCCCCCCCCC(O)=O SZHOJFHSIKHZHA-UHFFFAOYSA-N 0.000 claims description 2
- KKBOOQDFOWZSDC-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)NCCN(CC)CC KKBOOQDFOWZSDC-UHFFFAOYSA-N 0.000 claims description 2
- AFFLGGQVNFXPEV-UHFFFAOYSA-N n-decene Natural products CCCCCCCCC=C AFFLGGQVNFXPEV-UHFFFAOYSA-N 0.000 claims description 2
- VLYFHHYLZLDEIU-UHFFFAOYSA-N n-ethyloctadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)NCC VLYFHHYLZLDEIU-UHFFFAOYSA-N 0.000 claims description 2
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 2
- FBUKVWPVBMHYJY-UHFFFAOYSA-M nonanoate Chemical compound CCCCCCCCC([O-])=O FBUKVWPVBMHYJY-UHFFFAOYSA-M 0.000 claims description 2
- IIGMITQLXAGZTL-UHFFFAOYSA-N octyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCC IIGMITQLXAGZTL-UHFFFAOYSA-N 0.000 claims description 2
- 229940055577 oleyl alcohol Drugs 0.000 claims description 2
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 2
- 229940120511 oleyl erucate Drugs 0.000 claims description 2
- PXDJXZJSCPSGGI-UHFFFAOYSA-N palmityl palmitate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 claims description 2
- 239000000312 peanut oil Substances 0.000 claims description 2
- 229940096956 ppg-11 stearyl ether Drugs 0.000 claims description 2
- 229940078491 ppg-15 stearyl ether Drugs 0.000 claims description 2
- 229940116987 ppg-3 myristyl ether Drugs 0.000 claims description 2
- ZPWFUIUNWDIYCJ-UHFFFAOYSA-N propan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C ZPWFUIUNWDIYCJ-UHFFFAOYSA-N 0.000 claims description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 229960003656 ricinoleic acid Drugs 0.000 claims description 2
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000001509 sodium citrate Substances 0.000 claims description 2
- NGSFWBMYFKHRBD-UHFFFAOYSA-N sodium;2-hydroxypropanoic acid Chemical compound [Na+].CC(O)C(O)=O NGSFWBMYFKHRBD-UHFFFAOYSA-N 0.000 claims description 2
- 229940032094 squalane Drugs 0.000 claims description 2
- 229940032160 stearamidoethyl diethylamine Drugs 0.000 claims description 2
- 235000003702 sterols Nutrition 0.000 claims description 2
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 2
- 229940038773 trisodium citrate Drugs 0.000 claims description 2
- 229940099259 vaseline Drugs 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000010698 whale oil Substances 0.000 claims description 2
- 229910052725 zinc Inorganic materials 0.000 claims description 2
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Abstract
乳化剂组合物，其包含油包水乳化剂和具有R1-C(O)-NH-R2-N(R3)(R4)结构的酰胺基胺的脂肪盐或由相应的脂肪酸和酰胺基胺组成的其前体混合物。油包水型乳液的制备方法包括通过使用所述乳化剂组合物将全部油相和水相一起快速混合。本发明还提供包含所述乳化剂组合物的油包水型乳液。
Description
技术领域
本发明涉及一种乳化剂组合物以及其在油包水型乳液制备中的用途。
背景技术
油包水型乳液，特别是高内相含量油包水型乳液，以它们特有的皮肤感觉、耐水性和皮肤保湿性而闻名。目前，它们是通过在搅拌下将内部水相缓慢地添加到含乳化剂的油相中来制备的。然而，在该方法期间，水相必须"缓慢地"添加以使所有水能够作为内相被稳定地包封在油相中。如果直接混合全部水相和全部油相并均匀化，则即使延长匀化时间，也不能得到油包水型乳液。
上述方法与名为"一步乳化"的制备水包油型乳液的常规方法有很大不同，在该常规方法中，将所有水和油相立即混合，然后均匀化。由于水包油型乳液容易获得，因而化妆品厂商喜欢使用水包油型乳液。在一定程度上，目前制备油包水型乳液的不便利的方法限制了油包水型乳液的应用和推广。
发明内容
本发明提供一种乳化剂组合物，其可改进油包水型乳液的制备方法。
本发明进一步提供一种油包水型乳液，其包含本发明的乳化剂组合物。
本发明进一步提供本发明的油包水型乳液的制备方法。
通过使用本发明的乳化剂组合物，可通过将内相和外相简单混合得到油包水型乳液，这比常规方法更方便。
本发明的详细说明
本发明的乳化剂组合物包含
a)至少一种油包水乳化剂；
b)至少一种酰胺基胺的脂肪酸盐或由相应的脂肪酸和酰胺基胺组成的其前体混合物，所述脂肪酸具有8-22个碳原子，所述酰胺基胺具有下述结构：
R1-C(O)-NH-R2-N(R3)(R4)；
其中R1为具有7-21个碳原子的脂族烃基；R2为具有1-4个碳原子的亚烃基；R3和R4独立地为具有1-4个碳原子的烃基。
优选地，基于所述乳化剂组合物的总重量，组分a)构成50-99.5％、更优选80-99％；组分b)构成0.5-50％、更优选1-20％。
优选组分a)选自HLB值小于12、优选HLB值为2-8的表面活性剂，所述HLB根据Davies法计算。
优选组分a)具有选自聚氧化乙烯基、聚氧化丙烯基、聚甘油基、聚氧化乙烯山梨聚糖基的亲水基团。
优选组分a)可以是选自下述三类的一种或多种：
第一类：具有聚硅氧烷+亲水基团+烷基的分子链结构的乳化剂，其包含通过共价键连接的聚硅氧烷、聚醚多元醇和C1-C22脂族烷烃的嵌段共聚物乳化剂；具有聚硅氧烷链作为主链和分别通过共价键连接到聚硅氧烷主链的聚醚多元醇和C1-C22脂族烷基作为侧基的乳化剂；和具有聚硅氧烷链作为主链、通过共价键连接到聚硅氧烷链的C1-C22脂族烷基改性的聚醚多元醇作为侧基的乳化剂；优选C6-C20烷基共聚合的聚氧化乙烯聚二甲基硅氧烷，和更优选鲸蜡基PEG/PPG-10/1聚二甲基硅氧烷(例如，由EvonikGoldschmidt GmbH以商品名EM90或EM180供应的那种)；
第二类：具有聚硅氧烷+亲水基团的分子链结构的乳化剂，所述乳化剂包含具有通过共价键连接的聚硅氧烷和聚醚多元醇的嵌段共聚物乳化剂；具有聚硅氧烷链作为主链和通过共价键连接到聚硅氧烷主链的聚醚多元醇作为侧基的乳化剂；优选聚氧化乙烯聚二甲基硅氧烷、聚甘油聚二甲基硅氧烷，和更优选双-PEG/PPG-14/14聚二甲基硅氧烷(例如，由EvonikGoldschmidt GmbH以商品名EM97供应的那种)；和
第三类：由非直链结构或直链结构的聚醚多元醇或多元醇通过其羟基与C1-C22脂肪酸形成的酯类乳化剂；或由聚醚多元醇或多元醇通过其羟基与C1-C22脂肪醇形成的醚类乳化剂，其包含聚氧化乙烯脂肪酸酯、聚氧化乙烯烷基醚、单-或聚甘油脂肪酸酯、单-或聚甘油烷基醚，优选二异硬脂醇聚甘油基-3二聚物二亚油酸酯(例如由Evonik Goldschmidt GmbH以商品名GPS供应的那种)、聚甘油基-4二异硬脂酸酯/聚羟基硬脂酸酯/癸二酸酯(例如由Evonik Degussa GmbH以商品名GPS供应的那种)、聚甘油基-4硬脂酸酯(例如根据商品名GI 34的那种)和聚氧化乙烯山梨聚糖脂肪酸酯。
上述鲸蜡基PEG/PPG-10/1聚二甲基硅氧烷(例如由Evonik GoldschmidtGmbH以商品名EM90供应的那种)可具有下述结构：
其中R为鲸蜡基，x＝10，y＝1、n＝1-200、o＝1-100、m＝1-40，其分子量为14000g/mol。
优选地，在组分b)酰胺基胺的结构中，R1为烷基。优选R1为具有15-21个碳原子的直链或支链烷基。
优选地，在组分b)酰胺基胺的结构中，R2为亚烷基。
优选地，在组分b)酰胺基胺的结构中，R3和R4独立地为烷基。
更优选所述酰胺基胺选自硬脂酰胺基丙基二甲基胺、硬脂酰胺基丙基二乙基胺、硬脂酰胺基乙基二乙基胺、硬脂酰胺基乙基二甲基胺、棕榈酰胺基丙基二甲基胺、棕榈酰胺基丙基二乙基胺、棕榈酰胺基乙基二乙基胺、棕榈酰胺基乙基二甲基胺、山嵛酰胺基丙基二甲基胺、山嵛酰胺基丙基二乙基胺、山嵛酰胺基乙基二乙基胺、山嵛酰胺基乙基二甲基胺、花生酸酰胺基丙基二甲基胺、花生酸酰胺基丙基二乙基胺、花生酸酰胺基乙基二乙基胺、花生酸酰胺基乙基二甲基胺和二乙基胺基乙基硬脂酰胺。
组分b)的脂肪酸不限于直链或支链的、饱和或不饱和脂肪酸。
更优选组分b)的脂肪酸选自月桂酸、异硬脂酸、硬脂酸、肉豆蔻酸、油酸和棕榈酸。
脂肪酸与酰胺基胺的当量比优选为0.5-5:1，更优选0.9-1.5:1，特别是1:1。
任选地，本发明的乳化剂进一步包含：c)至少一种脂肪酸的金属盐，所述脂肪酸盐具有8-22个碳原子。
优选地，基于所述乳化剂组合物的总重量，当存在脂肪酸的金属盐时，组分a)构成30-90％、更优选40-80％，组分b构成0.5-10％、更优选1-8％，组分c)构成5-65％、更优选20-50％。
组分c)的脂肪酸不限于直链或支链的、饱和或不饱和脂肪酸。
更优选组分c)的脂肪酸选自月桂酸、异硬脂酸、硬脂酸、肉豆蔻酸、油酸和棕榈酸。
组分c)的金属优选选自Ba、Mg、Al、Zn和Ca。
本发明进一步提供包含d)油相、e)水相、f)本发明的乳化剂组合物的油包水型乳液。
优选地，基于所述乳液的总重量，所述油相构成15-65％、更优选20-50％，所述水相构成30-80％、更优选50-80％，所述乳化剂组合物构成1-10％、更优选2-5％。
所述油相优选为选自硅氧烷、脂肪族烃、醇类、酯类和醚类的一种或多种。
更优选所述油相为选自下述的一种或多种：聚二甲基硅氧烷、环聚二甲基硅氧烷、芳基-或烷基-或烷氧基-取代的聚二甲基硅氧烷或环聚二甲基硅氧烷、月桂酸甲酯、月桂酸正己酯、月桂酸2-乙基己酯、硬脂酸甲酯、硬脂酸异丙酯、硬脂酸正丁酯、硬脂酸辛酯、硬脂酸异辛酯、硬脂酸2-己基癸酯、庚酸甾醇酯、油酸甲酯、油酸异丙酯、油酸癸酯、油酸油醇酯、芥醇油酸酯、亚油酸癸酯、庚酸硬脂醇酯、肉豆蔻酸异丙酯、肉豆蔻酸肉豆蔻醇酯、棕榈酸异丙酯、棕榈酸辛酯、棕榈酸异壬酯、棕榈酸鲸蜡酯、棕榈酸2-乙基己酯、2-棕榈酸辛基十二烷基酯、异壬酸异壬酯、鲸蜡硬脂醇异壬酸酯、芥酸甲酯、芥酸油醇酯、乙基己酸鲸蜡酯、鲸蜡硬脂醇乙基己酸酯、蓖麻醇酸鲸蜡酯和碳酸二异辛酯、己二酸二正丁酯、癸二酸二正丁酯、己二酸二(2-乙基己基)酯、琥珀酸二(2-己基癸基)酯或壬二酸二异十三烷基酯、碳酸二乙基己酯、二油酸乙二醇酯、二异十三烷酸乙二醇酯、丙二醇二(2-乙基己酸酯)、二异硬脂酸丁二醇酯、二辛酸新戊二醇酯、椰油酸癸酯、棕榈酸异鲸蜡酯、辛酸/癸酸的混合物的三酸甘油酯、工业油酸的三酸甘油酯、异硬脂酸酯的三酸甘油酯、棕榈酸/油酸的混合物的三酸甘油酯、辛酸/癸酸三酸甘油酯、苯甲酸12-15烷基酯、苯甲酸异硬脂醇酯、苯甲酸辛基十二烷基酯、油醇、鲸蜡醇、硬脂醇、辛基十二烷醇、聚丙二醇-15硬脂基醚、聚丙二醇-14丁基醚、聚丙二醇-3肉豆蔻基醚、聚丙二醇-11硬脂基醚、二辛醚、PPG-11硬脂基醚、PPG-15硬脂基醚、PPG-14丁基醚、PPG-3肉豆蔻基醚、石蜡油、白矿油、异十六烷、聚异丁烯、聚癸烯、石油膏、轻液状石蜡、角鲨烷、橄榄油、向日葵籽油、豆油、花生油、菜籽油、杏仁油、棕榈油、霍霍巴油、椰子油、棕榈壳油的液体级分、鲸蜡油、牛脚油、和牛油的液体级分。
优选地，所述油包水型乳液包含任选的水可混溶性醇，优选所述水可混溶性醇为选自一元醇、二元醇或三元醇的一种或多种，更优选所述水可混溶性醇为选自1,2-丙二醇、1,3-丙二醇和甘油的一种或多种。
优选所述油包水型乳液进一步包含至少一种水溶性电解质，优选所述电解质为选自氯化钠、氯化钾、柠檬酸钠、乳酸钠、硫酸镁、氯化钙和氨基酸盐中的一种或多种。
任选地，所述油包水型乳液进一步包含至少一种用于化妆品的水溶性功能性添加剂，例如由Evonik Industries以商品名COSMO C 100、和NATURAL BETAIN供应的那些。
本发明进一步提供本发明的油包水型乳液的制备方法，其包括：1)在油相中溶解所述乳化剂组合物；2)混合水相和步骤1)中得到的产物；3)使步骤2)中得到的混合物匀化。
步骤1)优选在70-120℃下，更优选在80-110℃下进行。
步骤2)优选在70-100℃下，更优选在80-90℃下进行。
步骤3)优选在70-100℃下，更优选在80-90℃下进行。
优选步骤3)在1000-10000rpm的搅拌速度下，更优选在1500-7500rpm的搅拌速度下进行。
在本发明的油包水型乳液中，根据需要，在不损害本发明的效果的范围内，可任意引入常用于化妆品、药物等中的其它组分。
其实例包括UV防护剂、保湿剂、水溶性聚合物、增稠剂、涂布剂、金属离子螯合剂、低级醇、多元醇、pH调节剂、抗氧剂、抗氧剂助剂和香料。
本发明的油包水型乳液的应用没有特别限制，所述油包水型乳液可应用于化妆品产品如妆前霜、粉底霜、腮红、眼影膏、眼线、防晒产品和身体护理化妆品。
实施方式
化合物
以下用商品名描述的化学品具有表1中所示的组成和商业来源。
表1
配制物
下述实施例(EX1-21)和比较例(CE1、6-10)的配制物列在表2-20中。
表2
表3
表4
表5
表6
表7
表8
表9
表10
表11
表12
表13
表14
表15
表16
表17
表18
表19
表20
通用制备方法
在105℃下混合组A的组分(主要是油相和乳化剂组合物)，直到全部固体成分完全溶解。然后，将组A的混合物冷却至80℃。
在80℃下混合组B的组分(主要是水相)，直到全部固体成分完全溶解。然后，在80℃下立即混合组A和B的混合物，并在1000-10000rpm的搅拌速度下使其匀化2-5分钟。
任选地，随后添加组C的组分(防腐剂)。
并在搅拌下，将所得到的混合物冷却至室温。
对于实施例1-21，得到稳定且均匀的油包水型乳液体系。然而，对于比较例1、6-10，没有得到这种体系，在匀化停止后1分钟内，观察到层分离。
Claims (21)
1.一种乳化剂组合物，其包含
a)至少一种油包水乳化剂；
b)至少一种酰胺基胺的脂肪酸盐或由相应的脂肪酸和酰胺基胺组成的其前体混合物，所述脂肪酸具有8-22个碳原子，所述酰胺基胺具有下述结构：
R1-C(O)-NH-R2-N(R3)(R4)；
其中
R1为具有7-21个碳原子的脂族烃基；
R2为具有1-4个碳原子的亚烃基；
R3和R4独立地为具有1-4个碳原子的烃基。
2.根据权利要求1所述的乳化剂组合物，其中，基于所述乳化剂组合物的总重量，组分a)构成50-99.5％、优选80-99％；组分b)构成0.5-50％、优选1-20％。
3.根据权利要求1所述的乳化剂组合物，其进一步包含：c)至少一种脂肪酸的金属盐，所述脂肪酸盐具有8-22个碳原子。
4.根据权利要求3所述的乳化剂组合物，其中，基于所述乳化剂组合物的总重量，组分a)构成30-90％、优选40-80％，组分b)构成0.5-10％、优选1-8％，组分c)构成5-65％、优选20-50％。
5.根据前述权利要求任一项所述的乳化剂组合物，其中组分a)选自HLB值小于12、优选HLB值为2-8的表面活性剂，所述表面活性剂具有选自聚氧化乙烯基、聚氧化丙烯基、聚甘油基、聚氧化乙烯山梨聚糖基中的亲水基团。
6.根据前述权利要求任一项所述的乳化剂组合物，其中组分a)为选自下述三类中的一种或多种：
第一类：具有聚硅氧烷+亲水基团+烷基的分子链结构的乳化剂，其包含通过共价键连接的聚硅氧烷、聚醚多元醇和C1-C22脂族烷烃的嵌段共聚物乳化剂；具有聚硅氧烷链作为主链和分别通过共价键连接到聚硅氧烷主链的聚醚多元醇和C1-C22脂族烷基作为侧基的乳化剂；和具有聚硅氧烷链作为主链、通过共价键连接到聚硅氧烷链的C1-C22脂族烷基改性的聚醚多元醇作为侧基的乳化剂；
第二类：具有聚硅氧烷+亲水基团的分子链结构的乳化剂，所述乳化剂包含具有通过共价键连接的聚硅氧烷和聚醚多元醇的嵌段共聚物乳化剂；具有聚硅氧烷链作为主链和通过共价键连接到聚硅氧烷主链的聚醚多元醇作为侧基的乳化剂；和
第三类：由非直链结构或直链结构的聚醚多元醇或多元醇通过其羟基与C1-C22脂肪酸形成的酯类乳化剂；或由聚醚多元醇或多元醇通过其羟基与C1-C22脂肪醇形成的醚类乳化剂，其包含聚氧化乙烯脂肪酸酯、聚氧化乙烯烷基醚、单-或聚-甘油脂肪酸酯、单-或聚-甘油烷基醚。
7.根据前述权利要求任一项所述的乳化剂组合物，其中组分a)选自聚氧化乙烯聚二甲基硅氧烷、聚甘油聚二甲基硅氧烷，双-PEG/PPG-14/14聚二甲基硅氧烷、二异硬脂醇聚甘油基-3二聚物二亚油酸酯、聚甘油基-4二异硬脂酸酯/聚羟基硬脂酸酯/癸二酸酯、聚甘油基-4硬脂酸酯、聚氧化乙烯山梨聚糖脂肪酸酯和具有下述结构的鲸蜡基PEG/PPG-10/1聚二甲基硅氧烷：
其中R为鲸蜡基，x＝10、y＝1、n＝1-200、o＝1-100、m＝1-40，其分子量为14000g/mol，
优选组分a)为由Evonik Goldschmidt GmbH以商品名EM90或EM180提供的产品。
8.根据前述权利要求任一项所述的乳化剂组合物，其中，R1为烷基，优选具有15-21个碳原子的烷基，R2为亚烷基，R3和R4独立地为烷基，
和更优选所述组分b)的酰胺基胺选自硬脂酰胺基丙基二甲基胺、硬脂酰胺基丙基二乙基胺、硬脂酰胺基乙基二乙基胺、硬脂酰胺基乙基二甲基胺、棕榈酰胺基丙基二甲基胺、棕榈酰胺基丙基二乙基胺、棕榈酰胺基乙基二乙基胺、棕榈酰胺基乙基二甲基胺、山嵛酰胺基丙基二甲基胺、山嵛酰胺基丙基二乙基胺、山嵛酰胺基乙基二乙基胺、山嵛酰胺基乙基二甲基胺、花生酸酰胺基丙基二甲基胺、花生酸酰胺基丙基二乙基胺、花生酸酰胺基乙基二乙基胺、花生酸酰胺基乙基二甲基胺和二乙基胺基乙基硬脂酰胺。
9.根据前述权利要求任一项所述的乳化剂组合物，其中所述组分b)的脂肪酸选自月桂酸、异硬脂酸、硬脂酸、肉豆蔻酸、油酸和棕榈酸。
10.根据前述权利要求任一项所述的乳化剂组合物，其中在所述前体混合物中，所述脂肪酸与酰胺基胺的当量比为0.5-5:1，优选0.9-1.5:1，更优选1:1。
11.根据权利要求3-10任一项所述的乳化剂组合物，其中所述组分c)的脂肪酸选自月桂酸、异硬脂酸、硬脂酸、肉豆蔻酸、油酸和棕榈酸。
12.根据前述权利要求任一项所述的乳化剂组合物，其中所述组分c)的金属选自Ba、Mg、Al、Zn和Ca。
13.一种油包水型乳液，其包含
d)油相；
e)水相；
f)根据前述权利要求任一项的乳化剂组合物。
14.根据权利要求13所述的油包水型乳液，其中，基于所述乳液的总重量，所述油相构成15-65％、优选20-50％，所述水相构成30-80％、优选50-80％，所述乳化剂组合物构成1-10％、优选2-5％。
15.根据权利要求13或14所述的油包水型乳液，其中所述油相为选自硅氧烷、脂肪族烃、醇类、酯类和醚类中的一种或多种。
16.根据权利要求13-15任一项所述的油包水型乳液，其中所述油相为选自下述的一种或多种：聚二甲基硅氧烷、环聚二甲基硅氧烷、芳基-或烷基-或烷氧基-取代的聚二甲基硅氧烷或环聚二甲基硅氧烷、月桂酸甲酯、月桂酸正己酯、月桂酸2-乙基己酯、硬脂酸甲酯、硬脂酸异丙酯、硬脂酸正丁酯、硬脂酸辛酯、硬脂酸异辛酯、硬脂酸2-己基癸酯、庚酸甾醇酯、油酸甲酯、油酸异丙酯、油酸癸酯、油酸油醇酯、芥醇油酸酯、亚油酸癸酯、庚酸硬脂醇酯、肉豆蔻酸异丙酯、肉豆蔻酸肉豆蔻酯、棕榈酸异丙酯、棕榈酸辛酯、棕榈酸异壬酯、棕榈酸鲸蜡酯、棕榈酸2-乙基己酯、2-棕榈酸辛基十二烷基酯、异壬酸异壬酯、鲸蜡硬脂醇异壬酸酯、芥酸甲酯、芥酸油醇酯、乙基己酸鲸蜡酯、鲸蜡硬脂醇乙基己酸酯、蓖麻醇酸鲸蜡酯和碳酸二异辛酯、己二酸二正丁酯、癸二酸二正丁酯、己二酸二(2-乙基己基)酯、琥珀酸二(2-己基癸基)酯或壬二酸二异十三烷基酯、碳酸二乙基己酯、二油酸乙二醇酯、二异十三烷酸乙二醇酯、丙二醇二(2-乙基己酸酯)、二异硬脂酸丁二醇酯、二辛酸新戊二醇酯、椰油酸癸酯、棕榈酸异鲸蜡酯、辛酸/癸酸的混合物的三酸甘油酯、工业油酸的三酸甘油酯、异硬脂酸酯的三酸甘油酯、棕榈酸/油酸的混合物的三酸甘油酯、辛酸/癸酸的三酸甘油酯、苯甲酸12-15烷基酯、苯甲酸异硬脂醇酯、苯甲酸辛基十二烷基酯、油醇、鲸蜡醇、硬脂醇、辛基十二烷醇、聚丙二醇-15硬脂基醚、聚丙二醇-14丁基醚、聚丙二醇-3肉豆蔻基醚、聚丙二醇-11硬脂基醚、二辛醚、PPG-11硬脂基醚、PPG-15硬脂基醚、PPG-14丁基醚、PPG-3肉豆蔻基醚、石蜡油、白矿油、异十六烷、聚异丁烯、聚癸烯、石油膏、轻液状石蜡、角鲨烷、橄榄油、向日葵籽油、豆油、花生油、菜籽油、杏仁油、棕榈油、霍霍巴油、椰子油、棕榈壳油的液体级分、鲸蜡油、牛脚油、和牛油的液体级分。
17.根据权利要求13-16任一项所述的油包水型乳液，其中所述油包水型乳液包含任选存在的水可混溶性醇，优选所述水可混溶性醇为选自一元醇、二元醇或三元醇中的一种或多种，更优选所述水可混溶性醇为选自1,2-丙二醇、1,3-丙二醇和甘油中的一种或多种。
18.根据权利要求13-17任一项所述的油包水型乳液，其中所述油包水型乳液进一步包含水溶性电解质，优选所述电解质为选自氯化钠、氯化钾、柠檬酸钠、乳酸钠、硫酸镁、氯化钙和氨基酸盐中的一种或多种。
19.根据利要求13-18任一项所述的油包水型乳液的制备方法，其包括：
1)在所述油相中溶解所述乳化剂组合物；
2)混合所述水相和步骤1)中得到的产物；
3)使步骤2)中得到的混合物匀化。
20.根据权利要求19所述的方法，其中
步骤1)在70-120℃、优选80-110℃下进行，
步骤2)在70-100℃、优选80-90℃下进行，
步骤3)在70-100℃、优选80-90℃下进行。
21.根据权利要求19或20所述的方法，其中，步骤3)在1000-10000rpm、优选在1500-7500rpm的搅拌速度下进行。
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| CN104906553B (zh) * | 2015-07-09 | 2018-10-16 | 昆明贝泰妮生物科技有限公司 | 一种油包水婴儿护臀霜及其制备方法 |
| CN108208194B (zh) * | 2016-12-09 | 2021-12-31 | 嘉里特种油脂（上海）有限公司 | 一种抗渗油组合物 |
| JP6410873B1 (ja) | 2017-05-30 | 2018-10-24 | 高級アルコール工業株式会社 | Ｗ／ｏ型乳化物およびこれを製造するためのプレミックス |
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| ATE533832T1 (de) * | 2005-10-24 | 2011-12-15 | Procter & Gamble | Textilpflegezusammensetzungen und systeme mit siliciumorganischen mikroemulsionen sowie verfahren damit |
| DE102009002415A1 (de) * | 2009-04-16 | 2010-10-21 | Evonik Goldschmidt Gmbh | Emulgator enthaltend glycerinmodifizierte Organopolysiloxane |
| CN101987069B (zh) * | 2009-07-31 | 2013-09-04 | 赢创高施米特有限公司 | 热稳定的水包油微乳液 |
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2012
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105854965A (zh) * | 2016-06-12 | 2016-08-17 | 北京大学 | 一种用于离心法产生油包水液滴的油相组合物 |
| WO2017215429A1 (zh) * | 2016-06-12 | 2017-12-21 | 北京大学 | 一种用于离心法产生油包水液滴的油相组合物 |
| CN106967991A (zh) * | 2017-02-24 | 2017-07-21 | 谢松甫 | 铁丝脱脂、去杂的方法及其在镀锌生产工艺中的应用 |
| CN111356430A (zh) * | 2017-11-20 | 2020-06-30 | 赢创运营有限公司 | 油包水乳化剂组合物及其用途 |
| US11814619B2 (en) | 2021-06-04 | 2023-11-14 | Enumerix, Inc. | Compositions, methods, and systems for single cell barcoding and sequencing |
| US11834714B2 (en) | 2021-12-20 | 2023-12-05 | Enumerix, Inc. | Detection and digital quantitation of multiple targets |
Also Published As
| Publication number | Publication date |
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| CN104284970B (zh) | 2018-03-09 |
| WO2013170419A1 (en) | 2013-11-21 |
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