CN104276979A - 阿戈美拉汀中间体的制备方法 - Google Patents
阿戈美拉汀中间体的制备方法 Download PDFInfo
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- CN104276979A CN104276979A CN201310288975.4A CN201310288975A CN104276979A CN 104276979 A CN104276979 A CN 104276979A CN 201310288975 A CN201310288975 A CN 201310288975A CN 104276979 A CN104276979 A CN 104276979A
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- VPXDDUIYFMKQBI-UHFFFAOYSA-N CCOC(Cc1c(cc(cc2)OC)c2ccc1)=O Chemical compound CCOC(Cc1c(cc(cc2)OC)c2ccc1)=O VPXDDUIYFMKQBI-UHFFFAOYSA-N 0.000 description 2
- LGYBVRIYYBHYCX-UHFFFAOYSA-N COc1ccc(cccc2CC(N)=O)c2c1 Chemical compound COc1ccc(cccc2CC(N)=O)c2c1 LGYBVRIYYBHYCX-UHFFFAOYSA-N 0.000 description 2
- YGQGNMIYRSARLD-UHFFFAOYSA-N C1C2=C1C[IH]C2 Chemical compound C1C2=C1C[IH]C2 YGQGNMIYRSARLD-UHFFFAOYSA-N 0.000 description 1
- DZVOFMZTFOZYJS-UHFFFAOYSA-N CCOC(Cc1c(cc(cc2)[U]C)c2ccc1)=O Chemical compound CCOC(Cc1c(cc(cc2)[U]C)c2ccc1)=O DZVOFMZTFOZYJS-UHFFFAOYSA-N 0.000 description 1
- HQEWKSLKIYGZPI-UHFFFAOYSA-N CCOC(Cc1cccc(cc2)c1cc2OC)=[U-] Chemical compound CCOC(Cc1cccc(cc2)c1cc2OC)=[U-] HQEWKSLKIYGZPI-UHFFFAOYSA-N 0.000 description 1
- WEGCBJCHDIGTOV-UHFFFAOYSA-N CC[O](C(Cc1cccc(cc2)c1cc2OC)=O)I Chemical compound CC[O](C(Cc1cccc(cc2)c1cc2OC)=O)I WEGCBJCHDIGTOV-UHFFFAOYSA-N 0.000 description 1
- SOBVVRLZLPQQLE-UHFFFAOYSA-N CC[O](C)C(CC(c1c2)=CCCc1ccc2OC)=O Chemical compound CC[O](C)C(CC(c1c2)=CCCc1ccc2OC)=O SOBVVRLZLPQQLE-UHFFFAOYSA-N 0.000 description 1
- GABLTKRIYDNDIN-UHFFFAOYSA-N COc1ccc(CCCC2=O)c2c1 Chemical compound COc1ccc(CCCC2=O)c2c1 GABLTKRIYDNDIN-UHFFFAOYSA-N 0.000 description 1
- PYJMGUQHJINLLD-UHFFFAOYSA-N COc1ccc(cccc2CC#N)c2c1 Chemical compound COc1ccc(cccc2CC#N)c2c1 PYJMGUQHJINLLD-UHFFFAOYSA-N 0.000 description 1
Abstract
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Priority Applications (1)
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CN201310288975.4A CN104276979B (zh) | 2013-07-10 | 2013-07-10 | 阿戈美拉汀中间体的制备方法 |
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CN201310288975.4A CN104276979B (zh) | 2013-07-10 | 2013-07-10 | 阿戈美拉汀中间体的制备方法 |
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CN104276979A true CN104276979A (zh) | 2015-01-14 |
CN104276979B CN104276979B (zh) | 2018-09-07 |
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CN201310288975.4A Active CN104276979B (zh) | 2013-07-10 | 2013-07-10 | 阿戈美拉汀中间体的制备方法 |
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CN (1) | CN104276979B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112574066A (zh) * | 2019-09-27 | 2021-03-30 | 江苏豪森药业集团有限公司 | 一种阿戈美拉汀中间体的制备方法 |
CN113444020A (zh) * | 2021-06-23 | 2021-09-28 | 常州大学 | 一种α-异丙基-3,4-二甲氧基苯乙腈的合成方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0530087A1 (fr) * | 1991-08-23 | 1993-03-03 | Adir Et Compagnie | Nouvelles naphtyléthylurées et naphtyléthylthiourées, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
WO2008141033A1 (en) * | 2007-05-08 | 2008-11-20 | Auspex Pharmaceuticals Inc. | Substituted naphthalenes |
WO2011097166A2 (en) * | 2010-02-02 | 2011-08-11 | Board Of Regents, The University Of Texas System | Combination therapy for treating cancer comprising an igf-1r inhibitor and an hdac inhibitor |
CN102452951A (zh) * | 2010-10-25 | 2012-05-16 | 天津泰普药品科技发展有限公司 | 阿戈美拉汀及其药物组合物 |
WO2012070025A1 (en) * | 2010-11-26 | 2012-05-31 | Cadila Pharmaceuticals Ltd | Process for the preparation of agomelatine |
-
2013
- 2013-07-10 CN CN201310288975.4A patent/CN104276979B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0530087A1 (fr) * | 1991-08-23 | 1993-03-03 | Adir Et Compagnie | Nouvelles naphtyléthylurées et naphtyléthylthiourées, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
WO2008141033A1 (en) * | 2007-05-08 | 2008-11-20 | Auspex Pharmaceuticals Inc. | Substituted naphthalenes |
WO2011097166A2 (en) * | 2010-02-02 | 2011-08-11 | Board Of Regents, The University Of Texas System | Combination therapy for treating cancer comprising an igf-1r inhibitor and an hdac inhibitor |
CN102452951A (zh) * | 2010-10-25 | 2012-05-16 | 天津泰普药品科技发展有限公司 | 阿戈美拉汀及其药物组合物 |
WO2012070025A1 (en) * | 2010-11-26 | 2012-05-31 | Cadila Pharmaceuticals Ltd | Process for the preparation of agomelatine |
Non-Patent Citations (2)
Title |
---|
TANG, JIA-DENG等: "A practical synthesis of (7-methoxynaphth-1-yl)acetic acid", 《ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL》 * |
顾翼东: "《化学词典》", 30 September 1989 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112574066A (zh) * | 2019-09-27 | 2021-03-30 | 江苏豪森药业集团有限公司 | 一种阿戈美拉汀中间体的制备方法 |
CN113444020A (zh) * | 2021-06-23 | 2021-09-28 | 常州大学 | 一种α-异丙基-3,4-二甲氧基苯乙腈的合成方法 |
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CN104276979B (zh) | 2018-09-07 |
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Address after: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Applicant after: JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. Applicant after: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address before: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Applicant before: JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. Applicant before: JIANGSU HANSOH PHARMACEUTICAL GROUP LIANYUNGANG HONGCHUANG PHARMACEUTICAL Co.,Ltd. |
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Address after: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Applicant after: JIANGSU HANSOH PHARMACEUTICAL GROUP Co.,Ltd. Applicant after: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address before: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Applicant before: Jiangsu best Pharmaceutical Co.,Ltd. Applicant before: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address after: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Applicant after: Jiangsu best Pharmaceutical Co.,Ltd. Applicant after: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address before: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Applicant before: JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. Applicant before: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. |
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