CN104274455B - 含苄基哌嗪槲皮素衍生物制法及其对胃黏膜保护作用 - Google Patents
含苄基哌嗪槲皮素衍生物制法及其对胃黏膜保护作用 Download PDFInfo
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- CN104274455B CN104274455B CN201410492930.3A CN201410492930A CN104274455B CN 104274455 B CN104274455 B CN 104274455B CN 201410492930 A CN201410492930 A CN 201410492930A CN 104274455 B CN104274455 B CN 104274455B
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- Prior art keywords
- quercetin
- containing benzyl
- benzyl diethylenediamine
- quercetin derivative
- medicine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
样品 | 胃黏膜损伤抑制率(%) |
阳性药物组 | 72.5±2.6 |
目标化合物低剂量组 | 80.4±3.4 |
目标化合物中剂量组 | 86.3±2.8 |
目标化合物高剂量组 | 98.0±4.1 |
Claims (6)
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CN201410492930.3A CN104274455B (zh) | 2014-09-24 | 2014-09-24 | 含苄基哌嗪槲皮素衍生物制法及其对胃黏膜保护作用 |
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CN201410492930.3A CN104274455B (zh) | 2014-09-24 | 2014-09-24 | 含苄基哌嗪槲皮素衍生物制法及其对胃黏膜保护作用 |
Publications (2)
Publication Number | Publication Date |
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CN104274455A CN104274455A (zh) | 2015-01-14 |
CN104274455B true CN104274455B (zh) | 2018-04-27 |
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CN201410492930.3A Active CN104274455B (zh) | 2014-09-24 | 2014-09-24 | 含苄基哌嗪槲皮素衍生物制法及其对胃黏膜保护作用 |
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CN (1) | CN104274455B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113549044B (zh) * | 2021-07-23 | 2024-01-23 | 中国药科大学 | 8-氮杂环取代色酮类衍生物及其制备方法与制药用途 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4970301A (en) * | 1987-12-01 | 1990-11-13 | Adir Et Cie | 2-(piperazinyl)-2-oxoethylene-substituted flavonoid compounds |
US5013852A (en) * | 1987-05-12 | 1991-05-07 | Kali-Chemie Pharma Gmbh | 3-flavone carboxylic acid compounds |
EP1212312A1 (en) * | 1999-09-03 | 2002-06-12 | INDENA S.p.A. | Novel derivatives of flavones, xanthones and coumarins |
CN101774993A (zh) * | 2010-02-05 | 2010-07-14 | 江苏工业学院 | 白杨素含氮衍生物及其制备方法和用途 |
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2014
- 2014-09-24 CN CN201410492930.3A patent/CN104274455B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5013852A (en) * | 1987-05-12 | 1991-05-07 | Kali-Chemie Pharma Gmbh | 3-flavone carboxylic acid compounds |
US4970301A (en) * | 1987-12-01 | 1990-11-13 | Adir Et Cie | 2-(piperazinyl)-2-oxoethylene-substituted flavonoid compounds |
EP1212312A1 (en) * | 1999-09-03 | 2002-06-12 | INDENA S.p.A. | Novel derivatives of flavones, xanthones and coumarins |
CN101774993A (zh) * | 2010-02-05 | 2010-07-14 | 江苏工业学院 | 白杨素含氮衍生物及其制备方法和用途 |
Non-Patent Citations (1)
Title |
---|
Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent;Girish D. Hatnapure等;《Bioorganic & Medicinal Chemistry Letters》;20120824(第22期);6385-6390 * |
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CN104274455A (zh) | 2015-01-14 |
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Inventor after: Zhou Quancheng Inventor after: Sheng Guihua Inventor after: Feng Chuanxing Inventor after: Wang Qi Inventor after: Li Hui Inventor after: Wang Meng Inventor before: Zhou Quancheng Inventor before: Zhang Guangyao Inventor before: Sheng Guihua Inventor before: Zhu Hailiang Inventor before: Chen Xiangfei Inventor before: Yan Shikai Inventor before: Lu Hao Inventor before: Ren Ke Inventor before: Yang Xiaoyu Inventor before: Feng Chuanxing |
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